252 research outputs found

    Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

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    Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer

    Kai-wang-chuntian-de-ditie = Spring subway

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    He has pretented that he is going to work everything by subway. For what

    The Effects of Nickel Substitution on Bismuth Ferrite

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    AbstractIn this paper, we studied the electrical conduction and spectroscopic properties of the Ni-doped BiFeO3 (BFO), which were prepared by the sol–gel method and sintered into powders or compact pellets. The changes of sintering conditions due to the addition of Ni were studied and the solubility of Ni in BFO was estimated. Photoluminescence measurements were carried out for the Ni-doped BFO samples and observed four emissions at about 451, 468, 513, and 689nm, respectively. The resistivity of the Ni doped BFO was reduced by more than three orders of magnitude than the un-doped BFO. The conductivity vs. temperature measurements revealed three activation energies, whose levels in the band gap matched well with the observed PL emission wavelengths

    The Economic Consequences of IPO Spinning

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    Using a sample of fifty-six companies going public in 1996--2000 in which top executives received allocations of other hot initial public offerings (IPOs) from the bookrunner, a practice known as spinning, we examine the consequences of spinning. The fifty-six IPOs had first-day returns that were, on average, 23% higher than similar IPOs. The profits collected by these executives were only a small fraction of the incremental amount of money left on the table by their companies when they went public. These companies were dramatically less likely to switch investment bankers in a follow-on offer: only 6% of issuers whose executives were spun switched underwriters, whereas 31% of other issuers switched. These findings suggest that the spinning of executives accomplished its goal of affecting corporate decisions. The Author 2010. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: [email protected]., Oxford University Press.

    Restoration Strategy Based on Optimal Relay Node Placement in Wireless Sensor Networks

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    In wireless sensor networks (WSNs), connecting disjoint segments is significant for network restoration, especially in some mission critical applications. However, the variability of distances between disjoint segments has tremendous influence on relay nodes deployment. In fact, finding the optimal solution for connecting disjoint segments in terms of the number and positions of relay nodes is NP-hard. To address this issue, plenty of heuristics, such as STP-MSP (Cheng et al., 2008), MST-1 t RN (Lloyd et al., 2007), and CORP (Lee and Younis, 2010) are deeply pursued. In this paper, we propose a distributed restoration algorithm based on optimal relay node placement (simply, ORNP). It aims at federating separated segments by populating the minimum number of relay nodes in a WSN that has suffered a significant damage. In addition, both of complexity and upper bound of the relay count for ORNP are explored. The simulation results show that ORNP performs better than STP-MSP, MST-1 t RN, and CORP in terms of relay count and the connectivity of resulting topology
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