2,683 research outputs found
Reg I. White
No full text"PM2281 Reg. I. White E.R.A. H.M.A.S. Kara Kara. " Koompartoo. " Kangaroo. Dec. 42 - Aug. 44."PM2281 Reg. I. White Engine Room Artificer, His Majesty's Australian Ship Kara Kara. H.M.A.S. Koompartoo. H.M.A.S. Kangaroo. December 42 - August 44
Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s Syndrome.
No full textPhDA continuous process of tissue remodelling and regeneration is a fundamental feature of the
homeostatic response of the target organ of several autoimmune diseases. In type 1 diabetes (T1D)
the β cell mass is in a constant process of death and renewal in order to regenerate the islets
damaged by the autoimmune process. The relationship linking inflammation and regeneration
during autoimmunity remains elusive. Reg genes, a multigene family discovered using cDNA
libraries derived from rat regenerating islets, have been suggested to play an important role in
epithelial regeneration not only in the pancreas but also in the salivary glands (SG) of Sjogren’s
Syndrome (SS) during autoimmune sialoadenitis.
Both in patients and animal models of T1D and SS, the chronic inflammatory/autoimmune process
is heterogeneous and display high immunological variability. In particular, in a sizeable subset of
cases, inflammatory lesions display ectopic lymphoid structures (ELS) characterised by T/B cell
segregation, follicular dendritic cells networks and differentiation of germinal center B cells.
However, there is limited evidence on the cellular and molecular mechanisms underlying ELS
formation and their contribution to autoimmunity in the pancreas during autoimmune insulitis and
in SG during autoimmune sialoadenitis. In this PhD project, I used the NOD mouse model of T1D
and SS in order to investigate i) the cellular and molecular mechanisms regulating ELS formation,
ii) the functionality of ELS in supporting in situ autoreactive B cell differentiation and iii) the
relationship between formation of ELS and the expression of REG genes.
In this work I showed that ELS formation was preceded by local up-regulation of lymphotoxins
(LTαβ) and lymphoid chemokines CXCL13 and CCL19 and that, once formed, ELS were fully
functional in promoting autoreactive B cell activation. Importantly, inhibition of the LT-β pathway
prevented the formation of ELS and B cell autoimmunity. Finally, I showed that the expression
pattern of Reg genes was strictly related to the development of inflammatory infiltrates in NOD
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mice and that Reg proteins were target of the autoimmune process itself, as shown by the
development of anti-Reg1 antibodies in patients with T1D. Overall, these results suggest that the
processes of destruction and regeneration occurring in chronic autoimmune/inflammatory diseases
are strongly interdependent whereby autoimmunity may be further enhanced by the attempt to
regenerate
08.01.026: Portrait, "A. J. White, Reg. [No.] 2832, England, Died Nov 21 1917"
No full textPortrait, "A. J. White, Reg. [No.] 2832, England, Died Nov 21 1917", inscribed in pencil on verso: b&w; 6.5 x 3.7 (oval) on mat 15.2 x 7.5 cm, [Hawick, Scotland]: J. E. D. Murray [between 1914 and 1917
An edition of the cartulary of St. Mary's Collegiate Church, Warwick.
No full textIn 2 volsAvailable from British Library Document Supply Centre-DSC:DXN034790 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
‘A Class Apart’?: South Asian Immigrants and the White Working Class Left, Yorkshire 1960-1981
No full textDuring the 1960s many thousands of South Asian immigrants arrived in the United Kingdom. At first they were, by and large, economic migrants looking to fill British labour shortages and send remittances back home. Through the 1960s and into the 1970s, however, the arrival of wives and dependents, and the growth of a British-born or raised generation of South Asians, led to the creation of a permanent settlement in the UK.
This thesis aims to examine the reactions of the white working class Left in Yorkshire to these new arrivals from 1960 to 1981, analyse the factors which prompted these reactions, and assess the implications of this reaction for our understanding of concepts such as ‘class’, and ‘identity’
I «nuovi» diritti dei passeggeri ferroviari alla luce del Reg. UE 2021/782
No full textQuesto scritto si focalizza sulle principali novità per quanto riguarda i di-ritti dei passeggeri ferroviari introdotte dal reg. Ue 2021/782 che troverà appli-cazione dal 7 giugno 2023.
In particolare vengono illustrati i «nuovi» diritti sia di tutti i passeggeri ferroviari (con particolare attenzione al diritto all’informazione, nonché ai diritti in caso di ritardo, perdita di coincidenza e cancellazione del treno) sia delle per-sone con disabilità ed a mobilità ridotta e dei passeggeri che trasportano a bor-do dei treni le loro biciclette.
Pur apprezzando il rafforzamento della tutela dei passeggeri ferroviari operato dal reg. Ue 2021/782 l’Autore termina con alcune osservazioni critiche sull’approccio unimodale seguito dal legislatore unionale nella regolamentazione dei diritti dei passeggeri nelle diverse modalità di trasporto.The author focuses on the main innovations regarding the rail passengers’ rights introduced by Regulation (EU) 2021/782 which shall apply from 7 June 2023.
In particular, the author reviews the «new» rights of all rail passengers (with particular attention to the right of information and to the rights in the event of delay, missed connection and cancellation of the train) as well as the rights of persons with disabilities and persons with reduced mobility and of passengers entitled to take their bicycles on board the train.
While acknowledging the strengthening of the protection of rail passengers made by Regulation (EU) 2021/782, the author concludes with some critical remarks on the unimodal approach followed by the EU legislator in regulating passengers’ rights in different means of transport
Environmental influences on moult and movement strategies in southern African waterfowl
No full textIncludes abstract.Includes bibliographical references.Waterfowl annual life history events in north-temperate regions are driven primarily by predictable seasonal variations in temperature. In contrast, the spatio-temporal availability of adequate resources to waterfowl in the semi-arid regions of southern Africa is determined by rainfall which is extremely variable in timing and intensity. I studied the environmental influences on flight-feather moult and movement strategies of southern African waterfowl. Six duck species that are fairly common in most parts of South Africa were selected for the study, namely; Egyptian Geese, Alopochen aegyptiaca, Spur-winged Geese, Plectropterus gambensis, South African Shelducks, Tadorna cana, Yellow-billed Ducks, Anas undulata, Red-billed Teals, A. erythrorhyncha and Southern Pochards, Netta erythrophthalma. I chose two study sites to represent the extremes of environmental conditions in southern African, namely Barberspan (summer-rainfall region) and Strandfontein (temperate winter-rainfall region). I investigated the underlying responses of Afrotropical waterfowl to stochastic varying environmental conditions in southern Africa and the life-history strategies they have evolved to cope with this variability. The study also compares and contrasts the life-history strategies of southern hemisphere waterfowl with those of the northern hemisphere
The ecological effects of grazing by the White Rhino (Ceratotherium simum simum) at a landscape scale
No full textIn this thesis I generated hypotheses concerning the top down effect of grazing ungulates on grass communities and fire behavior from work done within grazing exclosures in Hluhluwe iMfolozi Park. White Rhino had a large influence in controlling grass biomass in Hluhluwe, a high rainfall mesic savanna. Other smaller species of grazers could not replicate the effect of White Rhino when their grazing was removed. In Umfolozi, a semi-arid savanna, other species of grazer could replace the effect of White Rhino grazing and exert a controlling influence on grass biomass. Hence the relative importance of different species of grazers changed along a rainfall gradient. When examined at a larger spatial scale I found that the removal of White Rhino led to a detectable change in grass biomass and in the grazing behavior of other species in the area of the removal. The effect that herbivores exerted on the grass layer also had consequences for the movement of fire through the landscape by reducing fuel loads. Burnt areas were larger and less patchy in areas from which White Rhino had been removed in comparison to control areas. This effect was larger in Hluhluwe but still significant in Umfolozi. I suggest that both fire and grazing are in competition for the same resource, grass, and that each results in conditions favorable to the recurrence of that event (fire or grazing). This allows the system to switch between mammal and fire dominated states. Rainfall shifts the balance of this competition and in mesic savannas White Rhino appear to be the only animal capable of competing successfully with fire. This work has application for the management of ecosystems that are influenced by top down control and for the maintenance of heterogeneity in mesic savannas
Evaluation of the HemoCue® WBC System as a Point of Care Diagnostic Tool for White Blood Cell Quantification in Pinnipeds
No full textPoint of care (POC) hematology testing can be valuable in triage and field settings. We assessed the accuracy between the HemoCue® WBC system and two comparative analyzers, as well as the precision of the HemoCue® WBC system in five different pinniped species: Zalophus californianus, Arctocephalus townsendi, Callorhinus urcinus, Phoca vitulina, and Mirounga angustirostris for white blood cell (WBC) quantification. In Zalophus (n = 164; 106 from U.S. Navy Marine Mammal Program (Navy); 58 from The Marine Mammal Center (TMMC)), the HemoCue® was compared to two hematology analyzers, Sysmex Xe-5000 and Vet ABC Plus. In Phoca (n = 50; TMMC), Callorhinus (n = 29; TMMC), Arctocephalus (n = 17; TMMC), and Mirounga (n = 67; TMMC), the HemoCue® was compared to Vet ABC Plus only. Bland–Altman and Passing–Bablok agreement of HemoCue® with Sysmex Xe-5000 and Vet ABC Plus analyzers were good for Zalophus, Arctocephalus, Phoca, and Mirounga but marginal with Callorhinus; bias = 0.56 × 109/L (Zalophus; Navy), −2.13 × 109/L (Zalophus; TMMC), −1.59 × 109/L (Arctocephalus), −2.48 × 109/L 0.917 (Phoca), −0.01 × 109/L (Mirounga), and −6.05 × 109/L (Callorhinus). The coefficient of variation from triplicate runs of samples were within acceptable limits for all species (2.50% ± 1.63 (Zalophus; TMMC), 3.09% ± 2.14 (Arctocephalus), 2.47% ± 1.35 (Callorhinus), 2.88% ± 1.75 (Phoca), and 3.44% ± 2.53 (Mirounga)), respectively. The presence of nucleated red blood cells (nRBC; 1–37 nRBC/100 WBC) did not significantly interfere with WBC counts in Zalophus, Callorhinus, and Phoca at the population level, but their presence should be evaluated at the individual level. The HemoCue® provides an accurate method for WBC quantification with WBC counts up to 30 × 109/L (upper limit of linearity of the analyzer) in Zalophus, Arctocephalus, Phoca, and Mirounga, but is less accurate in Callorhinus, and showed good precision in all species
Topics, techniques and applications in urban and regional science in the nineties: a bibliometric analysis
No full textThe current state of regional and urban science has been much discussed and a number of studies have speculated on possible future trends in the development of the discipline. However, there has been little empirical analysis of current publication patterns in regional and urban journals. This paper studies the kinds of topics, techniques and data used in articles published in nine top international journals during the 1990s with the aim of identifying current trends in this research fieldEl actual estado de la ciencia regional y urbana ha sido un tema discutido en un amplio número de estudios que han especulado sobre las futuras
tendencias en el desarrollo de esta disciplina. Sin embargo, se han realizado pocos análisis empíricos sobre los actuales patrones de publicación de las revistas especializadas en los ámbitos regional y urbano. Este documento estudia los diferentes tópicos, técnicas y tipos de datos usados en los artículos publicados en nueve de las más importantes revistas internacionales durante la década de los noventa con el objetivo de identificar las actuales tendencias en
este campo investigació
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