367,204 research outputs found
Identification of Immune Gene Signature Associated with T Cells and Natural Killer Cells in Type 1 Diabetes [Corrigendum]
Full text linkWang N, Wang G, Feng X, Yang T. Diabetes Metab Syndr Obes. 2024;17:2983—2996.
The authors have advised the affiliation callouts in the author list on page 2983 are incorrect. The correct author callouts should read as follows:
Na Wang1, Guofeng Wang1,2, Xiuli Feng1, Teng Yang
Wang Shuo and the commercialisation of contemporary Chinese culture
Full text linkThis thesis examines the commercialisation of Chinese culture that has taken place over the past twenty years in mainland China. It explores the contribution of Wang Shuo, a cultural figure who straddles different fields of culture, moving from literature to the ultimate mass culture medium of television, this study plots Wang Shuo' s development from educational failure, to business failure, to fiction writer, film & TV editor, film director and cultural critic and analyst. His stories, films, TV series and articles have caused shock-waves throughout national cultural circles as he has transformed the terms of the debate from academic discourse to a validation of the role of the market in the culture field. Although Wang Shuo has not been labelled as a dissident, his approach to the culture market has had a more subversive effect on official ideology that those overt dissidents who have had to live in exile or have been imprisoned. He has utilised the language of official ideology to satirise the authorities, turning the ideology and its supporters into figures of fun. Yet his own goals have been strictly personal and economic ones. The authorities recognize the value of Wang Shuo's work in the cultural market but at the same time distrust his works and place him under strict censorship. Examining the way Wang Shuo and people surround him have succeeded in different fields of cultural achievement is a mirror to understanding the process of the transformation of contemporary Chinese culture from a socialist state-controlled culture to a market-oriented mass culture industry
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer
Full text linkCopyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.This article has been made available through the Brunel Open Access Publishing Fund.T-cell responses are induced by antigen presenting cells (APC) and signals from the microenvironment. Antigen persistence and inflammatory microenvironments in chronic infections and cancer can induce a tolerant state in T-cells resulting in hyporesponsiveness, loss of effector function, and weak biochemical signaling patterns in response to antigen stimulation. Although the mechanisms of T-cell tolerance induced in chronic infection and cancer may differ from those involved in tolerance to self-antigen, the impaired proliferation and production of IL-2 in response to antigen stimulation are hallmarks of all tolerant T cells. In this review, we will summarize the evidence that the immune responses change from non-self to “self”-like in chronic infection and cancer, and will provide an overview of strategies for re-balancing the immune response of antigen-specific T cells in chronic infection and cancer without affecting the homeostasis of the immune system.Arthritis Research UK and Medical Research Council UK
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Insight into the Progress in CAR-T Cell Therapy and Combination with Other Therapies for Glioblastoma
No full textTingyu Liang,* Yixuan Song,* Lingui Gu, Yu Wang, Wenbin Ma Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenbin Ma; Yu Wang, Email [email protected]; [email protected]: Glioblastoma (GBM) is the most common malignant primary brain cancer in adults. It is always resistant to existing treatments, including surgical resection, postoperative radiotherapy, and chemotherapy, which leads to a dismal prognosis and a high relapse rate. Therefore, novel curative therapies are urgently needed for GBM. Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved life expectancy for hematological malignancies patients, and thus it increases the interest in applying CAR-T cell therapy for solid tumors. In the recently published research, it is indicated that there are numerous obstacles to achieve clinical benefits for solid tumors, especially for GBM, because of GBM anatomical characteristics (the blood–brain barrier and suppressive tumor microenvironment) and the tumor heterogeneity. CAR-T cells are difficult to penetrate blood–brain barrier, and immunosuppressive tumor microenvironment (TME), which induces CAR-T cell exhaustion, impairs CAR-T cell therapy response. Moreover, under the pressure of CAR-T cell therapy, the tumor heterogeneity and tumor plasticity drive tumor evolution and therapy resistance, such as antigen escape. Nonetheless, scientists strive for strategies to overcome these hurdles, including novel CAR-T cell designs and regional delivery. For instance, the structure of multi-antigen-targeted CAR-T cells can enrich CAR-T accumulation in tumor TME and eliminate abundant tumor cells to avoid tumor antigen heterogeneity. Additionally, paired with an immune modifier and one or more stimulating domains, different generation of innovations in the structure and manufacturing of CAR-T cells have improved efficacy and persistence. While single CAR-T cell therapy receives limited clinical survival benefit. Compared with single CAR-T cell therapy, the combination therapies have supplemented the treatment paradigm. Combinatorial treatment methods consolidate the CAR-T cells efficacy by regulating the tumor microenvironment, optimizing the CAR structure, targeting the CAR-T cells to the tumor cells, reversing the tumor-immune escape mechanisms, and represent a promising avenue against GBM, based on multiple impressive research. Moreover, exciting results are also reported to be realized through combining effective therapies with CAR-T cells in preclinical and clinical trials samples, have aroused inspiration to explore the antitumor function of combination therapies. In summary, this study aims to summarize the limitation of CAR-T cell therapies and introduces novel strategies to enhance CAR-T cell function as well as prospect the potential of the therapeutic combination.Keywords: CAR-T, GBM, novel strategies, therapeutic combinatio
Wang Meng and contemporary Chinese literature: the vicissitudes of a committed writer
Full text linkThis thesis examines the way Wang Meng has developed as a writer from the 1950s to the 1990s in the context of New China's political and literary background. It looks at the compromises he was forced to make between his political beliefs in the Communist Party and his chosen role as a professional writer. After his disastrous early foray into what was deemed to be unacceptable political criticism with The Young Newcomer in the Organisation Department in the 1950s, when the opportunity came to start publishing again in the late 1970s he was boldly innovative in style, helping to transform New Period literature, but conservative in content, sticking to politically acceptable topics. It was only with Hard Porridge in 1989 that he ventured again, and very successfully, into political comment. There is no outstanding leading writer in contemporary China, but Wang Meng is a leading contender for the title
taiyi-wang/seis3D: v1.0.0
No full textCode that accompanies the publication of:
Wang, T. A., Dunham, E. M., Hindcasting injection-induced aseismic slip and microseismicity at the Cooper Basin Enhanced Geothermal Systems Project: Scientific Reports (2022)
H ? filtering for stochastic singular fuzzy systems with time-varying delay
Full text linkThis paper considers the H? filtering problem
for stochastic singular fuzzy systems with timevarying
delay. We assume that the state and measurement
are corrupted by stochastic uncertain exogenous
disturbance and that the system dynamic is modeled
by Ito-type stochastic differential equations. Based on
an auxiliary vector and an integral inequality, a set of
delay-dependent sufficient conditions is established,
which ensures that the filtering error system is e?t -
weighted integral input-to-state stable in mean (iISSiM).
A fuzzy filter is designed such that the filtering
error system is impulse-free, e?t -weighted iISSiM and
the H? attenuation level from disturbance to estimation
error is belowa prescribed scalar.Aset of sufficient
conditions for the solvability of the H? filtering problem
is obtained in terms of a new type of Lyapunov
function and a set of linear matrix inequalities. Simulation
examples are provided to illustrate the effectiveness
of the proposed filtering approach developed in
this paper
Sv40 T/T-Common Polypeptide Specifically Induces Apoptosis in Human Cancer Cells That Overexpress Her2/Neu
No full textPreviously, we reported that SV40 T/t-common polypeptide, which contains the NH2-terminal common domain of SV40 large T and small t antigens, can repress HER2/neu (also known as erbB-2) expression and consequently suppress the tumorigenic potential of the HER2/neu-overexpressing ovarian carcinoma cells. Here we report that T/t-common could specifically induce apoptosis in HER2/neu-overexpressing human cancer cell lines but not in nontransformed cell lines and HER2/neu low-expressing human cancer cell lines. The ability of T/t- common to induce apoptosis in HER2/neu- overexpressing cancer cells was derived from its ability to inhibit HER2/ neu because reexpression of a large amount of HER2/neu could block apoptosis induced by T/t-common. T/t-common expression in HER2/neu- overexpressing SK-OV-3 cancer cells led to down-regulation of Bcl-2 and Bcl-X-L, and overexpression of Bcl- 2 could inhibit the ability of T/t- common to induce apoptosis in these cells. Therefore, the apoptosis- inducing activity of T/t-common is related to its ability to inhibit Bcl-2 expression in HER2/neu- overexpressing cancer cells. Consistent with the apoptosis- inducing activity of T/t- common, we found that T/t-common could specifically inhibit the soft-agarose colony-forming ability of the HER2/neu- overexpressing human cancer cell lines but not that of the HER2/ neu low-expressing human cancer cell lines. Finally, we showed that T/t- common could specifically sensitize HER2/ neu-overexpressing human cancer cell lines, but not HER2/neu. low-expressing human cancer cell lines, to chemotherapeutic agent etoposide. Together, these data suggest that T/t- common alone or in combination with chemotherapy may provide a new approach for treatment of cancers that overexpress HER2/neu
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