5,399 research outputs found
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
BIODEGRADATION OF CYANIDE COMPOUNDS BY PSEUDOMONAS-FLUORESCENS IMMOBILIZED ON ZEOLITE
No full textA cyanide-degrading bacteria, Pseudomonas fluorescens NCIB 11764, was used for the treatment of wastewater containing cyanide. After successive subculture for 2 months in cyanide-containing medium, cultures were fully adapted to cyanide and able to grow in a medium containing up to 260 mg l(-1) of cyanide. By fed-batch culture supplying only cyanide, it was confirmed that cyanide was the limiting nutrient as a nitrogen source. Ammonia was found to inhibit cyanide degradation, and the rate of degradation was halved when the ammonia concentration was higher than 1 mM. In a 15-l jar fermenter, 26 mg l(-1) of cyanide was consumed almost completely within 48 h and the final yield of growth on cyanide was calculated as 4.21 mg dry cell wt mg(-1) CN. Cells of P. fluorescens were immobilized on zeolite and applied to a modified activated sludge-type reactor to mimic the actual activated sludge system of a coke-plant wastewater treatment system. In this immobilized system operated batchwise, 26 mg l(-1) of cyanide was degraded completely by 8 g l(-1) of immobilized particles within 10 h. The same reactor system was operated in a continuous mode, and the cyanide concentration of the outlet reached the stationary-state level of less than 0.1 mg l(-1) within 2 days at 0.041 h(-1) of dilution rate and within 3 days at 0.082 h(-1) of dilution rate, respectively
Root culture using a mist culture system and estimation of scale-up feasibility
No full textNormal root of Hyoscyamus niger was cultivated in four different culture systems; a flask, a stirred tank reactor, a mist bioreactor, and a unified mist bioreactor. The scopolamine/hyoscyamine contents of the roots in the various reactor configurations were at similar levels, but the growth rates were different. The dry weight of the root in the flask increased 21.4 times in 25 days, 12.9 times in the stirred tank reactor, and 4.76 times in the first mist bioreactor respectively. This low growth rate in the first mist bioreactor was probably due to limited nutrient supply of the air-carrier method. Root growth increased 9.29 times using the unified mist bioreactor in which mist can be sufficiently supplied without dilution of mist by air flow. It was estimated that a scale-up of over 10 dm(3) of reactor volume would not be effective if the air-carrier method were used in a mist culture system
The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene
No full textContinuous production of uniform calcium alginate beads by sound wave induced vibration
No full textA new process for the immobilization of sodium alginate, which employs a vibration of membrane induced by sound waves from a horn-type speaker, is developed to produce uniformly-sized beads of predictable diameter. Frequency of sound wave and production rate are varied to find the optimal control ranges for the bead production. The controllable bead size range is 1.50-3.50 mm and the experimental production rates are 0-12 dm(3) h(-1) by a single nozzle. This method of bead production is a practical alternative to conventional continuous bead production methods with low apparatus cost and easier and better control of bead size and shape
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene
No full textUterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
- …
