3,418 research outputs found
On-chip Microdialysis System with Flow-through Glucose Sensing Capabilities
No full textThe published version of this article is available at http://www.journalofdst.org/May2007/pdf/VOL-1-3-ORG3-HSIEH.pd
World Happiness Report 2017
No full text1. Overview
John F. Helliwell, Richard Layard and Jeffrey D. Sachs
2. Social Foundations of World Happiness
John F. Helliwell, Haifang Huang and Shun Wang
3. Growth and Happiness in China, 1990-2015
Richard A. Easterlin, Fei Wang and Shun Wang
4. ‘Waiting for Happiness’ in Africa
Valerie Møller, Benjamin Roberts, Habib Tiliouine and Jay Loschky
5. The Key Determinants of Happiness and Misery
Andrew Clark, Sarah Flèche, Richard Layard, Nattavudh Powdthavee and George Ward
6. Happiness at Work
Jan-Emmanuel De Neve and George Ward
7. Restoring American Happiness
Jeffrey D. Sach
sj-pdf-1-pim-10.1177_14750902221123845 – Supplemental material for Comparison of open- and closed-loop operating strategies for exhaust gas scrubbing in marine applications: Modeling and sea-trial data
No full textSupplemental material, sj-pdf-1-pim-10.1177_14750902221123845 for Comparison of open- and closed-loop operating strategies for exhaust gas scrubbing in marine applications: Modeling and sea-trial data by Ihsuan Lee, Ting Chang, Changken Chang, Van Dai Hai Truong and Jeffrey D Ward in Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment</p
Non-Invasive Glucose Monitoring: A Novel Approach
No full textBackground: The main concern in noninvasive (NI) glucose measurement is achieving high accuracy readings, although no blood (or other fluid) is involved in the process. Using methods based on different physical properties of a measured object can ensure the independence of each of the readings and therefore improve the validity of the end result. By using a combination of (three) independent technologies—ultrasonic, electromagnetic, and thermal—GlucoTrack™ presents a unique approach for a real-time, truly NI blood glucose spot measurement. Methods: Clinical trials were performed in two stages. Stage 1 was an initial method validation and performance verification of the device. In this stage, 50 type 1 and 2 diabetic patients, as well as healthy subjects, were evaluated with GlucoTrack against Ascensia Elite® (Bayer). In the second stage, 85 additional diabetic subjects were evaluated in half and full daytime sessions using a GlucoTrack comparison with HemoCue® (Glucose 201+). Results: A total of 135 subjects were tested during the trial period, producing 793 data pairs. Using Clarke error grid analysis, 92% of the readings fell in the clinically acceptable zones A and B, with 50% in the A zone. Mean and median relative absolute differences were 29.9 and 19.9%, respectively. Conclusions: Integrating several modalities for NI assessment of glucose level enables more accurate readings, while a possible aberration in one modality is bypassed by the others. The present generation of GlucoTrack gives promising results; however, further improvement of the accuracy of the device is needed.The published version of this article is available at http://www.journalofdst.org/amember/plugins/protect/new_rewrite/login.php?v=-any&url=/March2009/Articles/VOL-3-2-SYM4-HARMAN-BOEHM.pdf%3
sj-docx-1-dhj-10.1177_20552076231216547 - Supplemental material for Using web analytics data to identify platforms and content that best engage high-priority HIV populations in online and social media marketing advertisements
No full textSupplemental material, sj-docx-1-dhj-10.1177_20552076231216547 for Using web analytics data to identify platforms and content that best engage high-priority HIV populations in online and social media marketing advertisements by Tyler B Wray, Philip A Chan, Jeffrey D Klausner, Lori M Ward, Abraham Y Liu, Daniel J Carr, Erik MS Ocean, Chanda Phelan and Tao Liu in DIGITAL HEALTH</p
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
Full text linkMutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in presymptomatic CTSD knockout (Ctsd) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease progression in the hippocampus and thalamus of the Ctsd mice. Electrophysiology revealed a markedly decreased frequency of miniature excitatory postsynaptic currents (mEPSCs) with no effect on paired-pulse modulation of the evoked excitatory post synaptic potentials in the hippocampus of Ctsd mice. The reduced mEPSCs frequency was observed before the appearance of epilepsy or any morphologic sign of synaptic degeneration. Taken together, these data indicate that CTSD is required for normal synaptic function and that a failure in synaptic trafficking or recycling may bean early and important pathologic mechanism in Ctsd mice; these presynaptic abnormalities may initiate synaptic degeneration in advance of subsequent neuronal loss
Recommended from our members
Louis D. Brandeis ::American Prophet /
No full textA riveting new examination of the leading progressive justice of his era, published in the centennial year of his confirmation to the U.S. Supreme Court According to Jeffrey Rosen, Louis D. Brandeis was "the Jewish Jefferson," the greatest critic of what he called "the curse of bigness," in business and government, since the author of the Declaration of Independence. Published to commemorate the hundredth anniversary of his Supreme Court confirmation on June 1, 1916, Louis D. Brandeis: American Prophet argues that Brandeis was the most farseeing constitutional philosopher of the twentieth century. In addition to writing the most famous article on the right to privacy, he also wrote the most important Supreme Court opinions about free speech, freedom from government surveillance, and freedom of thought and opinion. And as the leader of the American Zionist movement, he convinced Woodrow Wilson and the British government to recognize a Jewish homeland in Palestine. Combining narrative biography with a passionate argument for why Brandeis matters today, Rosen explores what Brandeis, the Jeffersonian prophet, can teach us about historic and contemporary questions involving the Constitution, monopoly, corporate and federal power, technology, privacy, free speech, and Zionism
- …
