198,460 research outputs found
Error analysis of finite element methods with triangles for elliptic boundary value problems
No full textLetter re: cakes
No full textLetter from Ferne Whiteman Smith, sister of band leader Paul Whiteman, to James M. North, Jr., vice president of Carter Publications Inc. and editor of the Fort Worth Star-Telegram, regarding some cakes being sent.Mr Carter Letter from Paul's sister about the cake 3/3/37 JMN My dear Mr North When Brother was in St. Louis last month he asked me to send a certain cake to you and one to Mr. Carter. You should have received them last Saturday. You may like to know that this is a Rhume cake made without flour. Just ground hazelnuts, sugar and eggs with a filling of cream and rhume. Hope you enjoy it. And will you please pass this information on to Mr. Carter? Sincerely Ferne Whiteman Smith 4612 Sundell Blvd, St Loui
Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.
No full textHydrogen sulfide is rapidly emerging as a key physiological mediator and potential therapeutic tool in numerous areas such as acute and chronic inflammation, neurodegenerative and cardiovascular disease, diabetes, obesity and cancer. However, the vast majority of the published studies have employed crude sulfide salts such as sodium hydrosulfide (NaSH) and sodium sulfide (Na2S) as H2S "donors" to generate H2S. Although these salts are cheap, readily available and easy to use, H2S generated from them occurs as an instantaneous and pH-dependent dissociation, whereas endogenous H2S synthesis from the enzymes cystathionine γ-lyase, cystathionine-β-synthase and 3-mercaptopyruvate sulfurtransferase is a slow and sustained process. Furthermore, sulfide salts are frequently used at concentrations (e.g. 100 μM to 10 mM) far in excess of the levels of H2S reported in vivo (nM to low μM). For the therapeutic potential of H2S is to be properly harnessed, pharmacological agents which generate H2S in a physiological manner and deliver physiologically relevant concentrations are needed. The phosphorodithioate GYY4137 has been proposed as "slow-release" H2S donors and has shown promising efficacy in cellular and animal model diseases such as hypertension, sepsis, atherosclerosis, neonatal lung injury and cancer. However, H2S generation from GYY4137 is inefficient necessitating its use at high concentrations/doses. However, structural modification of the phosphorodithioate core has led to compounds (e.g. AP67 and AP105) with accelerated rates of H2S generation and enhanced biological activity. In this review, the therapeutic potential and limitations of GYY4137 and related phosphorodithioate derivatives are discussed
Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners.
No full textThe purpose of this brief review is to help researchers in their initial approach to the H2S field and to provide answers for the
most frequently posed questions by newcomers to the topic related to H2S donors and inhibitors of H2S synthesis, as well as
methods to measure H2S production. Here the reader will find a practical guide that provides fast and to the point
information on how to (i) deliver H2S to cells; (ii) modulate its endogenous production; and (iii) measure its levels in fluids,
cells and tissues in order to gain an understanding of its role in health and disease
Statesmen , Scholars and Merchants. Essays in Eighteenth-Century History presented to Dame Lucy Sutherland. Edited by Anne Whiteman, J. S. Bromley and P. G. M. Dickson, 1973
No full textMichaud Claude. Statesmen , Scholars and Merchants. Essays in Eighteenth-Century History presented to Dame Lucy Sutherland. Edited by Anne Whiteman, J. S. Bromley and P. G. M. Dickson, 1973. In: Dix-huitième Siècle, n°7, 1975. pp. 386-387
Statesmen , Scholars and Merchants. Essays in Eighteenth-Century History presented to Dame Lucy Sutherland. Edited by Anne Whiteman, J. S. Bromley and P. G. M. Dickson, 1973
No full textMichaud Claude. Statesmen , Scholars and Merchants. Essays in Eighteenth-Century History presented to Dame Lucy Sutherland. Edited by Anne Whiteman, J. S. Bromley and P. G. M. Dickson, 1973. In: Dix-huitième Siècle, n°7, 1975. pp. 386-387
Regional dynamics: studies in adjustment theory
No full textThe full-text of this book is not available in ORA. Citation: Clark, G. L., Gertler, M. S. & Whiteman, J. E. M. (1986). Regional dynamics: studies in adjustment theory. Boston: Allen and Unwin
Effect of emotion on attentional processing
No full textPrevious research on the relationship between emotion and attention has
focused primarily on attention to emotionally valenced stimuli; trait anxiety and
attentional biases for threat; or the relationship between emotion and attention in
clinical contexts. Few studies have investigated the effect of emotion on attentional
processing irrespective of the valence of the stimuli that is being attended.
However, such studies are important as they shed light on issues central to
emotions theory such as whether the experience of discrete emotions is associated
with distinct patterns of attentional processing. In this thesis six experiments and
one correlational study are described. The experimental studies investigate whether
the experience of discrete emotions - specifically amusement, happiness, sadness
and fear - influence attentional processing in comparison to a neutral condition.
Film clips, emotional images and music were used to elicit a target emotional state.
A modified version of the Attention Network Test (ANT) was used to assess three
forms of attention – phasic alerting, covert exogenous orienting and executive
attention. The correlational study required participants to complete a set of
emotion-related questionnaires including the Basic Emotion Scale (BES) and to
perform the ANT. The results suggest that: i) fear reduces executive attention costs,
ii) sadness reduces intrinsic alerting, but does not influence alerting, orienting or
executive attention, iii) amusement and happiness do not differentially influence
alerting, orienting or executive attention, iv) individual differences in the tendency
to experience high arousal negative emotions are associated with phasic alerting, i.e.
faster mobilisation of attentional resources in response to an impending stimulus
and v) exogenous orienting of attention may be impervious to the influence of
emotion, at least in context of neutrally valenced stimuli. Results relating to anxiety,
emotion regulation and attention network performance are also discussed. Taken
together these findings provide only limited support for the broaden-and-build
theory (Fredrickson, 1998) of positive emotions. Amusement and happiness did not
result in broadening (as assessed by executive attention costs) in the present studies.
An attentional narrowing effect was found for fear but not for sadness. It is
proposed that fear, but not sadness, facilitates inhibition and reduces executive
attention costs, indicative of more focused attention. The results here also suggest a relationship between negative emotions characterised by high arousal and phasic
alerting – an aspect of attention which has received little coverage in emotions
research to date. Implications relating to the use of the ANT as a measure of
attentional performance, and the challenges associated with manipulating emotion
in a lab setting are discussed
Finite element solutions to boundary value problems
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis consists of two distinct parts which deal with two-point boundary value problems and parabolic problems, respectively. In Section 1 we examine the numerical solution of a two-point boundary
value problem by a collocation method based on the consistency relationship of regular splines. An existence and convergence result
is established which generalises the 0(h^2) convergence result of the cubic spline collocation scheme for the problem in question. Contrary to most previously documented finite element schemes this method
employs splines that may be non-linear in structure. Consequently, by a judicious choice of regular spline, the dominant terms of the true solution may be imitated more accurately than by the conventional polynomial based splines. The scheme is implemented by an algorithm that examines the suitability of various classes of regular splines and determines the subsequent deployment of them. The second section investigates semi-discrete finite element schemes for approximating the linear parabolic equation. A standard finite element discretization is employed for the space variable whilst an A0-stable, linear multistep, multiderivative discretization
scheme, (L.M.S.D.) is used in time. We consider both the homogeneous and the nonhomogeneous linear parabolic equations and derive optimal convergence results for the above schemes. The convergence results
achieved with a k-step L.M.S.D. scheme, incorporating the first m derivatives, generalise and extend the studies of several authors who concentrate on the particular cases of linear multistep formulae, m-l, and one-step schemes, k=1. Ao-stable L.M.S.D. 's are constructed and their implementation procedures examined. The suitability of selecting a L.M.S.D. method, with m, k>1, in a semi-discrete Galerkin scheme is discussed, and its superiority over semi-discrete Galerkin schemes, that incorporate linear multistep or one-step formulae, is confirmed in several aspects. Finally, a class of quasi-linear parabolic equations is solved by a semi-discrete Galerkin scheme that is third order accurate in time. This method is based on a particular third order L.M.S.D. scheme and requires the solution of linearly algebraic systems of equations at
each time level. Thus, we improve on all the previously documented linearised schemes as they are only second order accurate in time. All the schemes described in Section 2 are unconditionally stable
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