1,721,093 research outputs found
sj-docx-1-tam-10.1177_17588359221097934 – Supplemental material for Real-world efficacy and safety of cabozantinib in Korean patients with advanced hepatocellular carcinoma: a multicenter retrospective analysis
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221097934 for Real-world efficacy and safety of cabozantinib in Korean patients with advanced hepatocellular carcinoma: a multicenter retrospective analysis by Yeong Hak Bang, Choong-kun Lee, Changhoon Yoo, Hong Jae Chon, Moonki Hong, Beodeul Kang, Hyung-Don Kim, Sook Ryun Park, Won-Mook Choi, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Min-Hee Ryu and Baek-Yeol Ryoo in Therapeutic Advances in Medical Oncology</p
sj-TIF-1-tam-10.1177_17588359221097934 – Supplemental material for Real-world efficacy and safety of cabozantinib in Korean patients with advanced hepatocellular carcinoma: a multicenter retrospective analysis
No full textSupplemental material, sj-TIF-1-tam-10.1177_17588359221097934 for Real-world efficacy and safety of cabozantinib in Korean patients with advanced hepatocellular carcinoma: a multicenter retrospective analysis by Yeong Hak Bang, Choong-kun Lee, Changhoon Yoo, Hong Jae Chon, Moonki Hong, Beodeul Kang, Hyung-Don Kim, Sook Ryun Park, Won-Mook Choi, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Min-Hee Ryu and Baek-Yeol Ryoo in Therapeutic Advances in Medical Oncology</p
저산소조건에서 담즙산이 Mcl-1 및 COX-2 매개 간성상세포의 활성화에 미치는 영향
Full text link학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2015. 2. 윤정환.Background: Activated hepatic stellate cells (HSCs) are the major subtype of stromal cells in the liver tumor microenvironment which can promote the growth and migration of hepatocellular carcinoma (HCC) cells. Indeed, senescent and cancer-associated fibroblasts express numerous inflammatory and tumor promoting factors that are collectively referred to as the senescence-associated secretory phenotype (SASP). In the present study, we investigated the mechanisms of bile acid-mediated induction of HSC activation as the SASP in hypoxic conditions.
Methods: The immortalized human stellate cells (LX-2 cells) were used in this study. Invasion assay were done to evaluate the invasion of HSCs either in a normoxic or hypoxic conditions. IL-8 mRNA was quantitated using real-time PCR. To investigate the mechanisms, western blot analyses were performed either in a normoxic or hypoxic conditions.
Results: Bile acid significantly increased the invasion of HSCs in hypoxic conditions as compared to that in normoxic conditions by IL-8 expression, which is an inflammatory cytokine involved in tumor promotion and key component of the SASP. Bile acid increased protein expressions of the mesechymal markers including α-SMA and vimentin in HSCs. Moreover, bile acid increased the protein expressions of Mcl-1 and cyclooxygenase-2 (COX-2) in HSCs. The inhibitors of either Mcl-1 induction by siRNA transfection or COX-2 activity by celecoxib decreased the bile acid-mediated HSC invasion in hypoxic conditions. Mcl-1 and COX-2 induction was found to be due to transcriptional enhancement dependent on TGR-5 activation.
Conclusions: Bile acid-mediated induction of HSC activation and invasion as the SASP was due to TGR-5 dependent overexpression of Mcl-1 and COX-2, which may lead to HCC progression in hypoxic conditions.Abstract ............................................. i
Contents ............................................ iv
List of figures ..................................... v
List of abbreviations and symbols ........ vi
Introduction ........................................ 1
Materials and methods ........................ 3
Results .............................................. 8
Discussion ........................................ 19
References ........................................ 25
국문초록 ............................................ 32Maste
Preparation of Si/C/rGO granular composites via spray drying method and application as lithium-ion battery anode material
No full text리튬이온전지는 최근 몇 년 동안 휴대용 전자 기기, 전기 자동차, 그리고 대규모 에너지 저장 시스템과 같은 다양한 응용 분야에서 널리 사용되고 있습니다. 그러나 에너지 시장의 수요 증가로 인해 에너지 밀도가 높은 차세대 리튬이온 배터리를 개발에 대한 필요성이 증가하고 있습니다. 대안으로 떠오르는 다양한 음극 소재 중 최근 실리콘(Si)이 주목을 받고 있습니다. 실리콘의 이론용량은 4200 mAh g⁻1 로, 현재 널리 사용되는 흑연의 약 10 배 이상의 높은 이론용량을 가지고 있습니다. 그러나, 실리콘은 충전과정 중에 약 3 배의 급격한 부피 팽창이 발생하여 전극에 손상을 일으키거나 활물질이 집전체에서 탈리되어 리튬이온전지의 내구성 및 전기화학적 성능이 저하되는 문제가 있습니다. 이러한 문제를 해결하기 위해 부피팽창을 억제하는 Si/C 복합체를 개발하거나 Si 표면에 여러 탄소나노재료를 코팅 하는 등 다양한 연구가 진행되고 있습니다. 본 연구에서는 상기한 단점을 해결하기 위해 볼밀과 스프레이 드라이 기법를 이용하여 물리적, 구조적으로 안정된 Si/C/rGO 구형 구조 복합체를 합성하였습니다. 합성된 복합체를 리튬이온전지 음극재로 활용하여 전기화학적 물성들을 테스트한 결과 우수한 전기화학적 특성과 함께 안정한 충/방전 테스트 결과를 보여주었습니다.Maste
Synthesis of N doped Cu3Mo2O9 as a bifunctional electrocatalyst for water splitting
No full textThe content of this thesis includes 2 main parts
Chapter 1 illustrates water splitting reaction. firstly, the overview is about energy consumption and the pressure to environment, the development of economics of many countries which causes by using and exploiting natural resources for energy demand. Then, hydrogen energy becomes potential candidate to replace fossil fuels. Next, theory about water splitting is mentioned. Besides, some catalyst concepts can be understood due to principle of the reaction. Finally, this chapter also give information about popular parameters to evaluate electrocatalyst
In chapter 2, basing on the necessity of water splitting process, the electrocatalyst for water splitting is studied. This part supports the explanation about composite design. Secondly, the practical methods to synthesize material is describes. Analytical measurements to understand the composite and to confirm the efficiency of catalyst for water splitting are also researched. After that, the result is recorded to analysis and compare with commercial productMaste
Boosting Reversibility and Stability of Zn Anodes via Manipulation of Electrolyte Structure and Interface with Addition of Trace Organic Molecules
Full text linkPublished online: August 17, 2022The practical application of aqueous zinc-ion batteries (AZIBs) is significantly limited by poor reversibility and stability of the Zn anode. Here, the first time addition of trace organic gamma butyrolactone (GBL) is reported to a typical ZnSO₄ electrolyte to controllably manipulate the electrolyte structure and interface. Judiciously combined experimental characterization and theoretical computation confirm that the GBL additive weakens the bonding strength between Zn²⁺ ion and solvated H₂O and rearranges the “Zn²⁺−H₂O−SO₄²– GBL” bonding network to reduce water activity and suppress corrosion and side products. The GBL molecules preferentially absorb on the surface of the Zn anode to give a uniform and compact Zn deposition. As a result, the Zn anode is boosted to run over 3105 cycles (6210 h) with average Coulombic efficiency of 99.93% under 1 mA cm−² and 1 mAh cm−², and exhibit stable cycling for 1170 h under harsh testing conditions of 10 mA cm−² and 10 mAh cm−². Additionally, the Zn–MnO₂ full cells using the ZnSO₄–GBL electrolyte exhibit a high capacity of 287 mAh g−¹ at 0.5 A g−¹ and good capacity retention of 87% following 400 cycles. These findings will be of immediate benefit to design low cost AZIBs for clean energy storage.Haiji Huang, Dongmei Xie, Jiachang Zhao, Pinhua Rao, Won Mook Choi, Kenneth Davey, and Jianfeng Ma
Boosting the performance of Zn electrode in aqueous electrolytes via trace amount of organic molecules
No full textVersion of record online: December 20, 2023The poor performance of Zn electrode in aqueous electrolytes prevents the practical application of aqueous zinc-ion batteries (AZIBs). Here, 2-Pyrrolidinone (Pr) is introduced into conventional ZnSO4 electrolytes as additive and only 3 vol.% addition (Pr−to−H2O volume ratio) enables boosted performance. The Pr molecules are preferentially adsorbed on the surface of Zn electrodes to promote the uniform deposition of Zn ions and modulate the solvation structure of Zn2+ to inhibit the side reactions. As a result, the Zn electrode is boosted to run over 1200 h during charge/discharge cycling processes and delivers high average coulombic efficiency (CE) of 99.9 % under 1 mA cm−2, 1 mAh cm−2. Even under harsh testing conditions of 20 mA cm−2 and 20 mAh cm−2, Zn electrode still run over 100 h, which is much longer than that at pristine electrolyte (25 h). Moreover, the Zn||MnO2 full cells with the Pr additive exhibit a high capacity of 201 mAh g−1 and good capacity retention of 89 % after 550 cycles at 0.5 A g−1.Haiji Huang, Yan Wang, Dongmei Xie, Jianyang Sun, Jiachang Zhao, Pinhua Rao, Won Mook Choi, and Jianfeng Ma
Facile synthesis of rare earth metal Vanadate Neodymium Vanadate anchored on GQD decorated Silver Nanowire for Efficient Electrochemical Water splitting
No full textIn this work we synthesized the Neodymium Vanadate anchored on GQD decorated silver nanowire for electrochemical water splitting HER and OER. The composite was prepared through simple hydrothermal method and investigated the composite's structural and catalytic qualities. The AgNW@ GQD gave the entire composite a larger surface area and greater structural stability. To generate 50mA cm current density and a low Tafel slope value of 107 mV/dec , NdVO4/AgNW@GQD requires 267 mV of overpotential which is low compared to NdVO4, AgNW @GQD and commercial Pt/C electrode. Additionally, composite was used as an anode material in the OER reaction; however, 150 mV (vs RHE) overpotential was required to produce the current density of 10 mA cm current density, while the tafel slope value is 131 mV/dec .In the long-term chronoamperometric investigation, the current density for HER and OER increased up to 87% and 92%, respectively, over 100 hours, with nearly no changes. Keywords: NdVO4, AgNW@GQD, Water splitting, Electrocatalyst, hydrogen evolution reactionMaste
Synthesis of carbon-based nanomaterials and composites toward energy storage applications
No full textIn this dissertation work, we mainly study the carbon-based nanomaterials and
composites for energy storage applications, like anode materials for Li-ion materials
and electrode materials for supercapacitors.
Urchin-like MnO2/carbon nanofiber composites was prepared for anode
materials of Li-ion battery, The carbon nanofibers (CNFs) are uniformly deposited on
u-MnO2 to improve the electrical conductivity and to utilize the hierarchical
architecture of u-MnO2. As the anode electrode of Li-ion batteries, the u-MnO2/CNFs
nanocomposites exhibit an comparable cycle performance of 988 mAh·g−1 after 100
cycles with a good rate capability. The superior electrochemical performances of the
u-MnO2/CNFs nanocomposites can be attributed to the hierarchical urchin-like
structures and the superior electrical conductivity of the nanocomposites, which can
facilitate fast electron and ion transport and accommodate a large volume change
during charge/discharge.
Then obtained q-MC//CC composite is employed as a binder-free electrode of
supercapacitor. The g-C3N4 quantum dots could effectively enhance the interface
electrical conductivity and ion transportation of MnCO3 electrode, which results in
superior electrochemical performances. The q-MC//CC electrode delivers a high
specific capacity of 1001 F·g-1 at a current density of 1 A·g-1 and a good cycling
stability of 96% capacity retention after 5000 cycles. Moreover, asymmetric flexible
supercapacitor (ASC) are assembled with q-MC//CC as a positive electrode and
carbon cloth as a negative electrode, which exhibits a high energy density of 27.1
Wh·kg-1 at a power density of 500 W·kg-1. Also, the fabricated ASC device
demonstrates to power the light-emitting diode effectively under mechanical bending.
Also, as electrode materials of supercapacitors, GH-CN (graphene
hydrogel-g-C3N4 quantum dots) composites were prepared by hydrothermal method.
The results demonstrated that the addition of g-C3N4 QDs into graphene hydrogel
improved the electrochemical performance distinctly, because the nitrogen-riched
quantum dots embedded in graphene hydrogel which has high theoretically surface
area, the quantum dots can provide more active sites for faradic reactions, then promote ion diffusion\transport capability at the electrode/electrolyte interface and
enhance the faradic reaction and electron transfer, leading to the observed increased
capacitance. The symmetric supercapacitor (SSC) was assembled using GH-2.5CN as
positive electrode and negative electrode. The assembled SSC exhibited a high energy
density of 22.5 Wh kg-1 at 250 W kg-1, and illuminated a red light-emitting diode
(LED). It also exhibited excellent flexibility and reached 83.3% capacitance retention
after 15000 cycles at 5 A g-1. These results demonstrate the potential GH-CN as a
next-generation electrode material for energy storage system.
The novel hierarchical N-GQDs/MnCO3/ZnMn2O4 (N/MC/ZM) composite was
grown directly on Ni foam by simple hydrothermal method followed by calcinations
treatment for applications as high rate electrodes in supercapacitors. The N/MC/ZM
composites exhibited excellent electrochemical properties, including a high specific
capacitance of 960.6 F g-1, as well as better cycling stability than MC/ZM (450.3 F g-1).
The homogenously dispersed N-GQDs can increase the conductivity and activity sites.
Results clearly indicate that the combination of N-GQDs and MC/ZM can constitute a
promising binary metal-based electrode material with superior supercapacitive
performance, which can provide an alternative to design the quantum dots decorated
novel binary metal compounds materials with sample methods for a wide variety of
energy storage devices such as supercapacitors, batteries.Docto
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