162,999 research outputs found
Towards Novel Nonparametric Statistical Methods and Bioinformatics Tools for Clinical and Translational Sciences
No full textAs the field of functional genetics and genomics is beginning to mature, we become confronted with new challenges. The constant drop in price for sequencing and gene expression profiling as well as the increasing number of genetic and genomic variables that can be measured makes it feasible to address more complex questions. The success with rare diseases caused by single loci or genes has provided us with a proof-of-concept that new therapies can be developed based on functional genomics and genetics. Common diseases, however, typically involve genetic epistasis, genomic pathways, and proteomic pattern. Moreover, to better understand the underlying biologi-cal systems, we often need to integrate information from several of these sources. Thus, as the field of clinical research moves toward complex diseases, the demand for modern data base systems and advanced statistical methods increases. The traditional statistical methods implemented in most of the bioinformatics tools currently used in the novel field of genetics and functional genomics are based on the linear model and, thus, have shortcomings when applied to nonlinear biological systems. The previous work on partially ordered data (Wittkowski 1988; 1992), when combined with theoretical results (Hoeffding 1948) and computational strategies (Deuchler 1914) has opened a new field of nonparametric statistics. With grid technology, new tools are now feasible when screening for interactions between genetics (Wittkowski, Liu 2002) and functional genomics (Wittkowski, Lee 2004). Having more complex study designs and more specific methods available increases the demand for decision support when selecting appropriate bioinformatics tools. With the advent of rapid prototyping systems for Web based database application, we have recently begun to complement previous work on knowledge based systems with graphical Web-based tools for acquisition of DESIGN and MODEL knowledge.Biostatistics Bioinformatics NIH NCRR ROADMAP
Studying travel-related individual assessments and desires by combining hierarchically structured ordinal variables
No full textSubjective mobility, Travel desires, Ordinal variables, Factor analysis, Multidimensional data,
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Supplemental Material, STT_Advice_Compliance_l_Executive_Summary_l_Dec_28 - What Gets Measured Gets Done: Can Self-Tracking Technologies Enhance Advice Compliance?
No full textSupplemental Material, STT_Advice_Compliance_l_Executive_Summary_l_Dec_28 for What Gets Measured Gets Done: Can Self-Tracking Technologies Enhance Advice Compliance? by Kristina Wittkowski, Jan F. Klein, Tomas Falk, Jeroen J. L. Schepers, Jaakko Aspara and Kai N. Bergner in Journal of Service Research</p
Tests of stellar model atmospheres by optical interferometry
No full textContext: .Optical interferometry allows a measurement of the intensity profile across a stellar disc, leading to a direct test and calibration of theoretical model atmospheres as well as to a precise determination of fundamental stellar parameters. Aims: .We present a comparison of the visual and near-infrared intensity profile of the M0 giant γ Sagittae to plane-parallel ATLAS 9 as well as to plane-parallel and spherical PHOENIX model atmospheres. Methods: .We use previously described visual interferometric data obtained with the Navy Prototype Optical Interferometer (NPOI) in July 2000. We apply the recently developed technique of coherent integration, and thereby obtain visibility data of more spectral channels (526-852 nm) and with higher precision than before. In addition, we employ new measurements of the near-infrared K-band (~2200 nm) diameter of γ Sagittae obtained with the instrument VINCI at the ESO VLT Interferometer (VLTI) in 2002. Results: .The spherical PHOENIX model leads to a precise definition of the Rosseland angular diameter and a consistent high-precision diameter value for our NPOI and VLTI/VINCI data sets of Θ_Ross=6.06 ± 0.02 mas, with the Hipparcos parallax corresponding to R_Ross=55 ± 4~R_☉, and with the bolometric flux corresponding to an effective temperature T_eff=3805 ± 55 K. Our visual visibility data close to the first minimum and in the second lobe constrain the limb-darkening effect and are generally consistent with the model atmosphere predictions. The visual closure phases exhibit a smooth transition between 0 and π. Conclusions: .The agreement between the NPOI and VINCI diameter values increases the confidence in the model atmosphere predictions from optical to near-infrared wavelengths as well as in the calibration and accuracy of both interferometric facilities. The consistent night-by-night diameter values of VINCI give additional confidence in the given uncertainties. The closure phases suggest a slight deviation from circular symmetry, which may be due to surface features, an asymmetric extended layer, or a faint unknown companion...
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Variable cant angle winglets for improvement of aircraft flight performance
No full textTraditional winglets are designed as fixed devices attached at the tips of the wings. The primary purpose of the winglets is to reduce the lift-induced drag, therefore improving aircraft performance and fuel efficiency. However, because winglets are fixed surfaces, they cannot be used to control lift-induced drag reductions or to obtain the largest lift-induced drag reductions at different flight conditions (take-off, climb, cruise, loitering, descent, approach, landing, and so on). In this work, we propose the use of variable cant angle winglets which could potentially allow aircraft to get the best all-around performance (in terms of lift-induced drag reduction), at different flight phases. By using computational fluid dynamics, we study the influence of the winglet cant angle and sweep angle on the performance of a benchmark wing at Mach numbers of 0.3 and 0.8395. The results obtained demonstrate that by adjusting the cant angle, the aerodynamic performance can be improved at different flight conditions
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
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