9,576 research outputs found

    Caliscelis rhabdocladis Che & Wang & Zhang 2011, sp. nov.

    No full text
    Caliscelis rhabdocladis, sp. nov. Figs 7–12, 35–44 Description. Length, male: 4.0– 4.4 mm, length of tegmen: 2.3–2.4mm; female: 5.8–6.0mm, length of tegmen: 2.4–2.6mm. Male. Body dark brown, with pale brown maculae (Fig. 7). Vertex brown, suffused with blackish brown (Fig. 7). Eyes blackish brown. Frons brown, suffused with dark brown spots; clypeus dark brown (Fig. 8). Rostrum pale brown. Pronotum white and mesoscutellum brown with dark brown spots (Fig. 7). Tegmina dark brown with white stripe (Fig. 7). Legs reddish brown, fore femora and tibia blackish brown, hind femora with black stripe (Fig. 9). Dorsum of the abdomen brown with pale brown stripe and dark brown spots, and venter blackish brown with yellow stripe (Figs 7, 9). Female. Body pale brown with brown maculae, with pale brown stripe in the middle of dorsum (Figs 10–12). Vertex subquadrilateral, with anterior margin somewhat convex and posterior margin nearly truncate, 3.3× wider at apex than length in middle line (Fig. 7), disc evidently depressed. Frons not elevated with lateral carinae present only near apical part; disc finely granulose, anterior margin evidently concave, 1.1× wider at widest part than at base, midlength 1.3× longer than greatest width (Fig. 8). Frontoclypeal suture nearly straight. Clypeus smooth, without carina, disc evidently elevated (Fig. 8). Pronotum wide, medial carina absent. Mesoscutellum broad and short; disc evidently elevated, with lateral carinae, which curves inwards as in Figure 8; 2.1 × wider at widest part than medial length (Fig. 8). Tegmina short, subquadrilateral, with pits on disc; 1.3× longer than widest part; one clubbed stripe from base to inner apex (Fig. 8). Fore femora and tibia distinctly foliately dilated (Figs 9, 35); hind tibia with a lateral tooth near apex. Spinal formula of hind leg 6–2–2. Male genitalia: Anal segment in dorsal view elliptical, apical margin distinctly convex with angles obtuse, evidently longer than medial width, anal foramen near middle (Fig. 37). In lateral view, anal segment relatively small, latero-apical angles downcurved, tapering directed caudad, ventral margin nearly straight (Fig. 36). In lateral view, pygofer with laterodorsal angles slightly prominent, lateral margin strongly sinuate, dorsocaudal angle shallowly produced and narrowed near middle (Fig. 37). Phallus tubular in profile, asymmetrical, connective rod-like and with one short spiniform process near base and one short spiniform process near apex (Figs 38–39). Aedeagus terminating in lobes directed caudad (Figs 38–39), dorsal margin serrulate as Figs 39. Genital styles moderately long, nearly rectangular, about as wide near base as apex; basal margin evidently convex, ventral margin nearly straight; apical margin more or less rounded; dorsal margin near middle produced dorsad in one large and long finger-like lobe (Fig. 36). Female genitalia: Anal segment in dorsal view nearly triangular, apical margin convex with angles rounded, lateral margin smoothly, length in middle longer than widest part, anal foramen in basal half (Fig. 40). Ovipositor with first valvulae narrow with 3 finger-like processes at apex, first valvifer nearly square (Fig. 41); second valvulae with two laminae in apical half united in basal half, the lamina with a row of teeth (about 11) on dorsal margin, proximally, the valvulae with pair of short processes (Figs 42, 43); third valvulae stout, flat medially, nearly rectangular, dorsal part with short notch (Fig. 44). Pregenital sternite with apical margin nearly straight. Material examined Holotype: ♂, China: Beijing, Langfang, 10 Sept. 2010, coll. P. Wang. Paratypes: 1♂ 1♀, same data as holotype; 4♂ 3♀, Beijing, Langfang, 13 June 2011, coll. P. Wang; 1♂, Beijing, Pinggu, 15 July 1981, coll. X. L. Wang. (NWAFU). Distribution. China (Beijing). Remarks. This species resembles C. affinis but it can be distinguished by: 1) frons without median carina, present in C. affinis; 2) mesoscutellum with lateral carinae, absent in C. affinis; 3) fore femora and tibiae distinctly foliately dilated, while in C. affinis, fore femora and tibiae are more or less expanded. Etymology. The specific epithet “rhabdocladus” is derived from Latin, referring to the rod-like connective of the phallus. Notes. This species usually likes to crawl slowly, or jump quickly on reeds, it rarely flies (P. Wang, pers. obs.).Published as part of Che, YL, Wang, YL & Zhang, YL, 2011, Two new species and one new record of the genus Caliscelis de Laporte (Hemiptera: Fulgoroidea: Caliscelidae) from China, pp. 35-48 in Zootaxa 3067 on pages 41-4

    Caliscelis triplicata Che & Wang & Zhang 2011, sp. nov.

    No full text
    Caliscelis triplicata, sp. nov. Figs 13–18, 45–56 Description. Length, male: 4.2–4.3mm, length of tegmen: 2.2mm; female: 5.5–5.7 mm, length of tegmen: 2.3 mm Male. Body brown, with pale brown maculae and dark brown spots (Fig. 13). Vertex and frons brown, suffused with blackish brown spots (Figs 13, 14). Eyes blackish brown. Clypeus brown, with dark brown spots (Fig. 14). Rostrum pale brown. Pronotum and mesoscutellum brown, with dark brown spots and pale brown stripes (Fig. 13). Tegmina brown, with dark brown spots and white stripe (Fig. 13). Legs reddish brown, fore femora and tibia blackish brown, hind femora with black stripe (Figs 13, 15). Dorsum of the abdomen brown with pale brown stripe and dark brown spots, and venter blackish brown with yellow stripe (Figs 13, 15). Female. Body pale brown with brown maculae, with pale brown stripe in the middle of dorsum (Figs 16–18). Vertex subquadrilateral, with anterior margin somewhat convex and posterior margin nearly truncate, 3.2× wider at apex than length in middle line (Fig. 13), disc evidently depressed. Frons not elevated, disc finely granulose, anterior margin evidently concave; frons with median carina and inversed U-shaped lateral carina, 0.9× wider at widest part than at base, midlength 1.4× longer than greatest width (Fig. 14). Frontoclypeal suture nearly straight. Clypeus smooth, without carina, disc evidently elevated. Pronotum wide, medial carina absent. Mesoscutellum broad and short; disc elevated, with lateral carinae, which curved inwards as Fig. 18; 2.2 × wider at widest part than medial length. Tegmina short and subquadrilateral, with pits on disc, 1.3× longer than widest part, one clubbed stripe from base to inner apex (Fig. 13). Fore, middle and hind femora and tibiae more or less foliately dilated (Figs 45–47); Hind tibia with lateral tooth near apex. Spinal formula of hind leg 6–2–2. Male genitalia: Anal segment in dorsal view nearly square, apical margin distinctly convex with angles obtuse, evidently longer than medial width, anal foramen near middle (Fig. 49). In lateral view, anal segment relatively small, tapering caudad, ventral margin nearly straight (Fig. 48). In lateral view, pygofer with laterodorsal angles slightly prominent, lateral margin strongly sinuate, dorsocaudal angle shallowly produced and strongly produced near middle, then narrowed (Fig. 48). Phallus tubular in profile, symmetrical, with two short spiniform processes. Aedeagus terminating in lobes directed caudad (Figs 50–51), ventral margin serrated as in Fig. 50. Genital styles narrow and long, about as wide near base as apex; basal margin evidently convex, ventral margin nearly straight; apical margin more or less rounded; dorsal margin near middle produced dorsad in one large and long finger-like lobe (Fig. 48). Female genitalia: Anal segment in dorsal view nearly elliptical, apical margin strongly convex with angles rounded, lateral margin smoothly but obviously curved, much wider with middle as widest part, anal foramen in basal half (Fig. 52). In lateral view, anal segment relatively narrow, latero-apical angles decurved and acute, ventral margin distinctly curved. Ovipositor with first valvulae narrow and curved dorsally, with three finger-like processes, first valvifer nearly rectangular (Fig. 53); second valvulae with two laminae in apical half united in basal half, the lamina with row of teeth (about 9) on dorsal margin, proximally, the valvulae with pair of short processes dorsally (Figs 54–55); third valvulae flat and stout, nearly rectangular, dorsal part with narrow notch (Fig. 56). Pregenital sternite with apical margin nearly straight. Material examined. Holotype: ♂, China: Xinjiang, Changji, 27 Jun. 1987, coll. M. Wang. Paratypes: 1♂, Xinjiang, Changji, 19 June 1984, collector unknown; 1♀, Xinjiang, Changji, 26 June 1987, coll. M. Wang; 1♀, Xinjiang, Shihezi, 14 July 1979, coll. T. Chen; 1♀, Xinjiang, Manasi, 1984, coll. J. Z. Yang. (NWAFU). Distribution. China (Xinjiang). Remarks. This species resembles C. chinensis, but differs in the following characteristics: 1) fore, middle and hind femora and tibiae are all expanded foliately, while in C. chinensis, only the fore femora and tibia are dilated; 2) tegmina with one pale stripe along the posterior margin, absent in C. chinensis; 3) pronotum and mesoscutellum without median carina, which is present in C. chinensis. Etymology. The specific epithet is derived from the Latin word triplicatus, referring to the foliately expanded fore, middle and hind femora and tibiae.Published as part of Che, YL, Wang, YL & Zhang, YL, 2011, Two new species and one new record of the genus Caliscelis de Laporte (Hemiptera: Fulgoroidea: Caliscelidae) from China, pp. 35-48 in Zootaxa 3067 on pages 42-4

    N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-L-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

    No full text
    Jianhui Wu,1–4 Ming Zhao,1–5 Yuji Wang,1–4 Yaonan Wang,1–4 Haimei Zhu,1–4 Shurui Zhao,1–4 Lin Gui,1–4 Xiaoyi Zhang,1–4 Shiqi Peng1–4 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, 2Engineering Research Center of Endogenous Prophylactic, Ministry of Education of China, 3Beijing Laboratory of Biomedical Materials, 4College of Pharmaceutical Sciences, Capital Medical University, Beijing, People’s Republic of China; 5Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China Abstract: It is well documented that the surfaces of cancer cells, activated platelets and inflammatory cells are rich in P-selectin. N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-l-Phe (HMCEF) is a P-selectin inhibitor capable of simultaneously inhibiting thrombosis and inflammation. Based on the knowledge that P-selectin is a common target for antithrombotic, anti-inflammatory and antitumor drugs, the aim of this study article was to estimate the possibility of HMCEF as a nanoscaled antitumor drug. Images of transmission electron micro­scopy, scanning electron microscopy and atomic force microscopy proved that HMCEF forms nanoparticles with a diameter of <120 nm that promote delivery in blood circulation. In vitro HMCEF intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells. In vivo HMCEF dose dependently (0.2, 2 and 200 nmol/kg per day) slows tumor growth in treated S180 mice, and has a minimal effective dose of 2 nmol/kg per day. At 200 nmol/kg per day, HMCEF does not affect the liver and the kidney of the treated S180 mice, and at 20,000 nmol/kg HMCEF does not affect the liver and the kidney of the treated healthy ICR mice. HMCEF is a promising antitumor drug, which is characterized by its high safety and efficacy in the prevention of the complications of thrombosis and inflammation in patients. Keywords: P-selectin, antitumor, antithrombosis, anti-inflammation, nanomedicin
    corecore