69 research outputs found
Enhanced killing of colon cancer cells by mesoporous silica nanoparticles loaded with ellagic acid
No full textAbstract: Natural compounds, including ellagic acid (ELG), have potentially a great antitumor efficacy with low adverse effects. However, their efficacy needs to be improved Nanotechnology permits to create nanoparticles as natural drug carriers and improve their in cancer therapy. We report an inorganic-organic nanostructure composed of mesoporous silica nanoparticles (MSN) functionalized with triptycene (TRP) and loaded with ELG, further called MSN-TRP-ELG nanoformulation. The nanoformulation contained over 11 wt.% TRP and approximately 25 wt.% ELG. It was tested for anticancer effects against two colon cancer cells: HCT-116 and HT-29 for treatment with up to 200 µM. Comparing to free ELG, we have shown a 3 times higher cancer inhibition. The lowest IC50 values were for HCT-116 (88.1±0.1 µM) and HT-29 (77.6±0.1 µM). When treated with free ELG the values were 187.1±0.10µM, and 300.0±0.07 µM, respectively. MSN-TRP-ELG enhanced cell death apoptosis primally via activating caspase-3, p53 and Bax. It also inhibited receptor tyrosine kinases (HER2 and VEGFR2) and upregulated Bcl-2 in HCT-116 and HT-29 cells. An important finding was that B-RAF CRAF and K-RAS were inhibited. The expression of B-RAF, C-RAF, and K-RAS oncogenes was also highly inhibited by the nanoformulation compared to free ELG. This research confirms the potential of nanomedicine for enhancing the efficiency in application of natural prodrugs, and in. particular ELG in cancer therapy and opens the way for further preclinical research.</p
Optimization of Conditions of Preparation of YAG Nanopowders for Sintering of Translucent Ceramics
No full textEffect of low-temperature high-pressure sintering on BiFeO3 density, electrical magnetic and structural properties
No full textSingle-phase multiferroic BiFeO3 (BFO) powders were prepared by hydrothermal microwave synthesis and dense BiFeO3 ceramics were fabricated for the first time by the low-temperature high-pressure (LTHP) sintering technique. Effect of sintering temperature ranging from 400 to 800 °C (3 min and 10 min) and pressure of 3-8 GPa on structural, microstructural, electric and magnetic properties were investigated through X-ray diffraction, scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS), density and magnetic measurements. The results highlighted that LTHP sintering method, thanks to the high pressure involved, requires lower temperature and shorter time than other techniques, avoiding BiFeO3 phase degradation. SEM images show that for short experimental time (t = 3 min) the average grain size of the sintered samples was approximately the same size of raw powder. Extending the sintering time up to 10 min the grain growth phenomena occurred. Moreover the results indicate that the best obtained density value was around 98% of theoretical density. The dielectric behavior of BiFeO3 ceramics was not significantly influenced by the LTHP sintering conditions. Magnetic measurements showed that ceramic BiFeO 3 is weakly ferromagnetic at room temperature. © 2013 Taylor & Francis
Study of Grain Size Distribution in Nanocrystalline Iron Oxides Synthesized by Hydrothermal Method
No full textscore: 0collation: 239-24
How Can the Intra-Shell Emissions of Rare Earth and Transition Metal Ions in Thin Films and Nanoparticles Be Stimulated?
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