200,318 research outputs found
Ultrastructural changes of the midgut cells during overwintering of Meta menardi (Latreille 1804) (Araneae, Tetragnathidae) in natural habitats
Get PDFMeta menardi je troglofilna vrsta. Večino življenjskega cikla preživi v podzemeljskih habitatih. V svojem življenjskem ciklu nima programiranega prezimovanja, kar pomeni, da se pozimi priložnostno prehranjuje. Ob nedostopnosti plena in posledičnem stradanju v celicah potečejo procesi, značilni za vrste s programiranim prezimovanjem, ki se pozimi ne prehranjujejo. S svetlobno in transmisijsko elektronsko mikroskopijo smo proučili strukturo in ultrastrukturo divertiklov srednjega črevesa M. menardi med prezimovanjem v naravnih habitatih. Samce in samice M. menardi smo nabrali v različnih obdobjih prezimovanja – na začetku (november), na sredi (januar) in ob koncu prezimovanja (marec). Zanimale so nas spremembe v strukturi in ultrastrukturi pri obeh spolih, spreminjanje količine založnih snovi, značilnosti sferitov in pojav avtofagnih struktur, ki odražajo trajanje stradanja med prezimovanjem. Epitel divertiklov srednjega črevesa je bil zgrajen iz prebavnih, sekrecijskih in založnih celic. V strukturi in ultrastrukturi med spoloma ni bilo razlik. Med prezimovanjem so se v epitelnih celicah divertiklov pojavile spremembe, značilne za stradanje. Količina založnih snovi (glikogena in lipidov) se je zmanjšala. Sferiti so imeli med prezimovanjem vse več elektronsko svetlejših, izpraznjenih plasti. Število avtofagnih struktur, stopnja vakuolizacije citoplazme in poraba materiala iz vakuol so se povečali. Ultrastrukturne značilnosti, ki so odraz stradanja med prezimovanjem, so pri M. menardi posledica pomanjkanja in nedostopnosti plena, ki prezimuje v jamah. Nutriente in energijo za vzdrževanje različnih fizioloških procesov, potrebnih za preživetje med stradanjem, so pajki pridobivali s porabo energijsko bogatih založnih snovi, iz mineralnih in organskih sestavin sferitov, z razgradnjo celičnih sestavin v procesu avtofagije in intenzivne vakuolizacije ter priložnostno s prebavo ujetega plena. Ob koncu prezimovanja so se pri eni samici v tkivu z značilnostmi stradanja pojavile velike, elektronsko temne prebavne vakuole, z lipidnimi kapljami, kar je dokaz, da je samica ob koncu prezimovanja ujela plen. Ujetje plena je najverjetneje sovpadlo z zaključkom prezimovanja nekaterih nevretenčarjev v jami in posledično migracijo določenega plena iz jame.Meta menardi is a troglophile species. They spend most of their life cycle in hypogean habitats. There is no programmed overwintering in the life cycle of M. menardi, which means that they can occasionally feed during the wintertime. In the absence of prey, the spiders starve and in the epithelial cells of the midgut diverticula appear processes, typical of species with programmed overwintering, i. e., programmed starvation in winter. Using the light and transmission electron microscopy we studied structure and ultrastructure of the epithelial cells of midgut diverticula in M. menardi during overwintering in natural habitats. Males and females were collected in different time frames of overwintering – at the beginning (November), in the middle (January) and at the end (March) of overwintering. The aim of this study was to investigate structural and ultrastructural changes in both sexes, changes in quantity of reserve substances, ultrastructure of spherites and occurrence of autophagic structures, which progressive changes reflect the duration of starvation during overwintering. The midgut epithelium was constituted of digestive, secretory and reserve cells. There were no differences in the structure and ultrastructure in the midgut diverticula epithelium between the sexes. During overwintering, in the midgut diverticula epithelial cells, changes typical of starvation occurred. The quantities of reserve substances (glycogen and lipids) diminished. During overwintering spherites became gradually more electron lucent, since the concentric layers were exploited. The abundance of the autophagic structures, the degree of cytoplasm vacuolization and the use of the cytoplasmic material increased. Ultrastructural features of the M. menardi midgut epithelium reflected processes typical of starvation during overwintering. These features are the consequence of absence and unavailability of prey in caves during the wintertime. All M. menardi obtained nutrients and energy for maintenance of different physiological processes, indispensable for survival during the starvation period, from different sources. Nutrients and energy were provided from lipid and glycogen reserves, mineral and organic compounds from spherites and degradation of cytoplasmic components in the processes of autophagy and intensive vacuolization. Occasionally, some individuals captured and digested prey. Consequently, at the end of overwintering, in a female at the same time characteristics typical of starvation, and large, electron dense digestive vacuoles with lipid droplets occurred. This case of prey capture probably coincided with the end of overwintering of some invertebrates in caves, and their migration out of the cave
Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer
No full textAbstract not availableJulia M. Humphries, Megan A.S. Penno, Florian Weiland, Manuela Klingler-Hoffmann, Agnieszka Zuber, Alex Boussioutas, Matthias Ernst, Peter Hoffman
Bey Höchstseeligen Absterben des Weiland Wohl-Ehrwürdigen/ Groß-Achtbahren und Wohlgelahrten Herrn/ Hn. M. Johannis Fabricii, Alhier an der Haupt-Kirchen ... Archi-Diaconi und Pastoris, Wolten mit gegenwärtigen Zeilen Ihre Schuldigkeit abstatten/ Ihro Magnificentz Herrn Doct. Hannekenii Tisch-Compagnie
Get PDFBEY HÖCHSTSEELIGEN ABSTERBEN DES WEILAND WOHL-EHRWÜRDIGEN/ GROSS-ACHTBAHREN UND WOHLGELAHRTEN HERRN/ HN. M. JOHANNIS FABRICII, ALHIER AN DER HAUPT-KIRCHEN ... ARCHI-DIACONI UND PASTORIS, WOLTEN MIT GEGENWÄRTIGEN ZEILEN IHRE SCHULDIGKEIT ABSTATTEN/ IHRO MAGNIFICENTZ HERRN DOCT. HANNEKENII TISCH-COMPAGNIE
Bey Höchstseeligen Absterben des Weiland Wohl-Ehrwürdigen/ Groß-Achtbahren und Wohlgelahrten Herrn/ Hn. M. Johannis Fabricii, Alhier an der Haupt-Kirchen ... Archi-Diaconi und Pastoris, Wolten mit gegenwärtigen Zeilen Ihre Schuldigkeit abstatten/ Ihro Magnificentz Herrn Doct. Hannekenii Tisch-Compagnie ([1])
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Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Heavy neutrinos with dynamic jet vetoes: multilepton searches at √s=14, 27, and 100 TeV
Get PDFHeavy neutrinos (N) remain one of most promising explanations for the ori-gin of neutrinos' tiny masses and large mixing angles. In light of broad advances in un-derstanding and modeling of hadron collisions at large momentum transfers, we revisit the long-standard search strategy for heavy N decaying to multiple charged leptons (), pp NX 3X. For electroweak and TeV-scale N, we propose a qualitatively new collider analysis premised on a dynamic jet veto and discriminating, on an event-by-event basis, according to the relative amount of hadronic and leptonic activity. We report that the sensitivity to heavy neutrinos at the CERN Large Hadron Collider (LHC) can be improved by roughly an order of magnitude at both L = 300 fb(-1) and 3 ab(-1). At =14 TeV with L=3 ab(-1), we find active-sterile mixing as small as |V-N|(2)=10(-2)(10(-3))[5x10(-4)] can be probed at 95% CL for heavy Dirac neutrinos masses m(N) less than or similar to 1200 (300) [200] GeV, well beyond the present |V-N|(2)less than or similar to 10(-3)-10(-1) constraints for such heavy states set by indirect searches and precision measurements. The improvement holds also for Majorana N, and is largely independent of whether charged lepton flavor is conserved or violated. The analysis, built almost entirely from inclusive, transverse observables, is designed to be robust across increasing collider energies, and hence serves as a basis for searches at future colliders: with L=15ab(-1) at 27 TeV,onecanprobemixingbelow |V-N|(2)=10(-2)(10(-3))[2x10(-4)] for m(N) less than or similar to 3500 (700) [200] GeV. At a hypothetical 100 TeV pp collider with L=30ab(-1), one can probe mixing down to 9 x 10(-5) for m(N) less than or similar to 200 GeV, below 10(-3) for m(N) less than or similar to 4 TeV, and below 10(-2) for m(N) less than or similar to 15 TeV. We anticipate these results can be further improved with detector-specific tuning and application of multi-variant / machines learning techniques. To facilitate such investigations, we make publicly available Monte Carlo libraries needed for the precision computations/simulations used in our study
A model of ganglion axon pathways accounts for percepts elicited by retinal implants
No full textM Beyeler, D Nanduri, JD Weiland, A Rokem, GM Boynton, I Fine (2018). A model of ganglion axon pathways accounts for percepts elicited by retinal implants. bioRxiv 453035. https://doi.org/10.1101/45303
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Christliche Leichpredigt bey der Begräbnuß, weiland deß ... Herrn, Laurentii Wolffen, gewesenen Rahtsverwandten zu Marpurg, etc.
No full textElektronische Reproduktion von: Christliche Leichpredigt Bey der Begräbnuß/ weiland deß ... Herrn/ Laurentii Wolffen/ gewesenen Rahtsverwandten zu Marpurg/ [et]c. : Welcher den XV. Octobr. ... dieses 1600. Jahrs/ ... entschlaffen/ vnd folgends ... zur Erden bestattet worden / Gehalten in der Pfarrkirchen zu Marpurg/ Durch M. Conrad Dieterich ... - Getruckt zu Marpurg : durch Paulum Egenolff, Jm Jahr/ 1600. - 26, [5] Seiten. -
Standort: Universität Marburg, Universitätsbibliothek. -
Signatur: VIII B 331 db, 27. -
Werktitel: Christliche Leichpredigt bey der Begräbnuß, weiland deß ... Herrn, Laurentii Wolffen, gewesenen Rahtsverwandten zu Marpurg, etc. -
Anmerkung: Text überwiegend deutsch, teilweise lateinisch. -
Umlaute mit übergestelltem "e" dargestellt. -
Titelvignette. -
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Imprints of massive inverse seesaw model neutrinos in lepton flavor violating Higgs boson decays
Get PDFIn this paper we consider a Higgs boson with mass and other properties compatible with those of the recently discovered Higgs particle at the LHC, and explore the possibility of new Higgs leptonic decays, beyond the standard model, with the singular feature of being lepton flavor violating (LFV). We study these LFV Higgs decays, H→lkl¯m, within the context of the inverse seesaw model (ISS) and consider the most generic case where three additional pairs of massive right-handed singlet neutrinos are added to the standard model particle content. We require in addition that the input parameters of this ISS model are compatible with the present neutrino data and other constraints, like perturbativity of the neutrino Yukawa couplings. We present a full one-loop computation of the BR(H→lkl¯m) rates for the three possible channels, lkl¯m=μτ¯, eτ¯, eμ¯, and analyze in full detail the predictions as functions of the various relevant ISS parameters. We study in parallel the correlated one-loop predictions for the radiative decays, lm→lkγ, within this same ISS context, and require full compatibility of our predictions with the present experimental bounds for the three radiative decays, μ→eγ, τ→μγ, and τ→eγ. After exploring the ISS parameter space we conclude on the maximum allowed LFV Higgs decay rates within the ISSThis work is supported by the European Union Grant No. FP7 ITN INVISIBLES (Marie Curie Actions, Grant No. PITN- GA-2011- 289442), by the CICYT through Grant No. FPA2012-31880, by the Spanish ConsoliderIngenio 2010 Programme CPAN (Grant No. CSD2007- 00042), and by the Spanish MINECO’s “Centro de Excelencia Severo Ochoa” Programme under Grant No. SEV-2012-0249. E. A. is financially supported by the Spanish DGIID-DGA Grant No. 2013-E24/2 and the Spanish MICINN Grants No. FPA2012-35453 and No. CPAN-CSD2007-00042. X. M. is supported through the FPU Grant No. AP-2012-670
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