923 research outputs found
William and Maud Beasley Collection
No full textPhotograph of William and Maud Beasley. Photo by Smith, Manchester, OH, c.1880-1885
The contribution of bronchoconstrictor prostanoids to the immediate allergen-induced airways response in asthma
No full textThis thesis is concerned with the airways effects of the broncho-constrictor prostanoids, and their contribution to the immediate allergen-induced airways response in asthma. The predominant prostanoid released following immunological activation of human lung mast cells in vitro is prostaglandin (PG)D2, which is initially metabolised to form 9α, 11β-PGF2, the 11β-hydroxyl epimer of PGF_2a. Initial experiments investigated the airways effects of 9α, 11β-PGF_2, PGD_2 and PGF_2a when inhaled by asthmatic subjects in vivo. Airways responses were assessed by measurement of specific airways conductance (sGaw), forced expiratory volume in one second (FEV_1) and flow at 30% of vital capacity (Vmax_30). Prostaglandin D_2 and 9α, 11β-PGF_2 were approximately equipotent as bronchoconstrictor agents, having similar activities on central and peripheral airways, and being about 30 times more potent than histamine. Subsequent use of the anticholinergic antagonist ipratropium bromide indicated that a significant component of the bronchoconstriction induced by PGD_2 and 9α, 11β-PGF_2 was mediated by cholinergic mediated mechanisms. In addition to PGD_2, immunological activation of dispersed human lung tissue also generated substantial quantities of thromboxane A_2 and PGF_2a, both of which are also potent contractile agonists of airway smooth muscle. The bronchoconstrictor prostanoids cause airway smooth muscle contraction in vitro through stimulation of thromboxane TP receptors, and the specific and potent TP receptor antagonist GR32191 competitively antagonises prostanoid-induced contraction of airway smooth muscle in vitro. In experiments in asthmatic subjects, pretreatment with oral GR32191 did not affect baseline airway calibre or methacholine-induced bronchoconstriction, but caused significant inhibition of PGD_2-induced bronchoconstriction, displacing the concentration-response curves to the right by > 10-fold. Further experiments in allergic asthmatic subjects demonstrated that GR32191 inhibited allergen-induced bronchoconstriction by about 25%. These studies suggest that the bronchoconstrictor prostanoids contribute to the immediate bronchoconstriction induced by inhaled allergen in allergic asthmatic subjects.</p
William and Maud Beasley Collection
No full textPhotograph of Maud Beasley and Mrs. Horner, June 20, 1900
Additional Tardigrada from Hubei Province, China, with the description of Doryphoribius barbarae sp. nov. (Eutardigrada: Parachela: Hypsibiidae)
No full textBeasley, Clark W., Miller, William R. (2012): Additional Tardigrada from Hubei Province, China, with the description of Doryphoribius barbarae sp. nov. (Eutardigrada: Parachela: Hypsibiidae). Zootaxa 3170: 55-63, DOI: 10.5281/zenodo.21270
BOOKS & VOICES A Guest Artist Lecture Talk by Becky Beasley
No full textOur Invited guest Artist from the UK Becky Beasley will explore her reading practices and spatial imagination in the context of her circular and revolutionary approach to learning from others’ perspectives and voices. The slide lecture will cover the background to her unique reading of, amongst others, William Faulkner and Thomas Bernard’s literary voices. She will also speak about her new-found understanding of how all this is an expression of her autistic point of view.
PUBLICS and LUGEMIK are inviting you to join the Festival of Books and Voices.
Initiated by PUBLICS and Lugemik, the Festival spreads out through the months of September, October and November, bringing together themes of Publishing and Voice. For this Autumn, our space in Vallila is showcasing an exhibition of 100 books published by Lugemik, an independent publishing initiative based in Tallinn. In celebration of the show, we will have a monthly program consisting of book launches, vinyl sound lounge, lectures, screenings, pop-up bookstores, discussions and readings!
Festival of Books and Voices brings together book-related practices and the presence of voice – the two strands of PUBLICS that have been visible and active throughout the years, evolving through our public events and Library program. The festival continues the tradition of bringing attention to books and emphasising the context of our Library – a crucial and ever growing part of PUBLICS identity. At the beginning of each month, a scheduled event program will be announced
Echiniscus reticulatus Murray 1905
No full textEchiniscus reticulatus Murray, 1905 Material examined. Five moss samples from Site 3 contained 85 specimens plus 25 exuvia containing eggs. Six moss samples from Site 5 contained 95 specimens plus 9 exuvia containing eggs. Remarks. In China this species has previously been reported from Sichuan Province (Beasley et al. 2006) and Shaanxi Province (Li 2007). The exuvia in this study contained from one to nine eggs, giving an average of 4.5.Published as part of Beasley, Clark W. & Miller, William R., 2012, Additional Tardigrada from Hubei Province, China, with the description of Doryphoribius barbarae sp. nov. (Eutardigrada: Parachela: Hypsibiidae), pp. 55-63 in Zootaxa 3170 on page 56, DOI: 10.5281/zenodo.21270
Lt. Gov. Jere Beasley
No full textLt. Gov. Jere Beasley discusses the new rules and schedule for the upcoming session of the legislature, as well as what issues he hopes will be prioritized in the upcoming session
Echiniscus viridissimus Peterfi 1956
No full textEchiniscus viridissimus Péterfi, 1956 Material examined. Two specimens were found in a moss sample from Site 5. Remarks. This is the first record of E. viridissimus for China.Published as part of Beasley, Clark W. & Miller, William R., 2012, Additional Tardigrada from Hubei Province, China, with the description of Doryphoribius barbarae sp. nov. (Eutardigrada: Parachela: Hypsibiidae), pp. 55-63 in Zootaxa 3170 on page 56, DOI: 10.5281/zenodo.21270
Cornechiniscus lobatus Ramazzotti 1943
No full text<i>Cornechiniscus lobatus</i> (Ramazzotti, 1943) <p> <b>Material examined.</b> Six moss samples from Sites 1 and 5 contained 99 specimens.</p> <p> <b>Remarks.</b> This species was first reported from China by Bartoš (1963), with the second record 43 years later by Beasley <i>et al.</i> (2006). This is only the third report of this species from China and is a new record for the Hubei Province.</p>Published as part of <i>Beasley, Clark W. & Miller, William R., 2012, Additional Tardigrada from Hubei Province, China, with the description of Doryphoribius barbarae sp. nov. (Eutardigrada: Parachela: Hypsibiidae), pp. 55-63 in Zootaxa 3170</i> on page 56, DOI: <a href="http://zenodo.org/record/212706">10.5281/zenodo.212706</a>
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