1,322 research outputs found
Raloxifene increases prefrontal activity during emotional inhibition in schizophrenia based on estrogen receptor genotype
Full text linkBiomarkers in schizophrenia: A brief conceptual consideration
Full text linkBiomarkers have been sought after in the field for schizophrenia research for decades. In this paper, we discuss some for the concepts around developing biomarkers in an effort to understand why the use for biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery for biomarkers in schizophrenia? What is the best use for biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia. Copyright © 2013 Cynthia S. Weickert et al
Nadere verfijning DUROSTA-model: Toetsing H/Tw-parameter en aanpassing t.b.v. porositeitsverschillen en strandtransporten
No full textTeneinde het DUROSTA-model verder te verbeteren zijn de effecten modellering nader onderzocht en is de schaalgrootheid H/Tw nader bekeken.TAW/EN
Development of a rotor model for the numerical simulation of helicopter exterior flow-fields
No full textIncludes bibliographical references (leaves 84-85).A numerical methodology is developed to model the effect of a rotor on the surrounding flow-field. The model calculates the time-averaged aerodynamic forces exerted on the air by the fan blades within the blade-swept region, and permits the user to specify blade properties such as cross-sectional profile and orientation at a particular radial and azimuthal location. The calculated forces are included as source terms within the Reynolds-averaged Navier-Stokes equations for an incompressible fluid, which are solved by the commercial CFD solver, FLUENT. The effects of turbulence are incorporated through the use of Launder and Spalding's k-g turbulence model. This method is selected as being the most efficient use of the resources available, giving the economic advantages of a steady simulation, while allowing radial and azimuthal variations of rotor characteristics. In order to validate the accuracy of the numerical model for both aligned and non-aligned inflow conditions, results are compared with experimental data reported for an axial flow fan. Agreement between experimental and numerical results is excellent to good. Fan static pressure rise is closely predicted by the numerical solution, while fan power consumption and fan static efficiency are under and over-predicted respectively. This error may be attributed to frictional losses not accounted for in the numerical model. These include physical rotational instabilities, leading to increased mechanical losses, and tip effects due to the clearance between the fan blade tips and the fan casing. Trends are nevertheless consistently predicted by the numerical model for inflow angles up to 45°, and for the range of blade pitch settings used. The adverse effect of off-axis inflow on the fan static pressure rise is numerically predicted, while fan power consumption is found to remain independent of inflow angle, as had been experimentally observed. The rotor model is finally integrated with the fuselage of the CIRSTEL (Combined Infra-Red Suppression and Tail rotor Elimination) prototype in an analysis of the helicopter exterior flow-field. No experimental data for this configuration was available for validation purposes. However, the model is used in the simulation of several common helicopter flight conditions. Results are presented graphically, and generally indicate good agreement with physically observed phenomena
Third body effects in the period changes of two Algol binaries: V342 Aql and TW Lac
Full text link32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYThe O - C diagrams of two Algol-type eclipsing binaries V342 Aql and TW Lac have been analyzed with the least-squares method by using all available minima times. The period changes in their O - C diagrams have been discussed with respect to the Light-Time Effect (LITE) that originates from gravitational influence of a third body. New LITE elements, orbital periods and possible minimum masses of third bodies are given.Turkish Phys So
Increasing science, technology, engineering, and mathematics skills using Project Lead the Way
Full text linkIncludes bibliographical references
C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls
Full text linkCopyright © 2018 Jacomb, Stanton, Vasudevan, Powell, O'Donnell, Lenroot, Bruggemann, Balzan, Galletly, Liu, Weickert and Weickert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.There is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical thickness, a measure of the degree of neuropathology, are unknown. In independent samples, we assessed the peripheral inflammation marker C-reactive protein (CRP) to determine the extent to which: (1) CRP was elevated and stable across admissions for acute psychosis, (2) cognition, daily function and symptom severity are characteristic of chronically ill patients with schizophrenia displaying elevated CRP, and (3) CRP levels predict cortical thickness. Study 1 assessed peripheral CRP (primary outcome) and other blood measures in 174/280 people with acute psychosis while Study 2 assessed peripheral CRP, cognition and cortical thickness (primary outcomes), symptoms, and daily function in 85/97 chronically ill patients with schizophrenia and 71/87 healthy controls. In acute psychosis, CRP and neutrophil-to-lymphocyte ratio were significantly elevated relative to a normal cutoff (with 59.8% of patients having elevated CRP) which remained elevated across admissions. CRP was significantly elevated in 43% of chronically ill patients with schizophrenia compared to 20% in controls. Elevated CRP patients displayed significantly worse working memory and CRP was inversely correlated with cortical thickness in frontal, insula, and temporal brain regions. This work supports the role of inflammation in psychotic illnesses and suggests that use of peripheral markers (e.g., CRP) in conjunction with diagnosis could be used to identify patients with more cortical neuropathology and cognitive deficits
Psychological, social and welfare interventions for psychological health and well-being of torture survivors
Full text linkThis is the protocol for a review and there is no abstract. The objectives are as follows: Primary objective 1. To assess beneficial and adverse effects of psychological, social and welfare interventions versus no treatment for the reduction of psychological distress in torture survivors. Secondary objectives 2. To describe the quality and generalisability of the studies evaluating the effects of these treatment approaches on torture survivors, and specifically: • to provide an objective assessment of risk of bias in these studies; • to describe the specific populations evaluated in studies of torture survivors (including demographics, torture experiences and psychological status); • to describe the variety of interventions that have been evaluated in these populations; and • to describe the outcomes evaluated in these intervention studies
High-efficiency supercontinuum generation in solid thin plates at 0.1 TW level
No full text
Supercontinuum generation in a solid-state medium was investigated experimentally. A continuum covering 460 to 950 nm was obtained when 0.8 mJ/30 fs Ti: sapphire laser pulses were applied to seven thin fused silica plates at a 1 kHz repetition rate. The primary processes responsible for spectral broadening were self-phase modulation (SPM) and self-steepening, while SPM and self-focusing were balanced to optimize the spectral broadening and suppress the multi-photon process. The output was compressed to a 5.4 fs and a 0.68 mJ pulse, corresponding to two optical cycles and 0.13 TW of peak power. (C) 2017 Optical Society of America</p
Flow compensation in a MEMS dual-thermal conductivity detector for hydrogen sensing in natural gas
Full text linkConventional thermal conductivity detectors (TCDs) demonstrate a flow dependence. The approach presented here to reduce the flow dependence is based on the on-line flow compensation using two thin-film sensors on membranes in parallel on the same chip that are differentially operated. These are laterally identically, but with a different depth of the detection chamber, resulting in different quasi-static sensitivities to the thermal conductivity of the sample gas. The effects of conduction and convection in the structure have been studied using COMSOL Multiphysics. First prototypes have been fabricated and are presently tested.Accepted Author ManuscriptElectronic Instrumentatio
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