6,930 research outputs found
Letter from Stephen Ward to Alden Partridge, approximately 1824
No full textStephen D. Ward writes from New Haven, Connecticut, to Alden Partridge in Norwich, Vermont, with an introduction to William Henry Brisbane, who wishes to enter Partridge's academy in Norwich; the letter is dated only 10 February but may have been written in 1824.Transcription by Raymond Bouchard. Transcriptions may be subject to error
Developing and implementing balanced incentive and risk sharing contracts
No full textAn important aspect of stakeholder management in construction projects is the contractual approach to managing risk and uncertainty. Chapman and Ward (2002) develops a balanced incentive and risk sharing (BIARS) contract, drawing on earlier research on management contracts, which lead to publications on risk allocation and risk sharing generally. This paper develops the BIARS contract concept further. It addresses choice of contract decisions as risk efficient choices in a best practice project risk management process concerned with the whole project lifecycle. It sets this discussion in the context of a range of popular contract choices, like fixed price, design and build (D&B), and design, build, finance and operate (DBFO). It was stimulated by the need to explain these ideas to a client using target contracts with unbalanced risk sharing, a common practice. Best practice requires a balanced approach, and the difference is significant. Best practice also involves a number of other relevant features. This paper concludes that full integration of contract choice decisions and other aspects of a best practice approach to risk management is practical and advantageous
Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia
Get PDFPI3K is critical for the normal function of the immune system, however dysregulated PI3K mediated signaling has been linked to the development of many immune mediated pathologies. This review describes current progress in the development of isoform-specific PI3K inhibitors that hold promise for the treatment of hematopoietic malignancies as well as for inflammatory and autoimmune diseases. A SH2-domain containing inositol-5-phosphatase (SHIP) is a regulator of PI3K signaling, and is also discussed as a potential drug target for immunomodulation and the treatment of leukemia. Recent progress has been made in the development of small molecule compounds that potently and selectively modulate SHIP activity and hence provide a novel mechanism to alter PI3K mediated signaling
Pharmacological Targeting of Phosphoinositide Lipid Kinases and Phosphatases in the Immune System: Success, Disappointment and New Opportunities
Get PDFThe predominant expression of the γ and δ isoforms of PI3K in cells of hematopoietic lineage prompted speculation that inhibitors of these isoforms could offer opportunities for selective targeting of PI3K in the immune system in a range of immune-related pathologies. While there has been some success in developing PI3Kδ inhibitors, progress in developing selective inhibitors of PI3Kγ has been rather disappointing. This has prompted the search for alternative targets with which to modulate PI3K signalling specifically in the immune system. One such target is the SH2-domain containing inositol-5-phosphatase-1 (SHIP-1) which de-phosphorylates PI(3,4,5)P3 at the D5 position of the inositol ring to create PI(3,4)P2. In this article, we first describe the current state of PI3K isoform-selective inhibitor development. We then focus on the structure of SHIP-1 and its function in the immune system. Finally, we consider the current state of development of small molecule compounds that potently and selectively modulate SHIP activity and which offer novel opportunities to manipulate PI3K mediated signalling in the immune system
Blacktown near the station [cartographic material] : for auction sale on the ground on Saturday 24th June 1893 at 3 p.m. /
No full textSales plan of land in Blacktown bordered by Railway Street, Government Road, Wallace Street, Oxford Street, Bruce Street, Boyd Street, Clifton Street, Gordon Street, Douglas Street, Sarsfield Street, Sydney Street, Cardiff Street, Harold Street, Mort Street, Stephen Street, Sackville Street and Cambridge Street.; "Terms:- for 1 allotment, 1.00 deposit, and 6 equal monthly instalments ; for 2 or more allotments, 15/. a lot deposit, and 12 equal monthly payments".; "J. Haydon Cardew, licensed surveyor under Real Property Act, 75 Pitt St., opposite the exchange, Sydney".; "Holdsworth & Son, solicitors to the estate 75 Pitt Street Sydney".; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map-lfsp316
Preparing the NDE engineers of the future: Education, training, and diversity
Get PDFAs quantitative NDE has matured and entered the mainstream, it has created an industry need for engineers who can select, evaluate, and qualify NDE techniques to satisfy quantitative engineering requirements. NDE as a field is cross-disciplinary with major NDE techniques relying on a broad spectrum of physics disciplines including fluid mechanics, electromagnetics, mechanical waves, and high energy physics. An NDE engineer needs broad and deep understanding of the measurement physics across modalities, a general engineering background, and familiarity with shop-floor practices and tools. While there are a wide range of certification and training programs worldwide for NDE technicians, there are few programs aimed at engineers. At the same time, substantial demographic shifts are underway with many experienced NDE engineers and technicians nearing retirement, and with new generations coming from much more diverse backgrounds. There is a need for more and better education opportunities for NDE engineers. Both teaching and learning NDE engineering are inherently challenging because of the breadth and depth of knowledge required. At the same time, sustaining the field in a more diverse era will require broadening participation of previously underrepresented groups. The QNDE 2016 conference in Atlanta, GA included a session on NDE education, training, and diversity. This paper summarizes the outcomes and discussion from this session.This proceeding may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.
This proceeding appeared in Holland, Stephen D. "Preparing the NDE engineers of the future: Education, training, and diversity." In AIP Conference Proceedings, vol. 1806, no. 1, p. 020015. AIP Publishing LLC, 2017. and may be found at
DOI: 10.1063/1.4974556.
Copyright 2017 Author(s).
Posted with permission
Stephen McCullagh
No full textThe author discusses the life of Stephen McCullagh, who was a pioneer Australian Adventist evangelist who worked closely with Ellen White to purchase the Brettville Estate, upon which Avondale College was later established
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