35,211 research outputs found

    INTRACELLULAR CA2+ STORES OF RAT CEREBELLUM - HETEROGENEITY WITHIN AND DISTINCTION FROM ENDOPLASMIC-RETICULUM

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    Rat cerebellum microsomes were subfractionated on isopycnic linear sucrose (20-42%)-density gradients. The distribution of endoplasmic reticulum (ER) markers (RNA, signal-sequence receptor alpha, calnexin, calreticulin, the immunoglobulin-binding protein Bip) and markers of intracellular rapidly exchanging Ca2+ stores [Ca2+ channels sensitive to either Ins(1,4,5)P3 or ryanodine) was investigated biochemically and immunologically. The comparison indicates that: (a) vesicles bearing the InsP3 receptor were separated from those bearing the ryanodine receptor; (b) ER markers, i.e. Bip, calnexin, signal-sequence receptor alpha, RNA, did not sediment as either InsP3 or ryanodine receptors did; (c) calreticulin, an intralumenal low-affinity high-capacity Ca(2+)-binding protein, had a widespread distribution, similar to that of Bip and calnexin, and was present in Purkinje, granule, Golgi and stellate neurons, as indicated by immunofluorescent labelling of cerebellum cortex cryosections. The present results show that the ER is not a homogeneous entity, and that Ca2+ stores are heterogeneous insofar as InsP3 receptors and ryanodine receptors are segregated, either to discrete intracellular organelles or to specialized ER subcompartment

    Dr. P.H. McCullough

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    Dr. P.H. McCullough, grandfather of F. Witcher McCullough,10.5x9.3cm grandfather of F. Witcher McCulloughhttps://mds.marshall.edu/cabell_wayne_hist_soc_collection/1793/thumbnail.jp

    Dr Robert King author

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    Dr. Robert King is pictured at the medical office on display at the Bishop Museum. King was the author of "A history of the practice of medicine in Manatee County, Florida", published in 1985. He was also a past president of the Manatee Historical Society

    Dr. Glendon Swarthout

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    Hosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness

    Dr. Arthur Pindle, Spelman College, April, 2012

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    This video is a conversation with Dr. Arthur Pindle. Dr. Pindle talks about his book, "Bayou St. John". Daniel Le, AUC Woodruff Library, is the interviewer

    Dr. Margaret Aymer, ITC, January 2012

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    This video is a conversation with Dr. Margaret Aymer. Dr. Aymer talks about her book, "Confessing the Beatitudes". Brad Ost, AUC Woodruff Library, is the interviewer

    Dr. Mark Ellingsen, ITC, November 2011

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    This video is a conversation with Dr. Mark Ellingsen. Dr. Ellingsen talks about his book, "Lectionary Preaching Workbook, Series IX, Cycle B". Brad Ost, AUC Woodruff Library, is the interviewer

    Dr. Tarshia Stanley, Spelman College, September 2011

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    This video is a conversation with Dr. Tarshia Stanley. Dr. Stanley talks about her book, "Encyclopedia of Hip Hop Literature". Yolanda Gilmore-Bivins, AUC Woodruff Library, is the interviewer

    Dr. L.H. Whelchel, ITC, June 27, 2014

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    This video is a conversation with Dr. L.H. Whelchel. Dr. Whelchel talks about his book, "Sherman's March and the Emergence of the Independent Black Church Movement". Brad Ost, AUC Woodruff Library, is the interviewer

    Dr. Lin Sun, CAU, March 2013

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    This video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
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