333 research outputs found
HPV and cervical cancer on Curaçao: towards implementation of an integrated prevention programme
No full textMeijer, C.J.L.M. [Promotor]Kenter, G.G. [Promotor]Lissenberg-Witte, B.I. [Copromotor]Quint, W.G.V. [Copromotor
Supplemental_file_2_-_Alveolar_overjet_building_plan_-_lower_part - The Reproducibility of the Jaw Index in the Measurement of Healthy Newborns
No full textSupplemental_file_2_-_Alveolar_overjet_building_plan_-_lower_part for The Reproducibility of the Jaw Index in the Measurement of Healthy Newborns by J.F. Mermans, S.M. Ghasemi, B.I. Lissenberg-Witte and J.P.W. Don Griot in The Cleft Palate-Craniofacial Journal</p
Supplemental_file_1_-_Alveolar_overjet_building_plan_-_upper_part_(Length_digits_in_mm) - The Reproducibility of the Jaw Index in the Measurement of Healthy Newborns
No full textSupplemental_file_1_-_Alveolar_overjet_building_plan_-_upper_part_(Length_digits_in_mm) for The Reproducibility of the Jaw Index in the Measurement of Healthy Newborns by J.F. Mermans, S.M. Ghasemi, B.I. Lissenberg-Witte and J.P.W. Don Griot in The Cleft Palate-Craniofacial Journal</p
Current Status Censoring Models: Smooth estimators and their asymptotic properties
No full textStatistics deals with answering questions based on collected data. In medical applications, the quantity of interest can often not be observed directly. They are censored. It is a challenge to answer the question as precisely as possible based on the incomplete data. The quantity of interest can be censored in many different ways. In HIV vaccine trials, censoring results in “current status continuous mark” data. This is a very specific type of censoring and the method of maximum likelihood that usually works very well does not work in this case. Hence, alternative methods are needed. In this thesis, different alternative methods are introduced and studied from different perspectives.Statistics and ProbabilityElectrical Engineering, Mathematics and Computer Scienc
Parliamentary oversight of security and intelligence agencies in the EU
No full textAnnex B.I of the report (on page 350) "Parliamentary Scrutiny of Justice and Home Affairs Agencies" is written by Bruno DE WITTE and Jorrit J. RIJPMA. Based on research in the framework of the project 'EUDO Institutions'.This study evaluates the oversight of national security and intelligence agencies by parliaments and specialised non-parliamentary oversight bodies, with a view to identifying good practices that can inform the European Parliament’s approach to strengthening the oversight of Europol, Eurojust, Frontex and, to a lesser extent, Sitcen. The study puts forward a series of detailed recommendations (including in the field of access to classified information) that are formulated on the basis of indepth assessments of: (1) the current functions and powers of these four bodies; (2) existing arrangements for the oversight of these bodies by the European Parliament, the Joint Supervisory Bodies and national parliaments; and (3) the legal and institutional frameworks for parliamentary and specialised oversight of security and intelligence agencies in EU Member States and other major democracies
Bilateral squamous cell carcinoma of the temporal bone: A report of two cases and a systematic review of the literature
No full textObjective: two new cases of temporal bone squamous cell carcinoma (TBSCC) with a bilateral occurrence are presented. Furthermore, a review of the literature was performed and the yearly incidence was calculated. Methods: A systematic review of the literature was conducted using PRISMA guidelines. Results: Twenty-two more cases were found in literature. With a total of 24 cases, the calculated yearly incidence of bilateral TBSCC is 49:10^12 A history of chronic otitis or regional radiotherapy was found in respectively 50% and 12% of patients. In nine patients, the tumors developed synchronously (within 6 months) and in 13 metachronously. Conclusions: The calculated incidence is 89 times higher than mathematically expected considering the incidence of unilateral cases. An explanation might be a history of chronic otitis or prior radiotherapy. The tumor staging of both the first tumor group and the contralateral tumor group are similar to unilateral temporal bone squamous cell carcinoma series
Activity-based profiling of glycoconjugate processing enzymes
No full textGlycoconjugates (a carbohydrate connected to a lipid, protein or other carbohydrate) play a key role in great variety of biological processes. The synthesis of these constructs is tightly regulated by enzymes. Defects in these enzymes may result in an impaired degradation of the glycoconjugate. Consequently, the levels of glycoconjugates are increased and this may eventually lead to storage disorders such as Gaucher disease. The research described in this thesis focuses on the synthesis of chemical tools (activity-based probes, ABPs) to study the enzymes involved in the degradation of glycoconjugates. Using these probes, it was demonstrated that the activity of peptide N-glycanase (the enzyme that is responsible for the hydrolysis of N-linked glycoproteins)inhibitors is determined by its reactive group. Furthermore, the activity-based protein profiling strategy was used to study degradation of glycosy lated proteins. It appeared that deglycosylation of O-GlcNAclated proteins is not a prerequisite for proteasomal degradation. To study beta-glucosidases (enzymes that catalyze the hydrolysis of O-glycosidic linkages), ABPs based on cyclophellitol have been developed. Especially fluorescently labeled probes bind efficiently and selectively to beta-glucosidases. These probes have been used to investigate Gaucher disease. Both wild-type and mutant forms of the enzyme could be labeled in vitro and in living cells which allowed rapid identification activity of this glucosidase.UBL - phd migration 201
Academic authorship: who, why and in what order?
No full textWe are frequently asked by our colleagues and students for advice on authorship for scientific articles. This short paper outlines some of the issues that we have experienced and the advice we usually provide. This editorial follows on from our work on submitting a paper1 and also on writing an academic paper for publication.2 We should like to start by noting that, in our view, there exist two separate, but related issues: (a) authorship and (b) order of authors. The issue of authorship centres on the notion of who can be an author, who should be an author and who definitely should not be an author, and this is partly discipline specific. The second issue, the order of authors, is usually dictated by the academic tradition from which the work comes. One can immediately envisage disagreements within a multi-disciplinary team of researchers where members of the team may have different approaches to authorship order
Maximum smoothed likelihood estimation and smoothed maximum likelihood estimation in the current status model
No full textWe consider the problem of estimating the distribution function, the density and the hazard rate of the (unobservable) event time in the current status model. A well studied and natural nonparametric estimator for the distribution function in this model is the nonparametric maximum likelihood estimator (MLE). We study two alternative methods for the estimation of the distribution function, assuming some smoothness of the event time distribution. The first estimator is based on a maximum smoothed likelihood approach. The second method is based on smoothing the (discrete) MLE of the distribution function. These estimators can be used to estimate the density and hazard rate of the event time distribution based on the plug-in principle.Delft Institute of Applied MathematicsElectrical Engineering, Mathematics and Computer Scienc
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