8 research outputs found
In vitro phospholipid biosynthesis for growing and dividing minimal cells
No full textNatural life is extraordinarily complex, which by definition means that it has many interconnected and functioning parts. The goal of synthetic biology is to engineer living systems, though due to their very complexity they remain recalcitrant to engineering. What if it were possible to reduce the complexity to a finite amount of parts that are well understood and therefore possible to manipulate. That is the motivation for constructing a so called minimal cell
Attention-deficit/hyperactivity disorder: a systems perspective. A comprehensive qualitative analysis of the literature
No full textPlan BAttention-Deficit/Hyperactivity Disorder (ADHD) is a neurological syndrome resulting in problems with self-regulation. ADHD is characterized by inattention and/or hyperactivity-impulsivity which causes impairment in at least two settings. These characteristics often arise in childhood and were previously thought to diminish during adolescence and disappear by adulthood. However, studies over the past decade indicate that although some symptoms may decrease in severity, ADHD does continue throughout adulthood for many individuals. The impact of this disorder is felt not only by the individuals with ADHD, but also by the various systems in which these individuals live, work, and socialize. In this comprehensive analysis of the literature ADHD is discussed from a systemic perspective. Initially the symptoms and characteristics that define ADHD are reviewed along with other disorders that commonly coexist with ADHD, and what research tells us does and does not cause ADHD and the development of the co-morbid disorders. Prevalence of ADHD and co-morbidity is also reviewed. The term “system” is defined and the various systems presented as related to this topic, from the micro-system of the individual to the macro-system of society at large. As the characteristics of ADHD are exhibited inconsistently according to the age of the individual and the context of the interaction, these are addressed, as appropriate, in the categories of child, adolescent/teen, and adult for each system. The first system discussed is the internal system of the individual in which ADHD resides. This micro-system consists of the biological, intellectual, and psychological components. This is followed by examination of this micro-system of the individual interacting in the family system, both nuclear and extended. The common effects on other family members in the system and the system as a whole are discussed. With understanding of the individual and his/her family with ADHD as a foundation, the view is broadened to other systems in which both the individual and his/her family operate. The discussion includes the reciprocal effects of ADHD and the educational, employment, social/recreational, and legal systems, as well as the influence of interactions between these systems. The presentation of the pervasive impact of ADHD on all systems is followed by analysis of the different treatment options and effectiveness. Included are interventions in the areas of interpersonal relationships within the family, social relationships, leisure/recreation, school, work, and in the legal arena. Since the acceptance and attitude about ADHD are important factors in interaction and treatment effectiveness, these are also investigated throughout. A summary of the analysis of the literature is presented in the second chapter. This is followed by conclusions and a discussion of implications for marriage and family therapists
Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action
No full textFunding Information: We thank K. Murakami, H. Kimura, H. Kurumizaka, and J.M. Stark for materials. This work was supported by JSPS KAKENHI grant nos. JP19H03156 , JP18H04713 , JP18H05532 , and JP25116004 (to C.O.), JP17H06426 (to K.N.), JP18H04900 and JP19H04267 (to H.S.), the Mitsubishi Foundation (to H.S.), and by Cancer Research UK awards C1445/A19059 and DRCPGM/100013 (to S.H. and A.D.D. lab). Publisher Copyright: © 2021 The Author(s)Peer reviewe
A Historical Research Study of the Evolution of Attention Deficit Disorder
No full textAcross the United States of America, schools and social service agencies have become increasingly aware of a disability called Attention Deficit Disorder (A.D.D.). Families and employers are learning the name for this confusing, frustration, seemingly uncontrolled problem. The focus of this thesis will be to trace the origin and historical development of this disorder. It examines the work of those who were involved in identifying, defining and treating the disorder. The author has attempted to draw connections between history, discovery, research and implications for treatment, practice and public policy
Banana marketing performance in Blantyre Agricultural Development Division, Malawi
No full text1990 Fall.Includes bibliographical references.This study provides insight into the complexities underlying the marketing of bananas in Blantyre Agricultural Development Division (A.D.D.), in southern Malawi. While farmers formed the core of the study, varying numbers of wholesalers/dealers, retailers and truckers were also contacted. A dualistic system of marketing operated in the area; that is, farmers sold their bananas both directly to consumers and also through middlemen. Sales, in order of importance based on patronage, were directly to the urban markets by the farmers themselves, to the middlemen/traders, to the village or roadside markets and lastly to the local markets. The most important problem was that of transportation, especially in getting the bananas to the urban markets. The main issue was the condition of the outlet road system. It appears that there is a lot of risk taking on the part of the truckers who opt to operate in the area. A detailed market performance analysis was not possible due to the paucity of relevant data. However, imperfect indicators of performance were highlighted. These included physical losses as bananas passed through various channels; price setting by market authorities; erratic supplies and inconsistent volume measures. Retail prices for a period of 69 days showed highly significant differences among mean prices of the three grades of bananas - large, medium and small. There appeared to be no relationship at all between the price movements for the large and medium size bananas. However, those for large and small, as well as medium and small, showed considerably higher degrees of positive association
Cell-Free Phospholipid Biosynthesis by Gene-Encoded Enzymes Reconstituted in Liposomes
No full textThe goal of bottom-up synthetic biology culminates in the assembly of an entire cell from separate biological building blocks. One major challenge resides in the in vitro production and implementation of complex genetic and metabolic pathways that can support essential cellular functions. Here, we show that phospholipid biosynthesis, a multiple-step process involved in cell membrane homeostasis, can be reconstituted starting from the genes encoding for all necessary proteins. A total of eight E. coli enzymes for acyl transfer and headgroup modifications were produced in a cell-free gene expression system and were co-translationally reconstituted in liposomes. Acyl-coenzyme A and glycerol-3-phosphate were used as canonical precursors to generate a variety of important bacterial lipids. Moreover, this study demonstrates that two-step acyl transfer can occur from enzymes synthesized inside vesicles. Besides clear implications for growth and potentially division of a synthetic cell, we postulate that gene-based lipid biosynthesis can become instrumental for ex vivo and protein purification-free production of natural and non-natural lipids
A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists
No full textLarge language models LLMs have gained widespread interest owing to their ability to process human language and perform tasks on which they have not been explicitly trained. However, we possess only a limited systematic understanding of the chemical capabilities of LLMs, which would be required to improve models and mitigate potential harm. Here we introduce ChemBench, an automated framework for evaluating the chemical knowledge and reasoning abilities of state of the art LLMs against the expertise of chemists. We curated more than 2,700 question answer pairs, evaluated leading open and closed source LLMs and found that the best models, on average, outperformed the best human chemists in our study. However, the models struggle with some basic tasks and provide overconfident predictions. These findings reveal LLMs impressive chemical capabilities while emphasizing the need for further research to improve their safety and usefulness. They also suggest adapting chemistry education and show the value of benchmarking frameworks for evaluating LLMs in specific domain
Magrath Store News (September 11, 2002)
No full textAn archive of the Magrath Trading Store News.The University of Lethbridge Library received permission from the Wes Balderson to digitize and display this content.MAGRATH NEWS
Published Weekly Since 1932 by
The Magrath Trading Company ■t
50e
Water Damages Magrath Hospital’s Phones
A water-main break at Magrath Hospital early Monday morning
caused damage to the hospital’s phone system which necessitated the
need for a temporary phone line to be set up at the hospital until
repairs could be completed. ?
C
A major water pipe leading to the hospital burst early Monday
morning, damaging the telephone room. No other damage was
reported in the hospital, although there is flooding on the grounds.
The water main has been turned off, and the hospital has been set up
with a temporary tank. Normal services are being provided.
Engineering and maintenance staff from the Chinook Health Region
were working with the phone service provider to fix the system.
Citizens On Patrol (C.O.P.)
Citizens of Magrath: there will be a meeting at the Town Hall at
7:00 p.m. on Wednesday, September 11, 2002 regarding
Citizens On Patrol.
The RCMP will be present to explain the program,
i i5 ? All concerned citizens welcome.
-P--o--i-n--t-s-- -o--f- -I-n--t-e--r-e--s-t-\
» Senior’s News
* Grocery Specials
Home Hardware j
K6i
:
Î----------------------------s
Inside this Issue:
Community 1-3
Sports 4-5
Classified Ads 6-7
Calendar 8
Library News 8
Grocery Specials 9-11
Hardware Specials
—
12
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Golf Fundraiser
The Zenith Alumni Association will be hosting a charity fundraiser golf tournament later this month to
raise money for the athletes at the school. On September 28 at 1 p.m. shotgun start will occur at the
Magrath Golf Course to begin the event.
Prizes will be given out to the top three teams in three divisions plus closest to the pin and long drive
contests. A roast beef dinner will also be held at 6:30 p.m. after the round of golf is completed.
You can register as an individual for 200. A full tax receipt will be issued upon
request. Call 758-3054 to register. Have your handicap score ready when you call in. A silent auction
will also be held during the event. ? . •
2
Friday, September 13, 2002 - Cardston Civic Center
2:00 - 8:00 p.m.
Drop by for Classes & Demonstrations
Computer & Internet * Health Issues * Art * Furniture Refinishing * Aviation * Quilting * Careers &
Transition into the Work Fora: * Crafts * Stained Glass * Scrapbooking * Food Dehydration * Bead Work
* Finanrial Planning * Candy * Cooking & Menus * Photography * First Aid Hair Braiding * Family
Literacy * Home Decorating * Cake Decorating * Soap Making * Reading to Children * Picture Framing *
Scanning, Photo Refinishing & Using Digital Cameras * and ... much... Much... MORE!!
The Alberta government has asked all councils in the province to commemorate “International
Adult Learners Week” which has been set for September 8th through the 14th. We have selected
Friday, September 13 as the day to hold a “Learners Fair” to provide the residents of the County
of Cardston a chance to partake of some of the many learning opportunities that are available to
them because of the efforts of many businesses, groups and individuals.
Come & Participate & Celebrate:
International Adult Learners Week & the 30th Anniversary of Adult Education in the County
of Cardston
\]o
merits
Booth Participants Welcome
If youwould like to have a booth that promotes learning or teaches new skills
call Kathy at 653-4991 or 653-3472for information and to register.
DESIGN
We specialize in:
«Scanning: slides, photos, negatives, text...
•Photo repair, retouching, restoration &
photo collages
•Memory videos (weddings, reunions, sports...
Congratulations to Jaymi Miller
for winning the MAM Backpack and
school supplies at the
Magrath Trading Company.
MISSIONARYCORNER
All of the above can be preserved
on VHS, CD and
(phone for details)
We also do private tutoring, troubleshooting,
desktop publishing & more!
Phone Bonny/Brenda: 758-3844 eve./voicemail (day)
I Tiffany Anderson, daughter of Dick & jan, has
I been called to serve in the Brussels Belgium
* Netherlands Mission (french speaking). Her farewell |
* will be held on Sunday, September 15 at 1:00 pjn. in (
1 the Garden Place Chapel (5th Ward). She reports to |
’^the M.T.C. on October 2, 2002. y
3
Now Booking Appointments!!
Wakeup 'With Make-up!
Permanent Cosmetics
«S' Tina D. Reid cpcr
Phone: (403) 758-3930
758-3936
Call for your Free Consultation
“Our Past, Present, & Future”
MAGRATH LIONS CLUB
Invites all to attend our
Friendship Night.
Come learn more about what we do here in
Magrath. Free. Light Refreshments. Displays.
7:00 - 8:00 p.m.
Tuesday, September 17th
Magrath Senior’s Center
Call Lion Roger 758-3827 for more info.
HomeLife
Higher Standards
M.L.S.
Jim Anderson
agent
Residential ~ Farm
Acreage ~ Commercial
in Magrath and Area
2 Houses for Sale in Del Bonita
2 teacherages for sale in Del Bonita
House for Sale in Magrath
N.E. corner of 1st Ave. S. and 3rd St. E. 49,000
Comparative Market Analysis
(No Charge) - For people interested in getting an
evaluation of marketability of your property.
Phone: 758-6725 (leave message)
331-8882 (cellular)
SENIOR’S NEWS
Our September Suppers will be held Wednesdays,
September 11 & I8 at 5:00 p.m.
Pot Luck will be on Friday, September 27
with Entertainment
*******
Contact Hazel Rasmussen for rental of the
Senior’s Centre. Fee 75.00 Phone 758-3545
*******
Garage Sale
Friday, September 20th 10:00 a.m. - 3:00 p.m.
Scones & Juice or Coffee available
Contact Bob Clifton or Grace Navratil
Donations gratefully accepted.
COME AND JOIN THE WONDERFUL MEALS,
CARDS, GAMES & SOCIAUTY.
*******
BINGO ~ BINGO ~ BINGO '
Next Bingo will be held on ;
Thursday, September 12,2002 x >
Doors open at 6:30 p.m. i
Bingo - 7:00 p.m.
Public Welcome!
Scott A Cassandra Long and
their children Truman, Hannah
& Kansas are happy to
announce the arrival of their
baby brother,
Izaak Ivan
Born August 27, 2002
weighing 61b. 13 oz.
Equally happy are
grandparents:
Pam Long and
Dean A Liz Truman
JUDO
K
GYMNASTICS I
RAYMOND JUDO CLUB
REGISTRATION &
CLASSES
SEPTEMBER 18
.. Social Hall
Raymond Care Center
For more Info Call:
Monica Zaugg 758-3832
Collette Iwaasa 752-3984
'Qsrden City Oyronsstfcs?'
Fall Registration
Ages 4 and up
40 per session
(space is limited)
;
To register phone: '
Tammy Noad 758-3604 or
Allyson Christensen 758-6630
GOLF
2 FOOTBALL
Wolverines Open Season with Win
The Southern Alberta Minor Football
Association opened its regular season Saturday
with the Magrath Wolverines cruising to 21-0
victory over the Claresholm Raiders.
Quarterback Raye Wilde led the way for
Magrath with a pair of rushing touchdowns
from 40 and 10 yards out, while Wilde also
hooked up with Jordan Smart on a 45-yard TD
toss.
Cole Barnett added 86 yards rushing in the win
and led the defense with nine tackles. Adam
Williams, Todd Perks and Ben Schow each
accounted for 8 tackles as well. Jordan Smart
booted three converts.
STEELE SHERIDAN
RR8-20-18, Lethbridge, Alberta T1J4P4
No Sunday Deliveries : ~ Bus: 328-2460
Meldrum Tops Field
Bryan Meldrum fired a three-over par 75 to
claim the Magrath Golf Club’s Men’s Senior
Open Thursday by one shot.
Meldrum edged Ken Roome, who fired a 76,
and Don Haavusrud, who carded a 77, to take
home the top prize.
Overall Champion - Bryan Meldrum 75
Championship Flight Low Gross - 2. Kenn Roome 76. Low
Net - 1. Lloyd Currie 71. First Flight Low Gross - 1. Don
Haavusrud 77; 2. Ken Walter 78. Low Net - 1. Bill Traber 69.
Second Flight Low Gross - 1. Robert Comai 85; 2. Walt
Pashuk 87. Low Net - 1. Jim Moore 74. Third Flight Low
Gross - 1. Earl Johnson 86; 2. Jerry Smith 89. Low Net - 1.
Fred Andrews. Fourth Flight Low Gross - 1. Warren
Hennigar 89; 2. Ken Blomm 91. Low Net - 1. Eric Hohm 75-
---------------------------- A
ATTENTION ALL
MOTHERS
Magrath Wolverines Football , . are
looking for missing equipment (jersey’s
& helmets). Please look around your
house and see if yoù have any of the
missing equipment. Call Dave Clark @
758-3134 and I will gladly pick it up. k_________ _________J
5
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CALL KIM @
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fl LIBRA MA55AÛE THERAPY 75S-32/0 TO BOOK APPONIMENT 185E-1AVEN flSfla|
ILI SIDE DOOR
ir=3XE=S --=
î I
Free Self Help
Workshop
on
Head & Neck Pain
□ 1 *. * ài
•s
- t T
Wednesday, September 25
T i
6:00 p.m.
: i
■
Magrath Public Library
• -TT
Speaker
• - *
Dr. Alan Dudley
’*
For more information
& to register call
iif
758-3203
BEATRICE JOSEPHINE HARKER ,
On September 5, 2002, Beatrice Harker passed away at the age of 87 years.
She is survived by three daughters, Sharon Patey, Malonie Vance, Christal Shurdiff, two sons Robert and Darrel Harker, twenty-nine grandchildren and 42 great-grandchildren, one sister Allie Robinson.
She is predeceased by her husband Ray, one daughter Jewel, two sisters Afton Keeler and Cleo Ririe and one brother Lalavee Jensen.
A funeral service will be held on Saturday, September 14, 2002 at 2:00 p.m. at the Magrath Garden Place Chapel with interment to follow in the Magrath Cemetery.
The Magrath Golf Club Ladies Scramble
was held on August 31, 2002 and was a great success. We would like to thank the following sponsors for their contributions and helping to make our tournament a success:
The Magrath Trading Company; ATB Financial, Magrath Branch; First Choice Savings & Credit Union, Magrath; Sky Reach Equipment Ltd.; Rick Gross Golf Shop; Sunita’s Dog Salon; Park Meadows Hair Dezigns; ATB Financial, Lethbridge Hub; Marg Spicer; TA Excavating; Merle Norman, Downtown Cosmetics Studios; Quality Holdings (Gina Davies); Saigonese Restaurant; 3 Anonymous Magrath Golf Club Ladies Members; International House of Beauty; Coca-Cola Bottling Ltd.; Heather Roest; Auto Appearance Centre Ltd.; Lethbridge Meats & Seafood Ltd.; Roest Acoustics Ltd.; Strength In Motion; Galaxy Bowling & Billiards; Kathy Rollingson; Carrie Kohuch; Merlin’s Audio & Electronics; Magrath Golf Club; Cranbrook Golf Club; Land-O-Lakes Green Fees; Crowsnest Pass Golf Club; Picture Butte Golf Club; Taber Golf Club; Henderson Lake Golf Club; Nanton Golf Club; Lethbridge Country Club; Kokanee Springs Golf Club; Lee Creek Golf Club• CLASSIFIED ADS
FREE MARKET
• *******
& FOUND - at No Cost Clothing - a set of keys with red & white beads on a string - Call 758-3483.
•J» MISSING - Left in the boys locker (by the Tom Karren
■ Gym) ANDI runners. Light gray/red - size 9!6. Phone
758-3427. •
■■■ ' ' ■ ■
& KEATON MOORE has lost his brand new red & white i mountain Bike. Reward offered. 758-6835.
❖
TO GIVE AWAY - Cats!! One female black & white (1 yr. old), 1 male gray with white & black paws (1 yr. old), and 2 kittens (12 weeks old): 1 white male and 1 black & white female. Phone 758-3316.
BUY & SELL
*******
> TV GUARDIAN - Now taking orders. Eliminate foul language on your TV. Works with CC. Call for Demo or more information. 180 + tax. 758-3827 Shawna.
❖
DANBY older working fridge for sale. 50.°° o.b.o. 758-6158.
❖
FOR SALE - Ping Pong Table. 14,450.°° o.b.o.
Phone (403) 758-6093 or (403) 360-3972. .
❖
FOR SALE -1992 XLT Sport Ford Aerostar extended Van. 7 passenger, 4 captain seats, new transmission, Wftll maintained 3500.°° o.b.o. Phone 758-3169.
BUSINESS
*******
❖
HELP WANTED-full & part-time light, steady labor. Magrath area. Phone or Fax to Bruce Sabey 758-6846.
❖
Still looking for a PIANO TEACHER? Limited space left! Call Lani @ 758-3027.
❖
PIANO LESSONS -I have a couple more openings during the day either Beginning Adult or Kelly Kirby K indergaiten piano For more information phone Shardn Ragan @ 758-3427.
❖
KSL Piano Tuner (Stan Keeling) is coming to Magrath. To make an appointment please phone Sharon @ 7583427.
<£• Jonathan Stubbs is teaching PIANO LESSONS to beginners. Call 758-3473.
❖
STITCHING DREAMS - Will do: Custom Dressmaking, Wedding Dresses, Bridesmaid Gowns, Women’s/Children’s clothing, Alteration/repairs, ... and much more. Inquire about sewing instruction. By appointment only. Stephanie Humphreys 758-6127.
❖
NEED TO GET YOUR BOAT WINTERIZED? - call 758-3302 for professional on-site service.
❖
JUST RIGHT ROTOTILLING by David & Mark Harker. 758-3009.
❖
MIKE HARKER is back and ready to rototill your garden. Call me whenever you’re ready at 758-6664.
❖
FREE SECURITY INSPECTIONS. We’ll tour your home or business and provide you with no cost security tips anyone can use. Call Canadian Security Systems 758-3945.
❖
For all your cleaning needs from hospital dean to a touch-up, carpet to ceiling & everything in between. No job too big or too small.
Call Wayne’s Carpet & Upholstery Cleaning 758-6414.7
CLASSIFIED ADS
REALESTATE
*******
FOR RENT
❖
HOUSE FOR RENT - Available October 1st. 4 bedroom, includes fridge & stove. Detached garage. 758-6420.
❖
FOR RENT - Old home - 3 bedrooms. Close to schools Phone 758-6892 after 6 pjn.
❖
HOUSE IN MAGRATH FOR RENT-400/month (water included). Contact Kim or Marilyn Stevens at 780-962-5361 (collect calls accepted).
❖
HOUSE FOR RENT INMAGRATH-Newer 4 bedroom family home. 3 bathrooms. 1.78
Niagara Orange Juice, frozen
341 ml
.88
Western Family Soft Margarine
454 g
3 for 5.00
Breyer’s All Natural Ice Cream - select varieties
2 litre
3.48
Dairyland Yogurt - regular or fat free - select varieties
500 g
2.58
Western Family Chip Dip - select varieties
225 g
2 for 4.00
Kraft Cracker Barrel Old Cheese-select varieties
750 g
7.98 |
Groceries...
Folgers Coffee - regular or decaf
300 g
2 for 2.28
Western Family Pineapple-select varieties
398 ml
.88
Western Family Mandarin Oranges-select varieties
284 ml
4 for 6.98
Dole Pineapple Juice Blends-select varieties
1 litre
2 for 6.00
Del Monte Fruit Cups - select varieties
4 pack
2.78
Quaker Oats - select varieties
Ikg
3.98
Aunt Jemima Pancake Mix-select varieties
905 g
2.98
Western Family Peanut Butter-select varieties
500 g
1.98
Western Family Soup - selected varieties
284 ml
5 for 3.00
Value Priced Noodles - select varieties “
85g
4 for 4.98
Cloverleaf Light Tuna - chunk or flaked, in water
170 g
3 for 3.00
Lipton Sidekicks - Potatoes, Pasta, Aslan Noodles or Risotto - select varieties
113-168 g
3 for 1.68 <
Coke, Sprite or Flavors-select varieties
12 pack
2 for 5.98
McCain Fruit Punch-select varieties
1 litre
3 for 3.48
Lays Potato Chips-select varieties
255-270 g
2 for 5.00
Kellogg’s Rice Krispies Souares-select varieties
