12 research outputs found
Numerical Study of the Combustion Field in Dual-cavity Scramjet Combustor
No full textAbstractAs one of the most effective structures of flame stabilizer, cavity owns an important position in scramjet combustor research, especially the tandem dual-cavity, which has a remarkable advantage in promoting fuel airmixing and flame stability.In this paper,flow field characters of dual-cavity scramjet combustor were analyzed in details without and with combustion. The results show that, under the interaction of cavity flow and fuel injection, two sizes of vortexes were formed in the upstream cavity after combustion. The bigger vortex provides a stable flame and the smaller one protects the upstream cavity back wall from heat in a certain extent. Additionally, the unburned fuel was blew away to the downstream cavity for a further combustion as soon as it meets high-speed main stream, which is helpful to improve combustion efficiency and to make the scramjet combustor shorter. And the mass of kerosene drifted into cavities was determined by fuel-jet velocity, whichwould have an indirect effect on the combustion efficiency
Numerical Simulation of Ignition Process in Multi-cavity Combustors at High Supersonic Flight Condition
No full textNumerical investigation on the assistant restarting method of variable geometry for high Mach number inlet
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Application of hNGF<i>β</i>-Modified Adipose-Derived Stem Cells in Treating Cavernous Nerve Injury-Induced Erectile Dysfunction in Rat Models
No full textRapid and low-cost strategy for detecting genome-editing induced deletion: A single-copy case
No full textIbrutinib Inhibits BTK Signaling in Tumor-Infiltrated B Cells and Amplifies Antitumor Immunity by PD-1 Checkpoint Blockade for Metastatic Prostate Cancer
No full textMetastatic prostate cancer (PCa) remains incurable and causes considerably diminished overall survival. Despite significant progress in pharmacotherapy, the disease prognosis remains unchanged. Immune checkpoint inhibitors (ICIs) have demonstrated effectiveness in treating various advanced malignancies, but their efficacy in metastatic PCa is relatively limited. Previous studies have confirmed the immunosuppressive role of tumor-infiltrating B cells (TIL-Bs) in the PCa microenvironment, which accounts for their poor immunogenic potency. In this study, we demonstrated that an oral kinase agent, ibrutinib, strongly potentiated anti-PD-1 checkpoint blockade efficacy and successfully controlled tumor growth in a murine orthotopic PCa model constructed using a metastatic and hormone-independent cell line (RM-1). We identified close relationships between TIL-Bs, Bruton’s tyrosine kinase (BTK), and immunosuppressive molecules by bioinformatics and histological analysis. An in vitro study showed that a low dose of ibrutinib significantly inhibited B cell proliferation and activation as well as IL-10 production through the BTK pathway. Moreover, ibrutinib-treated B cells promoted CD8+ T cell proliferation and inhibitory receptor (IR) expression. However, the same dose of ibrutinib was insufficient to induce apoptosis in cancer cells. An in vivo study showed that ibrutinib monotherapy failed to achieve tumor regression in murine models but decreased B cell infiltration and inhibited activation and IL-10 production. More importantly, CD8+ T cell infiltration increased with high IR expression. Ibrutinib synergized with anti-PD-1 checkpoint blockade enormously improved antitumor immunity, thereby reducing tumor volume in the same scenario. These data set the scene for the clinical development of ibrutinib as an immunogenic trigger to potentiate anti-PD-1 checkpoint blockade for metastatic PCa immunotherapy
MicroRNA-145 engineered bone marrow-derived mesenchymal stem cells alleviated erectile dysfunction in aged rats
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