428 research outputs found
MSO885984 Supplemetal Material - Supplemental material for Serum hepcidin levels in multiple sclerosis
No full textSupplemental material, MSO885984 Supplemetal Material for Serum hepcidin levels in multiple sclerosis by Gabriel Bsteh Piotr Tymoszuk Klaus Berek Verena Petzer Florian Deisenhammer Guenter Weiss Thomas Berger in Multiple Sclerosis Journal—Experimental, Translational and Clinical</p
Bulk temperature and heat transport in turbulent Rayleigh–Bénard convection of fluids with temperature-dependent properties
No full textWe critically analyse the different ways to evaluate the dependence of the Nusselt number ( Nu) on the Rayleigh number ( Ra) in measurements of the heat transport in turbulent Rayleigh–Bénard convection under general non-Oberbeck–Boussinesq conditions and show the sensitivity of this dependence to the choice of the reference temperature at which the fluid properties are evaluated. For the case when the fluid properties depend significantly on the temperature and any pressure dependence is insignificant we propose a method to estimate the centre temperature. The theoretical predictions show very good agreement with the Göttingen measurements by He et al. (New J. Phys., vol. 14, 2012, 063030). We further show too the values of the normalized heat transport Nu/Ra1/3are independent of whether they are evaluated in the whole convection cell or in the lower or upper part of the cell if the correct reference temperatures are used.<br
Actions of gonadotropin-releasing hormone analogues in pituitary gonadotrophs and their modulation by ovarian steroids
No full textRecently, GnRH antagonists (GnRHant) like cetrorelix and ganirelix have been introduced in protocols of controlled ovarian hyperstimulation for assisted reproductive techniques to prevent premature luteinizing hormone (LH) surges. Here we tested, whether the actions of cetrorelix and the GnRH agonist (GnRHag) triptorelin in gonadotrophs are dependent on the steroid milieu. Furthermore, we characterized the actions of cetrorefix and triptorelin on LH secretion and the total LH pool. Female rat pituitary cells were treated either with 0.1 nM triptorelin for 1, 2, 4 and 6 days or for 1, 3, 5 and 6 h or with 1, 10 or 100 nM cetrorelix for 1, 2, 3 and 5 h or for 10 min. Cells were stimulated for 3 h with different concentrations of GnRH (10 pM-1 mu M). For analysis of the total LH pool, which is composed of stored and released LH, cells were lysed with 0.1% Triton X-100 at -80 degrees C overnight. To test, whether the steroid milieu affects the actions of cetrorelix and triptorelin, cells were incubated for 52 h with 1 nM estradiol (E) alone or with combinations of 100 nM progesterone (P) for 4 or 52 h, respectively. Cells were then treated with 0.1 nM triptorelin for 9 h or I nM cetrorelix for 3 h and stimulated for 3 h with different concentrations of GnRH (10 pM-1 mu M). The suppressive effect of triptorelin on LH secretion was fully accomplished after 3 h of treatment, for cetrorelix only 10 min were sufficient. The concentration of cetrorelix must be at least equimolar to GnRH to block LH secretion. Cetrorelix shifted the EC50s of the GnRH dose-response curve to the right. Triptorelin suppressed total LH significantly (from 137 to 36 ng/ml) after 1 h in a time-dependent manner. In contrast, only high concentrations of cetrorelix increased total LH. In steroid treated cells the suppressive effects of triptorelin were more distinct. One nanomolar cetrorelix suppressed GnRH-stimulated LH secretion of cells not treated with steroids from 10.1 to 3.5 ng/ml. In cells, additionally treated with estradiol alone or estradiol and short-term progesterone, LH levels were higher (from 3.5 to 5.4 or 4.5 ng/ml, respectively). In cells co-treated with estradiol and progesterone for 52 h LH secretion was only suppressed from 10.1 to 9.5 ng/ml. Steroid treatments diminished the suppressive effect of cetrorelix on LH secretion. In conclusion, the depletion of the total LH pool contributes to the desensitizing effect of triptorelin. The actions of cetrorelix and triptorelin are dependent on the steroid milieu. (c) 2006 Elsevier Ltd. All rights reserved
Short text authorship attribution via sequence kernels, Markov chains and author unmasking: An investigation
No full textWe present an investigation of recently proposed character and word sequence kernels for the task of authorship attribution based on relatively short texts. Performance is compared with two corresponding probabilistic approaches based on Markov chains. Several configurations of the sequence kernels are studied on a relatively large dataset (50 authors), where each author covered several topics. Utilising Moffat smoothing, the two probabilistic approaches obtain similar performance, which in turn is comparable to that of character sequence kernels and is better than that of word sequence kernels. The results further suggest that when using a realistic setup that takes into account the case of texts which are not written by any hypothesised authors, the amount of training material has more influence on discrimination performance than the amount of test material. Moreover, we show that the recently proposed author unmasking approach is less useful when dealing with short texts
Short Text Authorship Attribution via Sequence Kernels, Markov Chains and Author Unmasking: An Investigation
No full textWe present an investigation of recently proposed character and word sequence kernels for the task of authorship attribution based on relatively short texts. Performance is compared with two corresponding probabilistic approaches based on Markov chains. Several configurations of the sequence kernels are studied on a relatively large dataset (50 authors), where each author covered several topics. Utilising Moffat smoothing, the two probabilistic approaches obtain similar performance, which in turn is comparable to that of character sequence kernels and is better than that of word sequence kernels. The results further suggest that when using a realistic setup that takes into account the case of texts which are not written by any hypothesised authors, the amount of training material has more influence on discrimination performance than the amount of test material. Moreover, we show that the recently proposed author unmasking approach is less useful when dealing with short texts.
Short text authorship attribution via sequence kernels, Markov chains and author unmasking: An investigation
No full textWe present an investigation of recently proposed character and word sequence kernels for the task of authorship attribution based on relatively short texts. Performance is compared with two corresponding probabilistic approaches based on Markov chains. Several configurations of the sequence kernels are studied on a relatively large dataset (50 authors), where each author covered several topics. Utilising Moffat smoothing, the two probabilistic approaches obtain similar performance, which in turn is comparable to that of character sequence kernels and is better than that of word sequence kernels. The results further suggest that when using a realistic setup that takes into account the case of texts which are not written by any hypothesised authors, the amount of training material has more influence on discrimination performance than the amount of test material. Moreover, we show that the recently proposed author unmasking approach is less useful when dealing with short texts
Vaccine efficacy and iron deficiency: an intertwined pair?
No full text: Vaccines are the most effective measure to prevent deaths and illness from infectious diseases. Nevertheless, the efficacy of several paediatric vaccines is lower in low-income and middle-income countries (LMICs), where mortality from vaccine-preventable infections remains high. Vaccine efficacy can also be decreased in adults in the context of some common comorbidities. Identifying and correcting the specific causes of impaired vaccine efficacy is of substantial value to global health. Iron deficiency is the most common micronutrient deficiency worldwide, affecting more than 2 billion people, and its prevalence in LMICs could increase as food security is threatened by the COVID-19 pandemic. In this Viewpoint, we highlight evidence showing that iron deficiency limits adaptive immunity and responses to vaccines, representing an under-appreciated additional disadvantage to iron deficient populations. We propose a framework for urgent detailed studies of iron-vaccine interactions to investigate and clarify the issue. This framework includes retrospective analysis of newly available datasets derived from trials of COVID-19 and other vaccines, and prospective testing of whether nutritional iron interventions, commonly used worldwide to combat anaemia, improve vaccine performance
Intestinal Irony: How Probiotic Bacteria Outcompete Bad Bugs
No full textIn this issue of Cell Host & Microbe, Deriu et al. present a mechanistic explanation underlying the benefits of certain probiotic bacteria. Intestinal bacteria compete for the essential nutrient iron, leading to replacement of pathogenic Salmonella by the probiotic Escherichia coli Nissle, which is better equipped with iron acquisition systems, and resolution of infectious colitis
Boundary zonal flow in rotating turbulent Rayleigh-Bénard convection
No full textFor rapidly rotating turbulent Rayleigh–Bénard convection in a slender cylindrical cell, experiments and direct numerical simulations reveal a boundary zonal flow (BZF) that replaces the classical large-scale circulation. The BZF is located near the vertical side wall and enables enhanced heat transport there. Although the azimuthal velocity of the BZF is cyclonic (in the rotating frame), the temperature is an anticyclonic traveling wave of mode one, whose signature is a bimodal temperature distribution near the radial boundary. The BZF width is found to scale like Ra1/4Ek2/3 where the Ekman number Ek decreases with increasing rotation rate
- …
