163,388 research outputs found
Letter from Frank Chin
No full textA letter from Frank Chin arguing that their should be a day name after Japanese American activist James Omura, and describing the kind of celebration that should take place in his honor. The day Chin proposes in November 27th, Omura's birthday.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Letter from [Frank] Chin to Paul [Tsuneishi], December 23, 1997
No full textA letter to Paul [Tsuneishi] from [Frank] Chin about planning the speakers and the media outreach for "Michi Day," the event to celebrate author Michi Weglyn and her book "Years of Infamy."These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Letter from [Frank] Chin to David
No full textA letter from [Frank] Chin to David about buying space for a classified ad in the New York Times Sunday Book Review, that will mention the tribute to Michi Weglyn in February of 1998. The purpose of the ad is to solicit "photos and artifacts depicting the different phases of Michi's life." Chin writes that the materials will be used in"Yosh Kurimoya's Michi Show" at the event.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Letter from Frank Chin to Dale [Minami], December 7, 1997
No full textA letter from Frank Chin to Dale [Minami] thanking him for sending a VHS clip for "Michi Day." Chin devotes the bulk of the letter to a proposal for creating a bell, that would be made of pieces of metal from incarceration camps, to celebrate Japanese American redress.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Letter from [Frank Chin] to Momo and Lawson, January 21, 1998
No full textA letter to Momo and Lawson, possibly from Frank Chin, about a performance of the story Kaguya Hime, princess of the moon in Japanese folklore. The purpose of the performance is to drum up interest for the children's storytelling event that would be part of the tribute to Michi Weglyn on February 21, 1998.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Sogana robustocarina Liang & Wang 2008
No full textSogana robustocarina Liang & Wang, 2008 (Fig. 3) Sogana robustocarina Liang & Wang, 2008: 40. Geographical data (Liang & Wang, 2008). Malaysia, Sabah (Borneo) Kalabakan (coordinates: 4°25'N 117°29'E); Keningau (erroneously spelled “Keningan” in Liang & Wang, 2008) (coordinates: 5°20'N 116°10'E).Published as part of Constant, Jerome, 2010, Sogana from the Greater Sunda (Hemiptera: Fulgoromorpha: Tropiduchidae), pp. 63-68 in Zootaxa 2693 (1) on page 67, DOI: 10.11646/zootaxa.2693.1.6, http://zenodo.org/record/530363
Identification and Functional Analysis of Two New De Novo KCNMA1 Variants Associated with Liang-Wang syndrome.
Get PDFAIM
Loss-of-function KCNMA1 variants cause Liang-Wang syndrome (MIM #618729), a newly-identified multiple malformation syndrome with a broad spectrum of developmental and neurological phenotypes. However, the full spectrum of clinical features and underlying pathogenic mechanisms need full elucidation.
METHODS
Exome sequencing was used to identify pathogenic variants. Patch-clamp recordings were performed to access the effects of KCNMA1 variants on BK channels. Total and membrane protein expression levels of BK channels were characterized using Western blotting.
RESULTS
We report identification and functional characterization of two new de novo loss-of-function KCNMA1 variants p.(A172T) and p.(A314T) with characteristics of Liang-Wang syndrome. Variant p.(A172T) is associated with developmental delay, cognitive impairment, and ataxia. Mechanistically, p.(A172T) abolishes BK potassium current, inhibits Mg2+ -dependent gating, but shifts conductance-voltage (G-V) curves to more positive potentials when complexed with WT channels. Variant p.(A314T) is associated with developmental delay, intellectual disability, cognitive impairment, mild ataxia, and generalized epilepsy, suppresses BK current amplitude, and shifts G-V curves to more positive potentials when expressed with WT channels. In addition, two new patients with previously reported gain-of-function variants p.(N536H) and p.(N995S) are found to show epilepsy and paroxysmal dyskinesia as reported previously, but also exhibit additional symptoms of cognitive impairment, and dysmorphic features. Furthermore, variants p.(A314T) and p.(N536H) reduced total and membrane levels of BK proteins.
CONCLUSION
Our findings identified two new loss-of-function mutations of KCNMA1 associated with Liang-Wang syndrome, expanded the spectrum of clinical features associated with gain-of-function KCNMA1 variants, and emphasized the overlapping features shared by gain-of-function and loss-of-function mutations
An Empirical Analysis of Amazon EC2 Spot Instance Features Affecting Cost-effective Resource Procurement
No full text<p>This repository contains code and data for the paper "An Empirical Analysis of Amazon EC2 Spot Instance Features Affecting Cost-effective Resource Procurement", by Cheng Wang, Qianlin Liang and Bhuvan Urgaonkar.</p>
Letter from Michi Weglyn to Frank Chin
No full textA letter from Michi Weglyn to Frank Chin about another letter written by Lilian Baker, a conservative author who denied that Japanese American incarceration had taken place during World War II.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
Mes de la fotografía: Tzeng - Chin Fa
No full textEl Mes de la fotografía compartirá en esta edición las obras de cinco reconocidos fotógrafos de Taiwán que serán expuestas en el emblemático pasaje Santa Rosa a pocos metros de la Plaza Mayor de Lima. La carrera de Comunicación y Fotografía de la Universidad Peruana de Ciencias Aplicadas (UPC) con el apoyo de la Oficina Económica y Cultural de Taipéi en Lima y el Programa Spotlight Taiwán del Ministerio de Cultura de Taiwán compartirán a la sociedad peruana el trabajo fotográfico de Annie Hsiao-Ching Wang, Yehlin Lee, Shen Chao-Liang, Ze Wei y Tzen Chin-Fa
- …
