172 research outputs found
Otitis Media Progressing to Community-Acquired Meningitis in Diabetic Patients: A Case Report of K2-ST375 hypervirulent Klebsiella pneumoniae and Literature Review
No full textShanshan Jin,1,2,* Hui Xie,1,* Ruilan Wang1,2 1Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, People’s Republic of China; 2Department of Critical Care Medicine, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ruilan Wang, Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, People’s Republic of China, Email [email protected]: Community-acquired Klebsiella pneumoniae meningitis (CA-KPM) can rapidly progress to invasive infection in healthy individuals. We present the case of a 54-year-old man with a history of acute suppurative otitis media and uncontrolled type 2 diabetes mellitus (T2DM), who had been treated with oral antibiotics intermittently and irregularly for one month. His symptoms did not improve and continued to worsen, leading to fever and coma. Metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) identified Klebsiella pneumoniae (KP) after 24 hours in the intensive care unit (ICU). Subsequent CSF culture confirmed a hypervirulent KP (hvKp) strain with capsular genotype K2 and sequence type (ST) 375. Fortunately, the patient made a full recovery with targeted antimicrobial therapy and was discharged. Despite the delayed diagnosis, the outcome was favorable. This case highlights the importance of clinicians, particularly otolaryngologists, maintaining a high index of suspicion for CA-KPM in patients with both otitis media and T2DM, emphasizing the need for timely multidisciplinary consultation.Keywords: Klebsiella pneumoniae, hypervirulent, case report, meningitis, community-acquire
ADVANCING POLYMER MEMBRANES THROUGH CONFIGURATIONAL FREE VOLUME AND MEASUREMENT INNOVATIONS
No full textThis dissertation explores the impacts of configurational free volume, introduced through triptycene units, on the transport properties of condensable vapors and gases in thermally rearranged polybenzoxazole-based polymers as well as their polyhydroxyimide precursors which are not thermally treated. Through a series of in-depth studies, we elucidate the fundamental mechanisms governing solubility, diffusivity, and selectivity in these materials, offering insights into their potential applications in molecular separations. Chapter 1 presents pioneering findings on how triptycene-containing polybenzoxazoles (TPBOs) mediate condensable vapor transport, demonstrating size-controlled (entropically driven) sorption and diffusion, quite unlike conventional glassy polymers. This configurational free volume facilitates the tuning of sorption and diffusion selectivity, potentially unlocking routes to de-bottleneck limitations in current state-of-the-art membrane performance. Chapter 2 extends this investigation to light gases (N2, CH4, and CO2), proposing a mechanism for molecule transport in configurational free volume. By varying triptycene content, we analyze the effects (and lack thereof) on the components of CO2/CH4 selectivity, uncovering that configurational free volume exclusively regulates light gas diffusion selectivity in the Langmuir mode without affecting the other components of selectivity. Chapter 3 addresses the critical issue of data reliability in solubility measurements, proposing a standardized methodology for estimating uncertainty in sorption and adsorption measurements. This study lays out a framework for understanding factors that contribute to measurement error, and comprehensively addresses accurate comparison between solubility measurements within a single lab, as well as across laboratories worldwide, which is critical in the previous two chapters. Chapter 5 investigates the swelling behavior of TPBOs, revealing that configurational free volume and thermal rearrangement collectively and synergistically enhance swelling resistance, a crucial factor for membrane stability and performance in real-world applications. It also brings in techniques from Chapter 3 and data science to demonstrate a novel dilatometry analysis method. This comprehensive study not only lays out an advancement in our understanding of configurational free volume, but also provides measurement and error analysis standardizations in the membrane field. The work may be of practical use to researchers seeking to improve the rational design of membranes and the design of extremely accurate apparatuses geared towards membrane and polymer sciences, such as the sorption and dilation apparatuses discussed herein
The Apply of the Adjustable Modifying Factor Fuzzy-PID Control in Constant Pressure Water Supply System
No full textThe Design of Temperature and Humidity Control System Based on Fuzzy Control in Multi Incubators
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The Miniaturization of Active Vibration Control System Based on Digital Signal Processor
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The design of temperature and humidity control system in multi incubators based on single-chip microcomputer
No full textPorous Se@SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress
No full textYong Zhu,1,* Guoying Deng,2,* Anqi Ji,2 Jiayi Yao,1 Xiaoxiao Meng,1 Jinfeng Wang,1 Qian Wang,2 Qiugen Wang,2 Ruilan Wang1 1Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, 2Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China *These authors contributed equally to this work Abstract: Acute paraquat (PQ) poisoning is one of the most common forms of pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative stress and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells were used in this study. Rats were categorized into 3 groups: control (n=6), PQ (n=18), and PQ + Se@SiO2 (n=18). The PQ and PQ + Se@SiO2 groups were randomly and evenly divided into 3 sub-groups according to different time points (24, 48 and 72 h) after PQ treatment. Porous Se@SiO2 nanospheres 1 mg/kg (in the PQ + Se@SiO2 group) were administered via intraperitoneal injection every 24 h. Expression levels of reduced glutathione, malondialdehyde, superoxide dismutase, reactive oxygen species (ROS), nuclear factor-κB (NF-κB), phosphorylated NF-κB (p-NF-κB), tumor necrosis factor-α and interleukin-1β were detected, and a histological analysis of rat lung tissues was performed. The results showed that the levels of ROS, malondialdehyde, NF-κB, p-NF-κB, tumor necrosis factor-α and interleukin-1β were markedly increased after PQ treatment. Glutathione and superoxide dismutase levels were reduced. However, treatment with porous Se@SiO2 nanospheres markedly alleviated PQ-induced oxidative stress and inflammation. Additionally, the results from histological examinations and wet-to-dry weight ratios of rat lung tissues showed that lung damage was reduced after porous Se@SiO2 nanosphere treatment. These data indicate that porous Se@SiO2 nanospheres may reduce NF-κB, p-NF-κB and inflammatory cytokine levels by inhibiting ROS in PQ-induced ALI. This study demonstrates that porous Se@SiO2 nanospheres may be a therapeutic method for use in the future for PQ poisoning. Keywords: porous Se@SiO2 nanospheres, acute lung injury, paraquat poisoning, oxidative stress, inflammatory cytokines, ROS, NF-kappa
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