279 research outputs found
Caisson Foundations for Competitive Offshore wind Farms in ITALY
No full textAbstractThe research presented in the paper moves from the results of a feasibility study recently carried out for the development of an offshore wind farm off the cost of Rimini, in the Northern Adriatic Sea. The work, based on in-situ measurements of the environmental conditions, assessed the suitability of the considered area for the development of a relatively large wind farm, although at the profitability limit. The study has considered 60 offshore wind turbines installed on monopiles, as they are, at present, the most common solution and a quantification of the investment costs could be reliably completed. With reference to such case, the paper addresses the use of caisson foundations, a convenient alternative to monopiles in water of shallow to intermediate depth, with the final aim of improving the overall cost-effectiveness of the investment
No Rising Tide: Theology, Economics and the Future
No full textTitle: No rising tide : theology, economics, and the future Author: Joerg Rieger Publisher: Minneapolis: Fortress Press, 2009 ISBN: 978080066459
Role of oxygen vacancies for resistive switching in noble metal sandwiched Pr<sub>0.67</sub>Ca<sub>0.33</sub>MnO<sub>3-δ</sub>
No full textNon-volatile resistance change under electric stimulation in oxides is a promising path to next generation memory devices. However, the underlying mechanisms are still not fully understood. We report here on the study of switching in Pr0.67Ca0.33MnO3-delta (PCMO) films sandwiched by noble metal Pt electrodes, where electrode oxidation can be excluded. In order to develop an understanding of the switching induced oxygen migration, its initial concentration is modified by post-annealing of the deposited PCMO films. The oxygen distribution is obtained by manganese valence determination using spatially resolved electron energy loss spectroscopy in scanning transmission electron microscopy mode. We observe correlations between virgin state resistance, resistive switching properties, oxygen vacancy distribution, and stress/strain state of the PCMO films and propose a simplified interface resistance model based on the measured valence distribution. It assumes a linear correlation of oxygen vacancy concentration with conductivity and a metal to insulator transition above a critical vacancy concentration threshold. Our results suggest that resistance changes can take place at both interfaces of symmetric devices and only requires small changes in oxygen vacancy concentration. (C) 2017 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).DFG [Jo 348/10-01
Author instructions regarding trial registration.
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No full textThe biotrophic fungus Ustilago maydis causes smut disease in maize with characteristic tumor formation and anthocyanin induction. Here, we show that anthocyanin biosynthesis is induced by the virulence promoting secreted effector protein Tin2. Tin2 protein functions inside plant cells where it interacts with maize protein kinase ZmTTK1. Tin2 masks a ubiquitin-proteasome degradation motif in ZmTTK1, thus stabilizing the active kinase. Active ZmTTK1 controls activation of genes in the anthocyanin biosynthesis pathway. Without Tin2, enhanced lignin biosynthesis is observed in infected tissue and vascular bundles show strong lignification. This is presumably limiting access of fungal hyphae to nutrients needed for massive proliferation. Consistent with this assertion, we observe that maize brown midrib mutants affected in lignin biosynthesis are hypersensitive to U. maydis infection. We speculate that Tin2 rewires metabolites into the anthocyanin pathway to lower their availability for other defense responses
Tactile Feedback for Artery Detection in Minimally Invasive Robotic Surgery –Preliminary Results of a New Approach
No full textMinimally invasive robotic surgery (MIRS) entails
total absence of haptic feedback due to the spatial separation
of patient and surgeon. In conventional surgery, however,
palpation to detect superficial arteries by a slight pulsation is
an important, commonly applied, and security-relevant procedure.
Therefore, an ultrasound based unidirectional sensor for
MIRS was developed feeding back kinesthetic impulses to the
surgeon-sided haptic input device
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages
No full textSuccessful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator for phago-lysosome-mitochondria crosstalk in macrophages. By combining cellular imaging and metabolic profiling, we find that TFEB activation, in response to bacterial stimuli, promotes the transcription of aconitate decarboxylase (Acod1, Irg1) and synthesis of its product itaconate, a mitochondrial metabolite with antimicrobial activity. Activation of the TFEB–Irg1–itaconate signalling axis reduces the survival of the intravacuolar pathogen Salmonella enterica serovar Typhimurium. TFEB-driven itaconate is subsequently transferred via the Irg1-Rab32–BLOC3 system into the Salmonella-containing vacuole, thereby exposing the pathogen to elevated itaconate levels. By activating itaconate production, TFEB selectively restricts proliferating Salmonella, a bacterial subpopulation that normally escapes macrophage control, which contrasts TFEB’s role in autophagy-mediated pathogen degradation. Together, our data define a TFEB-driven metabolic pathway between phago-lysosomes and mitochondria that restrains Salmonella Typhimurium burden in macrophages in vitro and in vivo
Simulating multiple diffraction in imaging systems using a path integration method
No full textWe present a method for simulating multiple diffraction in imaging systems based on the Huygens–Fresnel principle. The method accounts for the effects of both aberrations and diffraction and is entirely performed using Monte Carlo ray tracing.We compare the results of this method to those of reference simulations for field propagation through optical systems and for the calculation of point spread functions. The method can accurately model a wide variety of optical systems beyond the exit pupil approximation.Accepted Author ManuscriptImPhys/Optic
Major influences on circus attendance.
No full textAlthough circus represents one of the most accessible art forms, the economics of the arts and culture has completely neglected to address this topic. This paper represents an attempt to fill in this lack by identifying the determinants of the demand for circus in Italy, both in terms of structural characteristics of the shows and socio-economic factors that impact on it. To this aim, we collect information on the tournee of the bigger circuses performing in Italy during 2005 and 2006. The results show a positive elasticity of demand to income and, differently from similar studies on performing arts, to ticket price. There also differences between circuses in the importance of numbers with animals.circus; demand; performing arts; Italy; attendance
UK Research Information Shared Service (UKRISS) Final Report, July 2014
No full textThe reporting of research information is a complex and expensive activity for research organisations (ROs). There is little alignment between funders of the reporting requests made to institutions and requests made to individual researchers about their research outputs and outcomes. This inevitably results in duplication and increased costs across the sector, whilst limiting the potential sharing and reuse of the information. The UK Research Information Shared Service (UKRISS) project conducted a feasibility and scoping study for the reporting of research information at a national level based on CERIF (Common European Research Information Format), with the objective of increasing efficiency, productivity and quality across the sector. The aim was to define and prototype solutions which are compelling, easy to use, have a low entry barrier, and support innovative information sharing and benchmarking. CERIF has emerged as the preferred format for expressing research information across Europe. To date, CERIF has been piloted for specific applications, but not as a format for reporting requirements across all UK ROs. The final report presents the work carried out by the UKRISS project, including requirements gathering, modelling and prototyping, as well as recommendation for sustainability. UKRISS was divided into two phases. Phase 1, mapping the reporting landscape, ran from March 2012 to December 2012. Phase 2, exploring delivery of potential solutions, began in February 2013 and ended in December 2013
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