468 research outputs found
“These articles of furniture could not be real…they must be ghosts of such articles”: the material Gothic of Charlotte Brontë’s Villette
No full textCanonized as a Gothic writer primarily for her novel Jane Eyre (1847), Charlotte Brontë‟s role within the Gothic tradition has been seen by some critics to be an unsuccessful venture and by others to be an attempt to defend the Racliffean school of Gothic literature from critics, such as Jane Austen. However, through tracing the progression of Brontë‟s Gothic through The Professor (1857) and Jane Eyre to Brontë‟s last completed novel, Villette (1853), this essay argues that Brontë goes beyond simply using the standard tropes of the Gothic tradition and, instead, expands upon an already present material element in the tradition to reflect the cultural environment that her novels are written in—in a word, a material Gothic. Through her novels, Brontë develops a material Gothic in which items are inscribed with meaning and relationships are mediated through these items. By the time Villette is published, the value placed on this system of inscription is so great that the Gothic happy-ending experienced by Frances and Jane is not a feasible option for Lucy Snowe. When capitalistic motives interfere in the heroine‟s Gothic tale and are the catalyst for a catastrophic loss, such as the presumed death of Paul Emmanuel, the heroine is left with empty placeholders. Because the meaning of these objects has been eliminated, they cannot serve as an adequate substitute for the satisfying relationship the heroine was supposed to have with her Gothic hero-villain.M.A.Includes bibliographical referencesby Jamie M. Gibb
LaClede, St.Clere and Flush -Pottawatomie County
No full textJamie Pettus, “LaClede, St.Clere and Flush -Pottawatomie County,” Chapman Center Research Collections, https://ccrsresearchcollections.omeka.net/items/show/26.LaClede, St. Clere and Flush once had a growing population until the start of the construction of Route 40 in the 1880's. The author explains the similarities of population loss and the individual uniqueness of each community that is also gone
'The picturesqueness of his accent and speech': Methodist missionary narratives and William Henry Pierce's autobiography
No full textThe chapter, "'The picturesqueness of his accent and speech': Methodist missionary narratives and William Henry Pierce's autobiography" was written by Gail Edwards (Douglas College Faculty). Christian missions and missionaries have had a distinctive role in Canada's cultural history. With Canadian Missionaries, Indigenous Peoples, Alvyn Austin and Jamie S. Scott have brought together new and established Canadian scholars to examine the encounters between Christian (Roman Catholic and Protestant) missionaries and the indigenous peoples with whom they worked in nineteenth- and twentieth-century domestic and overseas missions.
This tightly integrated collection is divided into three sections. The first contains essays on missionaries and converts in western Canada and in the arctic. The essays in the second section investigate various facets of the Canadian missionary presence and its legacy in east Asia, India, and Africa. The third section examines the motives and methods of missionaries as important contributors to Canadian museum holdings of artefacts from Huronia, Kahnawaga, and Alaska, as well as China and the South Pacific.
Broadly adopting a postcolonial perspective, Canadian Missionaries, Indigenous Peoples contributes greatly to the understanding of missionaries not only as purveyors of western religious values, but also as vehicles for cultural exchange between Native and non-Native Canadians, as well as between Canadians and the indigenous peoples of other countries.book chapterPublished
Chemical applications of escience to interfacial spectroscopy
No full textThis report is a summary of works carried out by the author between October 2003 and September 2004, in the first year of his PhD studie
Correction: Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells
No full textPresent: Due to an omission on the part of the author, the affliations of the first author are incomplete.
Corrected: Additional affliation information for the first author is listed below. The authors sincerely apologize for this error.
Original article: Oncotarget. 2016; 7(10):11397-11411. DOI:10.18632/oncotarget.7242.
PRESENT LIST:
Yanli Zhang1, Jamie Sui-Lam Kwok2, Pui-Wah Choi1, Minghua Liu2, Junzheng Yang1, Margit Singh1, Shu-Kay Ng4, William R. Welch5, Michael G. Muto1, Stephen KW Tsui2, Stephen P. Sugrue3, Ross S. Berkowitz1, Shu-Wing Ng1
1 Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
2 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
3 Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA
4 School of Medicine and Menzies Health Institute Queensland, Griffith University, Meadowbrook, Australia
5 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
UPDATED LIST:
Yanli Zhang1,6, Jamie Sui-Lam Kwok2, Pui-Wah Choi1, Minghua Liu2, Junzheng Yang1, Margit Singh1, Shu-Kay Ng4, William R. Welch5, Michael G. Muto1, Stephen KW Tsui2, Stephen P. Sugrue3, Ross S. Berkowitz1, Shu-Wing Ng1
1 Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
2 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
3 Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA
4 School of Medicine and Menzies Health Institute Queensland, Griffith University, Meadowbrook, Australia
5 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
6 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaFull Tex
Nostalgia: content, triggers, functions
No full textSeven methodologically diverse studies addressed 3 fundamental questions about nostalgia. Studies 1 and 2 examined the content of nostalgic experiences. Descriptions of nostalgic experiences typically featured the self as a protagonist in interactions with close others (e.g., friends) or in momentous events (e.g., weddings). Also, the descriptions contained more expressions of positive than negative affect and often depicted the redemption of negative life scenes by subsequent triumphs. Studies 3 and 4 examined triggers of nostalgia and revealed that nostalgia occurs in response to negative mood and the discrete affective state of loneliness. Studies 5, 6, and 7 investigated the functional utility of nostalgia and established that nostalgia bolsters social bonds, increases positive self-regard, and generates positive affect. These findings demarcate key landmarks in the hitherto uncharted research domain of nostalgi
Turning urban studies inside/out
No full textProcess and practice have been watchwords for this book, as they were for the collaborative seminar that proceeded it. Along with our collaborators, we have been concerned to excavate and explicate generative modes and models of practice, in both creative research and constructive critique. The monographs that were the focus for Part II of the collection were each encountered, as we indicated in Chapter 3, not simply s ‘finished’ contributions but more as windows onto different forms of research practice. Specifically, they were each rea for methodology and reverse-engineered as a means to uncover the underlying conditions and constitutive practices involved in their production; to find and position both the author and her research practices in the text; and to derive lessons and insights from this process in a manner attuned to the interests and concerns of researchers entering the field. Furthermore, in tracing the path from a collaborative seminar for graduate students to a published collection of essays, reflections, and keyword entries, we have sought in a parallel fashion to be transparent and reflexive about our own (shared) processes and practices
Expeditionary warfare in the age of global terrorism: a critical assessment of Britain's war against Al Qaeda
No full textThe war against Al Qaeda and its allies may well become the defining conflict of our age. Certainly it is cited as evidence of a transformation of war that is sweeping away older modes of warfare. This paper seeks to explain the reasons for the failure of the military campaign so far, but looks at this debate from the perspective of the British rather than the American experience of the war on terror.
This paper was presented as part of Rethinking the Postcolonial in the Age of the War on Terror joint symposium, by the MnM Centre in conjunction with the UNESCO Chair in Transnational Diasporas and Reconciliation Studies, at the University of South Australia, on 16 and 17 September 2010. The aim of the symposium was to explore the postcolonial condition in the era of the \u27war on terror\u27 and to rethink postcolonialism in order to reformulate or reinforce its critical insights.
Author: Warren Chin, Defence Studies Department, King\u27s College London, Joint Services Command and Staff College. The views expressed in this paper are the author‟s own and do not reflect the official position of MOD or the British Government
Multiple-sprint sport exercise and carbohydrate-protein ingestion in humans
No full textThe aim of the present thesis was to examine the potential for acute carbohydrate-protein (CHO-P) ingestion to enhance performance and recovery from exercise designed to simulate the demands of multiple-sprint sports (MSSs). Chapter 3 of the thesis explored the inter- and intra-day reliability and concurrent validity of non-motorised treadmill ergometry (NMT) for the assessment of short-distance sprint performance [i.e. 10-30 m). There were no significant mean differences between NMT variables recorded on the same day or between days. Ratio limits of agreement indicated that the best agreement was in 20 [1.02 */-=- 1.09) and 30 m [1.02 */* 1.07) sprint times, peak [1.00 */T 1.06) and mean (0.99 */+ 1.07) running speed and step length (0.99 */-=- 1.09) and frequency (1.01 */+ 1.06). The poorest agreement was observed for time to peak running speed (1.10 */* 1.47). Significant differences were observed between NMT and over-ground sprint times across all distances, with times being lower (faster) by approximately 25-30% over-ground. The correlations between NMT and over-ground variables were generally modest (r5 = 0.44 - 0.67), and optimal for time to cover 30 m on Day 2 (rs = 0.8). Chapter 4 sought to examine the efficacy of CHO-P ingestion during 4 h of recovery from the Loughborough Intermittent Shuttle Test (LIST) when compared to CHO matched for energy (ISOEN) or CHO (ISOCHO) in a typical CHO beverage. There were significant increases over time in muscle soreness, and reductions in extensor and flexor peak torque (by approximately 9%, 9% and 8%, and 13 %, 13% and 11% at 60 deg-s-1) and jump performance (10%, 7% and 5%) with the ingestion of CHO-P, ISOEN and ISOCHO, respectively. Beverage type x time interactions were not significant for any of these variables, indicating that changes in each variable were similar for all groups. Decrements in sprint performance assessed on the NMT were typically small and not different between beverage types (<4%), although sprint times over 20 and 30 m remained elevated for 48 h post-exercise. Accordingly, Chapter 4 provided no clear evidence for a benefit of ingesting CHO-P in the hours after exercise to enhance recovery of muscle function and selected performance variables following MSS activity. Chapters 5 and 6 of the thesis aimed to examine the effect of CHO-P ingestion during simulated MSS exercise. In Chapter 5, it was observed that sprint times, HR and gut fullness increased over the course of the LIST, with no influence of consuming each of the different beverages. In contrast, there was a main effect of time (P < 0.001), and drink (P = 0.042) observed for RPE, which was lower (P < 0.001) during the LIST in the CHO-P condition (16.9 ± 1.4) than in either the ISOCHO (17.8 ± 1.1) or ISOEN (17.7 ± 1.3). However, time to exhaustion was not different (P = 0.29) between CHO-P (468.3 ± 268.5 s), ISOCHO (443.4 ± 286.3 s) and ISOEN (446.2 ± 282.08 s), although these times did equate to a non-significant mean improvement of 4% in the CHO-P trial. Chapter 6 demonstrated that during a modified version of the LIST with two self-regulated blocks of exercise intensity, participants had a higher average speed (8.1 ± 0.3 cf. 7.9 ± 0.5 knvlr1) during the final (self-regulated) 15 min block of the LIST in the CHO-P condition compared to CHO. Whilst the mechanisms for such an improvement are not certain, the attenuated rise in RPE observed in Chapter 5, and increased blood urea concentration observed in Chapter 6, with CHO-P ingestion may suggest altered central fatigue and/or increased protein oxidation enhances performance during MSSs
Functional Data Analysis Applied to Modeling of Severe Acute Mucositis and Dysphagia Resulting From Head and Neck Radiation Therapy
No full textPurposeCurrent normal tissue complication probability modeling using logistic regression suffers from bias and high uncertainty in the presence of highly correlated radiation therapy (RT) dose data. This hinders robust estimates of dose-response associations and, hence, optimal normal tissue–sparing strategies from being elucidated. Using functional data analysis (FDA) to reduce the dimensionality of the dose data could overcome this limitation.Methods and MaterialsFDA was applied to modeling of severe acute mucositis and dysphagia resulting from head and neck RT. Functional partial least squares regression (FPLS) and functional principal component analysis were used for dimensionality reduction of the dose-volume histogram data. The reduced dose data were input into functional logistic regression models (functional partial least squares–logistic regression [FPLS-LR] and functional principal component–logistic regression [FPC-LR]) along with clinical data. This approach was compared with penalized logistic regression (PLR) in terms of predictive performance and the significance of treatment covariate–response associations, assessed using bootstrapping.ResultsThe area under the receiver operating characteristic curve for the PLR, FPC-LR, and FPLS-LR models was 0.65, 0.69, and 0.67, respectively, for mucositis (internal validation) and 0.81, 0.83, and 0.83, respectively, for dysphagia (external validation). The calibration slopes/intercepts for the PLR, FPC-LR, and FPLS-LR models were 1.6/−0.67, 0.45/0.47, and 0.40/0.49, respectively, for mucositis (internal validation) and 2.5/−0.96, 0.79/−0.04, and 0.79/0.00, respectively, for dysphagia (external validation). The bootstrapped odds ratios indicated significant associations between RT dose and severe toxicity in the mucositis and dysphagia FDA models. Cisplatin was significantly associated with severe dysphagia in the FDA models. None of the covariates was significantly associated with severe toxicity in the PLR models. Dose levels greater than approximately 1.0 Gy/fraction were most strongly associated with severe acute mucositis and dysphagia in the FDA models.ConclusionsFPLS and functional principal component analysis marginally improved predictive performance compared with PLR and provided robust dose-response associations. FDA is recommended for use in normal tissue complication probability modeling
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