534 research outputs found
sj-docx-1-trr-10.1177_03611981231203225 – Supplemental material for Psychological Factors Influencing College Students’ Mobile Phone Use While Walking
No full textSupplemental material, sj-docx-1-trr-10.1177_03611981231203225 for Psychological Factors Influencing College Students’ Mobile Phone Use While Walking by Jianrong Liu, Yating Wei, Xutong Zhu and Ziyang Shi in Transportation Research Record</p
18-0197_Supplemental_Material – Supplemental material for Treatment Strategies and Outcomes of Symptomatic Spontaneous Isolated Superior Mesenteric Artery Dissection: A Systematic Review and Meta-analysis
No full textSupplemental material, 18-0197_Supplemental_Material for Treatment Strategies and Outcomes of Symptomatic Spontaneous Isolated Superior Mesenteric Artery Dissection: A Systematic Review and Meta-analysis by Yating Zhu, Yanghong Peng, Mingyue Xu, Yingqi Wei, Shanshan Wu, Wei Guo, Zhongyin Wu and Jiang Xiong in Journal of Endovascular Therapy</p
sj-docx-1-tar-10.1177_17534666231213715 – Supplemental material for The future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease in various GOLD groups: a focus on the GOLD 2017 and GOLD 2023 reports
No full textSupplemental material, sj-docx-1-tar-10.1177_17534666231213715 for The future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease in various GOLD groups: a focus on the GOLD 2017 and GOLD 2023 reports by Qing Song, Wei Cheng, Cong Liu, Xueshan Li, Ling Lin, Yating Peng, Yuqin Zeng, Rong Yi, Yi Liu, Xin Li, Yan Chen, Shan Cai and Ping Chen in Therapeutic Advances in Respiratory Disease</p
Unraveling the quantum dynamics origin of high photocatalytic activity in nitrogen-doped anatase TiO2: time-domain ab initio analysis
No full textA wide bandgap and short-lived charge carrier constitutes two major issues for restricting anatase titanium dioxide (TiO2) photocatalytic activity in the ultraviolet light region of the solar spectrum. Interestingly, experiments reported that anatase TiO2 doping with substitutional N can achieve a high visible-light photocatalytic activity but the mechanism remains controversial and unclear yet. N substituting oxygen creates a mid-gap state, which typically acts as a nonradiative charge recombination center. Using the nonadiabatic (NA) molecular dynamics, we demonstrate that charge carrier lifetimes of N-doped anatase TiO2 are notably prolonged regardless of the oxidation states of the N dopant, but it operates by different mechanisms. The neutral and negatively charged N dopant reduces the bandgap by creating either an electron or a hole trap state prior to recombination with free holes and free electrons, respectively. While the direct recombination of free electrons and free holes, bypassing the electron trap state, dominates the nonradiative relaxation in the neutral N-doped TiO2 and extends the charge carrier lifetimes over 4-fold compared to the pristine anatase TiO2; the hole-trap-assisted electron–hole recombination beats the direction pathway in the negatively charged N-doped TiO2 system, delaying the nonradiative charge recombination over (22 times slower) the pristine system. Our simulations point out to changes in the relative values of NA coupling, decoherence times and energy gaps as determinants of the aforementioned changes in the carrier lifetimes. In this way, our study rationalizes the long-term debate on the enhanced visible-light photocatalytic activity of the TiO2 doping with N and, therefore, it contributes to rational defect engineering for design of high performance of photocatalytic and optoelectronic devices based on TiO2 and other metal oxides.Fil: Yang, Yating. Beijing Normal University; ChinaFil: Zhang, Zhaosheng. Beijing Normal University; China. Hebei University; ChinaFil: Fang, Wei Hai. Beijing Normal University; ChinaFil: Fernández Alberti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Long, Run. Beijing Normal University; Chin
Role of WD domain-containing proteins in cell cycle progression
No full textIn the eukaryotic proteome, WD domain is one of the most abundant protein motifs. The structure of WD domain allows it to interact with diverse protein partners and proteins containing WD domain have been shown to function in various cellular processes. In this thesis, I describe how two WD domain-containing proteins, LRWD1/ORCA and RFWD3, regulate different aspects of cell cycle progression.
In eukaryotic cells, the duplication of the genome starts from the loading of a six-subunit complex, Origin Recognition Complex (ORC), onto replication origins on the chromosome. The loading of ORC triggers the assembly of the pre-replicative complex (pre-RC) at origins, which licensed the origins prior to entering S phase. Unlike yeast, replication origins in higher eukaryotes do not have consensus sequence and metazoan ORC does not bind to DNA in a specific manner. Thus, a long-standing question in the field has been, how are origins specified and how are ORCs recruited to origins? Studies suggest that ORC loading may be facilitate by ORC-associated proteins. LRWD1/ORCA is an ORC-associated protein that stabilizes ORC on chromatin. We have previously characterized ORCA’s role in replication initiation and heterochromatin organization. In Chapter 2, I describe my work to map the binding sites of ORCA genome-wide by ChIP- seq method at specific time points of G1. ORCA associates with chromatin in a dynamic manner and ORCA binding regions are enriched for heterochromatic marks, including H3K9me3 and methylated-CpGs. ORCA co-localizes with a subset of origins that are enriched for repressive marks, consistent with the fact that these origins replicate late during S phase. Further, ORCA directly associates with the repressive marks and interacts with the enzymes that catalyze these marks. ORCA regulates the level of H3K9me3 and methylated-CpG at its binding sites, suggesting a role of ORCA in maintaining the repressive chromatin marks at its binding sites. Importantly, repressive marks are required for ORCA’s association on chromatin. I propose that ORCA localizes to a subset of origins by association with repressive marks and recruits the enzymes to maintain the repressive chromatin environment.
In Chapter 3, I focus on another WD domain containing protein, RFWD3, and describe how RFWD3 regulates cell cycle progression. Unlike previous studies that described how RFWD3 regulates DNA damage response, I focus on how RFWD3 regulate unperturbed cell cycle progression. I show that RFWD3 is required for proper cell cycle progression. Depletion of RFWD3 causes S phase defects including slower replication fork progression and prolonged S phase. There is also increased loading of replication fork proteins on S phase chromatin in the absence of RFWD3, potentially due to stalled replication fork. RFWD3 associates with the replication fork component, PCNA, via a PIP box motif. I purpose that RFWD3 localizes to replication fork by interacting with PCNA and regulate proper replication fork progression.
In Chapter 4, I summarize my findings on the regulation of DNA replication, chromatin organization and S phase progression. I also discussed interesting areas of research that my work has opened up.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01The student, Yating Wang, accepted the attached license on 2017-07-07 at 10:35.The student, Yating Wang, submitted this Dissertation for approval on 2017-07-07 at 10:47.This Dissertation was approved for publication on 2017-07-09 at 16:22.DSpace SAF Submission Ingestion Package generated from Vireo submission #11332 on 2017-09-29 at 11:14:35Made available in DSpace on 2017-09-29T16:39:20Z (GMT). No. of bitstreams: 2
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Previous issue date: 2017-07-09Embargo set by: Colleen Fallaw for item 103402
Lift date: 2019-09-29T16:39:52Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Colleen Fallaw for item 103402
Lift date: 2019-09-29T17:52:45Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 103402 on 2019-09-30T09:15:17Z
A novel method for objectively, rapidly and accurately evaluating burn depth via near infrared spectroscopy
No full textThe accurate and objective evaluation of burn depth is a significant challenge in burn wound care. Herein, we used near infrared spectroscopy (NIRS) technology to measure the different depth of thermal burns in ex vivo porcine models. Based on the intensity of the spectral signals and the diffuse reflection theory, we extracted the optical parameters involved in functional (total hemoglobin and water content) and structural (tissue scattered size and scattered particles) features that reflect the changes in burn depth. Next, we applied support vector regression to construct a model including the optical property parameters and the burn depth. Finally, we histologically verified the burn depth data collected via NIRS. The results showed that our inversion model could achieve an average relative error of about 7.63%, while the NIRS technology diagnostic accuracy was in the range of 50 μm. For the first time, this novel technique provides physicians with real-time burn depth information objectively and accurately
Flexible tactile sensors for gesture recognition in gloves
No full textThis study presents the design, fabrication, and evaluation of ffexible tactile sensors
integrated data glove for gesture recognition.
The primary objective was to develop a comfortable, cost-effective wearable device
capable of monitoring ffnger joint movements accurately. The data glove
integrates ten ffexible sensors, each attached to a ffnger, to capture the nuances
of hand gestures. Through a series of experiments, we collected data on static
gestures and applied ffltering techniques to enhance the signal quality. The results
demonstrated the potential of our ffexible sensor-based system in recognizing
a range of gestures with reasonable accuracy.
Despite the promising outcomes, the project faced challenges, including data
noise due to the sensors’ sensitivity to minor movements and the limited diversity
of the gesture dataset. Future work will focus on reffning sensor design
for better conformity with ffnger joints, expanding the gesture library, and enhancing
real-time gesture recognition capabilities. The study concludes that with
further development, ffexible sensor technology holds signiffcant potential for applications
in wearable computing and human-computer interaction.Master's degre
Dynamic Simulation of Ecological Flow Based on the Variable Interval Analysis Method
No full textEcological flow is an important basis for maintaining the structure and function of river ecosystems, and ensuring the sustainable development of economies and societies in river basins. In order to solve the problems of unclear concepts of ecological flow, difficulty in adapting to dynamic changes in demands, and the hydrological conditions and poor operability of calculated results of a practical application, a variable interval analysis method (VIAM) was proposed to calculate the ecological flow. The method comprehensively considered a variety of variable factors, such as spatial–temporal scale changes, hydrological condition changes, ecological service object changes, and calculation method changes. On the basis of a relatively fixed ecological base flow, a variable lifting amount was added to determine the ecological flow, and the ecological flow was a variable interval. Taking the Wei River as an example, the VIAM was validated and applied. With the support of a knowledge visualization integrated platform, the ecological flow simulation system of the Wei River was constructed. The results show that: (1) the VIAM makes the ecological flow calculation more scientific and reasonable, and the ecological flow of the Wei River from the upper reaches to the lower reaches increases gradually under the influence of water inflow, sewage discharge, and erosion and deposition of sediment, and the annual total water demand of the upper limit of ecological flow in a dry year is 1.04 billion m3, 1.63 billion m3, 2.29 billion m3, 4.09 billion m3, and 4.66 billion m3; (2) the variable interval is used to describe the ecological flow, which has strong applicability and operability; (3) the simulation system can quickly adapt to the demand changes in practical application, and provide visual decision support for managers. The VIAM provides new ideas and references for comprehensively promoting the control of the ecological flow
The clinical efficacy of the 3D-printed transparent facemask on management of facial burn scars
No full text- …
