735 research outputs found

    sj-docx-1-tag-10.1177_17562848231210375 – Supplemental material for Peptic ulcer disease burden, trends, and inequalities in 204 countries and territories, 1990–2019: a population-based study

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    Supplemental material, sj-docx-1-tag-10.1177_17562848231210375 for Peptic ulcer disease burden, trends, and inequalities in 204 countries and territories, 1990–2019: a population-based study by Zhongmian Zhang, Weitian Yan, Xiyan Zhang, Jiaqi Wang, Zhonghan Zhang, Zili Lin, Lan Wang, Jiaqin Chen, Daming Liu, Wen Zhang and Zhihong Li in Therapeutic Advances in Gastroenterology</p

    Zircon U-Pb ages, geochemistry, and Nd-Hf isotopes of the TTG gneisses from the Jiaobei terrane: implications for Neoarchean crustal evolution in the North China Craton

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    Abstract not availableHouxiang Shana, Mingguo Zhaia, Fang Wang, Yanyan Zhou, M.Santosh, Xiyan Zhu, Huafeng Zhang, Wei Wan

    Acute kidney injury : more awareness needed, globally

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    Comment on : Li Yang, Guolan Xing, Li Wang, Yonggui Wu, Suhua Li, Gang Xu, Qiang He, Jianghua Chen, Menghua Chen, Xiaohua Liu, Zaizhi Zhu, Lin Yang, Xiyan Lian, Feng Ding, Yun Li, Huamin Wang, Jianqin Wang, Rong Wang, Changlin Mei, Jixian Xu, Rongshan Li, et al., Acute kidney injury in China: a cross-sectional survey, Lancet 2015 The Lancet, Volume 386, Issue 10002, 10–16 October 2015, Pages 1465-147

    Une frontière ouverte à tous les vents : la construction de l’identité collective de l’île de Kinmen

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    L’île de Kinmen, située à seulement 10 km au large des côtes chinoises, en face de Xiamen (capitale de la province du Fujian), fut envahie par Tchang Kaï-Chek en 1949 après son exil à Taïwan, et transformée en base militaire de reconquête de la Chine continentale. En 1992, le gouvernement de Taïwan mit fin à la loi martiale, et métamorphosa l’île en un lieu touristique pour les Taïwanais ainsi que pour les nouveaux touristes venus de Chine continentale. Les touristes viennent à la fois profiter d’espaces préservés de l’expansion urbaine et frissonner devant les images d’un conflit possible entre les deux Républiques de Chine qui continuent de s’ignorer mutuellement du point de vue juridique mais ne cessent d’intensifier leurs échanges. À l’aune de cette conjoncture frontalière, Kinmen semble être un excellent terrain d’observation des recompositions des notions de patrimoine naturel et culturel chinois. À partir d’enquêtes ethnographiques sur les pratiques patrimoniales mises en œuvre sur cette « île-bordure » entre la Chine et Taïwan, nous établirons qu’il a été possible de conserver un héritage architectural autrefois menacé par la guerre, et que ce défi s’est incarné dans l’aphorisme « Le vent Wen souffle fort » (Wen feng ding sheng, 文風鼎盛). Nous mettons ici en évidence que cet adage est la résultante de longs débats qui révèlent peu à peu l’attachement viscéral des autochtones à leur passé et à leur environnement, et une évolution du concept même d’architecture traditionnelle. Cet article nous permet d’expliquer plus profondément le concept du Wen à la lumière du contexte marginal de l’île, ensemble situé au milieu de deux espaces économiques et politiques antagonistes. Après observation, il paraît évident que les habitants de Kinmen ont la volonté de construire et défendre leur identité en faisant souffler fort le vent « Wen ».Kinmen Island, only about 10 kilometres away from mainland China, is located opposite the city of Xiamen, Fujian Province. After retreating from the mainland in 1949, Chiang Kai-shek fled to Taiwan and made this island a military base where the KMT (the Chinese nationalist party) stationed much of the army with a view to retaking the mainland. Taiwan’s martial law was lifted in 1987 and the de-militarisation of Kinmen has led to a gradual influx of tourists. Visitors come to Kinmen for different reasons. Some people come to appreciate the natural scenery and historic dwellings that have not been affected or damaged by urban expansion, while others come to visit the remaining fortifications and military heritage of the Civil War. Given its crucial border situation, Kinmen has become an ideal field of observation to study Chinese culture and the natural heritage. Through the ethnographic fieldwork on the heritagisation process of Kinmen, the author tries to explain how the widely prevalent concept of ‘the wind of Wen blows strongly’ (Wen Feng Ding Sheng,文风鼎盛, flourishing literature and education) is reflected through the post-war heritage buildings. This expression actually reveals the Kinmen citizens’ strong attachment to their own history and environment. By describing and analysing the architectural and cultural phenomena in this particular border area between mainland China and Taiwan, this article helps us to obtain an in-depth understanding of the concept of ‘literary culture’ (Wen) in Chinese culture, as well as how residents of Kinmen establish and maintain a new post-war collective identity through the wind of Wen

    Genetic engineering-based approach to explore the bioactive potential of <i>Pseudoalteromonas rubra</i> S4059, a prodigiosin-producing marine bacterium

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    Antimicrobial resistance is a huge threat to global public health and we urgently need to discover novel antibiotics to treat infectious diseases. Most antibiotics are derived from natural products of microorganisms and they are typically encoded by biosynthetic gene clusters (BGCs) which are collections of the genes encoding biosynthetic enzymes that are responsible for natural compounds production. Mining of bacterial genomes has indicated that there is a large number of BGCs for which we do not yet know the chemistry; so a potentially untapped source of bioactive compounds in microorganisms. More recently, marine bacteria, for instance from the genus Pseudoalteromonas, have received attention due to their production of bioactive compounds, both enzymes and chemicals with drug activities with potential for pharmaceutical and industrial applications. The purpose of this project is to explore the bioactive potential of a pigmented bacterium Pseudoalteromonas rubra S4059 with genetic manipulation and cultivation-based approaches.Genome mining on pigmented Pseudoalteromonas has shown that these species harbor large amounts of orphan BGCs and have a large potential for novel compounds production, however, these orphan BGCs are considered “silent” under laboratory conditions. Mimicking the natural environment using ecological niche associated nutrients such as chitin, can induce secondary metabolite production in some Vibrios and also activate unknown BGCs. Chitin degradation is a trait for pigmented Pseudoalteromonas species and thus, we hypothesized that there also in Pseudoalteromonas could a link between chitin degradation and bacterial secondary metabolites production. Using proteomic, metabolomic and genetic approaches, we found that chitin does not significantly influence secondary metabolites production in S4059 as compared to other carbon sources, however, its degradation products, chitin monomer can induce the overall high production of secondary metabolites in S4059. Surprisingly, we found that growth on natural chitin surface leads to spontaneous mutation of S4059 that abolishes pigment production. The non-pigmented mutants appeared to have a fitness advantage as compared to the wildtype as the degree of autolysis was lower. Thus, we here for the first time report that growth on chitin surface can provide genetic diversity driving bacterial evolution of pigmented Pseudoalteromonas. Furthermore, we used the developed genetic manipulation approach to verify a prodigiosin BGC and found that a blue pigment, dipyrrolyldipyrromethene prodigiosin, was produced by the pigC mutant of P. rubra S4059. In conclusion, this work has contributed by developing a genetic approach to manipulate S4059 and thus has extended the genetic manipulation tools in this genus. Also, this work provides a novel sight on ecological niche driving pigmented Pseudoalteromonas evolution

    Research of Capacitance Voltage Balance Strategies for MMC

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    In order to achieve capacitance voltage balance of modular multilevel converter(MMC), it analyzed the components of the leg current, and then the quasi proportional resonance controller (PRC) was adopted to improve the inner loop tracking performance of voltage balance control based on the proportional plus integral(PI). At last, the simulation was carried out to verify this algorithm ability
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