58,524 research outputs found
Huangdi nei jing Ling shu zhu zheng fa wei
No full textV.1-12. 黃帝内經素問註證發微 : 九卷 -- v.13-20. 黃帝内經靈樞註證發微 : 九卷, 補遺.V.1-12. Huangdi nei jing Su wen zhu zheng fa wei : jiu juan -- v.13-20. Huangdi nei jing Ling shu zhu zheng fa wei : jiu juan, bu yi.馬蒔註證.綫裝.框20.6x13.8公分, 10行22字. 白口, 四周單邊, 單黑魚尾. 版心上鐫子目名, 中鐫卷次, 下鐫葉次.書名頁刻"黃帝内經素問靈樞合編, 馬元臺先生註, 大文堂藏板"《黃帝内經靈樞註證發微》第十卷為"補遺"前有嘉慶十年[1805]鮑漱芳序, 言刻書事.《中國中醫古籍總目》(00009)著錄.鈐"莊兆祥印", "莊兆祥".Xian zhuang.Kuang 20.6 x 13.8 gong fen, 10 hang 22 zi. Bai kou, si zhou dan bian, dan hei yu wei. Ban xin shang juan zi mu ming, zhong juan juan ci, xia juan ye ci.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Ma Shi zhu zheng.Qian "Zhuang Zhaoxiang yin", "Zhuang Zhaoxiang"
John Wei Ling rehursing, undated
No full textSouthwest Ballet Center; Fort Worth City Ballet; Fort Worth, Texas; John Wei Ling; Bill Martin-Viscount; Joyce Cuoco
John Wei Ling rehursing, undated photograp
John Wei Ling and Joyce Couco rehearsal performance
No full textJohn Wei Ling and Joyce Couco rehearsal performance
Southwest Ballet Center; Fort Worth City Ballet; Fort Worth, Texas; John Wei Ling; Bill Martin-Viscount; Joyce Cuoc
Premier Wang Ching-wei and Archbishop Mario Zanin in Nanjing
No full textArchbishop Mario Zanin meeting with Wang Ching-wei (Wang Jingwei 汪精衛, president of the Executive Yuan), at the bishop residence inNanjing; first row from left to right: Mgr Joseph Commisso (secretary of the apostolic delegation), Premier Wang Ching-wei, Bishop Auguste Haouisée of Shanghai, Bishop Simon Tsu (Zhu Kaimin 朱開敏) of Haimen.https://digitalcommons.whitworth.edu/g51_lebbe1/1096/thumbnail.jp
Studies of Scavenging Phenomenon in the Upper Water Column Off Northeast Taiwan:Application of 234Th/238U Disequilibrium
No full textJohn Wei Ling directing a rehersal performance
No full textSouthwest Ballet Center; Fort Worth City Ballet; Fort Worth, Texas; John Wei Ling; Bill Martin-Viscount; Joyce Cuoc
Phosphorylation of Human Choline Kinase Beta by Protein Kinase A: Its Impact on Activity and Inhibition.
Get PDFCholine kinase beta (CKβ) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. CKβ is important for normal mitochondrial function and muscle development as the lack of the ckβ gene in human and mice results in the development of muscular dystrophy. In contrast, CKα is implicated in tumorigenesis and has been extensively studied as an anticancer target. Phosphorylation of human CKα was found to regulate the enzyme's activity and its subcellular location. This study provides evidence for CKβ phosphorylation by protein kinase A (PKA). In vitro phosphorylation of CKβ by PKA was first detected by phosphoprotein staining, as well as by in-gel kinase assays. The phosphorylating kinase was identified as PKA by Western blotting. CKβ phosphorylation by MCF-7 cell lysate was inhibited by a PKA-specific inhibitor peptide, and the intracellular phosphorylation of CKβ was shown to be regulated by the level of cyclic adenosine monophosphate (cAMP), a PKA activator. Phosphorylation sites were located on CKβ residues serine-39 and serine-40 as determined by mass spectrometry and site-directed mutagenesis. Phosphorylation increased the catalytic efficiencies for the substrates choline and ATP about 2-fold, without affecting ethanolamine phosphorylation, and the S39D/S40D CKβ phosphorylation mimic behaved kinetically very similar. Remarkably, phosphorylation drastically increased the sensitivity of CKβ to hemicholinium-3 (HC-3) inhibition by about 30-fold. These findings suggest that CKβ, in concert with CKα, and depending on its phosphorylation status, might play a critical role as a druggable target in carcinogenesis
The behavior of scavenged isotopes in marine anoxic environments: 210Pb and 210Po in the water column of the Black Sea
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