383 research outputs found
Interview with Sofie Abdullah
No full textفي هذه المقابلة، تتحدث الكاتبه صوفى عبد الله عن أسرار مهنة الكتابة.In this interview, Sofie Abdullah, a well-known Egyptian author, discusses the intricacies of the writing industry
Affine-Invariant Querying of Spatial Data using a Triangle-Based Logic
No full textIf the same land area is photographed from two different angles, then a computer can recognize the two images to show the same land area by proving that the images are affine-invariant. In practice, images are abstracted as a type of spatial data that is a finite set of triangles. Hence we propose a simple affine-generic query language with variables over finite sets of triangles. The proposed query language is intuitive and has the same expressive power as the affine-generic fragment of first-order logic over the reals on triangle databases.Kuijpers, B (corresponding author), Hasselt Univ, Data Sci Inst, Databases & Theoret Comp Sci Res Grp, B-3590 Diepenbeek, Belgium.
[email protected]; [email protected]; [email protected]
”Hon har inte alla besticken i lådan” En kritisk diskursanalys av hur kvinnliga respektive manliga mördare framställs i Veckans Brott
No full textAbstract
Title: ”Hon har inte alla besticken i lådan” – En kritisk diskursanalys av hur kvinnliga respektive manliga mördare framställs i Veckans Brott
Author: Sofie Furusäter & Mikaela Söderberg
Subject: Undergraduate research paper in Journalism studies, Dept. Of Journalism,
media and communication (JMG) Gothenburg University
Term: Spring 2017
Supervisor: Marina Ghersetti, JMG Gothenburg
Pages/words: 38/15648, excluding appendix and reference-list
Purpose: The purpose of this paper is to examine how the Swedish television program Veckans Brott portraits female and male murderers.
Method: Critical Discourse Analysis
Procedure: 10 cases (within 14 episodes) were analyzed through Critical discourse analysis.
Results: Our analysis show some differences between the portrayal of the male and female offenders in the Swedish television program Veckans Brott.
Key words: Crime, gender, media, murderer, Veckans Brott, narratology, discourse analysis, norm
Nyckelord: Brottslighet, genus, medier, mördare, Veckans Brott, narratologi, diskursanalys, nor
Islamist movements at crossroads: the choice between ideology and context-driven approach to politics. Case study on the Hashemite Kingdom of Jordan
No full textThe aim of the paper is to analyse the ongoing transformation process within the Islamist movements using the example of the moderate Islamic Action Front party in Jordan. The dilemma of participation in the 2010 general elections raised tensions between the Muslim Brotherhood in Jordan and its political wing, the Islamic Action Front, and between doves and hawks of the same organizations. Internal debate on the future has started recently among different groups within the Islamist movement in Jordan. The research is based on the author‘s recent field experience in Jordan (April–July 2010, Andrew W. Mellon Fellowship at the American Centre of Oriental Research, Amman, Jordan). The author also conducted research in Syria, Lebanon, Palestine and Egypt, where several interviews were carried out with leading and lower level Islamist politicians. The dynamic changes within Islamic Action Front Party in Jordan and its relation with the regime has been used as reference point. The main question of the research was aa how the changing political and regional context shapes decisions of the Islamist with special attention to the acceptance of democratic values and human rights, political participation, and the meanings of Islamic values in the 21st century, possible cooperation with secular parties/movements/the regime
The Netherlands
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Water Resource
Case Study of Physiotherapeutic Care for a Patient Diagnosed with Rheumatoid Arthritis Following Total Hip Replacement
No full textAuthor: Sofie Šafková Thesis supervisor: PhDr. Ivana Vláčilová, Ph.D. Title: Case Study of Physiotherapeutic Care for a Patient Diagnosed with Rheumatoid Arthritis Following Total Hip Replacement Objectives: This bachelor's thesis aimed to summarize theoretical knowledge on total hip replacement in patients with rheumatoid arthritis and to apply this knowledge in clinical practice through a case study. The focus was on evaluating the effectiveness of selected physiotherapeutic methods, their impact on the patient's functional condition after surgery, and a comparison with current recommendations from the literature. Methods: The thesis was developed during clinical practice at the Revmatologický ústav in Prague, where the patient underwent twelve days of physiotherapeutic care following a total hip replacement of the right hip joint. The thesis consists of a theoretical and a special (case study) part. The theoretical section focuses on the anatomy and kinesiology of the hip joint, describes total hip replacement and rheumatoid arthritis, their clinical presentation, treatment options, and rehabilitation approaches. The special part includes a kinesiological analysis, therapeutic goals, the course of therapy, final assessment, and evaluation of therapeutic outcomes. Results: The physiotherapeutic...Autor: Sofie Šafková Vedoucí práce: PhDr. Ivana Vláčilová, Ph.D. Název: Kazuistika fyzioterapeutické péče o pacientku s diagnózou revmatoidní artritida se stavem po TEP kyčelního kloubu Cíl: Cílem této bakalářské práce bylo shrnout teoretické poznatky o problematice totální endoprotézy kyčelního kloubu u pacientů s revmatoidní artritidou a jejich uplatnění v klinické praxi prostřednictvím zpracování kazuistiky. Důraz byl kladen na hodnocení efektu vybraných fyzioterapeutických metod, jejich dopad na funkční stav pacientky po operaci a porovnání s doporučeními odborné literatury. Metody: Práce byla zpracována v rámci odborné praxe v Revmatologickém ústavu v Praze, kde pacientka absolvovala dvanáctidenní fyzioterapeutickou péči po implantaci totální endoprotézy (TEP) pravého kyčelního kloubu. Bakalářská práce je rozdělena na část teoretickou a speciální. Teoretická východiska práce jsou zaměřena na anatomii a kineziologii kyčelního kloubu, popis totální endoprotézy a revmatoidní artritidy, jejich klinický obraz, možnosti léčby a rehabilitaci. Speciální část obsahuje kineziologický rozbor, cíle terapie, průběh jednotlivých terapeutických jednotek, výstupní kineziologický rozbor a zhodnocení efektu terapie. Výsledky: V rámci terapie došlo ke zlepšení rozsahu pohybu v oblasti pravého kyčelního kloubu,...Katedra fyzioterapieDepartment of PhysiotherapyFakulta tělesné výchovy a sportuFaculty of Physical Education and Spor
Case Study of Physiotherapeutic Care for a Patient Diagnosed with Rheumatoid Arthritis Following Total Hip Replacement
No full textAuthor: Sofie Šafková Thesis supervisor: PhDr. Ivana Vláčilová, Ph.D. Title: Case Study of Physiotherapeutic Care for a Patient Diagnosed with Rheumatoid Arthritis Following Total Hip Replacement Objectives: This bachelor's thesis aimed to summarize theoretical knowledge on total hip replacement in patients with rheumatoid arthritis and to apply this knowledge in clinical practice through a case study. The focus was on evaluating the effectiveness of selected physiotherapeutic methods, their impact on the patient's functional condition after surgery, and a comparison with current recommendations from the literature. Methods: The thesis was developed during clinical practice at the Revmatologický ústav in Prague, where the patient underwent twelve days of physiotherapeutic care following a total hip replacement of the right hip joint. The thesis consists of a theoretical and a special (case study) part. The theoretical section focuses on the anatomy and kinesiology of the hip joint, describes total hip replacement and rheumatoid arthritis, their clinical presentation, treatment options, and rehabilitation approaches. The special part includes a kinesiological analysis, therapeutic goals, the course of therapy, final assessment, and evaluation of therapeutic outcomes. Results: The physiotherapeutic..
Den självständige specialisten : En studie av personligstyper hos dagens kommunikatörer
No full textAbstractAuthor: Sofie JakobssonCourse: Media and Communication Studies CUniversity: Division of Media and Communication, Department of Information Science, Uppsala UniversityPeriod: Spring 2012Key words: Job ads, Professional Communicator, Public Relations Officer, Trait Theory, Five Factor Theory, Big Five, personal traits, work tasks.Title: The Independent Specialist. A study of requested personal types in Professional Communicators.Number of pages: 35Purpose/ Aim: The study aims to evaluate what kind of personality type that would make a good fit for a Professional Communicator. The study examines personal traits and work tasks that are presented in job ads for Professional Communicators in Sweden today. From this material the author wants to calculate what kind of personal type that characterize the profession with the help of the Big Five theory.Material/ Method: Quantitative research method based on job ads.Main results: The study shows that personal traits that employers look for in Professional Communicators today are mainly traits from the Conscientiousness group with characteristics such as independent, structured and planning. The second biggest personality group is Extraversion where personal traits like driving, outgoing and social were put. The results also indicate that the professional should enjoy working independently but also be able to cooperate with other people. A big part of the profession involves tasks which are of a producing nature which indicates that a talent or personality that fits for that kind of tasks is to prefer
Worin unterscheiden und gleichen sich die Bedingungen alternativ geführter Bibliotheken, die nach der Schließung von Stadtteilbibliotheken der Bücherhallen Hamburg entstanden sind?
No full textDas Stadtteilbibliotheksnetz der Hamburger Öffentlichen Bücherhallen wurde in den letzten Jahren immer weiter ausgedünnt.
Diese Arbeit untersucht die Bedingungen von fünf alternativ geführten Bibliotheken, die nach der Schließung der örtlichen Bücherhallen ent-standen sind. Dazu wird zunächst die Konzeption und Durchführung ei-ner Umfrage über Bestand, Personal, Kunden, Finanzen und Veranstal-tungen beschrieben und deren Ergebnisse vorgestellt.
Im Anschluss erfolgt die Auswertung von Leitfaden-Interviews mit fünf Ehrenamtlichen zu den Themen: persönliche Motivation, Aufgabenberei-che, Aufwandsentschädigung und Betreuung.
Abschließend soll die Frage geklärt werden, ob alternativ geführte Bibliothe-ken hauptamtlich geführte ersetzten können
Tissue specific regulation of human ILC2 in allergy and asthma
No full textAsthma is one of the most common non-communicable diseases, affecting over 300 million people worldwide. It is a heterogeneous condition comprising several endotypes, yet all share the hallmark of dysregulated immune responses driving airway inflammation. The most prevalent form, type 2-high asthma, is mediated by aberrant activation of type 2 immune cells, including type 2 innate lymphoid cells (ILC2), type 2 T helper (Th2), and type 2 cytotoxic T (Tc2) cells. We and others have previously shown that the phenotype and function of ILC2 are strongly shaped by their microenvironment, but how human ILC2 are regulated in asthma and allergy remains incompletely understood.In this thesis, we investigated how metabolic status, biologics therapy, lipid mediators, and epithelial-immune crosstalk shape ILC2 function in asthma. By combining patient cohorts with mechanistic studies, we aimed to clarify the factors that sustain or modulate type 2 airway inflammation. Although this work primarily focused on ILC2, related lymphocytes were also analyzed to capture the broader network of immune cells orchestrating airway inflammation.In Paper I, we studied how metabolic dysregulation affects ILC2 function in a cohort of asthmatic individuals with overweight or obesity, well-known risk factors for asthma. In those patients, ILC2 displayed an inflammatory phenotype characterized by elevated CD45RO expression, while IL-7Ra expression correlated with body-fat percentage, suggesting a link between metabolic status and ILC2 activation. Functionally, these ILC2 displayed features of corticosteroid resistance, the mainstay of asthma therapy, suggesting a mechanism underlying poor treatment response.In Paper II, we analyzed blood samples from patients with severe asthma before and after initiation of biologics therapy targeting IL-5 (mepolizumab) or IL-4Ra (dupilumab). Type 2 lymphocytes, including ILC2, Th2, and Tc2 cells, accumulated in the circulation during mepolizumab therapy, while ILC2 exhibited a similar trend in patients on dupilumab. ILC2 acquired a mature CD117low phenotype, while Th2 and Tc2 cells adopted a central memory profile in patients on mepolizumab. Single-cell RNA sequencing and stimulation assays of mepolizumab-treated patients further revealed altered expression of tissue-homing receptors and increased inflammatory potential, indicating that biologics may redistribute rather than eliminate pathogenic cells capable of reigniting inflammation once treatment ends.In Paper III, we examined how bioactive lipid mediators regulate ILCs. We found that ILC3 produce prostaglandin E2 (PGE2), which enhances their cytokine production, but inhibits ILC2, which instead produce and depend on prostaglandin D2 (PGD2). During ILC2-to-ILC3 transdifferentiation, PGD2 synthesis decreased while PGE2 increased alongside type 3 cytokine production. Despite this metabolic shift, transdifferentiated cells remained sensitive to PGE2 inhibition, indicating incomplete reprogramming and a hybrid ILC2/ILC3 phenotype. Such mixed effector profiles have been observed in chronic inflammatory diseases, including mixed granulocytic asthma, highlighting the need to better understand the regulators of this plasticity.In Paper IV, we developed a co-culture model combining both human bronchial epithelial cells (BECs) and ILC2 to study their reciprocal interactions. Rhinovirus (RV) infection of BECs induced TSLP release, which activated ILC2 to produce type 2 cytokines. Notably, BECs from asthmatic donors secreted TSLP even at baseline, sustaining chronic ILC2 activation. These findings highlight epithelial-immune crosstalk as a key driver of persistent airway inflammation in asthma and provide a model for future mechanistic studies.Collectively, our findings demonstrate that ILC2 function is dynamically regulated by metabolic, pharmacologic, and tissue-derived signals. The persistence and adaptability of ILC2 and related lymphocytes across different disease contexts may explain why certain asthma phenotypes are difficult to treat and point to new avenues for more precise and effective therapeutic intervention.List of scientific papersI. Sophia Björkander, Paul Maier, Maura Kere, Simon Kebede Merid, Lorenz Wirth, Whitney Weigel, Sandra Ekström, Inger Kull, Anna Bergström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt. Innate lymphoid cells type 2 and CD8+ T cells are perturbed in overweight and obese individuals with asthma. Allergy 2023 Sep; 78(9):2533-2536. https://doi.org/10.1111/all.15728II. Lorenz Wirth, Whitney Weigel, Christoper T Stamper, Johan Kolmert, Sabrina de Souza Ferreira, Quirin Hammer, Maria Sparreman Mikus, Jakob Theorell, Lars | Andersson, Ann-Sofie Lantz, Eva Wallen- Nielsen, Anne Petrén, Craig E Wheelock, Apostolos Bossios, Nikolaos Lazarinis, Andrei Malinovschi, Christer Janson, Barbro Dahlén, Thomas Hochdörfer, Christopher Andrew Tibbitt, Sven-Erik Dahlén, Valentyna Yasinska, Jenny Mjösberg. High-Dimensional Analysis of Type 2 Lymphocyte Dynamics During Mepolizumab or Dupilumab Treatment in Severe Asthma. Allergy 2025 Sep; 80(9):2541-2556 https://doi.org/10.1111/all.16633III. Lorenz Wirth, Whitney Weigel, Efthymia Kokkinou, Johan Kolmert, Anna-Karin Johnsson, Alessandro Quaranta, Craig E Wheelock, Mattias Jangard, Sven-Erik Dahlen, Christopher Andrew Tibbitt, Thomas Hochdorfer, Jenny Mjösberg. PGE2 Enhances Human ILC3 Function But Inhibits ILC2-to-ILC3 Transdifferentiation. [Manuscript]IV. Jelena Pesic, Lorenz Wirth, Annemarie Hasselberg, Thomas Hochdörfer, Oliwia Slettengren, Katerina Pardali, Stephen Delaney, Jenny Mjösberg, Henric Olsson and Lena Uller. Exploring Bronchial Epithelial and ILC2 Interactions: A Novel Co-Culture Model for Asthma and Viral Infections. [Manuscript]</p
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