1,721,243 research outputs found
Supplemental_figure2 – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_figure2 for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Supplemental_Figure_4 – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_Figure_4 for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Supplemental_figure1 – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_figure1 for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Supplemental_Table2-PSM – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_Table2-PSM for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Supplemental_figure3 – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_figure3 for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Supplemental_Table1-PSM – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_Table1-PSM for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Supplemental_figure5 – Supplemental material for De-escalating chemotherapy for stage II colon cancer?
No full textSupplemental material, Supplemental_figure5 for De-escalating chemotherapy for stage II colon cancer? by Jianfei Fu, Lunpo Wu, Chenyang Ge, Tiantian Xu, Dan Li, Wei Fu, Liangjing Wang and Jinlin Du in Therapeutic Advances in Gastroenterology</p
Molecular Insights on the Cyclic Peptide Nanotube-Mediated Transportation of Antitumor Drug 5-Fluorouracil
No full textSelf-assembled cyclic peptide nanotubes (CPNs) show a potential use in drug delivery. In this study, the CPN composed of (Trp-d-Leu)<sub>4</sub>-Gln-d-Leu was synthesized and tested for the transport of the antitumor drug 5-fluorouracil (5-FU). CPN-mediated release of 5-FU from liposomes experimentally tested the transportation function of the synthetic CPNs. To explore the transportation mechanism of CPNs, computational studies have been performed on the CPN models stacked by 8 subuints, including conventional molecular dynamics (CMD) simulations, and steered molecular dynamics (SMD) simulations in the environment of hydrated dimyristoylphosphatidylcholine (DMPC) lipid bilayer. Our CMD simulations demonstrated that the <i>ortho</i>-CPN is the most stable nanotube, in which the Gln residue is in the <i>ortho</i>-position relative to other residues. The calculated diffusion coefficient value for inner water molecules was 1.068 × 10<sup>−5</sup> cm<sup>2</sup>·s<sup>−1</sup>, almost half that of the bulky water and 24 times faster than that of the typical gramicidin A channel. The CPN conserved its hollow structure along the 10 ns CMD simulations, with a tile angle of 50° relative to the normal of DMPC membrane. Results from SMD simulations showed that the 5-FU molecule was transported by hopping through different potential energy minima distributed along subunits, and finally exited the nanotube by escaping from the kink region at the last two subunits. The hopping of 5-FU was driven by switching from hydrophobic interactions between 5-FU and the interior wall of the nanotube to hydrogen bonding interactions of 5-FU with the backbone carbonyl group and amide group of <i>ortho</i>-CPN. The calculated binding free energy profile of 5-FU interacting with the CPN indicated that there was an energy well near the outer end of the nanotube
Broadband nested antenna
No full textThis thesis investigates a novel dual frequency range low profile antenna system containing two nested spiral antennas operating over 2 – 18 GHz and 30 – 40 GHz respectively. The exploration and development of a broadband microstrip spiral without cavity backing has been implemented in the range of 2 - 18 GHz. The relationship between the structural parameters of equiangular spirals and their performance is investigated by simulating a variety of spiral structures. The input impedance, gain, axial ratio and radiation patterns of spiral antennas on a grounded dielectric substrate are compared with that of a spiral in free space to demonstrate the shortcomings of such a structure (i.e. narrow impedance bandwidth and poor gain). An effective way to achieve a broad bandwidth is proposed by introducing an impedance profile to remove the residual current along the spiral arms. Initially a Thin Film Resistive Layer (TFRL) was incorporated into a microstrip equiangular spiral antenna to absorb the residual current along the arms. Four spiral antennas with TFRLs of different thickness were developed to explore the TFRL application technique. Measured results and the difficulties in both simulation and fabrication experienced are demonstrated, analysed and addressed. An alternative to the use of a TFRL as an impedance profile on microstrip spirals, an exploration of spirals with embedded chip resistors had been conducted. The radiation physics of microstrip equiangular spirals are examined in the time domain using the XFDTD simulation package. XFDTD is used to analyse the current density distribution on the spiral arms under the excitation of pulse and harmonic waves. An analysis of the current density distribution at steady state provides guidelines for arranging the chip resistors efficiently. Chip resistor loading rules have been developed from these outcomes. A two dual arm equiangular spiral antennas with embedded chip resistors has been simulated, fabricated and measured. The antenna has a compact tapered balun which is horizontally placed inside the spiral antenna substrate to reduce the volume of the completed spiral/feed structure. The spiral with embedded chip resistors and a compact balun is selected as the low frequency element (2 – 18 GHz) for a nested antenna system. A dual arm Archimedean spiral antenna with cavity backing (operating over 30 – 40 GHz) is developed to be nested within the aperture of the low frequency spiral. The high frequency antenna was integrated into the substrate of the low frequency element, in the opening between the spiral arms. An Electronic Band Gap (EBG) architecture was applied to the rim of the nested antenna substrate to mitigate the consequences of surface waves. The entire nested antenna system was fabricated and measured, and the results are presented and discussed.<br
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