96 research outputs found
Analisa Keandalan Struktur pada Container Crane SWL 40 Ton Menggunakan Metode Monte Carlo
No full textIn its operation, container crane are significantly affected by usage and environmental conditions. The structure of the container crane must be able and show the best performance in overcoming the loading and environmental conditions. This study aims to determine the reliability of the container crane structure of the container crane type quay crane with SWL 40 tons. The method used is perform a static analysis by calculating the value of von mises stress and deflection due to loading condition. The loads use variation, 60% SWL, 100% SWL, and 110% SWL. To calculate the reliability of the structure, the author uses the Monte Carlo method. With the help of CATIA V5R21 software to model and perform FEM analysis of container crane structures and the result compared with manual calculation. The error rate between software and normal calculation is 6,86 %. The critical point of stress occurs at boom. The results of the analysis of the reliability of the container crane structure using Monte Carlo show that the reliability value of the structure after 21 years is decreasing
What is the best way to manage ureteric calculi in the time of COVID‐19? A comparison of extracorporeal shockwave lithotripsy (SWL) and ureteroscopy (URS) in an Australian health‐care setting
No full textOBJECTIVES: To determine the best way to intervene for ureteric stones which still require treatment during the COVID-19 pandemic, with respect to infection control. In this setting, in which resources are constrained, extracorporeal shockwave lithotripsy (SWL) has prima facie advantages over ureteroscopy (URS). It is also necessary to also consider posttreatment resource consumption in regards to complications and repeat procedures. SUBJECTS AND METHODS: The ideal ureteric stone treatment during a pandemic such as COVID-19 would involve minimum resource consumption and a minimum number of patient attendances. We compared all patients initially treated with SWL to those initially treated with URS for acute ureteral colic within the state of Victoria, Australia in 2017. RESULTS: A total of 2724 ureteric stones were analyzed, a cumulative "3-month exposure and burden on the healthcare system" was calculated for each patient by their initial procedure type. The readmission rate for URS was significantly higher than for SWL, 0.92 readmissions/patient for URS versus 0.54 readmissions/patient for SWL (P < .001). The cumulative hospital stay per patient for these two procedures was 2.35 days for SWL versus 3.21 days for URS (P < .001). The number of procedures per patient was 1.52 for SWL versus 1.89 for URS (P = .0213). CONCLUSIONS: Patients with ureteric stones treated initially by SWL have shorter length of stay with fewer overall attendances and procedures at 3 months than those treated with URS. During a pandemic such as COVID-19, SWL may have benefits in preserving hospital resources and limiting opportunity for virus transmission, compared to URS
Central executive and speed of processing deficit in Chinese developmental dyslexia: Its impact on word decoding and reading comprehension
No full textThis study examined central executive (CE) and speed of processing (SOP), and their impacts on word decoding and reading comprehension among Chinese dyslexic children. Thirty dyslexic children, 30 chronological age-controls and 30 reading level-controls were recruited. Group comparisons showed that dyslexic children showed impairments of SOP and CE components such as inhibition of irrelevant information, handling two tasks simultaneously, long-term memory retrieval and working memory span. Regression analyses showed that CE and SOP had direct effects on word decoding; their effects on reading comprehension were mediated by word decoding. Results implied that untreated CE and SOP problems would magnify reading problems
An empirical study comparing three non-phonological accounts of dyslexia: automatization, executive functioning and speed-of-processing deficits hypotheses
No full textThe nature of the automatization deficit in Chinese children with dyslexia
No full textClarifying whether automatization deficits constitute the primary causes or symptoms of developmental dyslexia, we focused on three critical issues of the dyslexic automatization deficit, namely universality, domain specificity, and severity. Thirty Chinese dyslexic children (mean age 10 years and 5 months), 30 chronological-age-, and 30 reading-level-matched children were tested in 4 areas of automaticity: motor, visual search, Stroop facilitation effects, and automatic word recognition. The results showed that the dyslexic children performed significantly worse than the CA-controls but not the RL-controls in all the tasks except for Stroop congruent-color words, on which they performed worse than children in both control groups. The deficits reflect a lag in reading experiences rather than a persistent cognitive deficit. © 2010 Psychology Press.link_to_subscribed_fulltex
Efficient purification-immobilization of an organic solvent-tolerant lipase from Staphylococcus warneri EX17 on porous styrene-divinylbenzene beads
No full textLipase from Staphylococcus warneri EX17 (SWL) was purified and immobilized via interfacial adsorption using the hydrophobic supports Octyl-sepharose, Immobead 150, and MCI GEL CHP20P. The purity of the obtained immobilized biocatalysts, Octyl-SWL, Immobead-SWL, and MCI-SWL, was evaluated by SDS-PAGE and their thermal and solvent stability were tested. Results indicated that the intensity of the interaction between the lipase and the support surface interferes with the properties of the immobilized enzyme. The immobilized preparations Octyl-SWL and MCI-SWL were stable in the presence of 50% butanol, ethanol, n-hexane, isopropanol, and methanol. Containing only 8 mg g−1 of enzyme in relation to the support, Octyl-SWL and MCI-SWL preparations catalyzed the synthesis of ethyl butyrate in a 24 h reaction, showing conversions of 28% (51.3 mmol mg−1), and 35.6% (65.2 mmol mg−1), respectively. These results indicate that Octyl-SWL and MCI-SWL preparations present very high specific activities.The authors wish to thank the financial support (scholarship for the first author) from CAPES (Brazil) and grant CTQ2009-07568 from Spanish Ministerio de Ciencia e Innovación.Peer Reviewe
Wave overtopping at rubble mound breakwaters with a non-reshaping berm
No full textThis thesis focuses on wave overtopping at rubble mound breakwaters with a non-reshaping berm. The research was aimed at gaining insight into the influence of a permeable berm on the overtopping behaviour. Moreover it was desired to validate existing prediction methods for the spatial distribution of overtopping for breakwaters with a non-reshaping berm. Wave overtopping was investigated by means of a physical model. The breakwater scale model was divided into 8 collection bins. Overtopped volumes were collected and pumped into floating tanks further down the flume. After the experiment the mass of the floating tanks was measured and the mean overtopping discharge could be determined for 8 horizontal positions on the breakwater. The measured total overtopping discharges cannot be predicted accurately by existing prediction methods. On the basis of experimental data a new prediction method was proposed that achieves an excellent fit for total overtopping. The crest freeboard definition was adjusted to account for the permeability of the crest. The reduction factor accounting for slope roughness was made dependent on the Iribarren number. For Iribarren numbers higher than 6, this method calculates no reduction of overtopping due to slope roughness. The effect of a permeable berm on total overtopping was found to be remarkably different from the effect of an impermeable berm. Permeable berms below Still Water Level (SWL) lead to less reduction of overtopping than impermeable berms below SWL. Berms above SWL lead to wave breaking on the slope in front of the berm. Contrarily to impermeable berms above SWL, a permeable berm above SWL leads to significant reduction of overtopping. The measured spatial distribution of overtopping is associated with a lot of seemingly random behaviour. Large differences were found with the experimental data of Lioutas (2010). It is suspected that the used experiment setup gives rise to significant model effects for the spatial distribution of overtopping. An experiment setup was recommended that is expected to more accurately model the behaviour of the prototype situation. Data on the spatial distribution of overtopping could not accurately be predicted by existing prediction methods. In some cases existing prediction methods provided an upper limit for overtopping (Juul Jensen, 1984) but none led to a good fit with the experimental data. A new reduction factor was found that reduces the amount of scatter and provides a conservative prediction of the experimental data.Hydraulic EngineeringCivil Engineering and Geoscience
Dync1h1 Mutation Causes Proprioceptive Sensory Neuron Loss and Impaired Retrograde Axonal Transport of Dorsal Root Ganglion Neurons
No full textBackground and Purpose: Sprawling (Swl) is a radiation-induced mutation which has been identified to have a nine base pair deletion in dynein heavy chain 1 (DYNC1H1: encoded by a single gene Dync1h1). This study is to investigate the phenotype and the underlying mechanism of the Dync1h1 mutant. Methods and Results: To display the phenotype of Swl mutant mice, we examined the embryos of homozygous (Swl/Swl) and heterozygous (Swl/+) mice and their postnatal dorsal root ganglion (DRG) of surviving Swl/+ mice. The Swl/+ mice could survive for a normal life span, while Swl/Swl could only survive till embryonic (E) 8.5 days. Excessive apoptosis of Swl/+ DRG neurons was revealed during E11.5-E15.5 days, and the peak rate was at E13.5 days. In vitro study of mutated DRG neurons showed impaired retrograde transport of dynein-driven nerve growth factor (NGF). Mitochondria, another dynein-driven cargo, demonstrated much slower retrograde transport velocity in Swl/+ neurons than in wild-type (WT) neurons. Nevertheless, the Swl, Loa, and Cra mutations did not affect homodimerization of DYNC1H1. Conclusion: The Swl/Swl mutation of Dync1h1 gene led to embryonic mal-development and lethality, whereas the Swl/+ DRG neurons demonstrated deficient retrograde transport in dynein-driven cargos and excessive apoptosis during mid-to late-developmental stages. The underlying mechanism of the mutation may not be due to impaired homodimerization of DYNC1H1.National Natural Sciences Foundation of China [30870873, 81171187]SCI(E)[email protected]
Ten-Year Sepsis Rates Comparing Extracorporeal Shock Wave Lithotripsy and Ureterorenoscopic Laser Lithotripsy in an Australian Population
No full textObjectivesTo compare the rate and predictors of septic complications after shock wave lithotripsy (SWL) and flexible ureteroscopy and laser lithotripsy (FURS) in an Australian population.
MethodsHospital admission data were extracted from the Victorian Admitted Episodes Dataset (VAED) regarding all elective admissions for SWL and FURS for treatment of intrarenal stones from 2009 to 2018, inclusive. Sepsis was defined by the ICD-10 diagnostic code, A41.
ResultsThere were 13 154 inpatient episodes analysed, comprising SWL (6033) and ureterorenoscopic laser lithotripsy (7121). Males made up 67.43% of SWL patients and 63.34% of FURS patients. Median age was 57 years in both groups. Median American Society of Anesthesiologists physical status classification grade (ASA grade) was 2 for both groups, but proportionally more FURS patients were ASA grade 3 to 4 (P < 0.001). Postoperative sepsis was more common in the FURS group (1.43% vs. 0.03%), as was intensive care unit admission (1.00% vs. 0.10%). Average length of stay was longer for FURS (1.43 days vs. 1.06 days). There were 4 inpatient deaths, all from the FURS group. FURS procedure, female sex, and a higher ASA grade were each independent predictors of sepsis.
ConclusionsFURS may have a significantly higher relative risk of postoperative sepsis than SWL in high-risk patients as determined in this study. While overall risk is low, higher comorbidity (ASA grade 3 or 4) and female sex were independent predictors of sepsis. For these patients in particular, and when clinically appropriate, SWL may be considered as a potentially safer alternative to FURS
The Effects of Family-Based Mindfulness Intervention on ADHD Symptomology in Young Children and Their Parents: A Randomized Control Trial
No full textObjective: The aim of the study is to investigate the feasibility of a family-based mindfulness intervention in improving children with inattention and hyperactivity symptoms. Method: A total of 100 children aged 5 to 7 years with ADHD symptoms and their parents were randomly assigned to a family-based mindfulness intervention (n = 50) or a wait-list control group (n = 50). Results: Families from intervention group had greater improvements in children’s ADHD symptoms, with medium effect sizes of −0.60 for inattention and −0.59 for hyperactivity; overall behaviors; and parenting stress and well-being than those in wait-list control group. Conclusion: The positive results on the child primary outcome measures have provided initial evidence of the family-based mindfulness intervention as a treatment option to ADHD. The reduction of parental stress and increase in psychological well-being has demonstrated the value of mindfulness in enhancing parent’s self-management. © 2017, The Author(s) 2017.link_to_subscribed_fulltex
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