2,773 research outputs found
Rapporteur’s report – innovative geotechnologies for energy transition
No full textThe 9th Society for Underwater Technology (SUT) International Conference on Offshore Site Investigation and Geotechnics (OSIG) closed with a Rapporteur’s report given by the author. This paper provides a record of that report, transcribed from a video recording. The presentation slides are shown as Figures.</p
DEFRApH - Sample collection and handling procedures
No full textAll chemical and biogeochemical process in the sea are affected by the acidity of the water. Acidity is therefore fundamental property of seawater. The growing concern that the acidity of the oceans might be increasing has revealed weaknesses in our knowledge of this fundamental property and its variation in space and time. In 2008 the DEFRApH project (DEFRA contract ME4133) was initiated to provide this missing information in UK related waters. It required sampling for and analysis of the total inorganic carbon and total alkalinity content of samples. This reports documents the procedures sued for sampling. A companion document Hartman Dumousseaud and Roberts (NOC Internal Document No. 01) describes in detail the analytical procedures used and the calculation of the results
Author Correction:Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention (Nature Communications, (2019), 10, 1, (5280), 10.1038/s41467-019-13244-9)
No full textThe original version of this Article contained an error in the spelling of the author Wilma D.J. van de Berg, which was incorrectly given as Wilma D.J. van den Berg. This has now been corrected in both the PDF and HTML versions of the Article.</p
Asynchrobatic logic for low-power VLSI design
No full textIn this work, Asynchrobatic Logic is presented. It is a novel low-power design style that combines the energy saving benefits of asynchronous logic and adiabatic logic to produce systems whose power dissipation is reduced in several different ways. The term “Asynchrobatic” is a new word that can be used to describe these types of systems, and is derived from the concatenation and shortening of Asynchronous, Adiabatic Logic. This thesis introduces the concept and theory behind Asynchrobatic Logic. It first provides an introductory background to both underlying parent technologies (asynchronous logic and adiabatic logic). The background material continues with an explanation of a number of possible methods for designing complex data-path cells used in the adiabatic data-path. Asynchrobatic Logic is then introduced as a comparison between asynchronous and Asynchrobatic buffer chains, showing that for wide systems, it operates more efficiently. Two more-complex sub-systems are presented, firstly a layout implementation of the substitution boxes from the Twofish encryption algorithm, and secondly a front-end only (without parasitic capacitances, resistances) simulation that demonstrates a functional system capable of calculating the Greatest Common Denominator (GCD) of a pair of 16-bit unsigned integers, which under typical conditions on a 0.35μm process, executed a test vector requiring twenty-four iterations in 2.067μs with a power consumption of 3.257nW.
These examples show that the concept of Asynchrobatic Logic has the potential to be used in real-world applications, and is not just theory without application. At the time of its first publication in 2004, Asynchrobatic Logic was both unique and ground-breaking, as this was the first time that consideration had been given to operating large-scale adiabatic logic in an asynchronous fashion, and the first time that Asynchronous Stepwise Charging (ASWC) had been used to drive an adiabatic data-path
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Course 24 B
No full textPictured:
Crowthers W. - Rutherford R. - Wright D.T. - Roberts P.W. - Thomson I.H. - Stanley G.V. - Gait B. - Hicks L.A. - Butler T.F. - Hutton D.P.H. - Gibb A.D.
Webster I.B. - Hyland R.P. - Spencer C. - Challis G.P. - Sears B.L. - Henderson J.H. - Elliot F. - Crowhurst J.L.M. - Hill E.F. - Gillet A.E.L. - Hopkinson F.
White H.D. - Turrent E.R. - Rubery J.R. - Wilson K.S. - Webster A. - Turner L.A. - Woodhead C.A.B. - Twelves A. - Sim W. - Day A.A. - Willingham A.K. - Cooke D.J.
Nicholson G.S. - Scott F.A. - Roe R.D. - Bennett M.G. - Jackson S.F. - Doyle G. - Durrant J.K.B. - Hastings W.J.https://commons.erau.edu/bfts-clewiston-courses/1036/thumbnail.jp
Reply to the discussion by McCarron on “Modelling spatial variability in as-laid embedment for high pressure and high temperature (HPHT) pipeline design”
No full textN/AThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Asynchronous, quasi-Adiabatic (Asynchrobatic) logic for low-power very wide data width applications
No full textA system for calculating the greatest common denominator implemented using asynchrobatic logic
No full textAn asynchrobatic system that uses Euclid's algorithm to calculate the greatest common denominator of two numbers is presented. This algorithm is a simple system that contains both repetition and decision, and therefore demonstrates that asynchrobatic logic can be used to implement arbitrarily complex computational systems. Under typical conditions on a 0.35 mum process, a 16-bit implementation can perform a 24-cycle test vector in 2.067 mus with a power consumption of 3.257 nW
Wavelength tunable 10-GHz 3-ps pulse source using a dispersion decreasing fiber-based nonlinear optical loop mirror
No full textWe experimentally demonstrate the use of a dispersion decreasing fiber (DDF)-based nonlinear optical loop mirror (NOLM) for the generation of wavelength tunable soliton-like pulses at a repetition rate of 10 GHz. We compress ~12 ps Gaussian pulses from an electro-absorption modulator (EAM) (followed by 125 m of DCF for preliminary linear dispersion compensation) into 3 ps pedestal-free pulses using both high-order soliton compression and nonlinear switching effects within an 8.5 km DDF-based loop mirror. The output pulses from the DDF-based NOLM show considerable pedestal reduction compared to those obtained by directly compressing the EAM seed pulses via a single passage through the DDF. Wavelength tuning of the compressed pulses over a ~15 nm bandwidth (from 1541 to 1556 nm) is demonstrated without a significant increase in pulse duration or degradation in pulse quality
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