2,025 research outputs found
The Gothic threshold of Sabine Baring-Gould : a study of the Gothic fiction of a Victorian squarson
Full text linkThis thesis is a study of the Gothic fiction of Sabine Baring-Gould (1834-
1924), with particular attention given to Baring-Gould’s roles as squire and parson. I
have chosen to analyze two of Baring-Gould’s Gothic works, the novel Mehalah
(1880) and the novella Margery of Quether (1884), both which allow a particularly
profitable examination of the influence of Baring-Gould’s roles on his fiction.
In studying these texts I apply my theory of Gothic fiction as a particularly
modern genre built upon a "Gothic threshold," a meeting point of extreme opposites
which ambivalently contrasts and merges the categories of the modern and the
medieval.
In the first chapter I describe how Baring-Gould’s unique Hegelian-influenced
Tractarian philosophy influenced his creation of the dialectical setting of Mehalah. I
argue that because of this influence Mehalah should be recognized as a significant
contribution to the literature of the Oxford Movement.
In the second chapter I argue that Mehalah’s historical setting in the time of
the French Revolution and the influence of Wuthering Heights reinforce Mehalah’s
use of the “Gothic threshold” structure and contribute to its theme of ambivalent
progress.
In the third chapter I discuss the influence of Baring-Gould’s sermon-writing
on Mehalah and consider connections between Baring-Gould’s role as parson and the
novel’s botched marriage theme.
In the final chapter I discuss Margery of Quether as an innovation in the
Gothic and vampire tradition as perhaps the only Gothic work that directly dramatizes
the Land Law debate and presents that debate as a "Gothic" contest. I argue that
Margery channels Baring-Gould’s tensions as a landowner.
In the conclusion I argue that Mehalah and Margery display Baring-Gould’s
technique of constructing miniature Gothic battles that relate to larger confrontations,
and that the ultimate terror presented in these works is the conclusion of the battle
between ancient and modern forces
Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance
No full textThe Semliki-Forest virus (SFV) system was used to overexpress human wild-type and mutant prion proteins as well as FLAG-tagged human and bovine PrP in mammalian cells. The application of recombinant SFV vectors allowed a high-level production of highly glycosylated prion proteins with a molecular weight ranging from 25 to 30 kDa for recombinant wild-type human PrP and from 26 to 32 kDa for wild-type bovine PrP. Further, we report here the generation of recombinant mutant prion proteins that are associated with inherited human prion diseases such as fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD). Both mutated variants, the FFI-associated PrP carrying a mutation at amino acid position 178 and the CJD-linked form containing an insertion of nine additional octarepeats reveal proteinase K resistance, one of the typical biochemical properties of the infectious scrapie isoform of the prion protein. By contrast, recombinant wild-type PrP was completely proteinase K sensitive when expressed in SFV-transfected BHK cells. The subcellular location of both PrP mutants at the cell surface and in intracellular compartments of transfected BHK cells was similar to that of wild-type PrP. In order to purify recombinant human and bovine PrP from cell lysates, a FLAG-tag was introduced either at the N-terminus behind the signal peptide or at the C-terminus close to the adhesion site of the GPI anchor. N-terminal insertion did not extensively influence the trafficking of the FLAG-tagged protein to the cell surface, whereas insertion close to the GPI attachment site clearly affected the transport of the majority of PrP to the cell membrane, probably resulting in their retention within the secretory pathway. All FLAG-tagged prion proteins were expressed efficiently in BHK cells and showed a typical glycosylation pattern, allowing their rapid and simple purification via anti-FLAG antibody chromatography
Sabine Brauckmann to Viktor Hamburger, October 12, 1998
No full textShort note on her upcoming lectures on the Sperry-Weiss controversis at University of Chicago & Duke Univesity.Handwritten.1-page letterCorrespondenc
Binding of parallel cognitive-linguistic processes within the brain
No full textWeiss S. Binding of parallel cognitive-linguistic processes within the brain. Presented at the Neurobiology of Embodied Language Workshop, Bielefeld, ZIF, p.15
Sabine Brauckmann to Viktor Hamburger, August 5, 1998
No full textOn her upcoming appointment as a visiting scientist at the Medical center of Salt Lake City University. On her historical research on Weiss in the US.Handwritten.2-page letterCorrespondenc
Sabine Brauckmann to Viktor Hamburger, June 23, 1998
No full textAttached draft version of 10-page interview with Viktor Hamburger in German language (dated June 12 - June 16, 1998) on Weiss, Bertalanffy, Driesch, Spemann, Levi-Montalcini, Sperry, Kuehn, Roux, Portmann and Delbrueck and their relationship to Viktor Hamburger.Handwritten letter. Interview has handwritten corrections by Hamburger.12-page letterCorrespondenc
Neuronale Synchronisation als Indikator sprachlicher Repräsentation
No full textWeiss S. Neuronale Synchronisation als Indikator sprachlicher Repräsentation. Materialien Deutsch als Fremdsprache 76. 2006:39-53
Sabine Brauckmann to Viktor Hamburger, August 26, 1998
No full textAttached corrected version of 10-page interview with Viktor Hamburger in German language (dated June 12 - June 16, 1998) on Weiss, Bertalanffy, Driesch, Spemann, Levi-Montalcini, Sperry, Kuehn, Roux, Portmann and Delbrueck and their relationship to Viktor Hamburger.Handwritten letter. Interview has handwritten corrections by Hamburger.12-page letterCorrespondenc
Sprachverarbeitung im Gehirn, www.science.orf.at|science|news|36465
No full textWeiss S. Sprachverarbeitung im Gehirn, www.science.orf.at|science|news|36465. http://science.orf.at/science/news/36465. 21.12.2001
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