2,813 research outputs found
Intracranial pressure in African children with cerebral malaria
No full textOpening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD] 22·6 [7·4] cm CSF, range 10·5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria
The pathophysiology of severe falciparum malaria.
No full textBy the end of the 1940s, the clinical and pathological features of severe falciparum malaria had been well described by military physicians and pathologists working in theatres of war where the disease was endemic. From that time serious efforts were made to discover the pathophysiology of the severe manifestations of malaria because an understanding of these mechanisms forms an important basis for the clinical management of affected patients. Recently, after a period of neglect, there has been a revival of interest in malaria as a subject for clinical and laboratory research. In this article, Rodney Phillips and David Warrell review aspects of that work and attempt to unravel the mysteries of the pathophysiology of severe malaria in man
Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.
No full text1. A method is described for the measurement of phenobarbitone (PB) by reversed phase high performance liquid chromatography (h.p.l.c.) from small samples of whole blood dried onto filter paper strips. 2. The disposition of PB given prophylactically to young children with severe malaria on parenteral quinine is contrasted with that in aparasitaemic Kenyan children on no antimalarial drugs. There were no differences in the disposition of PB between the two groups. 3. Peak blood PB concentrations were equal to or greater than 15 mg l-1 in 27% of the patients on quinine and 23% of those not on quinine; a concentration of 10 mg l-1 was achieved or exceeded by 100% and 92% of each group, respectively, and was maintained for 39 +/- 24 h (mean +/- s.d.), and 33 +/- 21 h, respectively. 4. In an open, dose-finding study, the progress of young children with cerebral malaria given prophylactic PB (10 mg kg-1), was contrasted with that of controls given no seizure prophylaxis. 5. The drug had no apparent effect on depth or duration of coma, but neither was the incidence of seizures reduced. 6. A controlled trial of prophylactic PB in young children with cerebral malaria is needed, but a larger dose than 10 mg kg-1 should be studied
Design metrics for evaluating the propulsive efficiency of future ships
No full textThere is an increasing need for the ship design process to take account of environmental issues such as the emission of greenhouse gases and the likely extension of a carbon dioxide charging mechanism to international shipping. These issues, together with the need for economic viability, provide further incentives to improve the efficiency of propulsion of ships. The main components of powering are firstly reviewed. Individual components and other power saving devices are identified which should contribute to improvements in the overall efficiency of propulsion. Suitable design metrics and procedures, taking into account economic and environmental factors, are recommended for the design of future ships
Treatment of envenoming: the need for improved antitoxins and ancillary pharmacological agents
No full textBrief note: some observations on oscillating tangential forces and wear in general plane contacts
No full textFor general plane contact of elastically similar materials, including cases where there are multiple regions of contact, general properties of the partial slip solution for conditions of constant normal force and monotonically increasing shearing force have been found recently by the first author. An extension is given here to cover the unloading and cyclic loading cases. Further, it is shown that, if the tangential load varies between two fixed limits, the region of stick does not change, even if relative microslip causes wear, changing continuously the profile of the indenter. The contact area will change, but wear will not enter the original region of adhesion. The theoretical limit to which wear will eventually, asymptotically proceed is established, viz. almost complete contact over what is the initial stick zone, although it may, in practice, take a long time to reach this state
The description of Kabarda by D.A. Milutin in the context of the cauсasus version of russian orien-talism foundation
No full textThe paper pertains to the analysis of a manuscript authored by D.A. Milutin in the first half of the 19th century, regarding the region of Kabarda. This manuscript, hitherto unpublished in academic circles, has been the subject of our examination. Our endeavor was to uncover the utilization of orientalist clichés by the manuscript's author, in order to depict both the geographical delineations of this ethno-political entity and the ethnography, livelihood, societal structure, and customary legal norms of its inhabitants. A remarkable parallel can be observed between certain aspects of the manuscript and the ideas propounded by E. Said in his discourse on European Orientalism. The researcher drew a comparison between the political framework and traditions of the Kabardian people and those prevalent in Europe. Moreover, the researcher romanticized the region's historical past, employing the conceptof "reverse human progress," along with other typical methodologies embraced by Orientalist thinkers of that era. Concomitantly, D.A. Milutin provided detailed descriptions of the political, social, and everyday existence in Kabarda, thereby endowing the manuscript with an intrinsic value as an original historical and cultural resource for contemporary scholars. It is concluded that, similar to numerous analogous texts produced by Orientalist scholars, the significance of D.A. Milutin's man-uscript lies not in its political arguments concerning the military and economic dominion of the Russian Empire over the Caucasian peoples, or the imperative to extend colonial governance to these ethnic territorie
Elements of Ethnotaxonomy in Dhule and Nandurbar Districts (Maharashtra)
No full textDhule and Nandurbar districts of Maharashtra are mainly inhabited by tribals and rural folks. The author’s ethnobotanical and floristic forays in these districts brought out certain elements of ethnotaxonomy like ethnotaxonomic markers, classifications, principles of nomenclature and exomorphic features. The facts gathered indicated that the people in the area are fairly flooded with reckonable elements of ethnotaxonomy. And 22 ethnotaxonomic markers are identified. These are evaluated and discussed pertinently in this paper.-----------------------------------------------------------------------------------------------------Post Graduate Department of Botany, S.S.V.P.S’s L.K. P.R.Ghogrey Science College, Dhule-424005 (Maharashtra), India*Corresponding author, Email: [email protected] Cite This Article As: D.A. Patil. 2010. Elements of Ethnotaxonomy in Dhule and Nandurbar Districts (Maharashtra). J. Ecobiotechnol. 2(3): 18-25
Aanteekeningen omtrent de gevolgen van zware stormvloeden, tusschen 1500 en 1825 voorgekomen, voor de dijken en polders langs het Zuidwestelijk deel der Zuiderzee: samengesteld door den ingenieur van den Rijkswaterstaat D.A. van Heyst
No full textOverzicht van stormvloeden (1500 - 1825) die tot overstromingen langs de Zuiderzee geleid hebben. Aanleiding was de overstroming van 1916, en men wilde weten of deze stormvloed inderdaad uniek was
The dynamical influences of a hard transition zone on post-glacial uplifts and rotational signatures
No full textRecent investigations from laboratory and Monte-Carlo inversion of geophysical signatures have suggested that the transition zone of the mantle between 400 and 670 km depth may be stiffer than the lower and the upper mantle. By means of a five-layer viscoelastic spherical Earth model, we have calculated the displacement fields associated with post-glacial rebound, the induced polar motions, the temporal variations of the coefficients of the geopotential up to degree eight and the stress fields induced by deglaciation in the lithosphere and the upper mantle. Temporal variations of stress fields in the lithosphere reveal a non-monotonic behaviour due to the viscosity stratification. The results demonstrate the importance of the coming LAGEOS II geodetic satellite mission on constraining the rheological nature of the transition zone in the mantle. -from Author
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