3,131 research outputs found
Implantable Neural-Recording Modules for Monitoring Electrical Neural Activity in the Central and Peripheral Nervous Systems
No full textLow-power high-fidelity implantable neural-recording modules are presented to monitor electrical neural signals in the central and peripheral nervous systems. For clear measurement of neural spikes, the implemented modules employ double high-pass filters that effectively suppress low-frequency artifacts. Here, we present two different implantable recording modules: one produces analog output, and the other does digital output. The analog-output and digital-output modules are implemented to have 12 channels and 32 channels, respectively. Each implantable module is connected to an external module through a flexible printed-circuit cable. The 32-channel digital-output module has a size of 26 mm × 22 mm while consuming 97 μW of power. For the 12-channel analog-output module, the size is 25 mm × 17 mm, and the power of 57 μW is consumed. The implantable modules are designed to have a low-pass cutoff frequency of 10 kHz. The high-pass cutoff frequency can be controlled from sub-1 Hz to 500 Hz. The implemented implantable modules are successfully applied to in vivo experiments for neural recording in the central and peripheral nervous systems of a rat model
Franny Choi, 41st Annual ODU Literary Festival
No full textFranny Choi is a queer, Korean-American poet, playwright, teacher, organizer, pottymouth, GryffinClaw, and general overachiever. She is the author of Floating, Brilliant, Gone (2014), and a chapbook, Death by Sex Machine (2017). She has received awards from the Poetry Foundation and the Helen Zell Writers Program, as well as fellowships from the Vermont Studio Center and the Rhode Island State Council on the Arts. Her poems have appeared in journals including Poetry magazine, American Poetry Review, New England Review, and her work has been featured by the Huffington Post, PBS NewsHour, and Angry Asian Man
Serotonin Regulates Lipogenesis and Endoplasmic Reticulum Stress in Alcoholic Liver Disease
No full textBackground: Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine neurotransmitter that has various functions in central and peripheral tissues. While 5-HT is known to regulate various biological processes in liver, direct role of 5-HT and its receptors, especially 5-HT receptor 2A (HTR2A) and HTR2B, in development and progression of alcoholic liver disease (ALD) in vivo is not well understood. Methods: Blood 5-HT level was measured from both human ALD patients and ethanol (EtOH) diet-fed mouse models. Gut-spe-cific tryptophan hydroxylase 1 (Tph1) knockout mice, liver-specific Htr2a knockout mice, and liver-specific Htr2b knockout mice were fed with EtOH diet. Then we evaluated liver damage, hepatic steatosis, endoplasmic reticulum (ER) stress, and inflamma-tion. Results: Blood 5-HT concentrations are increased in both humans and mice with ALD. Both gut-specific Tph1 knockout and liv-er-specific Htr2a knockout mice are resistant to steatosis by down-regulating lipogenic pathways in liver of chronic EtOH diet-fed mice. Moreover, genetic inhibition of both gut-derived serotonin (GDS) synthesis and hepatic HTR2A signaling prevents ER stress in liver of chronic EtOH diet-fed mice. Additionally, we found that ablation of HTR2A signaling protects against disease progression by attenuating liver injury and inflammation in chronic plus binge EtOH diet-fed mice. Also, inhibiting HTR2A sig-naling ameliorates alcohol-induced liver injury and ER stress in an acute EtOH diet-fed mice model. Conclusion: GDS directly regulates lipogenesis and ER stress via signaling through hepatic HTR2A in the context of ALD. Inhib-iting HTR2A signaling protects against alcohol-induced steatosis, liver injury and disease progression in various ALD mouse models and may also provide a novel therapeutic strategy for ALD.
A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma
No full textAbstract The lack of an appropriate preclinical model of metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole disease spectrum impedes exploration of disease pathophysiology and the development of effective treatment strategies. Here, we develop a mouse model (Streptozotocin with high-fat diet, STZ + HFD) that gradually develops fatty liver, metabolic dysfunction-associated steatohepatitis (MASH), hepatic fibrosis, and hepatocellular carcinoma (HCC) in the context of metabolic dysfunction. The hepatic transcriptomic features of STZ + HFD mice closely reflect those of patients with obesity accompanying type 2 diabetes mellitus, MASH, and MASLD-related HCC. Dietary changes and tirzepatide administration alleviate MASH, hepatic fibrosis, and hepatic tumorigenesis in STZ + HFD mice. In conclusion, a murine model recapitulating the main histopathologic, transcriptomic, and metabolic alterations observed in MASLD patients is successfully established
QJE-STD-18-253.R2-Supplementary_Material – Supplemental material for Development and assessment of the Korean Author Recognition Test
No full textSupplemental material, QJE-STD-18-253.R2-Supplementary_Material for Development and assessment of the Korean Author Recognition Test by Hyosun Lee, Eunjin Seong, Wonil Choi and Matthew W Lowder in Quarterly Journal of Experimental Psychology</p
별아교세포 특이적으로 발현되는 PKM2의 억제성 시냅스 수 조절에 관한 역할 규명
No full text학위논문(석사) - 한국과학기술원 : 생명과학과, 2021.8,[ii, 31 p. :]Glial cells play an important role for regulating brain homeostasis by forming and eliminating synapses during brain development. However, the underlying mechanisms required for synapse formation and elimination are not well understood. In particular, the proteins that regulate synapse formation and elimination remain unknown. Conversely, the role of PKM2 protein, which is highly expressed in astrocytes, is well known in cancer cells but has not been studied in the brain. In this study, we found that astrocytic PKM2-deficient mice did not change the morphology and viability of astrocytes in the hippocampus. Additionally, although the number of excitatory synapses was not changed, the number of inhibitory synapses was significantly reduced. We also found that astrocytic PKM2-deficient mice showed repetitive behavior, behavioral phenotype associated with autism spectrum disorder (ASD) mouse model. Taken together, these results indicate that PKM2 plays an important role in regulating the number of inhibitory synapses and appropriate brain development and behavior.한국과학기술원 :생명과학과
From the Margins to the Forefront: Tillie Olsen's Mediation as Figure and Author
No full text45 pg.Tillie Olsen's life experiences and self-identification as a working class woman provide a strong basis for analyzing her fiction as partly autobiographical. As she wrote, she developed her position as a recognized and award winning author into that of a literary mediator for socially marginalized subjects, actively working to represent certain conditions of exclusion due to social, racial, economic, and sexual factors during the 1970's and 1980's. Through analysis of her fiction and non-fiction texts, her use of modernist writing techniques, her purpose as a writer, and her impact on the literary canon, it becomes possible to see how she has altered the literary landscape and has made those who suffer exclusion visible and legible.Advisor(s): Choi, Helen . Committee Member(s): Marshik, Celia.Stony Brook University Libraries. SBU Graduate School in Department of English. Charles Taber (Dean of Graduate School)
Replicating “Predicting the present with Google trends” by Hyunyoung Choi and Hal Varian (The Economic Record, 2012)
No full textIn this note, the author describes different ways one could try to replicate Choi and Varian (Predicting the present with Google trends, The Economic Record, 2012)
Replicating "Predicting the present with Google trends" by Hyunyoung Choi and Hal Varian (The Economic Record, 2012)
No full textIn this note, the author describes different ways one could try to replicate Choi and Varian (Predicting the present with Google trends, The Economic Record, 2012)
Replicating “Predicting the present with Google trends” by Hyunyoung Choi and Hal Varian (The Economic Record, 2012)
No full textIn this note, the author describes different ways one could try to replicate Choi and Varian (Predicting the present with Google trends, The Economic Record, 2012)
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