88,547 research outputs found
Thompson Estate, Landscape Architectural Drawings, 1920s
No full textThese images are a set of landscape architectural drawings done by A. D. Taylor, a landscape architect of Cleveland. The residence was commissioned by Henry L. Thompson Senior and the house was constructed in 1915. The Walker and Weeks firm of Cleveland initially designed the house. These drawings include an elevation cross section of the estate, planting details, and a drawing of a garden wall commisioned in 1923, 1927 and 1928
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Predictors of Stunting, Wasting and Underweight among Tanzanian Children Born to HIV-Infected Women.
No full textChildren born to human immunodeficiency virus (HIV)-infected women are susceptible to undernutrition, but modifiable risk factors and the time course of the development of undernutrition have not been well characterized. The objective of this study was to identify maternal, socioeconomic and child characteristics that are associated with stunting, wasting and underweight among Tanzanian children born to HIV-infected mothers, followed from 6 weeks of age for 24 months. Maternal and socioeconomic characteristics were recorded during pregnancy, data pertaining to the infant's birth were collected immediately after delivery, morbidity histories and anthropometric measurements were performed monthly. Multivariate Cox proportional hazards methods were used to assess the association between potential predictors and the time to first episode of stunting, wasting and underweight. A total of 2387 infants (54.0% male) were enrolled and followed for a median duration of 21.2 months. The respective prevalence of prematurity (<37 weeks) and low birth weight (<2500 g) was 15.2% and 7.0%; 11.3% of infants were HIV-positive at 6 weeks. Median time to first episode of stunting, wasting and underweight was 8.7, 7.2 and 7.0 months, respectively. Low maternal education, few household possessions, low infant birth weight, child HIV infection and male sex were all independent predictors of stunting, wasting and underweight. In addition, preterm infants were more likely to become wasted and underweight, whereas those with a low Apgar score at birth were more likely to become stunted. Interventions to improve maternal education and nutritional status, reduce mother-to-child transmission of HIV, and increase birth weight may lower the risk of undernutrition among children born to HIV-infected women
The stability of IQ in people with low intellectual ability: an analysis of the literature
No full textA meta-analysis of the stability of low IQ (IQ 80) was performed on IQ tests that have been
commonly used—tests that were derived by D. Wechsler (1949, 1955, 1974, 1981, 1991, 1997)
and those based on the Binet scales (L. M. Terman, 1960; L. M. Terman & Merrill, 1972). Weighted-
mean stability coefficients of .77 and .78 were found for Verbal IQ (V IQ) and Performance IQ
(P IQ) on the Wechsler tests and .82 for Full-Scale IQ (FS IQ) on both Wechsler and Binet tests,
for a mean test–retest interval of 2.8 years. Although the majority of FS IQs changed by less than
6 points, 14% changed by 10 points or more. The author suggests that the results of IQ assessment
should be treated with more caution than previously thought
Maternal 25(OH)-Vitamin D concentration (nmol/L) at 32 weeks gestation.
No full text<p>Maternal 25(OH)-Vitamin D concentration (nmol/L) at 32 weeks gestation.</p
Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D
No full textAdequate vitamin D status is essential for skeletal health. Paget's disease of bone (PDB) is a common metabolic skeletal disorder, but data regarding the vitamin D status in PDB patients are lacking. We performed a case-control study to estimate vitamin D status in 708 PDB patients and in 1803 healthy controls from Italy and an observational prospective study to evaluate the efficacy-safety profile of oral cholecalciferol treatment [400.000 International Units (UI) of cholecalciferol administered in cycles of 8 weeks until 25OHD levels reaches 70 nmol/L as primary therapy and 50.000 UI of cholecalciferol administered every 2 weeks for 52 weeks for the maintenance therapy] in 82 PDB patients with hypovitaminosis D, i.e., 25OHD < 50 nmol/L. The main outcome measures for the prospective study were 25OHD levels, metabolic risk factors (RF) for nephrolithiasis, bone pain score (BPS), and pain medication score (PMS). Over half of PDB patients had hypovitaminosis D. Among PDB patients treated with cholecalciferol, 76 patients reached 25OHD levels ≥ 70 nmol/L after the first cycle of primary therapy and the remaining six patients after a second cycle. The maintenance therapy guaranteed 25OHD levels ≥ 70 nmol/L during the entire follow-up. The increase in 25OHD levels reduced PTH, BPS, and PMS levels, without changes in RF for nephrolithiasis. We can conclude that (i) hypovitaminosis D is frequent in PDB patients, (ii) cholecalciferol significantly increased 25OHD levels in PDB patients, and (iii) the correction of hypovitaminosis D improves the quality of life of PDB patients without inducing significant changes in RF for nephrolithiasis
Graduate recital, trumpet. Weeks, T., 1973
No full textRecorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, March 28, 1973, the 191st concert of the Department of Music's 1972-1973 season.Tom Weeks, trumpet. Assisted by: Gayle Petrick, Anne Rubner, oboes ; Pat Nancarrow, cello ; Joan Nottke, harpsichord ; Marty Otto, Steve Reed, Britt Theurer, Anthony Womack, trumpets ; John Dickey, Dave Kalfsbeek, Tom Shannon, trombones ; Carl Marsman, Barb Deaton, Janet Graham, Tim Griffin, french horns ; Rick Watts, Andy Hagenbuch, tubas.In partial fulfillment of the requirements of the Master of Music degree in brass pedagogy, Western Michigan University, 1973.Information from performance program.Konzert D-dur / George Philip Telemann -- Suite for brass quintet (1971). (15:03) I. Toccata - Allegro ; (19:08) III. Scherzo - Vivace ; (26:47) IV. Arioso - Adagio ; (32:18) V. March - Allegro / Verne Reynolds -- (35:58) Caprice for trumpet and piano, op. 47 / Eugene Bozza -- Sonneries for brass choir (1971). (43:03) I. Allegro con brio ; (45:05) II. Adagio ; (49:04) III. Allegro / Donald Erb
D-4F and L-5F improves insulin sensitivity.
No full textBeginning at 6 weeks of age, C57BL/6 mice were fed a standard chow diet (ND) or high-fat diet for a total of 16 weeks. After 10 weeks, the high fat diet group was subdivided: HFD+endotoxin-free saline (HFD); HFD+D-4F (D-4F) or HFD+L-5F (L-5F) for the last 6 weeks of diet. Plasma glucose concentrations during intraperitoneal insulin tolerance test (ITT; insulin 0.5 IU/kg) (A) before treatment commenced and (B) after 5 weeks of treatment with the mimetic peptides. (C and D) Area under the curve for glucose (AUC glucose) was calculated using the trapezoid rule. Results are mean ± SEM (n = 8–10). †PP<0.05 vs. HFD.</p
D-4F and L-5F improves blood glucose.
No full textBeginning at 6 weeks of age, C57BL/6 mice were fed a standard chow diet (ND) or high-fat diet for a total of 16 weeks. After 10 weeks, the high fat diet group was subdivided: HFD+endotoxin-free saline (HFD); HFD+D-4F (D-4F) or HFD+L-5F (L-5F) for the last 6 weeks of diet. Plasma glucose concentrations during intraperitoneal glucose tolerance test (GTT; glucose 2g/kg) (A) before treatment commenced and (B) after 4 weeks of treatment with the mimetic peptides. (C and D) Area under the curve for glucose (AUC glucose) was calculated using the trapezoid rule. Results are mean ± SEM (n = 8–10). †PP<0.05 vs. HFD.</p
Impact of Vitamin D Supplementation on Arterial Vasomotion, Stiffness and Endothelial Biomarkers in Chronic Kidney Disease Patients
No full textBackground: Cardiovascular events are frequent and vascular endothelial function is abnormal in patients with chronic
kidney disease (CKD). We demonstrated endothelial dysfunction with vitamin D deficiency in CKD patients; however the impact of cholecalciferol supplementation on vascular stiffness and vasomotor function, endothelial and bone biomarkers in CKD patients with low 25-hydroxy vitamin D [25(OH)D] is unknown, which this study investigated.
Methods: We assessed non-diabetic patients with CKD stage 3/4, age 17–80 years and serum 25(OH)D ,75 nmol/L. Brachial
artery Flow Mediated Dilation (FMD), Pulse Wave Velocity (PWV), Augmentation Index (AI) and circulating blood biomarkers were evaluated at baseline and at 16 weeks. Oral 300,000 units cholecalciferol was administered at baseline and 8-weeks.
Results: Clinical characteristics of 26 patients were: age 50614 (mean61SD) years, eGFR 41611 ml/min/1.73 m2, males
73%, dyslipidaemia 36%, smokers 23% and hypertensives 87%. At 16-week serum 25(OH)D and calcium increased (43616
to 84629 nmol/L, p,0.001 and 2.3760.09 to 2.4260.09 mmol/L; p = 0.004, respectively) and parathyroid hormone
decreased (10.868.6 to 7.464.4; p = 0.001). FMD improved from 3.163.3% to 6.163.7%, p = 0.001. Endothelial biomarker
concentrations decreased: E-Selectin from 566662123 to 525662058 pg/mL; p = 0.032, ICAM-1, 3.4560.01 to
3.1061.04 ng/mL; p = 0.038 and VCAM-1, 54633 to 42633 ng/mL; p = 0.006. eGFR, BP, PWV, AI, hsCRP, von Willebrand
factor and Fibroblast Growth Factor-23, remained unchanged.
Conclusion: This study demonstrates for the first time improvement of endothelial vasomotor and secretory functions with vitamin D in CKD patients without significant adverse effects on arterial stiffness, serum calcium or FGF-23.
Trial Registration: ClinicalTrials.gov NCT0200571
Effects of four weeks L-Carnitine L-tartrate ingestion on substrate utilization during prolonged exercise
No full textIn a randomized, placebo-controlled, double-blind crossover design, 15 trained males undertook exercise trials during two 4 wk supplementation periods, with either 3 g L-Carnitine L-tartrate (LCLT) or 3 g placebo (P) daily. Total carbohydrate and fat oxidation during 90 min steady state cycling were not different between 0 or 4 wk within LCLT or P trials (mean ± standard deviation: carbohydrate oxidation P0 99 ± 36, P4W 111 ± 27, LCLT0 107 ± 33, LCLT4W 112 ± 32 g, respectively; fat oxidation P0 99 ± 28, P4W 92 ± 21, LCLT0 94 ± 18, LCLT4W 90 ± 22 g, respectively). Subsequent 20 km time trial duration was shorter after P (P0 31:29 ± 3:50, P4W 29:55 ± 2:58 min:s, P < 0.01), with no significant change over LCLT (LCLT031:46 ± 4:06, LCLT4W 31.19 ± 4.08 min:s). Four weeks LCLT supplementation had no effect on substrate utilization or endurance performance
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