1,317 research outputs found
Multiplexing autoradiography
No full textAutoradiography, the direct imaging of radioactive distribution in tissue sections, is a powerful technique that has several key advantages for the validation of PET radiotracers. Using autoradiography, we can localize radiotracer uptake to neighbours of cells, and when multiplexed with additional radiotracers, fluorescent probes, or in situ tissue analysis, autoradiography can help to characterize the mechanism of radiotracer uptake and assess functional heterogeneity in tissue. In this chapter, the author outlines the basic ex vivo autoradiography protocol and shows how it can be multiplexed using dual radionuclides 18F and 14C. They also highlight where autoradiography can be combined with other technologies to provide synergistic information for interrogating spatial biology
The election of President of the United States, considered.
No full textAttributed to Timothy Fuller in Richard H. Shoemaker, A Checklist of American Imprints for 1823.Mode of access: Internet
Evaluating Research Impact through Open Access to Scholarly Communication
Get PDFScientific research is a competitive business – in order to secure funding, promotion and tenure researchers must demonstrate their work has impact in their field. To maximise impact researchers undertake high priority research, aim to get results first, and publish in the highest impact journals. The Internet now presents a new opportunity to the scholarly author seeking higher impact: s/he can now make their work instantly accessible on the Web through author self-archiving. This growing body of open access literature (coupled with new publishing models that make journals available for-free to the reader) maximises research impact by maximising the number of people who can read it, and making it available sooner. Open access also provides a new opportunity for bibliometric research. This thesis describes the relatively recent phenomenon of open access to research literature, tools that were built to collect and analyse that literature, and the results of analyses of the effect of open access and its effect on author behaviour. It shows that articles self-archived by authors receive between 50-250% more citations, that rapid pre-printing on the Web has dramatically reduced the peak citation rate from over a year to virtually instant and how citation-impact – now widely used for evaluation – can be expanded to include a new web metric of download impact
Hidden in Plain Sight:Clinical Imaging of the Tumor Microenvironment with PET
No full textPET imaging enables the spatiotemporal assessment of tumor biomarkers. In this issue, Kong and colleagues describe the clinical PET imaging of tumor-associated fibroblasts, which improved the diagnostic accuracy and management of a subset of patients with medullary thyroid carcinoma.</p
Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy. Biochem.Soc.Trans
No full textAbstract Patients with similar tumour types frequently show different responses to the same therapy. The development of new treatments would benefit, therefore, from imaging methods that allow an early assessment of treatment response in individual patients, allowing rapid selection of the most effective treatment. We have been using 13 C MRSI (magnetic resonance spectroscopic imaging) of tumour cell metabolism, using hyperpolarized 13 C-labelled cellular metabolites, to detect treatment response. Nuclear spin hyperpolarization can increase sensitivity in the magnetic resonance experiment >10 000 times, allowing us to image labelled cell substrates in vivo and their subsequent metabolism. We showed that exchange of hyperpolarized 13 C label between lactate and pyruvate, catalysed by lactate dehydrogenase, was decreased in treated tumours undergoing drug-induced cell death, and that tissue pH could be imaged from the ratio of the signal intensities of hyperpolarized H 13 CO 3 − and 13 CO 2 following intravenous injection of hyperpolarized H 13 CO 3 . Tumour cell glutaminase activity, a potential measure of cell proliferation, can be determined using hyperpolarized [5-13 C]glutamine, and treatment-induced tumour cell necrosis can be imaged in vivo from measurements of the conversion of hyperpolarized [1,4-13 C 2 ]fumarate into malate. Since these substrates are endogenous and, in some cases, have already been safely infused into patients, these techniques have the potential to translate to the clinic
Analysis of watersheds and river systems: short course
Get PDFShort course: Analysis of Watersheds and River Systems, Session I and II, held on May 28-June 1, 1979 and June 4-June 8, 1979 at Colorado State University, Fort Collins, Colorado.Speakers: Dr. E. V. Richardson, Dr. David Duttweiller, Mr. Lee Mulkey, Dr. Stanley A. Schumm, Dr. Daryl B. Simons, Dr. Ross Carder.Includes bibliographical references.This short course is designed for individuals dealing with the analysis of watersheds and rivers. Practical applications concerning physical processes will be emphasized.Chapter 1. General introduction / Daryl B. Simons and Ruh-Ming Li -- Chapter 2. Introduction to watershed and river analysis / Daryl B. Simons and Ruh-Ming Li -- Chapter 3. Physical processes governing response of watersheds and rivers / Daryl B. Simons, Timothy J. Ward and Ruh-Ming Li -- Chapter 4. Sediment transport / H. W. Shen -- Chapter 5. Alluvial bed roughness / H. W. Shen -- Chapter 6. Overview of flood routing methods / Ruh-Ming Li and V. Miguel Ponce -- Chapter 7. Water routing and yield from watersheds, Part I and II / Ruh-Ming Li, Daryl B. Simons, and Kenneth G. Eggert -- Chapter 8. Water routing in rivers / Yung-Hai Chen -- Chapter 9. Stage discharge relations / Robert K. Simons, Ruh-Ming Li, and Daryl B. Simons -- Chapter 10. Watershed sediment yield / Ruh-Ming Li, Daryl B. Simons, and Timothy J. Ward -- Chapter 11. Unsteady sediment routing models in rivers / Yung-Hai Chen and Daryl B. Simons -- Chapter 12. Known discharge sediment routing / Glenn O. Brown and Ruh-Ming Li -- Chapter 13. Landslide potential delineation / Timothy J. Ward, Ruh-Ming Li, and Daryl B. Simons -- Chapter 14. Application of Kalman filtering in watershed and river analysis / Nguyen Duong -- Chapter 15. Handheld calculator programs for analysis / Kenneth G. Eggert, Ruh-Ming Li, and Daryl B. Simons -- Chapter 16. Overview of case studies and data management / Daryl B. Simons, Ruh-Ming Li, and Nguyen Duong -- Chapter 17. Canal and channel design and river response analysis / Daryl B. Simons, Ruh-Ming Li, and Yung-Hai Chen -- Chapter 18. Degradation and aggradation analysis / Ruh-Ming Li and Daryl B. Simons -- Chapter 19. Watershed best management analysis / Ruh-Ming Li, Timothy J. Ward, and Daryl B. Simons -- Chapter 20. Large river basin analysis: Yazoo River Sedimentation Study / Daryl B. Simons and Ruh-Ming Li
Increasing Distributed Generation Penetration using Soft Normally-Open Points
Get PDFThis paper considers the effects of various voltage control solutions on facilitating an increase in allowable levels of distributed generation installation before voltage violations occur. In particular, the voltage control solution that is focused on is the implementation of `soft' normally-open points (SNOPs), a term which refers to power electronic devices installed in place of a normally-open point in a medium-voltage distribution network which allows for control of real and reactive power flows between each end point of its installation sites. While other benefits of SNOP installation are discussed, the intent of this paper is to determine whether SNOPs are a viable alternative to other voltage control strategies for this particular application. As such, the SNOPs ability to affect the voltage profile along feeders within a distribution system is focused on with other voltage control options used for comparative purposes. Results from studies on multiple network models with varying topologies are presented and a case study which considers economic benefits of increasing feasible DG penetration is also given
The relationship between spatial pooling and attention in saccadic and perceptual tasks
No full textAbstractSaccades aimed at spatially extended targets land reliably at central locations determined by pooling information across the target shape [Melcher, D., & Kowler, E. (1999). Shape, surfaces and saccades. Vision Research, 39, 2929–2946; Vishwanath, D., & Kowler, E. (2003). Localization of shapes: Eye movements and perception compared. Vision Research, 43, 1637–1653]. Previous findings of saccadic errors when attempting to look at a target in the midst of distractors encouraged suggestions that pooling occurs indiscriminately, with little or no influence of a selective filter to eliminate the influence of nearby distractors. To determine the effectiveness of filtering, saccadic localization was studied for saccades made to a set of target elements (discs) interleaved with an equivalent set of distractors of a different color. With such interleaved elements, selection and spatial pooling are constrained to occur over the same spatial region. The results showed that filtering was effective and saccadic landing position was determined mainly by the target elements. Concurrent perceptual judgments made about the same stimuli (estimating the mean size of either target or distractor discs) showed better performance for the target discs than distractors, confirming that perceptual attention was allocated to the set of target elements. These results: (1) support the role of attention in setting the input to the spatial pooling process that guides saccades to spatially extended targets, and (2) show that perceptual judgments of mean value, often thought to impose modest attentional demands, are not immune to the constraints of this pre-saccadic filter
The Fighter
No full textThis essay seeks to establish the underlying dynamic in D H Lawrence's writing, the way his characters relate to each other and the way he as an author relates to his readers. Again and again, relationships appear to be based on conflict, where conflict is presented not as a necessary prerequisite of victory, but of self-knowledge. It is through violent confrontation with others that self-realization and self-knowledge are achieved. Curiously, the worst fate in his books befalls those who destroy their antagonists, for then they find themselves deprived of the conflict that made sense of their lives. The essay then seeks to demonstrate that Lawrence encouraged the same dynamic not only among his circle of friends, but likewise with regard to the critics and his readers in general
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