13 research outputs found
Human Papillomavirus Prevention Intervention\ud Feasibility Study in Tanzania
No full textWorldwide, Human papillomavirus (HPV) is one of the most common sexually transmitted viruses infecting humans. HPV infections may lead to the development of pre-cancer and if left untreated can lead to cancer; hence it has been established as the primary underlying cause of cervical cancer. In developed countries, it has been demonstrated that effective cytology (Pap test) screening can prevent up to 80% of cervical cancer. Although similar coverage can be attained in low-resource settings there are challenges at community and policy making levels. These include, lack of awareness, follow-up, quality control and assurance as well as human and financial resources. Vaccination before exposure to cancer-causing HPV is a particularly important intervention that has demonstrated potential for high health impacts in pilot settings. This report highlights the findings of a study that assessed the capacity, gaps and barriers for the implementation of HPV prevention interventions in Tanzania. Triangulation methods were employed using both quantitative and qualitative tools. Documents on policies and guidelines were reviewed to assess the current status of policies with regard to prevention. Assessment of the diagnosis and treatment options for cervical cancer to establish the gaps and opportunities for policy improvement were made. Information on incidence, prevalence and mortality from cervical cancer in the various regions in Tanzania were extrapolated from hospital records. These were supplemented by a literature review on HPV and cervical cancer at global level. Further literature review was done to gather information on sexual behaviour among youth in Tanzania and elsewhere in Africa. The training curriculum for nurse midwifery, assistant medical officer, medical officers and nursing officers was reviewed to identify gaps in knowledge, awareness and skills for cervical cancer prevention and management. Teachers responsible for training in the health institutes were interviewed to gain more insight into the curriculum regarding cancer. In-depth interviews were conducted with stakeholders to assess the opportunities, challenges and perceptions of intervention in the health system. Teachers were interviewed on their perceptions of the interventions and the possibility of using schools as vaccination delivery platforms. Focus group discussions (FGDs) were held with parents and guardians in rural and urban settings in Coast, Kilimanjaro and Lindi regions. This provided information on health needs, acceptability of interventions and strategies for advocacy. A questionnaire was administered to the head of sections among four referral hospitals (Ocean Road Cancer Institute (ORCI), Bugando Medical Centre (BMC), Kilimanjaro Christian Medical Centre (KCMC) and Peramiho Hospital) to gather information on human resources, training, equipment, drugs, and supplies specifically for cervical cancer prevention and control. A checklist adapted from the Alliance for Cervical Cancer Prevention (ACCP) was used to check for essential equipment, supplies and drugs for cervical cancer prevention and control. I. Non-communicable diseases (NCDs), including cervical cancer, have been recognized as an important public health problem in recent years and the government is committed to implement appropriate control measures, as noted in the most recent Health Strategic Plan which is a document for resource mobilization. A specific cervical cancer framework has been developed by various stakeholders led by the WHO country office as a basis for its strategic plan development. Furthermore a special reproductive cancer unit (cervical cancer, breast and prostate) has been established at the Ministry of Health and Social Welfare under the Reproductive and Child Health department. II. Cancer of the cervix is a critical public health problem as it was in 2007-2008 the leading form of cancer and accounted for more than 37% of all cancers diagnosed at the ORCI, the only dedicated cancer institute in the country. III. There is shortage of human resources and basic equipment necessary for cervical cancer screening, diagnosis and management in main hospitals. IV. There was heterogeneity of screening approaches among the five referral facilities surveyed. V. Tailored training courses for screening and management of cervical cancer have contributed to increased access of services in peripheral areas. However the approach was impaired by lack of essential equipments and thus efforts need to be made to increase availability. VI. The curriculum used by health institutes across Tanzania covers cervical cancer but the approach is very theoretical explanations with little practical ‘hands-on’ training in the diagnosis and management of cervical cancer. VII. Awareness about cervical cancer burden is low among stakeholders (community, policy makers and Non Governmental Organizations). Specifically those not dealing with cervical cancer directly. Most of them are not aware that there is an opportunity for prevention using vaccines. VIII. Promoting awareness is essential for appropriate cervical cancer management. The main channels of advocacy suggested include radio, community meetings and television. IX. There are key challenges regarding resources, particularly finance and human resources, and these have a bearing on sustaining such measures in the long run. X. There is an opportunity to integrate HPV vaccine within the Tanzanian health system infrastructure. The infrastructure for EPI is well established and well placed in the organogram of the ministry. However, the EPI cold chain facilities are currently fully utilized and there is a need to invest in storage infrastructure in case same facilities have to be used for HPV vaccine. XI. Primary schools were identified as the best channel for vaccination as there is high attendance in primary schools and the opportunity for special vaccination days. XII. The community members interviewed were positive regarding the introduction of HPV vaccine, as long as parents and the community were well informed
Pengaruh Spirit Of Entrepreneur terhadap Kinerja Usaha Para Pelaku UKM Tenant Pusat Inkubator Bisnis Cikal USU
No full textThis study aims to identify and analyze the effect of Spirit Of Entrepreneur
On Performance Business The Actors SME Tenant Pusat Inkubator Bisnis Cikal
USU is located at Jl. Dr. Mansur No. 9B Campus University of North Sumatra.
This research includes the study associative. The data used in this study is
primary data and secondary data. The population in this study are all ownwd by
Tenant SME Pusat Inkubator Bisnis Cikal USU, with respondent total as much as
70 respondents. Hypothesis testing at do by using doubled linear regression
analysis with free variable, that is Self-Directed, Self-Nurturing, Action-Orientd,
Highly-Energic,Tolerant of Uncertainty, Technological Change, Structure change
of Government and Politics, Intrapreneurship and bound variable that is Business
Performance.
The results showed that the independent variables simultaneously positive
and significant effect on the dependent variable. Based on the test results the
coefficient of determination (R2), the value of R Square of 0.633 means 63.3%
Business Performance variables can be explained by the variable Self-Directed,
Self-Nurturing, Action-Oriented, Highly-Energic, Tolerant of Uncertainty,
Technological Change, Structure change of Government and Politics, and
Intrapreneurship, while the remaining 36.7% is explained by other variables not
examined in this study. Effect of Spirit Of Entrepreneur which author researched
showed a tight relationship that is equal to 79.6%118 HalamanSkripsi Sarjan
Malar J
No full textBackgroundAs malaria control interventions are scaled-up, rational approaches are needed for monitoring impact over time. One proposed approach includes monitoring the prevalence of malaria infection among pregnant women and children at the time of routine preventive health facility (HF) visits. This pilot explored the feasibility and utility of tracking the prevalence of malaria infection in pregnant women attending their first antenatal care (ANC) visit and infants presenting at 9\u201312\ua0months of age for measles vaccination.MethodsPregnant women attending first ANC and infants nine to 12\ua0months old presenting for measles vaccination at a non-probability sample of 54 HFs in Tanzania\u2019s Lake Zone (Mara, Mwanza and Kagera Regions) were screened for malaria infection using a malaria rapid diagnostic test (RDT) from December 2012 to November 2013, regardless of symptoms. Participants who tested positive were treated for malaria per national guidelines. Data were collected monthly.ResultsOverall 89.9 and 78.1\ua0% of expected monthly reports on malaria infection prevalence were received for pregnant women and infants, respectively. Among 51,467 pregnant women and 35,155 infants attending routine preventive HF visits, 41.2 and 37.3\ua0% were tested with RDT, respectively. Malaria infection prevalence was 12.8\ua0% [95\ua0% confidence interval (CI) 11.3\u201314.3] among pregnant women and 11.0\ua0% (95\ua0% CI 9.5\u201312.5) among infants, and varied by month. There was good correlation of the prevalence of malaria among pregnant women and infants at the HF level (Spearman rho\ua0=\ua00.6; p\ua0<\ua00.001). This approach is estimated to cost $1.28 for every person tested, with the RDT accounting for 72\ua0% of the cost.ConclusionsMalaria infection was common and well correlated among pregnant women and infants attending routine health services. Routine screening of these readily accessible populations may offer a practical strategy for continuously tracking malaria trends, particularly seasonal variation. Positivity rates among afebrile individuals presenting for routine care offer an advantage as they are unaffected by the prevalence of other causes of febrile illness, which could influence positivity rates among febrile patients presenting to outpatient clinics. The data presented here suggest that in addition to contributing to clinical management, ongoing screening of pregnant women could be used for routine surveillance and detection of hotspots.20162016-07-29T00:00:00Z27473039PMC4966757672
Training needs assessment of community action for development and environment conservation trust - Arusha
No full textThis is a Training Needs Assessment (TNA) project: the case of CADECT CBO. The assessment came as a request of group leaders on conducting training on skills for community raining and facilitation. The assessment is an analysis of current training needs of the group. It is essentially based on primary data from the field i.e. group members, and it is closely related to works done by scholars involved in training and adult learning such as Frank et al (1978), Silberman (1996), Gajanayake (1986) and Prahad et al (1992) who have dwelt on how the community and organizations can be empowered in terms of skills so that to reach a common goal of development.
From CADECT's project implementation reports of 2002 and 2003, it was noted that there was a problem of failure to involve more community members in the development projects implemented in the community. It is four years now since the organization started its operations. Problems of unsanitary, seasonal hunger, low incomes, and environmental degradation have been insignificantly eliminated from the village. According to group leaders, there had been no formal training to the group on how to train the community regarding different developmental issues. It was observed that projects have been implemented by few people who are mostly members of the group. This might be due to lack of transfer of knowledge and experience from the group members to the rest of the community members, lack of awareness, lack of training and lack of confidence of the group members responsible for awareness creation among the community members.
A population of twenty one (21) group members was expected but only twenty (20) were reached. This was 96% of the expected population.
Findings showed that the group needed trainings in community training and facilitation skills, HIV/AIDS, Rain water harvesting, Food storage and preservation systems, training on Income generating activities, Environmental conservation training and Cleanliness and hygiene training.
A training package on community training and facilitation skills was prepared and four leaders of the group were trained to build their capacity in training the rest of group members.
The following was recommended:
Relevant and result based trainers/facilitators course should be conducted to group members for them to be able to train the community members on different projects and other developmental issues.
The group needs a refresher course in HIV/AIDS to be in a better position to disseminate relevant messages on the disease to the community.
The group need capacity building in issues of people's participation and bottom up approaches so as they may get away with dependency mentality.
The community should identify potential resources in the area (land, animals etc) so that they may be utilized effectively to improve incomes of the community members.
The group and community at large should be trained on practices which delays project implementation.
Heavy punishment should be given to those who misuse funds donated for projects for the community of Mkonoo. (Author abstract)Mgullo, R. J. (2005). Training needs assessment of community action for development and environment conservation trust - Arusha. Retrieved from http://academicarchive.snhu.eduMaster of Science (M.S.)School of Community Economic Developmen
Malar J
No full textBackgroundMalaria in pregnancy (MiP) remains a major public health challenge in areas of high malaria transmission. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended to prevent the adverse consequences of MiP. The effectiveness of SP for IPTp may be reduced in areas where the dhps581 mutation (a key marker of high level SP resistance) is found; this mutation was previously reported to be common in the Tanga Region of northern Tanzania, but there are limited data from other areas. The frequency of molecular markers of SP resistance was investigated in malaria parasites from febrile patients at health centres (HC) in seven regions comprising the Lake and Southern Zones of mainland Tanzania as part of the ongoing efforts to generate national-wide data of SP resistance.MethodsA cross-sectional survey was conducted in the outpatient departments of 14 HCs in seven regions from April to June, 2015. 1750 dried blood spot (DBS) samples were collected (117 to 160 per facility) from consenting patients with positive rapid diagnostic tests for malaria, and no recent (within past 2\ua0months) exposure to SP or related drugs. DNA was extracted from the DBS, pooled by HC, and underwent pooled targeted amplicon deep sequencing to yield estimates of mutated parasite allele frequency at each locus of interest.ResultsThe dhps540 mutation was common across all 14 sites, ranging from 55 to 98.4% of sequences obtained. Frequency of the dhps581 mutation ranged from 0 to 2.4%, except at Kayanga HC (Kagera Region, Lake Zone) where 24.9% of sequences obtained were mutated. The dhfr164 mutation was detected only at Kanyanga HC (0.06%).ConclusionBy pooling DNA extracts, the allele frequency of mutations in 14 sites could be directly determined on a single deep-sequencing run. The dhps540 mutant was very common at all locations. Surprisingly, the dhps581 was common at one health center, but rare in all the others, suggesting that there is geographic micro-heterogeneity in mutant distribution and that accurate surveillance requires inclusion of multiple sites. A better understanding of the effect of the dhps581 mutant on the efficacy of IPTp-SP is needed.20172017-06-05T00:00:00Z28583119PMC5460401672
Cost analysis for initiating an integrated package of essential non-communicable disease interventions (PEN-Plus) in Kondoa District Hospital, Tanzania: a time-driven activity-based costing (TDABC) study protocol
No full textIntroduction Non-communicable diseases (NCDs) constitute approximately 74% of global mortality, with 77% of these deaths occurring in low-income and middle-income countries. Tanzania exemplifies this situation, as the percentage of total disability-adjusted life years attributed to NCDs has doubled over the past 30 years, from 18% to 36%. To mitigate the escalating burden of severe NCDs, the Tanzanian government, in collaboration with local and international partners, seeks to extend the integrated package of essential interventions for severe NCDs (PEN-Plus) to district-level facilities, thereby improving accessibility. This study aims to estimate the cost of initiating PEN-Plus for rheumatic heart disease, sickle cell disease and type 1 diabetes at Kondoa district hospital in Tanzania.Methods and analysis We will employ time-driven activity-based costing (TDABC) to quantify the capacity cost rates (CCR), and capital and recurrent costs associated with the implementation of PEN-Plus. Data on resource consumption will be collected through direct observations and interviews with nurses, the medical officer in charge and the heads of laboratory and pharmacy units/departments. Data on contact times for targeted NCDs will be collected by observing a sample of patients as they move through the care delivery pathway. Data cleaning and analysis will be done using Microsoft Excel.Ethics and dissemination Ethical approval to conduct the study has been waived by the Norwegian Regional Ethics Committee and was granted by the Tanzanian National Health Research Ethics Committee NIMR/HQ/R.8a/Vol.IX/4475. A written informed consent will be provided to the study participants. This protocol has been disseminated in the Bergen Centre for Ethics and Priority Setting International Symposium, Norway and the 11th Muhimbili University of Health and Allied Sciences Scientific Conference, Tanzania in 2023. The findings will be published in peer-reviewed journals for use by the academic community, researchers and health practitioners
Pregnant Women and Infants as Sentinel Populations to Monitor Prevalence of Malaria: Results of Pilot Study in Lake Zone of Tanzania.
No full textAs malaria control interventions are scaled-up, rational approaches are needed for monitoring impact over time. One proposed approach includes monitoring the prevalence of malaria infection among pregnant women and children at the time of routine preventive health facility (HF) visits. This pilot explored the feasibility and utility of tracking the prevalence of malaria infection in pregnant women attending their first antenatal care (ANC) visit and infants presenting at 9-12 months of age for measles vaccination. Pregnant women attending first ANC and infants nine to 12 months old presenting for measles vaccination at a non-probability sample of 54 HFs in Tanzania's Lake Zone (Mara, Mwanza and Kagera Regions) were screened for malaria infection using a malaria rapid diagnostic test (RDT) from December 2012 to November 2013, regardless of symptoms. Participants who tested positive were treated for malaria per national guidelines. Data were collected monthly. Overall 89.9 and 78.1 % of expected monthly reports on malaria infection prevalence were received for pregnant women and infants, respectively. Among 51,467 pregnant women and 35,155 infants attending routine preventive HF visits, 41.2 and 37.3 % were tested with RDT, respectively. Malaria infection prevalence was 12.8 % [95 % confidence interval (CI) 11.3-14.3] among pregnant women and 11.0 % (95 % CI 9.5-12.5) among infants, and varied by month. There was good correlation of the prevalence of malaria among pregnant women and infants at the HF level (Spearman rho = 0.6; p < 0.001). This approach is estimated to cost $1.28 for every person tested, with the RDT accounting for 72 % of the cost. Malaria infection was common and well correlated among pregnant women and infants attending routine health services. Routine screening of these readily accessible populations may offer a practical strategy for continuously tracking malaria trends, particularly seasonal variation. Positivity rates among afebrile individuals presenting for routine care offer an advantage as they are unaffected by the prevalence of other causes of febrile illness, which could influence positivity rates among febrile patients presenting to outpatient clinics. The data presented here suggest that in addition to contributing to clinical management, ongoing screening of pregnant women could be used for routine surveillance and detection of hotspots
Use of insecticide quantification kits to investigate the quality of spraying and decay rate of bendiocarb on different wall surfaces in Kagera region, Tanzania
No full textBendiocarb was introduced for the first time for Indoor Residual Spraying (IRS) in Tanzania in 2012 as part of the interim national insecticide resistance management plan. This move followed reports of increasingly alarming levels of pyrethroid resistance across the country. This study used the insecticide quantification kit (IQK) to investigate the intra-operational IRS coverage and quality of spraying, and decay rate of bendiocarb on different wall surfaces in Kagera region.; To assess intra-operational IRS coverage and quality of spraying, 104 houses were randomly selected out of 161,414 sprayed houses. A total of 509 samples (218 in Muleba and 291 in Karagwe) were obtained by scraping the insecticide samples from wall surfaces. To investigate decay rate, 66 houses (36 in Muleba and 30 in Karagwe) were selected and samples were collected monthly for a period of five months. Laboratory testing of insecticide concentration was done using IQK(TM) [Innovative Vector Control Consortium].; Of the 509 samples, 89.5% met the World Health Organization (WHO) recommended concentration (between 100-400 mg/m(2)) for IRS target dosage. The proportion of samples meeting WHO standards varied between Karagwe (84.3%) and Muleba (96.3%) (p > 0.001). Assessment of quality of spraying at house level revealed that Muleba (84.8%) had a significantly higher proportion of households that met the expected target dosage (100-400 mg/m(2)) compared to Karagwe (68.9%) (p > 0.001). The quality of spraying varied across different wall substrates in both districts. Evaluation of bendiocarb decay showed that the proportion of houses with recommended concentration declined from 96.9%, 93.5% and 76.2% at months one, two, and three post IRS, respectively (p-trend = 0.03). The rate of decay increased in the fourth and fifth month post spraying with only 55.9% and 26.3% houses meeting the WHO recommendations, respectively. IQK is an important tool for assessing IRS coverage and quality of spraying. The study found adequate coverage of IRS; however, residual life of bendiocarb was observed to be three months. Results suggest that in order to maintain the recommended concentrations with bendiocarb, a second spray cycle should be carried out after three months
Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing
No full textAbstract Background Malaria in pregnancy (MiP) remains a major public health challenge in areas of high malaria transmission. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended to prevent the adverse consequences of MiP. The effectiveness of SP for IPTp may be reduced in areas where the dhps581 mutation (a key marker of high level SP resistance) is found; this mutation was previously reported to be common in the Tanga Region of northern Tanzania, but there are limited data from other areas. The frequency of molecular markers of SP resistance was investigated in malaria parasites from febrile patients at health centres (HC) in seven regions comprising the Lake and Southern Zones of mainland Tanzania as part of the ongoing efforts to generate national-wide data of SP resistance. Methods A cross-sectional survey was conducted in the outpatient departments of 14 HCs in seven regions from April to June, 2015. 1750 dried blood spot (DBS) samples were collected (117 to 160 per facility) from consenting patients with positive rapid diagnostic tests for malaria, and no recent (within past 2 months) exposure to SP or related drugs. DNA was extracted from the DBS, pooled by HC, and underwent pooled targeted amplicon deep sequencing to yield estimates of mutated parasite allele frequency at each locus of interest. Results The dhps540 mutation was common across all 14 sites, ranging from 55 to 98.4% of sequences obtained. Frequency of the dhps581 mutation ranged from 0 to 2.4%, except at Kayanga HC (Kagera Region, Lake Zone) where 24.9% of sequences obtained were mutated. The dhfr164 mutation was detected only at Kanyanga HC (0.06%). Conclusion By pooling DNA extracts, the allele frequency of mutations in 14 sites could be directly determined on a single deep-sequencing run. The dhps540 mutant was very common at all locations. Surprisingly, the dhps581 was common at one health center, but rare in all the others, suggesting that there is geographic micro-heterogeneity in mutant distribution and that accurate surveillance requires inclusion of multiple sites. A better understanding of the effect of the dhps581 mutant on the efficacy of IPTp-SP is needed
Susceptibility Status of Malaria Vectors to Insecticides Commonly used for Malaria Control in Tanzania.
No full textThe aim of the study was to monitor the insecticide susceptibility status of malaria vectors in 12 sentinel districts of Tanzania. WHO standard methods were used to detect knock-down and mortality in the wild female Anopheles mosquitoes collected in sentinel districts. The WHO diagnostic doses of 0.05% deltamethrin, 0.05% lambdacyhalothrin, 0.75% permethrin and 4% DDT were used. The major malaria vectors in Tanzania, Anopheles gambiae s.l., were susceptible (mortality rate of 98-100%) to permethrin, deltamethrin, lambdacyhalothrin and DDT in most of the surveyed sites. However, some sites recorded marginal susceptibility (mortality rate of 80-97%); Ilala showed resistance to DDT (mortality rate of 65% [95% CI, 54-74]), and Moshi showed resistance to lambdacyhalothrin (mortality rate of 73% [95% CI, 69-76]) and permethrin (mortality rate of 77% [95% CI, 73-80]). The sustained susceptibility of malaria vectors to pyrethroid in Tanzania is encouraging for successful malaria control with Insecticide-treated nets and IRS. However, the emergency of focal points with insecticide resistance is alarming. Continued monitoring is essential to ensure early containment of resistance, particularly in areas that recorded resistance or marginal susceptibility and those with heavy agricultural and public health use of insecticides
