196,098 research outputs found
Mecinus heydenii Wencker 1866
No full textMecinus heydenii Wencker, 1866 Records. DON [Yunakov et al., 2018: 218]. Localities. Donetsk Region. Donetsk, 16.04.2002 (M. Sergeev). Volnovakha Distr.:Zlatoustovka, 2.09.2011.Published as part of Arzanov, Yu. G., Martynov, V. V. & Nikulina, T. V., 2021, A contribution to the fauna of weevil beetles (Coleoptera: Curculionoidea) of the Central Donbass, pp. 5-44 in Caucasian Entomological Bulletin 17 (1) on page 24, DOI: 10.23885/181433262021171-544, http://zenodo.org/record/814564
Rare variants in alpha 1 antitrypsin deficiency: a systematic literature review
No full textBackground: Alpha 1 Antitrypsin Deficiency (AATD) is a largely underrecognized genetic condition characterized by low Alpha 1 Antitrypsin (AAT) serum levels, resulting from variations in SERPINA1. Many individuals affected by AATD are thought to be undiagnosed, leading to poor patient outcomes. The Z (c.1096G > A; p.Glu366Lys) and S (c.863A > T; p.Glu288Val) deficiency variants are the most frequently found variants in AATD, with the Z variant present in most individuals diagnosed with AATD. However, there are many other less frequent variants known to contribute to lung and/or liver disease in AATD. To identify the most common rare variants associated with AATD, we conducted a systematic literature review with the aim of assessing AATD variation patterns across the world. Methods: A systematic literature search was performed to identify published studies reporting AATD/SERPINA1 variants. Study eligibility was assessed for the potential to contain relevant information, with quality assessment and data extraction performed on studies meeting all eligibility criteria. AATD variants were grouped by variant type and linked to the geographical region identified from the reporting article. Results: Of the 4945 articles identified by the search string, 864 contained useful information for this study. Most articles came from the United States, followed by the United Kingdom, Germany, Spain, and Italy. Collectively, the articles identified a total of 7631 rare variants and 216 types of rare variant across 80 counties. The F (c.739C > T; p.Arg247Cys) variant was identified 1,281 times and was the most reported known rare variant worldwide, followed by the I (c.187C > T; p.Arg63Cys) variant. Worldwide, there were 1492 Null/rare variants that were unidentified at the time of source article publication and 75 rare novel variants reported only once. Conclusion: AATD goes far beyond the Z and S variants, suggesting there may be widespread underdiagnosis of patients with the condition. Each geographical region has its own distinctive variety of AATD variants and, therefore, comprehensive testing is needed to fully understand the true number and type of variants that exist. Comprehensive testing is also needed to ensure accurate diagnosis, optimize treatment strategies, and improve outcomes for patients with AATD
The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency
No full textST Schmid,1 J Koepke,1 M Dresel,1 A Hattesohl,1 E Frenzel,2 J Perez,3 DA Lomas,4 E Miranda,5 T Greulich,1 S Noeske,1 M Wencker,6 H Teschler,6 C Vogelmeier,1 S Janciauskiene,2,* AR Koczulla1,*1Department of Internal Medicine, Division for Pulmonary Diseases, University Hospital Marburg, Marburg, Germany; 2Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany; 3Department of Cellular Biology, University of Malaga, Malaga, Spain; 4Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom; 5Department of Biology and Biotechnology, Istituto Pasteur – Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy; 6Department of Pneumology, West German Lung Clinic, Essen University Hospital, Essen, Germany*These authors contributed equally to this workBackground: The major concept behind augmentation therapy with human α1-antitrypsin (AAT) is to raise the levels of AAT in patients with protease inhibitor phenotype ZZ (Glu342Lys)-inherited AAT deficiency and to protect lung tissues from proteolysis and progression of emphysema.Objective: To evaluate the short-term effects of augmentation therapy (Prolastin®) on plasma levels of AAT, C-reactive protein, and chemokines/cytokines.Materials and methods: Serum and exhaled breath condensate were collected from individuals with protease inhibitor phenotype ZZ AAT deficiency-related emphysema (n = 12) on the first, third, and seventh day after the infusion of intravenous Prolastin. Concentrations of total and polymeric AAT, interleukin-8 (IL-8), monocyte chemotactic protein-1, IL-6, tumor necrosis factor-α, vascular endothelial growth factor, and C-reactive protein were determined. Blood neutrophils and primary epithelial cells were also exposed to Prolastin (1 mg/mL).Results: There were significant fluctuations in serum (but not in exhaled breath condensate) levels of AAT polymers, IL-8, monocyte chemotactic protein-1, IL-6, tumor necrosis factor- α, and vascular endothelial growth factor within a week of augmentation therapy. In general, augmented individuals had higher AAT and lower serum levels of IL-8 than nonaugmented subjects. Prolastin added for 3 hours to neutrophils from protease inhibitor phenotype ZZ individuals in vitro reduced IL-8 release but showed no effect on cytokine/chemokine release from human bronchial epithelial cells.Conclusion: Within a week, augmentation with Prolastin induced fluctuations in serum levels of AAT polymers and cytokine/chemokines but specifically lowered IL-8 levels. It remains to be determined whether these effects are related to the Prolastin preparation per se or to the therapeutic efficacy of augmentation with AAT.Keywords: Prolastin, augmentation therapy, cytokines, IL-8, exhaled breath condensate, neutrophil
Mecinus heydenii Wencker 1866
No full textMecinus heydenii group Diagnosis. Rostrum in basal half strongly and abruptly curved. Elytra distinctly elongate. Dorsal integument black or blue, usually with metallic reflections. Body of penis with long sharp apex. Spermatheca with insertion of ductus placed perpendicular to length of nodus. Remarks and comparative notes. This group seems more closely related to the M. janthinus group than to other groups of Mecinus in both morphological characters (shape of body and colour of dorsal integument) and biology (hosts in Plantaginaceae different to Plantago). However, the species of the M. heydenii group clearly differ from those of the M. janthinus group by the rostrum being strongly curved in the basal half, and by the shape of the penis and spermatheca. 44. Mecinus heydenii Wencker Figs 39, 141, 156, 170 Mecinus heydenii Wencker, 1866: 130. Tournier, 1874: 41. Bedel, 1885: 148. Desbrochers des Loges, 1893: 59. Reitter, 1907: 8; 1916: 225. Hustache, 1931: 401, 405. Van Emden, 1938: 21. Hoffmann, 1958: 1267, 1269. Péricart, 1974: 65. Alziar, 1975: 5. Smreczyṅski, 1976: 4. Lohse & Tischler, 1983: 262. Arzanov, 2000: 1087. Mecinus laeviceps Tournier, 1873: 85; 1874: 42. Reitter, 1907: 8. Hoffmann, 1958: 1267, 1270. Smreczyṅski, 1960: 76; 1976: 4. Lohse & Tischler, 1983: 262. Arzanov, 2000: 1087. Mecinus bulgaricus Angelov, 1971: 115. Arzanov, 2000: 1087. Mecinus heydenii var. venturensis Hoffmann, 1940: 23; 1958: 1270. Alziar, 1975: 5. Smreczyṅski, 1976: 4. Type locality. Frankfurt (Germany). Type series. This species was described from specimens from Frankfurt (Germany), collected by Heyden, and from Haguenau (Alsace, France), collected by Wencker. We examined three syntypes: two at DEIM, labelled respectively “Frankfurt / 84 / 309 / Mecinus Heydenii orig. / Syntypus ” (male, lectotype here designated) and “Frankfurt / 85 / 310 / Heydenii Wenck. in litt. / Syntypus ” (female, paralectotype), and the third in Desbrochers des Loges' collection (MNHN) and labelled “Heydenii / type“ (a female lacking abdomen, paralectotype). Synonyms. The variety venturensis of M. heydenii was described from specimens collected at Malaucène at the base of Mont Ventoux. Hoffmann (1958) reported that this taxon is synonymous with M. laeviceps according to what was established by Smreczyṅski, who on the contrary (Smreczyṅski 1960) denied this assertion, which is only Hoffmann's misunderstanding. However, subsequently Smreczyṅski (1976) quoted venturensis among the synonyms of M. heydenii together with M. laeviceps. From study of the holotype (MNHN) we agree with the synonymy of venturensis with heydenii. Mecinus laeviceps was described from specimens collected at Sarepta (Volgograd, Russia). Tournier (1874) reported that this species appears to be intermediate between M. janthinus and M. heydenii, from which it should differ by having a smooth head, pronotum with darker colour of the integument and finer and more separated punctures. Reitter (1907) followed the opinion of Tournier, not knowing M. laeviceps himself. Hoffmann (1958) reported that M. laeviceps differs from M. heydenii by a slightly bigger size, bronze colour of the pronotum, longer and less curved rostrum in the female and usually lack of frontal fovea. These differences are also reported in a key by Lohse & Tischler (1983). On the contrary, Smreczyṅski (1976) placed (albeit doubtfully) M. laeviceps in synonymy with M. heydenii, without comments. Recently Arzanov (2000) confirmed the opinion by Smreczyṅski, after study of a male specimen from Sarepta (ZISP) which he supposed to belong to the type series and which he designated as lectotype. We here follow Arzanov's opinion although it is very probable that this taxon actually differs from the typical M. heydenii not only in subtle morphological characters but also in host plant and DNA (I. Toševski pers. comm.) Angelov (1971) described Mecinus bulgaricus from a single female specimen collected at Harmanli (eastern Rhodopi, south-eastern Bulgaria) on 16.IV.1970. He reported that M. bulgaricus has black integument with bronze reflections on pronotum and is related to both M. aubei Desbrochers des Loges, 1893 from northern Africa and M. heydenii, differing from the latter by the elytral striae and interstriae being more finely punctured and by the longer and thicker elytral scales. Arzanov (2000) reported to have examined the " holotype " of M. bulgaricus, received from MZHF where Angelov's collection was deposited after Angelov's death. He reports that this specimen was collected at Harmanli and identified as M. bulgaricus by Angelov, but it is labelled " 23.IV.1971 " and does not bear a label indicating that this is the holotype to the contrary of all other taxa described by Arzanov. He concluded that this taxon is synonymous with M. heydenii. Actually this specimen is not the holotype of M. bulgaricus since the date of collection clearly shows that it was collected at most contemporaneously but more probably after the publication of its description. Currently it is impossible to locate the specimen examined by Arzanov as well as the holotype of M. bulgaricus at MZHF (J. Muona and H. Silfverberg pers. comm.). Therefore presently we follow Arzanov's opinion. Redescription. Male. Length mm 2.0. Body: long, cylindrical, moderately slender (Fig. 39). Rostrum: blackish blue, moderately long (Rl/Pl 0.86), subcylindrical; in lateral view distinctly curved especially in basal half, weakly narrowed at apex (as in M. tavaresi, fig. 97); in dorsal view with parallel sides, slightly enlarged at antennal insertion, with distinctly visible scrobes, weakly striate-punctured, smooth and shining along midline, in basal half with recumbent to subrecumbent, sparse, white, moderately long (l/w 3–5), seta-like scales. Head: frons wide as rostrum at base, with wide and deep fovea; eyes nearly flat, with posterior margin abruptly raised from surface of head. Antennae: black, inserted at middle of rostrum; scape moderately short, 3.5x longer than wide; funicle distinctly longer than scape, with segment 1 2x longer than wide, slightly stouter and slightly longer than segment 2, which is 1.5x longer than wide, segments 2–4 about as long as wide, segment 5 transverse; club long, oval, segment 1 about as pubescent as others. Pronotum: blackish blue, with dense and regular punctures, intervals between punctures smooth and shining, clearly visible between recumbent, sparse, whitish, long (l/w 5–7), setalike scales; weakly transverse (Pw/Pl 1.15), with weakly rounded sides, with very prominent apical constriction, widest in basal third, somewhat convex. Elytra: black with blue reflexions, shining; very long (El/Ew 1.82), at base moderately concave, with subparallel sides, slightly wider than pronotum (Ew/Pw 1.23), widest at middle, somewhat convex on disc; interstriae clearly visible between recumbent, sparse, white, seta-like, 0.50–0.75x as long as width of interstria (l/w 5–7), seta-like scales, arranged in a single regular row; striae clearly visible, one third narrower than interstriae, with a row of scales similar to shorter ones covering interstriae. Legs: moderately slender, with recumbent to subrecumbent, sparse, whitish, distinctly shorter than width of tibia, seta-like scales; femora black, pro- and metafemora with small sharp tooth, metafemora unarmed; tibiae black, moderately slender; protibiae with apical part of ventral surface weakly directed outward; unci blackish, stout, all equal in size and length; tarsi blackish brown, tarsomere 1 1.5x longer than wide, tarsomere 2 about as long as wide, tarsomere 3 distinctly bilobed and distinctly wider than tarsomere 2, onychium shorter than tarsomeres 1–3 taken together; claws black, fused at base, asymmetrical with one claw distinctly smaller and about half shorter than other claw. Venter: metasternum black, clearly visible between recumbent to subrecumbent, sparse, whitish, moderately long, seta-like scales; mesothoracic epimera and meso- and metathoracic episterna with sparse, white, narrow, seta-like scales, and fringed wide scales; abdomen black with bronze reflexions, with dense and somewhat regular punctures, which are clearly visible between recumbent to subrecumbent, sparse, whitish, long, seta-like scales; ventrites length ratio: 1–2/3–4 1.84. Penis: fig. 141. Female. As in male except rostrum slightly longer from antennal insertion to apex (Rl/Pl 0.90) (as in M. tavaresi, fig. 98), less punctured, antennae inserted just before middle, femora unarmed. Sternite 8: fig. 156. Spermatheca: fig. 170. Variability. Length mm 1.6–2.3. Sometimes the elytra are parallel-sided, rarely with stria 3 unusually joining stria 6 instead of stria 8 at the apex. The fovea of the frons varies slightly in width and deepth. The tooth of the femora are sometimes also almost indistinct in the male. The unique North African specimen which we examined appears to differ from the European specimens by the rostrum that is more curved and by the convergent sides of the body of the penis from base to apex. Remarks and comparative notes. This species as presently considered is probably a assemblage of cryptic species differing by a few external characters, as well as in biology and DNA (I. Toševski pers comm.). Mecinus heydenii sensu lato is closely related to the other species of its group, but clearly differs from them by having blue elytral integument. Biological notes. The larva, whose morphology was described by Van Emden (1938), feeds on Linaria vulgaris L., where it digs tunnels causing a poorly visible swelling (Ruter 1934; Hoffmann 1958). The adult was also collected on L. striata L. by Ruter in France (Ariège: Mérens) (Péricart 1974). Arzanov (2000) reported that the adult of this species also lives on Linaria genistifolia (L.) Mill. in southern Russia. According to I. Toševski (pers. comm.) the specimens living on this plant do not belong to M. heydenii but to a closely related species. Distribution. France, Belgium, Denmark, Sweden, Germany, Poland, Ukraine, Hungary, Italy, Bulgaria, Russia including Siberia (Arzanov 2000), Mongolia, Morocco. Non-type specimens examined. FRANCE: Champagne-Ardennes, Mourons, VI.1929 (2, MNHN); Île de France, Forêt de Fontainebleau, 8.VI.1968, on Linaria vulgaris, Péricart leg. (1, MNHN); Hérault, 15 km E of Bédarieux, 23.IV.2010, on Linaria vulgaris, Toševski leg. (1, ITCB); Île de France, Nemours, Les Genevrais, 2.VIII.1975, Péricart leg. (1, MNHN); Languedoc-Roussillon, Gard, Les Angles, 28.VII.1963, ex galls on Linaria stem, leg. Riboulet (2, MNHN); Languedoc-Roussillon, Gard, Nîmes, 3.VI.1967, Tempère leg. (6, MNHN; 1, CPCM); Languedoc-Roussillon, Gard, Saint-Geniès-de-Comolas, 31.V.1967, Tempère leg. (1, MNHN); Lorraine, Montmedy, Meuse, 27.IX.1931, on Linaria vulgaris (1, MNHN); Lorraine, Vosges, Monthureux, 7.IV.1948, Agnus leg. (1, MNHN); Lorraine, Vosges, Raon-L'Étape, 25.IV.1934, Ruter leg. (15, MNHN); Midi-Pyrénées, Ariège, Merens les Vals, 20.VII.1950 (1, MNHN); Provence-Alpes-Côte d'Azur, Vaucluse, Bedoin, 3.V.1958, on Linaria (2, MNHN). BELGIUM: Rhode-Saint-Genèse, 10.VI.1968, Van Bellingen leg. (4, CPCM). DENMARK: Esbjerg, 25.IX.1927 (1, MNHN). GERMANY: Berlin, Forst Bredow (2, ZMHB); Brandenburg, Brieselang bei Nauen (15, ZMHB); Sachsen-Anhalt, Aken, Elbe, 28.IX.1933, Heidenreich leg. (4, ZMHB); Sachsen-Anhalt, Dessau, 6.IX.1934, Heidenreich leg. (5, ZMHB). UKRAINE: Poltava, 3.V.1924, Lukjanovitsh leg. (1, ZISP). HUNGARY: Balaton, Badacsony, 5.VI.1971, Strejček leg. (1, JSCP). ITALY: Emilia Romagna, Modena, Campogalliano, 17.IX.2011, on Linaria vulgaris, Toševski leg. (1, ITCB); Emilia Romagna, Ravenna, Castiglione di Cervia, 26.IX.2002, Pavanello leg. (1, SMCM); Abruzzo, L'Aquila, Secinaro, 25.X.1998, Osella leg. (1, GOCA); Calabria, Reggio Calabria, Aspromonte, Tre Aie, 1400 m, Baviera leg. (1, CBCM). ITALY (Sicily): Messina, 30.VII.1905, Vitale leg. (1, DBAM). RUSSIA: Moscow, Klin, Boblovo, 26.VIII.1905, Smirnov leg. (1, ZISP); Mozhaisk, 8.VIII.1903, Bianki leg. (1, ZISP); Volgograd, Becker leg. (1, ZISP); Yaroslavl, Berditsino, 6.VII.1902, Jakovlev leg. (1, ZISP); Yaroslavl, Jakovlev leg. (1, ZISP). MONGOLIA: Eastern Aimak, 13 km W Dash-Balbar, 23-24.VIII.1975, Emeljanov leg. (1, ZISP). MOROCCO: Casablanca, 10.I.21, Antoine leg. (1, MNHN).Published as part of Caldara, Roberto & Fogato, Valter, 2013, Systematics of the weevil genus Mecinus Germar, 1821 (Coleoptera: Curculionidae). I. Taxonomic treatment of the species, pp. 1-105 in Zootaxa 3654 (1) on pages 74-76, DOI: 10.11646/zootaxa.3654.1.1, http://zenodo.org/record/526548
A comparative atlas of selected skeletal elements of European urodeles (Amphibia: Urodela) for palaeontological investigations
No full textFigure 5. Otic–occipitum complexes of European Pleurodelinae. A, left complex of Calotriton asper (MNCN 16122). B, right complex of Euproctus montanus (BSPGM 4202). C, left complex of Ichthyosaura alpestris (MDHC 416). D, right complex of Lissotriton vulgaris (MDHC 133). E, left complex of Ommatotriton vittatus (MNCN 13193). F, right complex of Pleurodeles waltl (MDHC 253). G, right complex of Triturus carnifex (MDHC 38). H, left complex of Triturus carnifex (MDHC 299). From left to right: anterior, dorsal, lateral, posterior and ventral views. Scale bars: 1 mm.Published as part of Macaluso, Loredana, Wencker, Lukardis C M, Castrovilli, Maria, Carnevale, Giorgio & Delfino, Massimo, 2023, A comparative atlas of selected skeletal elements of European urodeles (Amphibia: Urodela) for palaeontological investigations, pp. 569-619 in Zoological Journal of the Linnean Society 197 (3) on page 576, DOI: 10.1093/zoolinnean/zlac063, http://zenodo.org/record/769095
Comparison of different algorithms in laboratory diagnosis of alpha1-antitrypsin deficiency
No full textAlpha1-antitrypsin deficiency (AATD) is an inherited condition that predisposes individuals to an increased risk of developing lung and liver disease. Even though AATD is one of the most widespread inherited diseases in Caucasian populations, only a minority of affected individuals has been detected. Whereas methods have been validated for AATD testing, there is no universally-established algorithm for the detection and diagnosis of the disorder. In order to compare different methods for diagnosing AATD, we carried out a systematic review of the literature on AATD diagnostic algorithms. Complete biochemical and molecular analyses of 5,352 samples processed in our laboratory were retrospectively studied using each of the selected algorithms. When applying the diagnostic algorithms to the same samples, the frequency of False Negatives varied from 1.94 to 12.9%, the frequency of True Negatives was 62.91% for each algorithm and the frequency of True Positives ranged from 24.19 to 35.15%. We, therefore, highlighted some differences among Negative Predictive Values, ranging from 0.83 to 0.97. Accordingly, the sensitivity of each algorithm ranged between 0.61 and 0.95. We also postulated 1.108 g/L as optimal AAT cut-off value, in absence of inflammatory status, which points to the possible presence of genetic AATD. The choice of the diagnostic algorithm has a significant impact on the correct diagnosis of AATD, which is essential for appropriate treatment and medical care. The fairly large number of possible false negative diagnoses revealed by the present paper should also warn clinicians of negative results in patients with clinically-suspected AATD
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Figure 15 in A comparative atlas of selected skeletal elements of European urodeles (Amphibia: Urodela) for palaeontological investigations
No full textFigure 15. Precaudal vertebrae of Ichthyosaura (A, B) and Lissotriton (C, D), as an example of the intrageneric variation of the posterodorsal area of the neural arch. Notice that in A and C, the posterodorsal area is vertical and followed by the forked neural crest, whereas in B and D the posterodorsal area is roof-shaped, and the neural crest terminates in the middle of the incisura dorsalis. In contrast, the medial edges of the prezygapophyses (dashed lines in A, C) are a less variable character (divergent in the case of Ichthyosaura and parallel in Lissotriton; see diagnoses section). Scale bars: 1 mm.Published as part of Macaluso, Loredana, Wencker, Lukardis C M, Castrovilli, Maria, Carnevale, Giorgio & Delfino, Massimo, 2023, A comparative atlas of selected skeletal elements of European urodeles (Amphibia: Urodela) for palaeontological investigations, pp. 569-619 in Zoological Journal of the Linnean Society 197 (3) on page 615, DOI: 10.1093/zoolinnean/zlac063, http://zenodo.org/record/769095
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Figure 8 in A comparative atlas of selected skeletal elements of European urodeles (Amphibia: Urodela) for palaeontological investigations
No full textFigure 8. Atlantes of European urodeles. A, Lissotriton vulgaris (MDHC 135). B, Lissotriton vulgaris (MDHC 133). C, Ommatotriton vittatus (MNCN 13193), with right postzygapophyses missing. D, Pleurodeles waltl (MDHC 253). E, Triturus carnifex (MDHC 38). From left to right: anterior, dorsal, lateral (right lateral for A, D; left lateral for B–C, E), posterior and ventral views. Scale bars: 1 mm.Published as part of Macaluso, Loredana, Wencker, Lukardis C M, Castrovilli, Maria, Carnevale, Giorgio & Delfino, Massimo, 2023, A comparative atlas of selected skeletal elements of European urodeles (Amphibia: Urodela) for palaeontological investigations, pp. 569-619 in Zoological Journal of the Linnean Society 197 (3) on page 579, DOI: 10.1093/zoolinnean/zlac063, http://zenodo.org/record/769095
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