12,020 research outputs found
(書簡)Date: 1972/7/31 ; Sender: Williams, Alan ; Receiver: Tsuru, S (Shigeto)
No full text附:Precis “Measuring the effectiveness of health care systems” / Alan Williams, “Social indicators: health” / A.J. Culyer, R.J.Lavers and A. Williams1枚タイプUniv. of York 用紙書簡オリジナルの所在: 一橋大学経済研究所資料室都留重人氏より寄贈1-B1-15-22/00
SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis
No full textRedirecting the adipogenic potential of bone marrow-derived mesenchymal stem cells to other lineages, particularly osteoblasts, is a key goal in regenerative medicine. Controlling lineage selection through chromatin remodeling complexes such as SWI/SNF, which act coordinately to establish new patterns of gene expression, would be a desirable intervention point, but the requirement for the complex in essentially every lineage pathway has generally precluded selectivity. However, a novel approach now appears possible by targeting the subset of SWI/SNF powered by the alternative ATPase, mammalian brahma (BRM). BRM is not required for development, which has hindered understanding of its contributions, but knockdown genetics here,designed to explore the hypothesis that BRM-SWI/SNF has different regulatory roles in different mesenchymal stem cell lineages, shows that depleting BRM from mesenchymal stem cells has a dramatic effect on the balance of lineage selection between osteoblasts and adipocytes. BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage. This effect is evident in primary bone marrow stromal cells as well as in established cell culture models. The altered precursor balance has major physiological significance, which becomes apparent as protection against age-related osteoporosis and as reduced bone marrow adiposity in adult BRM-null mice.Peer reviewe
Wireless operator Petty Officer A.J. Williams, B.A.N.Z. Antarctic Research Expedition, ca. 1930 [picture] /
No full textTitle devised by cataloguer from inscriptions.; Inscriptions: "Petty Officer A.J. Williams, wireless operator"--Printed on label below image.; In collection: B.A.N.Z. Antarctic Research Expedition photographs.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an10932811-32
Wireless operator Petty Officer A.J. Williams on deck with visitors to the Discovery, ca. 1929 [picture] /
No full textTitle devised by cataloguer from inscriptions.; Inscriptions: "Petty Officer A.J. Williams, (wireless operator)"--Printed on label below image.; In collection: B.A.N.Z. Antarctic Research Expedition photographs.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an10932811-35
Transporters responsible for the uptake and partitioning of nitrogenous solutes
No full textThe acquisition and allocation of nitrogenous compounds are essential processes in plant growth and development. The huge economic and environmental costs resulting from the application of nitrogen fertilizers make this topic very important. A diverse array of transporters varying in their expression pattern and also in their affinity, specificity, and capacity for nitrogenous compounds has been identified. Now the future challenge is to define their individual contribution to nitrogen nutrition and signalling processes. Here we have reviewed recent advances in the identification and molecular characterization of these transporters, concentrating on mechanisms existing at the plasma membrane. The review focuses on nitrate, ammonium, and amino acid transporter families, but we also briefly describe what is known at the molecular level about peptide transporters and a recently identified family implicated in the transport of purines and their derivatives.<br/
Drag Reduction by Applying Speedstrips on Rowing Oars
No full textAbstractThe objective of this study was to determine the advantage of the application of speedstrips to rowing oars for a lightweight single sculler. The research method comprehended three steps: (1) the analysis of the rowing oar movement, (2) the determination of the change in drag and (3) the composition of a rowing model to establish the advantage that could be achieved. The parameters needed for the model: boat velocity, oar angle velocity and power delivered by the rower, were recorded on a real single sculler. The change in drag due to speedstrips on cylinders was determined by performing wind tunnel experiments. The rowing model (Matlab) simulates a race by using real stroke data of a world-class rower as input, while calculating the drag with the coefficients determined by the wind tunnel experiments. The output of the model is the final advantage by the application of speedstrips to rowing oars. Speedstrips induce a 0.1% advantage over a 2000 m race under calm wind conditions. The advantage increases up to .4% with a headwind velocity of 5 m s-1. For bigger boats, the advantage could be even more significant
Drag and Power-loss in Rowing Due to Velocity Fluctuations
No full textAbstractThe flow motions in the turbulent boundary layer between water and a rowing boat initiate a turbulent skin friction. Reducing this skin friction results in better rowing performances. A Taylor-Couette (TC) facility was used to verify the power losses due to velocity fluctuations PV′ in relation to the total power , as a function of the velocity amplitude A. It was demonstrated that an increase of the velocity fluctuations results in a tremendous decrease of the velocity efficiency eV . The velocity efficiency eV for a typical rowing velocity amplitude A of 20 – 25% was about 0.92 – 0.95%. Suppressing boat velocity fluctuations with 60% will increase boat speed with 1.6%. Riblet surfaces were applied on the inner and outer cylinder wall to indicate the drag reducing ability of such surfaces. The results of the measurements at constant velocity are identical as the results reported earlier, while the experimental configuration was different. This confirms once more the consistency of the TC-system for drag studies. The maximum drag reduction DR was 3.4% at a Reynolds number Res 4.7 × 104, which corresponds to a shear velocity in this TC-system with water of V 4.7 m/s. For typical rowing velocity fluctuations, the riblets maintain to reduce the drag with 2.8% and corresponds to a averaged velocity increase of 0.9%. The drag reducing ability of riblets is partly lost due to velocity fluctuations with high amplitudes (A > 20%). From these results, it is concluded that the friction coefficient Cf will vary within one cycle. Higher acceleration/deceleration leads to a additional level of turbulent kinetic energy
A.J. Cronin. A doctor into lifelong writer
No full textReality and fiction might be strictly coexistent in the narrative world. The author of this article, after a deep reading of A.J. Cronin’s novels, has tried to find out the right key to penetrate into the novelist’s intricate world. After many interrogatives on A.J. Cronin both as a man and writer, the author , finally, has been able to grasp from the pages of the novelist, the suffering of a man who has made of his romance the history of his own life
Children's personal exposure to particulate matter in a UK urban environment - preliminary results
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