4,445 research outputs found
[Affidavit In Any Fact by Warren Allen Reynolds, March 16, 1964 #2]
No full textStatement by Warren Allen Reynolds concerning a man, identified by the author as Lee Harvey Oswald, running up Jefferson Street from Tenth Street
[Affidavit In Any Fact by Warren Allen Reynolds, March 16, 1964 #1]
No full textStatement by Warren Allen Reynolds concerning a man, identified by the author as Lee Harvey Oswald, running up Jefferson Street from Tenth Street
Warren G. Harding letter to Adolphe Danziger, February 21, 1921
No full textIn this letter dated February 21, 1921, President-elect Warren G. Harding writes to Adolphe Danziger, a Jewish scholar, lawyer and author, to thank him for the poem he wrote honoring Harding titled "Within the Storm."
This letter is part of the Warren G. Harding Papers (MSS 345). This collection includes correspondence, business records, and other materials documenting Harding’s business career as owner and editor-in-chief of The Daily Marion Star, as well as the various stages of his political career. A significant portion of the collection, and what’s available on Ohio Memory, highlights his 1920 presidential campaign, spanning just before publicly announcing his candidacy to handily defeating Ohio Governor James M. Cox in the election. Correspondents include both Ohio and national businessmen, political figures, and ordinary citizens writing with questions, support, congratulatory notes, and campaign advice. Some of the most interesting insights into the tumultuous political climate in the U.S., the extreme factionalism within the Republican Party in Ohio, and Harding’s campaign strategies are described in letters between Harding and his campaign manager, Harry M. Daugherty. Some of the topics addressed include women’s suffrage, Prohibition, the League of Nations, African American representation and issues, and lingering peace negotiations following World War I
Extended supplementary data for manuscript: A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons
No full text<p><span>Cocaine, and other addictive drugs, can induce long-term synaptic modifications in midbrain dopamine neurons (DNs) which play key roles in the development of addiction, but the cellular basis of these long-term changes are not well understood. In this work, we applied Genome Architecture Mapping and single nucleus transcriptomic analyses in mouse midbrain DNs and found extensive rewiring of 3D genome architecture lasting 1 and 14 days upon a single cocaine exposure. The affected genes have major roles in cocaine responses and are preferentially expressed in a DN sub-type that projects to secondary reward-pathway regions. <span>These results reveal an unexpected role for 3D genome remodelling in the long-term memory of a single cocaine exposure, providing new </span>insights about the inception of drug addiction and 3D genome plasticity<span>.</span><span> </span></span></p>
Extended supplementary data for manuscript: A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons
No full text<p><span>Midbrain dopamine neurons (DNs) respond to a first exposure to addictive drugs and play key roles in chronic drug usage</span><span>. As the synaptic and transcriptional changes that accompany an acute cocaine exposure are mostly resolved within hours and up to a few days</span><span>, the long-term molecular changes that encode the cellular memory of the exposure within DNs remains unknown. To investigate whether a single cocaine exposure induces long-term changes in 3D genome structure of DNs, we applied Genome Architecture Mapping and single nucleus transcriptomic analyses in mouse midbrain. We found extensive rewiring of 3D genome architecture at 24h past exposure which lasts or worsens by 14 days, outlasting transcriptional responses. The cocaine-induced chromatin rewiring occurs at all genomic scales and affects genes with major roles in cocaine-induced synaptic changes. Cocaine exposure triggers extensive changes in chromatin condensation in post-synaptic and post-transcriptional regulatory genes, for example the unfolding of <em>Rbfox1 </em>which becomes most prominent 14 days post exposure. Finally, structurally remodeled genes are most expressed in a DN sub-type with low expression of the dopamine auto-receptor <em>Drd2</em>, a key feature of highly cocaine-sensitive cells. These results reveal an important role for long-lasting 3D genome remodelling in the cellular memory of a single cocaine exposure, providing new hypotheses for understanding the inception of drug addiction and 3D genome plasticity.</span></p>
Extended supplementary data for manuscript: A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons
No full text<p><span>Cocaine, and other addictive drugs, can induce long-term synaptic modifications in midbrain dopamine neurons (DNs) which play key roles in the development of addiction, but the cellular basis of these long-term changes are not well understood. In this work, we applied Genome Architecture Mapping and single nucleus transcriptomic analyses in mouse midbrain DNs and found extensive rewiring of 3D genome architecture lasting 1 and 14 days upon a single cocaine exposure. The affected genes have major roles in cocaine responses and are preferentially expressed in a DN sub-type that projects to secondary reward-pathway regions. <span>These results reveal an unexpected role for 3D genome remodelling in the long-term memory of a single cocaine exposure, providing new </span>insights about the inception of drug addiction and 3D genome plasticity<span>.</span><span> </span></span></p>
Oral History Interview with Rueben C. Warren
No full textThis interview with Rueben Warren, DDS, DrPH, is part of “Moral Histories: Voices and Stories from the Founding Figures of Bioethics,” an oral history project of the Johns Hopkins Berman Institute of Bioethics. Dr. Warren is Dean Emeritus, School of Dentistry, Meharry Medical College and former Director of the National Center for Bioethics and Professor Emeritus of Bioethics at Tuskegee University. He also spent many years working at the Department of Health and Human Services and the Centers for Disease Control. His expertise includes dental health, access to oral healthcare, public health, faith communities, and environmental justice. He is the author of over one hundred journal articles.
Dr. Warren discussed the close-knit community of his childhood in the Watts neighborhood of South Central Los Angeles and his higher education experiences at San Francisco State University, Meharry Medical College, Harvard University, and the Interdenominational Theological Center. He described being on the Tuskegee Syphilis Study Legacy Committee, the 1997 apology from President Bill Clinton, and the subsequent establishment of the National Center for Bioethics in Research and Healthcare at Tuskegee University. While director, he shared how he focused on engaging descendants of the U.S. Public Health Service Syphilis Study, established programming with Black church leaders, and developed a bioethics honors program. He described the need for institutions to prove their trustworthiness to gain community trust, particularly in healthcare settings.
He discussed working in the Office of Minority Health and the Agency for Toxic Substances and Disease Registry, where he investigated environmental harms and the disproportionate impact on low-income and minority communities. The Covid-19 pandemic occurred during his last years at Tuskegee and he shares that experience as why medical providers and bioethicists should examine the trustworthiness of institutions versus implicating vaccine-hesitant communities. The conversation ends with a comparison of the Human Genome Project to the work of the Diaspora Human Genomic Institute, emphasizing the importance of involving Black scientists and communities in data collection, preservation, and analysis
Free all along the Robert Penn Warren civil rights interviews
No full text"A collection of previously unpublished interviews with key figures of the black freedom struggle by Pulitzer Prize-winning author Robert Penn Warren"..
Mary Warren letter to Mrs. Bachman, October 4, 1914
No full textMary Warren wrote this letter to Mrs. Bachman on October 4, 1914, to describe the efforts of her and fellow activists to convince voters to support women's suffrage. She states that they couldn't make a strong enough impression on voters without additional help. She requested Mrs. Bachman's help in the form of sending literature that could help convince voters to support suffrage.
The Franklin County Woman Suffrage Association was formed in 1912, after the Ohio Constitutional Convention elected to bring to a vote the question of removing the words "white male" from the state constitution with regard to voting rights. Headquartered in the Chamber of Commerce building in Columbus, Ohio, the organization put out regular publications, organized public speeches and meetings, distributed literature and held parades in support of the suffrage movement. Women's suffrage in Ohio was defeated in a special election in 1912 and again in 1914 and 1916 before a resolution narrowly passed in 1917 allowing municipal voting by women in Columbus. In 1920, the 19th Amendment passed, extending the vote to women and prohibiting state and federal government from denying suffrage on the basis of sex
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