588 research outputs found
Determinants of plasminogen activator inhibitor 1 activity in Chinese diabetic patients and its relationship to a polymorphism in the PAI 1 gene
No full textPhysiotherapists’ barriers and facilitators to the implementation of a behaviour change-informed exercise intervention to promote the adoption of regular exercise practice in patients at risk of recurrence of low back pain: a qualitative study (BMC Primary Care, (2024), 25, 1, (39), 10.1186/s12875-024-02274-y)
No full textPublisher Copyright: © The Author(s) 2024.Following publication of the original article [1], the authors reported an error in the affiliations of author Marta M. Marques. The correct affiliations are provided below. Incorrect affiliations: Marta M. Marques1,2,1Comprehensive Health Research Center (CHRC), NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisbon, Portugal 2EpiDoc Unit, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisbon, Portugal Correct affiliations: Marta M. Marques4, 54Comprehensive Health Research Center (CHRC), National School of Public Health, Universidade NOVA de Lisboa, Lisbon, Portugal 5National School of Public Health, Universidade NOVA de Lisboa, Lisbon, Portugal The original article has been corrected.publishersversionpublishe
Central obesity predicts the worsening of glycemia in southern Chinese
No full textAIMS: The association between obesity and type 2 diabetes has been found to be consistent across different ethnic populations. Our aim was to study the contribution of obesity to the development of type 2 diabetes in a non-obese Chinese population with a high prevalence of diabetes (9.8% in 1995-1996). METHODS: Six-hundred and forty-four non-diabetic subjects were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study (1995-1996). This was a community-based population study which involved the use of a 75 g oral glucose tolerance test and 1985 World Health Organization diagnostic criteria. Their glycemic status was reassessed at 2y. RESULTS: In subjects with impaired glucose tolerance (n = 322), the annual progression rate to diabetes (4.8%; 95% Cl 2.57.1%), was 8-fold that in control subjects (0.6%; 95% Cl 0.0-1.4%; P ≤ 0.001). Baseline waist-hip ratio (WHR; OR per unit increase = 1.05; 95% Cl 1.02-1.07, P = 0.0003) and post-load 2 h plasma glucose (OR per unit increase = 2.02; 95% Cl 1.762.34, P ≤ 0.0001) were significantly associated with glycemic status at 2y in stepwise polytomous logistic regression analysis. Subjects with high baseline waist circumference or WHR (≥ median) were more likely to have worsening of glucose tolerance at 2y than those with low waist circumference (≤ median; conversion to diabetes, OR 3.8, P = O.001) or WHR (≤ median; conversion to diabetes, OR 2.8, P = 0.019). CONCLUSION: Abdominal obesity, readily assessed by the measurement of WHR or waist circumference, was for the first time shown prospectively to be independently associated with the deterioration of glucose tolerance in a Chinese population.link_to_subscribed_fulltex
Comparison on 1997 ADA and 1998 WHO criteria for diagnosis of diabetes and glucose intolerance in Chinese
No full textAgri-food Trade Specialisation Pattern in the New EU Member States
Get PDFThe paper analyses development of agri-food trade specialisation pattern in eight EU Member States of the 2004 and 2007 enlargements (NMS) during the period 2000 – 2005. Over the period analysed, the NMS were not able to hold trade positions in the most competitive commodities, but on the other hand, positions of a number of previously uncompetitive commodities improved. We show convergence of dynamism of agri-food trade specialisation across NMS in trade with the partners/groupings investigated.agri-food trade, specialisation, EU Member States of 2004 and 2007 enlargements, International Relations/Trade,
Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene resistant polycystic ovaries: A randomized, double-blinded placebo-controlled trial
No full textBackground: Metformin, an insulin-sensitizing agent, has been used successfully as the first-line drug to induce ovulation in women with polycystic ovary syndrome. There are, however, very few studies evaluating metformin treatment in women with clomiphene citrate (CC)-resistant polycystic ovaries (PCO). Methods: Twenty infertile Chinese women aged <40 years, who had ultrasound features of PCO and remained anovulatory on CC, were randomized by computer using the sealed envelope method to receive placebo or metformin 500 mg three times a day for 3 months. Hormonal and metabolic profiles were determined before the therapy and were repeated after 3 months for women who failed to become pregnant within this period. Clomiphene was then added for one cycle to those women who did not ovulate after taking placebo or metformin alone. Results: The median ovulation rate in the placebo group was 0% (range: 0-50%) after placebo only and 6.9% (range: 0-50%) after placebo and CC, whereas the corresponding rates in the metformin group were 0% (range: 0-22%) and 0% (range: 0-22%) respectively. There was no improvement in the ovulation rate despite a significant reduction of body mass index, serum testosterone and fasting leptin concentrations in the metformin group. Conclusions: Metformin treatment may result in successful ovulation only in certain subgroups of these women.link_to_subscribed_fulltex
The -258 G-A variant of the glucokinase gene hepatic promoter is associated with higher insulin sensitivity in Chinese
No full textCirculating Dopamine Is Regulated by Dietary Glucose and Controls Glucagon-like 1 Peptide Action in White Adipose Tissue
Get PDFDopamine directly acts in the liver and white adipose tissue (WAT) to regulate insulin signaling, glucose uptake, and catabolic activity. Given that dopamine is secreted by the gut and regulates insulin secretion in the pancreas, we aimed to determine its regulation by nutritional cues and its role in regulating glucagon-like peptide 1 (GLP-1) action in WAT. Solutions with different nutrients were administered to Wistar rats and postprandial dopamine levels showed elevations following a mixed meal and glucose intake. In high-fat diet-fed diabetic Goto-Kakizaki rats, sleeve gastrectomy upregulated dopaminergic machinery, showing the role of the gut in dopamine signaling in WAT. Bromocriptine treatment in the same model increased GLP-1R in WAT, showing the role of dopamine in regulating GLP-1R. By contrast, treatment with the GLP-1 receptor agonist Liraglutide had no impact on dopamine receptors. GLP-1 and dopamine crosstalk was shown in rat WAT explants, since dopamine upregulated GLP-1-induced AMPK activity in mesenteric WAT in the presence of the D2R and D3R inhibitor Domperidone. In human WAT, dopamine receptor 1 (D1DR) and GLP-1R expression were correlated. Our results point out a dietary and gut regulation of plasma dopamine, acting in the WAT to regulate GLP-1 action. Together with the known dopamine action in the pancreas, such results may identify new therapeutic opportunities to improve metabolic control in metabolic disorders
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