1,167 research outputs found
Coherences and populations in the driven damped two-state system
No full textCoherences and populations in the driven damped two-state system / Milena Grifoni ; Manfred Winterstetter ; Ulrich Weiss. - In: Physical review. E. 56. 1997. S. 334-34
Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition
No full textThe natural resistance-associated macrophage protein 1, Slc11a1, is a phagolysosomal transporter for protons and divalent ions including iron that confers host protection against diverse intracellular pathogens including Salmonella. We investigated and compared the regulation of iron homeostasis and immune function in RAW264.7 murine phagocytes stably transfected with non-functional Slc11a1 and functional Slc11a1 controls in response to an infection with Salmonella enterica serovar Typhimurium. We report that macrophages lacking functional Slc11a1 displayed an increased expression of transferrin receptor 1, resulting in enhanced acquisition of transferrin-bound iron. In contrast, cellular iron release mediated via ferroportin 1 was significantly lower in Salmonella-infected Slc11a1-negative macrophages in comparison with phagocytes bearing Slc11a1. Lack of Slc11a1 led to intracellular persistence of S.?enterica serovar Typhimurium within macrophages, which was paralleled by a reduced formation of nitric oxide, tumour necrosis factor-alpha and interleukin-6 in Slc11a1-negative macrophages following Salmonella infection, whereas interleukin-10 production was increased. Moreover, Slc11a1-negative phagocytes exhibited higher cellular iron content, resulting in increased iron acquisition by intracellular Salmonella. Our observations indicate a bifunctional role for Slc11a1 within phagocytes. Slc11a restricts iron availability, which first augments pro-inflammatory macrophage effector functions and second concomitantly limits microbial iron access. <br/
Czech topics in work of Manfred Böckl
No full textDiese Abschlussarbeit beschäftigt sich mit tschechischen Themen in Werken des bayerischen Schriftstellers Manfred Böckl. Am Anfang werden das Leben und die Schöpfung dieses Autors vorgestellt, danach folgt die Analyse von tschechischen Themen bei ausgewählten Titeln. Die Arbeit ergänzt das Interview mit Manfred Böckl.Tato práce se zabývá českými tématy v dílech bavorského spisovatele Manfreda Böckla. Na začátku je představen život a tvorba tohoto autora, poté následuje analýza českých témat u vybraných literárních titulů. Práci doplňuje rozhovor s Manfredem Böcklem.This thesis is about czech topics in writings of bavarian author Manfred Böckl. In the first part there is described his life and literary output. After thet there is analysis of czech topics in selected literary works. Thesis is filled in with interview with Böckl himself.Katedra cizích jazykůDokončená práce s úspěšnou obhajobo
CCDC 2003150: Experimental Crystal Structure Determination
No full textRelated Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel D. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|ChemRxiv|||doi:10.26434/chemrxiv.12619064,Related Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|Chemical Science|11|9468|doi:10.1039/D0SC03727C
CCDC 2003155: Experimental Crystal Structure Determination
No full textRelated Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel D. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|ChemRxiv|||doi:10.26434/chemrxiv.12619064,Related Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|Chemical Science|11|9468|doi:10.1039/D0SC03727C
CCDC 2003153: Experimental Crystal Structure Determination
No full textRelated Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel D. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|ChemRxiv|||doi:10.26434/chemrxiv.12619064,Related Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|Chemical Science|11|9468|doi:10.1039/D0SC03727C
CCDC 2003151: Experimental Crystal Structure Determination
No full textRelated Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel D. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|ChemRxiv|||doi:10.26434/chemrxiv.12619064,Related Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|Chemical Science|11|9468|doi:10.1039/D0SC03727C
CCDC 2003154: Experimental Crystal Structure Determination
No full textRelated Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel D. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|ChemRxiv|||doi:10.26434/chemrxiv.12619064,Related Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|Chemical Science|11|9468|doi:10.1039/D0SC03727C
CCDC 2003152: Experimental Crystal Structure Determination
No full textRelated Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel D. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|ChemRxiv|||doi:10.26434/chemrxiv.12619064,Related Article: Simon Krause, Jack D. Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M. Többens, Dirk Wallacher, Manfred S. Weiss, Bin Zheng, Pascal G. Yot, Guillaume Maurin, Philip L. Llewellyn, François-Xavier Coudert, Stefan Kaskel|2020|Chemical Science|11|9468|doi:10.1039/D0SC03727C
Macromolecular crystallography and what it can contribute to antiparasite drug discovery
No full textThis issue of Acta Crystallographica Section F is dedicated towards structural investigations on proteins associated with molecular parasitology, specifically research linked to protozoan pathogens. It is in line with the previous special sections or issues contributed by the RIKEN UK structural genomics consortium December 2009 , the Joint Center for Structural Genomics in October 2010 Weiss amp; Einspahr, 2010[Weiss, M. S. amp; Einspahr, H. 2010 . Acta Cryst. F66, 1406.] and the Seattle Structural Genomics Center for Infectious Diseases in September 2011 Weiss amp; Einspahr, 2011[Weiss, M. S. amp; Einspahr, H. 2011 . Acta Cryst. F67, 1159.] . In contrast to the previous issues however, it is thematically much more focused on protozoan pathogens. Interest in these primitive eukaryotic organisms is often to exploit them as model systems and many significant advances have resulted from such research. As examples there are the fundamentally important discoveries relating to RNA editing, antigenic variation and the occurrence of glycosylphosphatidylinositol tags that anchor proteins on the cell surface, all accrued from research with the African trypanosome. However, a major impetus to study protists is the drastic toll they take on human life. The World Health Organization provide documentation and sobering statistics on the diseases and their impact on human health. For example http www.who.int mediacentre factsheets fs375 en is their recently updated information sheet on Leishmaniasis. Researchers have sought to understand the processes that allow pathogens to exist, to invade a host, to evade the immune response, and to cause debilitating and often fatal diseases. Extending from such investigations and alongside drug discovery efforts enter structural biology, in particular crystallography and the high quality chemical information it can provid
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