882 research outputs found

    The semiotics of printed instructions (graphic signa)

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    This thesis sets out to describe sign systems for communication using Axiomatic Functionalism as its theoretical framework. In doing so, the thesis also provides an important test to the claim of Axiomatic Functionalism that by using its premisses the semiotician (or linguist) has all the necessary "tools" s/he needs for the analysis and description (the one implies the other) of any semiotic system for communication (including Language). Using Axiomatic Functionalism the author attempts to describe a number of graphic semiotic systems for communication. He finds that for an adequate description of the signa (a generic term which includes various types of signs and symbols) in these systems further theoretical notions and definitions are needed. Discussing these the author concludes that for Axiomatic Functionalism to maintain its claim of universal applicability to any sign system for communication it needs to incorporate in its premisses the notions and definitions proposed here. The thesis begins by a brief general introduction to semiotics. This is followed by a discussion of what constitutes scientific theories in relation to semiotics (including linguistics). The relevant aspects of Axiomatic Functionalism are then discussed, after which certain original theoretical notions are introduced. These include: “mnemonic economy" (with its many manifestations including "mnemonic/pictorial motivation"), the "general organising principle" ("systemic principle"), "principle of coinage" (a mechanism for generating signa), and "signum-family”. Having established the necessary theoretical background, the author proceeds to describe various graphic “signum-systems" discussing their important features and establishing the types of signum they consist of and, consequently, the types of system they are, their complexity and the "plerology” (grammar) of each system, where present. The systems discussed include various systems used in books on plants; a system used in a book on "lace knitting"; a system used in working models; a system used in providing information about paintings in the "Classics of World Art" series of books; and a system used in the "Automobile Association" handbooks. Further Axiomatic Functionalist theoretical notions, directly relevant to the systems described thereafter, are then introduced. This is followed by a description of three systems: two computer "languages", the "Hexadecimal notation" and the "binary code", and the "Library of Congress classification system". A final brief "Epilogue" concludes the thesis

    Bioactivity-guided Isolation of Antiosteoporotic Compounds from Ligustrum lucidum

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    The fruits of Ligustrum lucidum (FLL) has long been used for the treatment of osteoporosis in China, but the antiosteoporotic compounds in FLL are still poorly understood. In this study, the alkaline phosphatase (ALP) activity-guided isolation of osteogenic components from FLL was carried out by using osteoblast-like UMR-106 cells. Eight compounds, namely tyrosol (1), tyrosyl acetate (2), hydroxytyrosol (3), salidroside (4), oleoside dimethyl ester (5), oleoside-7-ethyl-11-methyl ester (6), nuzhenide (7), and G13 (8), were isolated and identified. Further study showed that compounds 3, 4, 7, and 8 increased ALP activity in UMR-106 cells. Compounds 5, 6, and 7 promoted the proliferation of UMR-106 cells. The aqueous extract of FLL-activated ER/-mediated gene transcription, whereas the isolated compounds were inactive. All eight isolated compounds also exhibited antioxidative activity, with compounds 1, 2, and 3 being the most potent. These results indicate that the antiosteoporotic effect of FLL is derived from different compounds together with different mechanisms such as ER-dependent or independent pathways and antioxidative effects. Salidroside (4) and nuzhenide (7) warrant further investigation as new pharmaceutical tools for the prevention and treatment of osteoporosis

    Identification and Pathogenicity Analysis of Huaxiibacter chinensis Qf-1 in Mink (Neogale vison)

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    Mink (Neogale vison) is a commercially farmed animal of global importance. However, disease outbreaks during farming not only cause significant economic losses but also substantially increase the risk of zoonotic infections. The identification and characterization of pathogenic bacteria remain a major bottleneck restricting the development of healthy and sustainable mink farming. In this study, an LB medium was used to isolate a pale-white, rod-shaped, Gram-negative bacterial strain, Qf-1, from minks with pneumonia. Based on morphological characteristics, biochemical properties, 16S rRNA gene sequencing, and average nucleotide identity (ANI) analysis, strain Qf-1 was identified as Huaxiibacter chinensis Qf-1. Under laboratory conditions, H. chinensis Qf-1 induced typical pneumonia symptoms in Kunming mice. Furthermore, whole-genome sequencing of H. chinensis Qf-1 revealed its genome to be 4.77 Mb and to contain a single chromosome and one plasmid. The main virulence genes of H. chinensis Qf-1 were primarily associated with flgB, flgC, flgG, aceA, hemL, tssC1, csgD, hofB, ppdD, hcpA, and vgrGA, functioning in motility, biofilm formation, colonization ability, and secretion systems. Our findings contribute to a better understanding of their pathogenic mechanisms, thereby laying a theoretical foundation for further investigation into the complex interactions between gut microbiota and the host

    Kinetics fitting of Qf and Qb for apo and bound states for NCBD and TAD.

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    <p>Kinetics fitting of Qf and Qb for apo and bound states for NCBD and TAD.</p

    Phase Transition and Oxygen Ion Diffusion in (La_(1-x)Ln_x)_2Mo_2O_9 (Ln=Nd, Gd, x=0.05-0.25) Using Dielectric Relaxation Method

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    Dielectric relaxation method was employed to study the properties of oxygen ion diffusion and phase transition in the oxide-ion conductors (La_(1-x)Ln_x)_2Mo_2O_9 (Ln = Nd, Gd, x = 0.05-0.25). Two dielectric loss peaks were observed: peak Pd at about 600 K and peak Ph around 720 K. Peak Pd is a relaxational peak and associated with the short-range diffusion of oxygen ions, while peak Ph hardly changes its position and dramatically decreases in height with increasing frequency, exhibiting non-relaxational nature. With increasing Ln~(3+) concentration, the heights of peak Ph and Pd increase at first and then decrease after passing a maximum at 15% doping. It is suggested that peak Ph is related to the phase transition of a static disordered state to a dynamic disordered state in oxygen ions/vacancies distribution. It is found that the 15%Gd or 15%Nd doped La_2Mo_2O_9 samples exhibit the highest conductivity in accordance with the highest height of peak Pd at this doping content
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