2,412 research outputs found
Wong Wing and Wong Sing at Store
No full textWong Wing and Wong Sing stands in front of Wong Sing Merchandise store at Fort Duchesne
Wong Sing With Ute Women
No full textWong Sing stands with Ute women in front of the Wong Sing General Merchandise store in Fort Duchesne
Wong Sing
No full textWong Sing, an industrious business man of early Uintah County. Located on Disc 72 in UCLRHC
Wong Sing Store Window Display
No full textWong Sing Store window display during Vernal Rodeo week. The Wong Sing store was located on West Main Street
Specialised English: New Directions in ESP and EAP Research and Practice by Ken Hyland & Lillian L.C. Wong (2019): Routledge
Get PDFThe Book “Specialised English: New Directions in ESP and EAP Research and Practice by Ken Hyland & Lillian L.C. Wong (2019): Routledge†is a must-read book for ESP and EAP researchers and practitioners. It consists of three main sections: 1) conceptualizing issues in specialized language use (five chapters), 2) focusing on texts (six chapters), and 3) focusing on practice (six chapters). This book addresses some challenges in teaching and researching ESP courses across disciplines (Enesi et al., 2021). For example, contextualizing ESP teaching as “workplace English†is currently demanding, thus allowing ESP curriculum developers to formulate and infuse English materials in the workplace (V. K. Bhatia & Bremner, 2012)
Structural Geology of the Cariboo Gold Mining District, East-Central British Columbia:
Get PDFL.C. Struik.Memoir (Geological Survey of Canada) ; 421
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
Commercially available Mfsd2a antibody (Abcam, #ab105399) is non-specific
No full textA recent article was published last month in Science Advances by Jia Zhou et al entitled “Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis.” The conclusions that Zika virus infection downregulates Mfsd2a protein levels at the blood-brain barrier rely on the quality of the Mfsd2a antibody that they used, which was purchased from Abcam (#ab105399). The Silver lab discovered the function of Mfsd2a as a lysolipid transporter [1] and have published our findings using our own validated antibodies to Mfsd2a [1-9] that we have provided to other researchers who have confirmed their specificity [10-12]. It is disconcerting that there are more than 10 published articles in the literature that have relied on ab105399 for data generation without proof of validation of specificity. This figure shows a side-by-side test of ab105399 versus our published antibody against Mfsd2a, where we show that ab105399 does not detect Mfsd2a with any specificity. Note: #ab105399 appears to be distributed by Invitrogen (#PA5-21049), Genetex (#GTX85147), ProSci incorporated (#6025), and LSBio (#LS-B5348).References:1.Nguyen, L.N., et al., Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature, 2014. 509(7501): p. 503-6.2.Alakbarzade, V., et al., A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nat Genet, 2015. 47(7): p. 814-7.3.Berger, J.H., M.J. Charron, and D.L. Silver, Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism. PLoS One, 2012. 7(11): p. e50629.4.Chan, J.P., et al., The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain. PLoS Biol, 2018. 16(8): p. e2006443.5.Guemez-Gamboa, A., et al., Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat Genet, 2015. 47(7): p. 809-13.6.Harel, T., et al., Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination. Neurogenetics, 2018. 19(4): p. 227-235.7.Piccirillo, A.R., et al., The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8(+) Memory T Cell Maintenance and Secondary Response to Infection. J Immunol, 2019. 203(1): p. 117-126.8.Quek, D.Q., et al., Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a. J Biol Chem, 2016.9.Wong, B.H., et al., Mfsd2a Is a Transporter for the Essential omega-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem, 2016. 291(20): p. 10501-14.10.Wang, Y., et al., Elife, 2019. 8.11.Vanlandewijck, M., et al., Nature, 2018.12.Byrne, L.C., et al., Mol Ther, 2015. 23(2): p. 290-6
Les Observations sur l'éloquence de l'abbé de Saint-Pierre
No full textAbbé de Saint-Pierre : Observations sur l'éloquence. Presented by Lawrence Kerslake.
Many of the abbé de Saint-Pierre's writings remain little-known or even unpublished. The Observations sur l'éloquence constitute his chief discussion of literature. A preliminary draft appeared in the Mercure in 1726, but the work subsequently underwent two major revisions, both states represented in Ms. R.248 of the Bibliothèque publique et universitaire in Neuchâtel. A further copy (BNF. N.a.fr. 11232), with a few additional changes, is published here. The ideas in the text show the author to be a 'Modern' in his position on beauty and literary effect, and reflect his life-long concern for the improvement of his fellow-citizens.Kerslake L.C. Les Observations sur l'éloquence de l'abbé de Saint-Pierre. In: Dix-huitième Siècle, n°31, 1999. Mouvement des sciences et esthétique(s) sous la direction de Christine Rolland, François Azouvi et Michel Baridon. pp. 305-328
Faces of English Education: Students, Teachers, and Pedagogy
No full textReseña de: Faces of English Education: Students, Teachers, and Pedagogy. De Lillian L.C. Wong, Ken Hyland (Eds.). Por Tom Morton. Routledge, London/New York (2017), 278 p
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