97 research outputs found
Perspectives on intimate relationships and self-determination in young adults with Down syndrome
No full textIntimate relationships are significantly associated with quality of life for young people with Down syndrome (DS). These relationships are a facet of social participation within the scope of OT practice that is not often addressed in practice. This descriptive study explores self-determination and perceptions of intimate relationships from the perspective of young adults with DS (ages 18-30 years) and their caregivers. Implications of findings for OT practice are discussed. Primary Author and Speaker: Katherine Williams Contributing Authors: Evguenia Popova, Katie Fran
Frank Swinnerton : the life and works of a bookman
Get PDFFrank Swinnerton worked as a clerk for J.M. Dent & Co. between 1901 and 1907 and as a publisher's reader for Chatto & Windus from 1907 until 1926, during which time he began his career as a writer of fiction, became influential as a reviewer and commentator on literary fashions, and began close friendships with Arnold Bennett, HG Wells and Hugh Walpole. In 1926 he left London to live in Cranleigh, Surrey, as a full-time writer of novels, short stories, critical works, book and theatre reviews, and miscellaneous articles for newspapers and periodicals. He died at the age of ninety-eight in 1982. This is the first biography of Frank Swinnerton to be undertaken in Great Britain. An analysis has been made of each of his works, both novels and non-fiction. His influence in literary circles has been assessed, and his contribution to the book world is placed within the background of literary output and trends in the twentieth century. Swinnerton was not a great writer, but his temperament, circumstances and talent combined to produce a respected literary figure whose strength was his perception and understanding of the progress of the British literary world through the centuries.
Swinnerton's numerous friendships are dealt with as they occurred, although major relationships are examined more fully at the point where the friend died. For example, details on HG Wells can be found with his death in 1946 and on Compton Mackenzie with his death in 1972. Greater space has been given to his involvements with Arnold Bennett and Hugh Walpole, in separate chapters placed close to the time of their deaths in 1931 and 1941. One other chapter stands out of sequence. This examines Swinnerton's relationship with his two wives: his complex courtship of Helen Dircks and his second marriage to Mary Bennett. This period, between 1917 and 1924, which also includes a
description of his first lecture tour of the USA in 1923, has been placed immediately after chapters 7 and 8, which examine Swinnerton's general life and work during the same period. Apart from published works and newspaper and periodical articles, the main material used has been Swinnerton's personal diaries, which date from 1910 to 1978, and the correspondence and miscellaneous papers in his personal possession. Also consulted has been a doctoral thesis by Jesse Franklin McCartney presented to the University of Arkansas in 1965, which annotates the large collection of correspondence by Frank Swinnerton to writers, publishers, boakmen and other literary figures, as well as their
replies, which are housed in the University library. Full texts of these letters have been obtained where appropriate and used in this work. Professor Blair Rouse of the University of Arkansas wrote a critical appreciation of Swinnerton's work in the 1960s and his widow has allowed use of the unpublished manuscript and letters exchanged between Rouse and Swinnerton, and has sent correspondence between Swinnerton and the Pinker family. Finally, Swinnerton's friends and family have provided facts, opinions and reminiscences
The Moving Image in the Theatre: CONTEMPORARY SCHOLARSHIP AND THE COMBINATION OF FILM AND THEATRE GRAMMARS IN THE THEATRICAL EVENT
Get PDFA host of value judgments are implicit in the rhetoric and methodology of contemporary scholarship relating to the use of the moving image in the live theatre. Human performance is often fetishized in these studies, whilst the moving image is admonished as a contaminant which brings into the theatrical event a host of cultural paraphernalia including a perceived ideology derived from its mediatized code. These problematic assumptions have sustained a self-limiting paradigm of ‘intermediality’ that offers a narrow vocabulary through which to notate contemporary mainstream theatre productions that use video projection, such as Katie Mitchell’s Waves (2006) and the National Theatre of Scotland’s Black Watch (2006). This thesis offers a radical departure from contemporary scholarship by unpicking the logic of the existing discourse to construct a new paradigm that embraces the creative grammars of mainstream theatre and moving image productions
A revised protocol for culture of airway epithelial cells as a diagnostic tool for primary ciliary dyskinesia
No full textAir-liquid interface (ALI) culture of nasal epithelial cells is a valuable tool in the diagnosis and research of primary ciliary dyskinesia (PCD). Ex vivo samples often display secondary dyskinesia from cell damage during sampling, infection or inflammation confounding PCD diagnostic results. ALI-culture enables regeneration of healthy cilia facilitating differentiation of primary from secondary ciliary dyskinesia. We describe a revised ALI-culture method adopted from April 2018 across three collaborating PCD diagnostic sites, including current University Hospital Southampton COVID-19 risk mitigation measures, and present results. Two hundred and forty nasal epithelial cell samples were seeded for ALI-culture and 199 (82.9%) ciliated. Fifty-four of 83 (63.9%) ex vivo samples which were originally equivocal or insufficient provided diagnostic information following in vitro culture. Surplus basal epithelial cells from 181 nasal brushing samples were frozen in liquid nitrogen; 39 samples were ALI-cultured after cryostorage and all ciliated. The ciliary beat patterns of ex vivo samples (by high-speed video microscopy) were recapitulated, scanning electron microscopy demonstrated excellent ciliation, and cilia could be immuno-fluorescently labelled (anti-alpha-tubulin and anti-RSPH4a) in representative cases that were ALI-cultured after cryostorage. In summary, our ALI-culture protocol provides high ciliation rates across three centres, minimising patient recall for repeat brushing biopsies and improving diagnostic certainty. Cryostorage of surplus diagnostic samples was successful, facilitating PCD researc
Modernism, antisemitism and Jewish identity in the writing and publishing of John Rodker
Get PDFThis thesis examines the relationship between the English Jewish writer and publisher John Rodker and the modernism of the Pound circle. Previous considerations of the antisemitism of Ezra Pound and T. S. Eliot have either
ignored or cited in their defence their Jewish friends and acquaintances. This thesis shows that the modernist interest in the figure of `the Jew' took effect not only in
their poetry and social commentary but also in the social grouping which they formed in order to produce and circulate this writing. Rodker was both a necessary
figure to Pound's theory and practice of modernism, but one who had to be kept on the margins. This resulted in his being able to articulate certain aspects of his
experience as an assimilated Jew-loss, disconnection, feeling out of place place-while excluding any other possible aspects, including naming himself as Jewish.
Chapter 1 shows that Pound and Eliot's antisemitic statements and poetry functioned as part of the formation of the `men of 1914', and as a means of shocking their audience through a poetry of ugliness. Chapter 2 considers a printing error in Rodker's Ovid Press edition of Hugh Selwyn Mauberley (1920), and reads it as a sign of Pound's failure to carry out his social and poetic project, a failure which he blamed on Jews, but, because this failure was inevitable, part of the task for carrying the project out was assigned to Jews. Chapter 3 reads Rodker's volume
of poetry Hymns (1920), and traces how his marginal position within modernism resulted in a poetry which did not directly address Jewish issues, but was affected
by his Jewish social position. Chapter 4 considers Rodker and two other Jewish writers, Carl Rakosi and Louis Zukofsky, who Pound published in The Exile (1927-
28), showing that Pound's interest in these writers was combined with an unease with them that played out in editorial decisions and means of framing their work.
Chapter 5 examines Rodker's Memoirs of Other Fronts (1932). His selfdescriptions of himself as a foreigner are shown to be still influenced by the Pound circle's ideas of Jews, but also reworked through his increasing interest in
psychoanalysis
GWAS in myopia:Insights into disease and implications for the clinic
Get PDFMyopia is the most common eye trait worldwide and the prevalence is increasing. It is known to be highly heritable; total genetic variation explains up to 70–80% of variance. In an attempt to better understand the genetic architecture of myopia, with an ultimate view to better predict genetic risk and develop targeted treatments, several genome-wide association studies have been performed in the last 6 years. In this review we focus on what a genome-wide association study involves, what studies have been performed in relation to myopia to date, and what they ultimately tell us about myopia variance and functional pathways leading to pathogenesis. The current limitations of genome-wide association studies are reviewed and potential means to improve our understanding of the genetic factors for myopia are described
Using Literature to Teach about Technology and Social Manipulation in Society
Get PDFThis paper explores three dystopian novels: Fahrenheit 451 (1950) by Ray Bradbury, The Circle (2013) by Dave Eggers, and Tell the Machine Goodnight (2018) by Katie Williams to bring to light how dystopian novels foreshadow technological control over people. The novels and characters within the texts are analyzed to show how each author warns readers in distinctive ways about the dangers of allowing technology to consume their lives. Additionally, this paper also investigates how a secondary education teacher could go about teaching their students these lessons, after exploring the novels in this study
The Other Side of Silence: Using fiction to explore the resources and limitations in writing about women's lives
Get PDFThis dissertation consists of two distinct components: a creative manuscript, titled “The Other Side of Silence,” and an accompanying exegesis. Both pieces endeavour to answer key questions: What are the different ways fiction might be used to write about the life of a woman from the past? How might we write about such women, taking into account the constraints by which their stories have been forgotten, omitted or displaced? And what are the implications of foregrounding such silences in the writing and reading of narratives?
“The Other Side of Silence” tells the story of Alba, an Italian woman who, with her young family, is leaving her hometown of Salerno for Australia in 1952. The narrative focuses on Alba’s relationship with her mother, Serafina, who fears that Alba’s journey to Australia is motivated by a desire to distance herself from her past. Within this narrative I explore how each of these characters views and consequently deals with the past.
The exegesis discusses several texts that have influenced and inspired “The Other Side of Silence.” In reading contemporary texts about the lives of women in the past, I noted two distinct approaches in the ways women’s stories were written. Some writers use recuperative strategies that allow them to tell stories previously omitted from or distorted by historical discourse and dominant cultural ideologies. By contrast, other writers use poststructuralist narrative strategies to foreground the ways in which traditional realist narratives gloss over the gaps, contradictions and omissions in women’s stories. These alternative narratives indicate how revelation and closure in traditional realism can preclude the probing of some subtle and significant questions about narrating and making sense of women’s experiences. The exegesis examines the different ways writers have challenged and subsequently enlarged conventional notions of realist fiction to imagine and speculate on the possibilities for and limitations on narrative
Women's life writing 1760-1830 : spiritual selves, sexual characters, and revolutionary subjects
No full textPhDThis thesis uses print and manuscript sources to analyse and interpret women's life
writing at the end of the eighteenth and beginning of the nineteenth centuries. I
explore printed works by Catharine Phillips, Mary Dudley, Priscilla Hannah Gurney,
Ann Freeman, Elizabeth Steele, Mary Robinson, Helen Maria Williams, Mary
Wollstonecraft, Grace Dalrymple Elliott, and Charlotte West and discuss the
manuscripts of Mary Fletcher, Mary Tooth, Sarah Ryan, and Elizabeth Fox. Of these
sources, five have never been analysed in the critical literature and six have received
little attention. Considered as a group, this large corpus of texts offers new insights
into the personal and political implications of different models of female selfhood and
social being.
In chapter one, I compare the religious identities presented in the spiritual
autobiographies of Quakers and Methodists. For these women, religious identification
provides a powerful sense of social belonging and enables public participation.
However, it may also lead to a loss of self in the demand for religious conformity and
self-abnegation. In chapter two, I consider the life writing of late eighteenth-century
courtesans. These women adapt available models of femininity and female authorship
in order to establish themselves as socially connected subjects. However, their
narratives also reveal that dependence on the sexual and literary marketplace puts
female selfhood under pressure. In chapter three, I explore the eyewitness accounts of
British women in the French Revolution. I argue that, for these writers, connecting
personal identity to political history is an enabling source of self-definition but it also
exposes them to the risks of self-fragmentation.
In my focus on the social function of women's life writing, I present an alternative to
the traditional alignment of the eighteenth-century autobiographical subject with the
autonomous self of individualism. These narratives allow us to reconsider the
productive and problematic dialectic between personal expression and representative
selfhood, self-authorship and collective narratives, and individualism and social
being. They suggest that women's life writing has the potential to be both the self-expression
of a unique heroine and the self-inscription of a politicised subject
Risk factors for myopia in a discordant monozygotic twin study
No full textPurpose: Monozygotic (MZ) twin pairs discordant for disease allow careful examination of environmental factors whilst controlling for genetic variation. The purpose of this study was to examine differences in environmental risk factors in MZ twins discordant for myopia. Methods: Sixty four MZ twin pairs discordant for refractive error were interviewed. Discordant twins were selected from 1326 MZ twin pairs from the TwinsUK adult twin registry with non-cycloplegic autorefraction. Discordancy was defined as ≥2 Dioptres (D) difference in spherical equivalent (SphE) and discordant for class of refractive error. In a 35-item telephone questionnaire twins were separately asked (and scored) about the risk factors urban/rural residence, occupational status and highest educational level. They responded with more (1), less (-1) or the same (0) as their twin on time spent outside, playing outdoor sport, and on close work aged <16 and 16-25 years. The lower SphE twin's score was subtracted from the higher SphE twin's score, and mean values of the difference calculated for each variable. Results: Sixty four twin pairs were included (mean age 56, range 30-79 years; mean difference in refraction 3.35 D, S.D. 1.55 D, median difference 2.78 D). Within discordant MZ twin pairs, the more myopic twin was associated with having a higher occupational status (mean score between 16 and 25 years -0.11; 95% CI -0.19 to -0.04; mean score aged >25 years -0.23, 95% CI -0.28 to -0.17), being resident in urban area (mean score -0.26; 95% CI -0.33 to -0.18) and performing more close work (mean score <16 years -0.11; 95% CI -0.18 to -0.05; mean score aged 16-25 years -0.17, 95% CI -0.24 to -0.10) than their twin. The twins who spent more time outdoors (mean score <16 years 0.09; 95% CI 0.03-0.15; mean score aged 16-25 years 0.28, 95% CI 0.15-0.41) or performed more outdoors sports (mean score <16 years 0.13; 95% CI 0.04-0.21; mean score aged 16-25 years 0.23, 95% CI 0.10-0.36) were less likely to be myopic than their twin. Conclusions: This study has confirmed known environmental risk factors for myopia. These data will allow selection of discordant twins for epigenetic analysis to advance knowledge of mechanisms of refractive error development.</p
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