6,294 research outputs found
Two-dimensional analysis of axial segregation in batchwise and continuous Czochralski process
No full textTransient two-dimensional convection-diffusion model has been developed to simulate the segregation phenomena in batchwise and continuous Czochralski process. Numerical simulations have been performed using the finite element method and implicit Euler time integration. The mesh deformation due to the change of the melt depth in batchwise Czochralski process was considered. Experimental values of the growth and system, parameters for Czochralski growth of boron-doped, 4-in silicon single crystal were used in the numerical calculations. The experimental axial segregation in batchwise Czochralski process can be described successfully using convection-diffusion model. It has been demonstrated with this model that silicon single crystal with uniform axial dopant concentration can be grown and radial segregation can be suppressed in the continuous Czochralski process. (C) 1999 Published by Elsevier Science B.V. All rights reserved
Comparisons between different indices of exercise performance in absolute and normalized values in patients with chronic obstructive pulmonary diseases
No full textEffects of an abdominal binder and electrical stimulation on cough in patients with spinal cord injury.
No full textVentilatory and mouth occlusion pressure responses to hypercapnia in chronic tetraplegia
No full textTHE PAN-PACIFIC PLANET SEARCH. VI. GIANT PLANETS ORBITING HD 86950 AND HD 222076
No full textWe report the detection of two new planets orbiting the K giants HD 86950 and HD 222076, based on precise radial velocities obtained with three instruments: AAT/UCLES, FEROS, and CHIRON. HD 86950b has a period of 1270 +/- 57 days at a=2.72 +/- 0.08 AU, and m sin i=3.6 +/- 0.7 M-Jup. HD 222076b has P=871 +/- 19 days at a=1.83 +/- 0.03 AU, and m sin i=1.56 +/- 0.11 M-Jup. These two giant planets are typical of the population of planets known to orbit evolved stars. In addition, we find a high-amplitude periodic velocity signal (K similar to 50 m/s(-1)) in HD 29399, and show that it is due to stellar variability rather than Keplerian reflex motion. We also investigate the relation between planet occurrence and host-star metallicity for the 164-star Pan-Pacific Planet Search sample of evolved stars. In spite of the small sample of PPPS detections, we confirm the trend of increasing planet occurrence as a function of metallicity found by other studies of planets orbiting evolved stars.FONDECY
Effects of abdominal binder and electrical stimulation on cough in patients with spinal cord injury
No full text
Short-interval observational data to inform clinical trial design in Huntington's disease.
No full textOBJECTIVES: To evaluate candidate outcomes for disease-modifying trials in Huntington's disease (HD) over 6-month, 9-month and 15-month intervals, across multiple domains. To present guidelines on rapid efficacy readouts for disease-modifying trials. METHODS: 40 controls and 61 patients with HD, recruited from four EU sites, underwent 3 T MRI and standard clinical and cognitive assessments at baseline, 6 and 15 months. Neuroimaging analysis included global and regional change in macrostructure (atrophy and cortical thinning), and microstructure (diffusion metrics). The main outcome was longitudinal effect size (ES) for each outcome. Such ESs can be used to calculate sample-size requirements for clinical trials for hypothesised treatment efficacies. RESULTS: Longitudinal changes in macrostructural neuroimaging measures such as caudate atrophy and ventricular expansion were significantly larger in HD than controls, giving rise to consistently large ES over the 6-month, 9-month and 15-month intervals. Analogous ESs for cortical metrics were smaller with wide CIs. Microstructural (diffusion) neuroimaging metrics ESs were also typically smaller over the shorter intervals, although caudate diffusivity metrics performed strongly over 9 and 15 months. Clinical and cognitive outcomes exhibited small longitudinal ESs, particularly over 6-month and 9-month intervals, with wide CIs, indicating a lack of precision. CONCLUSIONS: To exploit the potential power of specific neuroimaging measures such as caudate atrophy in disease-modifying trials, we propose their use as (1) initial short-term readouts in early phase/proof-of-concept studies over 6 or 9 months, and (2) secondary end points in efficacy studies over longer periods such as 15 months
Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy.
No full textTRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD). The cross-sectional data from this large well-characterized dataset provide the opportunity to improve our knowledge of how the underlying neuropathology of HD may contribute to the clinical manifestations of the disease across the spectrum of premanifest (PreHD) and early HD. Two hundred and thirty nine gene-positive subjects (120 PreHD and 119 early HD) from the TRACK-HD study were included. Using voxel-based morphometry (VBM), grey and white matter volumes were correlated with performance in four domains: quantitative motor (tongue force, metronome tapping, and gait); oculomotor [anti-saccade error rate (ASE)]; cognition (negative emotion recognition, spot the change and the University of Pennsylvania smell identification test) and neuropsychiatric measures (apathy, affect and irritability). After adjusting for estimated disease severity, regionally specific associations between structural loss and task performance were found (familywise error corrected, P < 0.05); impairment in tongue force, metronome tapping and ASE were all associated with striatal loss. Additionally, tongue force deficits and ASE were associated with volume reduction in the occipital lobe. Impaired recognition of negative emotions was associated with volumetric reductions in the precuneus and cuneus. Our study reveals specific associations between atrophy and decline in a range of clinical modalities, demonstrating the utility of VBM correlation analysis for investigating these relationships in HD
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