3,044 research outputs found
A.S Byatt’ın Sahipler, David Lodge’un Yazar, Yazar ve Maggie Gee’nin Virginia Woolf Manhattan’da adlı yazar romanlarında yazar kimliğinin yeniden kurgulanması
No full textThis study analyses Possession (1990) by A.S Byatt, Author, Author (2004) by David Lodge and Virginia Woolf in Manhattan (2014) by Maggie Gee as examples of contemporary author fictions. By revisiting historical authors such as Victorian poets, Henry James and Virginia Woolf and juxtaposing these authors with contemporary author figures, these novels present a multi-layered discussion of authorship practices across centuries. The three novels analysed here all deal with the anxiety governing the work of the contemporary author: Is the Author dead? A.S Byatt challenges the death of the author through her Neo-Victorian tropes while David Lodge claims the authorial power as he negotiates the anxiety of influence he has over Henry James. Gee, on the other hand, establishes authorial power through imagining her heroine in a completely different setting as opposed to the historical reality. Due to the fact that these three authors are also novelists-critics, their author fictions also address the ambivalence caused by this double consciousness. Byatt, Lodge and Gee celebrate the author as a creator, an intellectual, a critic and a writer. Adopting a post-postmodern and reconstructive methodology, this study asserts that
in contemporary author fictions, the authorial identity is brought back to the textual world.Bu çalışma, A.S Byatt’ın Sahipler (1990), David Lodge’un Yazar, Yazar (2004) ve Maggie Gee’in Virginia Woolf Manhattan’da (2014) adlı eserlerini çağdaş yazar romanı türünün örnekleri olarak incelemektedir. Viktorya dönemi şairleri ile Henry James ve Virginia Woolf gibi modernist yazarların yeniden ele alındığı ve çağdaş yazar figürleri ile bir araya getirildiği bu romanlar, bu özellikleriyle, okuyucuya, yazarlık kavramı ve pratiklerinin yüzyıllar boyunca gelişimi ve değişimini gösteren çok katmanlı bir tartışma sunarlar. Bu teze konu olan her üç romanda da çağdaş yazarların eserlerinde karşımıza çıkan endişeye rastlanmaktadır: Yazar ölmüş müdür? A.S Byatt yazarın ölümünü, kullandığı Neo-Viktoryen perspektif ile eleştirirken, David Lodge, Henry James’e karşı duyduğu “etkilenme endişesini” James’i kurgusal bir kahraman olarak sunarak aşabilir ve metin üzerinde otoritesini sağlayabilir. Maggie Gee ise romanının kahramanını tarihsel gerçekliğinden çok farklı bir mekân ve zamanda hayal ederek kendisini metin üzerindeki tek otorite ilan eder. Bu üç yazar, aynı zamanda akademisyen ve eleştirmen olmaları sebebiyle, yazar romanlarında bu çift bilince sahip olmanın yarattığı belirsizliği de irdelemektedirler. Byatt, Lodge ve Gee; yazarı, yaratıcı, entellektüel, eleştirmen ve nihayet yazan kişi olarak yüceltirler. Post-postmodern ve yeniden yapılandırmacı bir yaklaşım benimseyen bu çalışma, çağdaş yazar romanlarında, yazarın kimliği ile birlikte metnin dünyasına geri getirildiğini öne sürmektedir.Ph.D. - Doctoral ProgramTÜBİTA
Congenital Kidney Diseases
No full textThis chapter focuses on the prospects of new therapies that can be used for congenital kidney diseases, including gene therapies, the use of renal precursor transplantation, and some other novel strategies. Diverse methodologies are devised to introduce genes into mammalian cells, including transfection of DNA by physical means and transduction by viruses. Gene transfer is relatively easy to achieve and can be highly efficient in the artificial and controlled environment of cell culture. An alternative to genetically engineering the kidney is to rebuild a damaged or malformed kidney with new cells. Laboratories demonstrate that it is possible to harvest murine metanephroi in the first days after the organs begin to form and transplant them into sites in the postnatal animal where the embryonic organ would form mature structures, including vascular glomeruli, which filters blood to make urine. The concept of using metanephric kidney transplants to replace the function of failing host kidneys is investigated extensively in a murine model in which rudiments are transplanted into the omentum around the peritoneal cavity where they grow and connect with the host vascular system. After a period of growth, the ureter of the transplanted organ can be anastomosed surgically with the lower urinary tract of the host, and these transplants have a high enough glomerular filtration rate to maintain the life of the host when it is rendered anephric. The transplantation of fetal kidney cells may also offer the additional advantage of rendering the host “tolerant” to immune attack from the host
On using Directional Information for Parameter Space Decomposition in Ellipse Detection
No full textIn this paper we use the parametric polar representation to extend the application of edge directional information from circle to ellipse extraction. As a result we obtain a mapping which decomposes the parameter space required for ellipse extraction into two independent sub-spaces and one final histogram accumulator. The mapping includes the tangent of the angle of the first and second directional derivatives. These tangents are computed by considering edge direction at two border points. We show that the use of gradient information for parameter space decomposition avoids the intensive point labelling imposed by geometric constraints used by other approaches
A questionnaire survey of radiological diagnosis and management of renal dysplasia in children
Full text linkBackgroundThe entity called renal dysplasia is considered to be a frequent cause of chronic kidney disease in children. Formally, the entity is defined by histological parameters. In current nephrology practice, however, the appearance of kidneys on ultrasound scanning is often used as a basis for the diagnosis.MethodsThe European Society for Paediatric Nephrology Working Group on Congenital Anomalies of the Kidney and Urinary Tract hypothesised that the current diagnostic approach with regard to renal dysplasia was not homogeneous. Accordingly, we here report the results of a survey targeting pediatric nephrologists with 12 questions regarding their perceptions of the ultrasonographic characteristics of renal dysplasia and further tests that they might undertake.ResultsOf almost 1200 physicians who successfully received the invitation, 248 from 54 countries completed the survey. There was a notable lack of homogeneity regarding the ultrasonographic diagnosis of renal dysplasia and also of follow up tests, including genetic testing and further radiology.ConclusionsBased on the responses to this large survey, a picture emerges of nephrologist’s current clinical practise with a focus on renal dysplasia. The Working Group consider that these results serve as an important sounding board that can inform more definitive recommendations regarding the challenges to clinical diagnosis and diagnostic follow-up of the this important entity
Development of Kidney Blood Vessels
No full textThe adult mammalian kidney is a highly vascular organ, receiving 20% of the cardiac output. This chapter discusses the anatomy of developing kidney vessels, including the genesis of renal arteries, glomerular capillaries, and the vasa recta microcirculation in the most often used experimental model—the mouse metanephros. Studies have been performed to address the origin of metanephric vessels and some experimental evidence supports the existence of both angiogenesis—the ingrowth of capillaries into the embryonic organ—and vasculogenesis—the in situ differentiation of endothelia. Diverse vascular growth factors are expressed in the developing kidney and these molecules direct the growth of renal blood vessels: they include vascular endothelial growth factor (VEGF) and the angiopoietins, which signal through receptor tyrosine kinases expressed by endothelial precursors. Less is known about cell adhesion molecules and transcription factors in the context of metanephric blood vessel development, although these classes of molecule are certainly important in vessel formation elsewhere in the embryo. The chapter focuses on the morphogenesis of the renal vasculature
A speech portrait of our contemporary in A.S. Kushner's lyrics
No full textThe article is devoted to the speech image of the author in A.S. Kushner's poetry. Combining various socially marked colloquial units with traditional poetic means forms individual style of the author and creates a vivid image of our time
Product mix of České dráhy, a.s.
No full textBakalářská práce se zaměřuje na společnost České dráhy, a.s. a její služby poskytované v rámci širokého portfolia produktů všem cestujícím. V první části práce se autor zaměří na všeobecné informace o nástrojích marketingového mixu. Ve druhé části tyto nástroje aplikuje na produkty a služby společnosti České dráhy, a.s., zejména pak na prvky marketingového mixu, kterými jsou 4P, 5P, 7P, SWOT analýza a nástroje 4C. V poslední části dojde k vyhodnocení navržených produktů na základě dotazníkového šetření. Navrhované produkty, které budou respondentům prezentovány, vznikly na základě briefingu se zástupcem Českých drah, a.s. a se zaměstnanci cateringové společnosti JLV, a.s.The Bachelor thesis focuses on the company České dráhy, a.s. and on its services, which are promoted in wide portfolio of products to all customers. In the first chapter the author focuses to general information about tools of Marketing Mix. In the next chapter are these tools applicated to products and services of České dráhy, a.s., mainly to the points of Marketing Mix, which are following tools 4P, 5P, 7P, SWOT analysis and tools of 4C. The conclusion deals with proposed products, which are based on questionnaire results. Proposed results, which will be presented to respondents, were created thanks to briefing with the representative of České dráhy, a.s. and with employees of catering company JLV, a.s.Dopravní fakulta Jana PerneraProblematiku řešenou ve své bakalářské práci dokázal student odpovídajícím způsobem obhájit. Prokázal schopnost samostatné práce. Na doplňkové otázky reagoval pohotově, se znalostí věci a bez závažných nepřesností je zodpověděl.Dokončená práce s úspěšnou obhajobo
A Lagrangian sub-grid model for the dispersion of clouds of tracers
No full textTurbulence models are expected to satisfy the conflicting requirements of accuracy and computational efficiency. Here we discuss a new model that was recently developed in order to accurately and efficiently describe the dynamic of a clouds of tracers particles in Large Eddy Simulations of homogeneous and isotropic turbulent flows. The models incorporates the multi-scale nature of time and space turbulent velocity correlations that are essential in order to correctly reproduce the relative dispersion of multi-particle clouds. The model can be seen as an off-grid solver for the Eulerian velocity field at the positions of a given number of Lagrangian tracers that self-consistently move with it. Extensions to non homogeneous and isotropic turbulence as well as to the dynamics of particles will be discussed
Rate of breakup of small inertial aggregates in homogeneous turbulence
No full textThe hydrodynamic breakup of small inertial aggregates in homogenous and isotropic turbulence is studied through numerical simulations. Small inertial aggregates are subject to shear stress caused by the local velocity gradient and drag stress caused by the relative velocity of the aggregate and the fluid flow. In our simulations, we follow aggregates moving through the flow and record the total stress acting on them. Breakup is assumed to occur when the total stress overcomes a predefined threshold representing the aggregate strength. By determining how long it takes for an aggregate to reach a stress exceeding its strength for the first time, we are able to derive a breakup rate. It is found that with increasing aggregate inertia, the drag stress rapidly becomes the dominant stress resulting in an increase of the breakup rate with increasing the aggregate inertia
Complex analysis of T-Mobile Czech Rpeublic a.s. corporate identity
No full textPráce Komplexní analýza Corporate Identity firmy T-Mobile srovnává teoreticky zpracova-né poznatky s Corporate Identitou již zavedené společnosti. Autor nejdříve popisuje vý-znam pojmu Corporate Identity a jeho součástí. V této části jsou zpracovány dostupné teo-retické poznatky o dané problematice a naznačena očekávání těchto poznatků aplikovaných v praxi. Ve druhé části práce se autor zabývá komplexní analýzou corporate identity firmy T-Mobile Czech Republic a.s. a využívá k tomu konkrétní podklady.The work Complex Analysis of T-Mobile Czech Republic a.s. Corporate Identity theoreti-cally describes known facts about corporate identity and compares them with on market already established company. In first part is author presenting the explanation of corporate identity itself and its components. In second part of this work is author describing the cor-porate identity of T-Mobile Czech Republic a.s. in deep analysis.Ústav marketingových komunikacíobhájen
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