345 research outputs found
Multi-disciplinary simulation and analysis of complex product in service oriented environment
No full textKwaliteit van arbeid, geautomatiseerd... Een studie naar kwaliteit van arbeid en de relatie tussen automatisering, arbeid en organisatie
No full textTechnology, Policy and Managemen
Temporomandibular Joint Pain is Negatively Correlated to TNF Alpha and Osteoprotegrin Content in Synovial Fluid in Patients with Juvenile Idiopathic Arthritis.
No full textObjective: Temporomandibular joint (TMJ) involvement occurs in up to 80% of children with juvenile idiopathic arthritis (JIA). Little is known with regard to the complexity of the protein profile in synovial fluid (SF) from JIA arthritis during growth as compared to both JIA and rheumatoid arthritis (RA) of adults.
Design: Synovial fluid was collected from 54 joints/30 patients with TMJ arthritis (JIA 35 joints/20 patients, JIA adults 9 joints/5 patients, RA 10 joints/5 patients). Three cytokines and seven bone markers were quantified using Luminex multiplex assays and compared to demographic and clinical data of function and pain.
Results: Pain (spontaneous and upon palpation) and duration of pain were all negatively correlated with the TMJ SF content of tumor necrosis factor (TNF)-α. The level of Adrenocorticotropic hormone (ACTH) was negatively correlated to TMJ pain upon palpation and post-treatment pain and function. The concentration of ACTH was significantly lower in SF in JIA (1.4 ± 2.8 pg/ml) compared to adults with JIA (4.7 ± 12.2 pg/ml) and significantly higher compared to adults with RA (0.8 ± 1.5 pg/ml). Osteoprotegerin (OPG) was negatively correlated to spontaneous pain.
Conclusions: Our results indicate that the local concentrations of TNF-α, ACTH and OPG in TMJ fluid may not contribute to TMJ pain and tissue destruction in JIA/RA patients.
© 2014 Olsen-Bergem H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Yanzhou shi liao qian ji: san shi juan. v.1
No full text王世貞纂撰 ; 董復表彙次.綫裝, 2函.框21.7x14.8公分, 9行18字, 白口, 單黑魚尾, 四周單邊, 版心上鐫"弇州史料", 中鐫卷次及"前集", 下鐫葉次及刻工名.刻書年據序.本館存卷一至十一及卷十五至二十四 ; 其中卷三, 六至八, 十八至十九有缺頁.Xian zhuang, 2 han.Kuang 21.7 x 14.8 gong fen, 9 hang 18 zi, bai kou, dan hei yu wei, si zhou dan bian, ban xin shang juan "Yanzhou shi liao", zhong juan juan ci ji "Qian ji", xia juan ye ci ji ke gong ming.Ke shu nian ju xu.Wang Shizhen zuan zhuan ; Dong Fubiao hui ci.Detailed notes in vernacualr field only
Damage detection in semiconductor devices by non-linear elastic wave spectroscopy
No full textSemiconductor devices can be found everywhere in our daily lives, for example in self-driving cars, bank cards and personal devices such as smart phones or notebooks. Once part of these personal devices, one does not want them to show failure. Although reliability of such devices is taken into account in the design, the fabrication process might lead to the emergence of small damages in the product. Since these damages or their propagation might cause failure of the device, a series of visual inspections and functional tests is part of the fabrication process. The obtained resolution by optical microscopy, currently the state of the art inspection method, is not sufficient for the detection of small damages such as microcracks or damages located inside a sample. To keep improving the reliability of semiconductor devices, these damages need to be detected in another high speed, low cost way.As semiconductor devices shrink in size, their natural vibration frequencies increase and approach theMHz-range. Vibration based damage detection methods might therefore offer an alternative high speed in-situ inspection method. The main goal of this thesis is to identify and experimentally verify vibration characteristics that indicate the presence of damage, with a focus on microcracks, in semiconductor devices. While linear vibration based damage methods have proven to be insensitive to small damages such as microcracks, non-linear vibration based damage detection methods show much higher sensitivities to this type of damage. The non-linear elastic wave spectroscopy (NEWS) of several damaged materials have shown two characteristic phenomena: amplitude dependent natural frequency shifts and the generation of higher harmonics. Both are explained by a phenomenological non-linear hysteric elastic model. While the applicability of NEWS is proven for several materials, its performance for silicon, in particular at microscale, is still unknown.Mechanical Engineering | Micro and Nano Engineerin
The drama of the forests, romance and adventure, by Arthur Heming; illustrated by the author with reproductions from a series of his paintings owned by the Royal Ontario museum.
No full textxiii, 324 p
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate a shed soluble form (solACE2) that mediates SARS-CoV-2 entry via receptor-mediated endocytosis. Currently, it is not known how the physiological regulation of ACE2 shedding contributes to the etiology of COVID-19 in vivo. The present study identifies Membrane-type 1 Matrix Metalloproteinase (MT1-MMP) as a critical host protease for solACE2-mediated SARS-CoV-2 infection. SARS-CoV-2 infection leads to increased activation of MT1-MMP that is colocalized with ACE2 in human lung epithelium. Mechanistically, MT1-MMP directly cleaves memACE2 at M706-S to release solACE2(18-706) that binds to the SARS-CoV-2 spike proteins (S), thus facilitating cell entry of SARS-CoV-2. Human solACE2(18-706) enables SARS-CoV-2 infection in both non-permissive cells and naturally insusceptible C57BL/6 mice. Inhibition of MT1-MMP activities suppresses solACE2-directed entry of SARS-CoV-2 in human organoids and aged mice. Both solACE2 and circulating MT1-MMP are positively correlated in plasma of aged mice and humans. Our findings provide in vivo evidence demonstrating the contribution of ACE2 shedding to the etiology of COVID-19
Differences in the Proportion of CYP2C19 Loss-of-Function Between Cerebral Infarction and Coronary Artery Disease Patients
No full textYuliang Shi,1,2 Yuxian Yang,1,2 Miaoling Feng,1,2 Weihan Ling,1,2 Tongguo Wei,1,2 Yumin Cao,1,2 Rui Zhong,1,2 Heming Wu2 1Department of Neurology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Center for Precision Medicine, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Heming Wu, Center for Precision Medicine, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, People’s Republic of China, Email [email protected]: Cytochrome P450 2C19 (CYP2C19) genotypes and metabolic phenotypes (extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM)) are related to the metabolism of therapeutic drugs for cardiovascular and cerebrovascular diseases. This study aimed to investigate the differences of CYP2C19 gene polymorphism distribution between coronary artery disease (CAD) patients and cerebral infarction (CI) patients.Methods: We identified 413 CI patients, 509 CAD patients, and 241 CI+CAD patients from 2016 to 2020 and studied genotypes of CYP2C19 rs4986893 (636G>A) and rs4244285 (681G>A) polymorphisms using PCR-gene chip detection method. Differences in CYP2C19 genotypes and metabolic phenotypes between the groups were compared. To analyze the efficacy of CYP2C19 metabolic phenotypes in discriminating between cerebral infarction and coronary artery disease, multiple logistic regression analysis was conducted after adjusting for gender, age, smoking history, drinking history, hypertension, and diabetes.Results: There were significant differences in the distribution of CYP2C19 genotypes and metabolic phenotypes between CI and CAD patients. The results of multivariate logistic regression (adjusted for sex, age, smoking, drinking, hypertension, and diabetes) indicated that CYP2C19 IM phenotype (IM vs EM: OR 1.443, 95% CI: 1.086– 1.918, P=0.011) and CYP2C19 IM+PM phenotype (IM or PM vs EM: OR 1.440, 95% CI: 1.100– 1.885, P=0.008) may be indicators of CI from CAD.Conclusion: CYP2C19 EM metabolic phenotype was dominant in CAD patients, and CYP2C19 IM metabolic phenotype was dominant in CI patients. After adjusting for other confounding factors, patients with the CYP2C19 IM metabolic phenotype were more likely to develop CI than CAD.Keywords: CYP2C19, genotype, metabolic phenotype, cerebral infarction, coronary artery diseas
Construction Technology and Application of Bonded Prestressed Tendons in Wind Turbine Mixed Towers
No full textThe post-tensioned bonded prestressing technology has been widely applied in wind power support structures due to its safety, reliability, economic efficiency, and durability. This paper provides a comprehensive introduction and explanation of the construction technology of post-tensioned bonded prestressed tendons based on an actual engineering case. Starting from key procedures such as construction preparation, tendon cutting and fabrication, placement of duct, tendon threading, tensioning and anchoring, and grouting and sealing, this paper details the critical points and precautions based on practical engineering experience. This work can serve as a reference for similar projects, aiming to promote the application and adoption of post-tensioned bonded prestressing technology in the wind power industry
Comparative assessment of erbium fiber ring lasers and reflective SOA linear lasers for fiber Bragg grating dynamic strain sensing
No full text- …
