17,417 research outputs found
Four unidentified men gathered around a table, Oregon, approximately 1890
No full textCaption on mount: Watson. 225 First Street. Portland, Oregon.
PH Coll 334 Watson.2The photographer is possibily Joseph E. Watson who owned a studio on First Street in Portland, Oregon between 1890-1892. There was also a studio called Watson and Woodruff in Portland that operated in 1916 which may be the photographer as well.To order a reproduction, inquire about permissions, or for information about prices see:
http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction
Please cite the Order Numbe
James and Hester Sykes, Portland, Oregon, approximately 1890
No full textCaption on mount: Watson. 225 First Street. Portland, Oregon.
Handwritten on verso: James and Hester Sykes.
PH Coll 334 Watson.1The photographer is possibily Joseph E. Watson who owned a studio on First Street in Portland, Oregon between 1890-1892. There was also a studio called Watson and Woodruff in Portland that operated in 1916 which maybe the photographer as well.To order a reproduction, inquire about permissions, or for information about prices see:
http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction
Please cite the Order Numbe
Parallel and antiparallel-stranded DNA duplexes depending on pH value (A) and chemical structure of the Watson-Crick and reverse Watson-Crick as well as Hoogsteen base pairs (B).
No full text<p>Parallel and antiparallel-stranded DNA duplexes depending on pH value (A) and chemical structure of the Watson-Crick and reverse Watson-Crick as well as Hoogsteen base pairs (B).</p
An intracellular pH gradient in the anammox bacterium Kuenenia stuttgartiensis as evaluated by (31)P NMR
No full textThe cytoplasm of anaerobic ammonium oxidizing (anammox) bacteria consists of three compartments separated by membranes. It has been suggested that a proton motive force may be generated over the membrane of the innermost compartment, the “anammoxosome”. 31P nuclear magnetic resonance (NMR) spectroscopy was employed to investigate intracellular pH differences in the anammox bacterium Kuenenia stuttgartiensis. With in vivo NMR, spectra were recorded of active, highly concentrated suspensions of K. stuttgartiensis in a wide-bore NMR tube. At different external pH values, two stable and distinct phosphate peaks were apparent in the recorded spectra. These peaks were equivalent with pH values of 7.3 and 6.3 and suggested the presence of a proton motive force over an intracytoplasmic membrane in K.stuttgartiensis. This study provides for the second time—after discovery of acidocalcisome-like compartments in Agrobacterium tumefaciens—evidence for an intracytoplasmic pH gradient in a chemotrophic prokaryotic cell.BiotechnologyApplied Science
In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles
No full textNanoparticles with pH-sensitive behavior may enhance the success of chemotherapy in many cancers by efficient intracellular drug delivery. Here, we investigated the effect of a bioactive surfactant with pH-sensitive properties on the antitumor activity and intracellular behavior of methotrexate-loaded chitosan nanoparticles (MTX-CS-NPs). NPs were prepared using a modified ionotropic complexation process, in which was included the surfactant derived from Nα,Nε-dioctanoyl lysine with an inorganic lithium counterion. The pH-sensitive behavior of NPs allowed accelerated release of MTX in an acidic medium, as well as membrane-lytic pH-dependent activity, which facilitated the cytosolic delivery of endocytosed materials. Moreover, our results clearly proved that MTX-CSNPs were more active against the tumor HeLa and MCF-7 cell lines than the free drug. The feasibilty of using NPs to target acidic tumor extracellular pH was also shown, as cytotoxicity against cancer cells was greater in a mildly acidic environment. Finally, the combined physicochemical and pH-sensitive properties of NPs generally allowed the entrapped drug to induce greater cell cycle arrest and apoptotic effects. Therefore, our overall results suggest that pH-sensitive MTX-CS-NPs could be potentially useful as a carrier system for tumor and intracellular drug delivery in cancer therapy
Glacier Peak Holiday (North Cascades Conservation Council Print) approximately 1957-1958 (complete work)
No full textPH Coll 1050.70
Charles and Marion Hessey are mountaineers and amateur film makers. Rowland Tabor is a geologist, Duke Watson and Warren Spickard are friends of the Hesseys and fellow mountaineers.To order a reproduction, inquire about permissions, or for information about prices, see: http://www.lib.washington.edu/specialcollections/services/reproduction/reproductio
Concept and development of an autonomous wearable micro-fluidic platform for real time pH sweat analysis
No full textIn this work the development of an autonomous, robust and wearable micro-fluidic platform capable of performing on-line analysis of pH in sweat is discussed. Through the means of an optical detection system based on a surface mount light emitting diode (SMD LED) and a light photo sensor as a detector, a wearable system was achieved in which real-time monitoring of sweat pH was performed during 55 minutes of cycling activity. We have shown how through systems engineering, integrating miniaturised electrical components, and by improving the micro-fluidic chip characteristics, the wearability, reliability and performance of the micro-fluidic platform was significantly improved
The time course of the transcriptomic response of Sinorhizobium meliloti 1021 following a shift to acidic pH
No full textHellweg C, Pühler A, Weidner S. The time course of the transcriptomic response of Sinorhizobium meliloti 1021 following a shift to acidic pH. BMC MICROBIOLOGY. 2009;9(1):37
Toward a theory of peace : the role of moral beliefs
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Political Science, 1997.Includes bibliographical references (p. [169]-205).by Randall Caroline Watson Forsberg.Ph.D
Finitism--an essay on Hilbert's programme
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 1991.Includes bibliographical references (p. 213-219).by David Watson Galloway.Ph.D
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