521 research outputs found
Frequently Asked Q
No full textMike Qaissaunee, an Associate Professor of Engineering and Technology at Brookdale Community College, is the author of this blog and "shares his experiences and perspectives on integrating new technologies in and approaches to teaching and learning." Qaissaunee's blog, titled "Frequently Asked Q," gives insight into everything from web design, Twitter, and Google, to how economic downturns can effect his profession. The author provides links to other related blogs that address, and sometimes further elaborate, his discussions. Links to helpful videos are also used to engage the reader. This is a nice collection of ideas and interactive media that present Qaissaunee's point of view towards the professional world of technology and engineering
Frequently Asked Q
No full textMike Qaissaunee, an Associate Professor of Engineering and Technology at Brookdale Community College, is the author of this blog and "shares his experiences and perspectives on integrating new technologies in and approaches to teaching and learning." Qaissaunee's blog, titled "Frequently Asked Q," gives insight into everything from web design, Twitter, and Google, to how economic downturns can effect his profession. The author provides links to other related blogs that address, and sometimes further elaborate, his discussions. Links to helpful videos are also used to engage the reader. This is a nice collection of ideas and interactive media that present Qaissaunee's point of view towards the professional world of technology and engineering
The transcription factor IRF4 and ThPOK regulates ILC3 lineage homeostasis and function during intestinal infection
No full textThe work described in this thesis adds several factors as essential regulators to the list of transcriptional network effectors that guide the development of ILC3s, including IRF4, GATA3, Tbx21, ThPOK, and RORγt. This study describes how these transcriptional networks interact in vivo to control the functionality and phenotypical polarization of mature ILC3 subpopulations, illustrating the complicated interactions between classical ILC-associated TFs and their varying post-developmental requirements.
IRF4 sustained ILC3s maintenance, as mice lacking IRF4 displayed dysregulated phenotype and function, resulting in increased susceptibility to C. rodentium and Candida albicans infection. The integrated analysis revealed that IRF4 sustains ILC3 function and maintenance via directly binding to Il17a, Il22, and Gata3. Another highly conserved transcription factor ThPOK sustained the maintenance of ILC3s, as ThPOK deficient mice displayed reduced NKp46 positive ILC3s and rising DN ILC3s. Loss of ThPOK also impaired the IFN-γ production of NKp46⁺ ILC3s, leading to increased susceptibility to S. Typhimurium infection. On the contrary, ThPOK modulates ILC3-mediated immunity against C. rodentium infection by negatively controlling IL-17A production through the IL-23/IL-17 axis. Taken together, this thesis has enabled preliminary integrated analysis of the interplay among ThPOK, RORγt, IRF4, GATA3, and T-bet to modulate ILC3 functionality and induce the balance of transition programs within ILC3 subpopulations. These findings emphasize the significance of taking into account both antagonistic and cooperative transcription factors as this thesis intends to clarify how ILCs retain their identity and essential functions after development and hence preserve tissue homeostasis
Laboratory Studies of Hypervelocity Impacts on Solar System Analogues
No full textImpact cratering and asteroid collisions are major processes throughout the Solar System. Although previous collision-related impact investigations exist (Flynn et al. 2015, Holsapple et al. 2002 and Burchell et al. 1998 are good examples), in the works covering this broad range of investigation, the targets are non-rotating (for the purposes of catastrophic disruption) and different temperature conditions are not considered (for impact cratering). Accordingly, I present experimental processes and data, regarding hypervelocity impact experiments into analogues of (1) rotating asteroids and (2) temperature dependant terrestrial planetary rock.
During the course of this work, it was necessary to develop new apparatus and new experimental techniques such as three separate target holders to aid in both catastrophic disruption and heated impact projects, a 3-dimensional model analysis of craters and a completely new, statistically robust, technique to determine a complete crater profile called the KDM method where KDM is Kinnear-Deller-Morris.
The main result from this work showed that during an asteroid impact collision where the asteroid is not rotating, the impact energy density for catastrophic disruption is Q*static = 1442 ± 90 J kg-1. However, when the target asteroid was rotating, the condition Q*rotation = 1097 ± 296 J kg-1. The mean value of Q* had thus reduced, but the spread in the data on individual experiments was larger. This leads to two conclusions. The mean value for Q*, based on measurements of many impacts, falls, due to the internal forces acting in the body which are associated with the rotation. This energy term reduction means that the amount of energy to instigate catastrophic disruption is lower and that a rotating asteroid is effectively weaker upon impact than a stationary asteroid. However, the spread in the results indicates that this is not a uniform process, and an individual result for Q* for a rotating or spinning target may be spread over a large range. For the temperature related impacts, as the targets were heated to approximately 1000 K, the target rocks showed an impact dependence more similar to a plastic phase-state than to solidus, due to being held close to temperatures associated with semi-plastic phases. Basalt impact craters displayed this relationship greatest with crater sizes becoming smaller at the higher temperature ranges but larger in the colder brittle solidus temperatures, partly explained in experiments by increased spallation
National architecture conference 2012
No full textMay was a particularly busy month with lots of exciting architectural things happening in Brisbane, including the sell-out 2012 National Architecture Conference. The total number of conference attendees was 1,625, which was the largest number of attendees to any Australian National Architecture Conference to date. This was the first time that the National Architecture Conference had been held in Brisbane in over 20 years, and the enormous turnout of 947 Queenslanders to the conference was testament to the positive decision to include Brisbane as a conference venue.\ud
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The theme of this year’s conference was ‘experience’. Building on ideas introduced in the recent ‘natural artifice’ conference, creative directors Shane Thompson, Michael Rayner and Peter Skinner focused closely on the\ud
real, sensed experience of architecture within its natural and constructed settings and the experience of designing and making architecture. The conference attracted a variety of high profile international speakers, including architect and professor, Wang Shu, the 2012 Pritzker Architecture Prize Laureate and co-founder of the Amateur Architecture Studio in China. Other highlights included presentations from Peter Rich [South Africa], Kathryn Findlay [United Kingdom], Rachel Neeson [Australia], Anuradha Mathur & Dilip da Cunha [United States] and Kjetil Thorsen [Norway].\ud
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QUT had a strong presence at the conference. In addition to pleasing attendance rates from QUT School of Design students and staff, our Head-of-School Professor Paul Sanders, was given the honourable task of introducing keynote speaker Peter Rich, and facilitating the Q&A session after his presentation, which received a standing ovation. There were many events organised for students and young architects by QUT’s SONA reps, including a masterclass, opening party, collaborative design and construction of the SONA Pavilion, and finally, organisation of the all important SONA Hangover Breakfast, the morning after the closing party.\ud
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The 2012 National Architecture Conference was truly memorable and an experience not to have been missed. I encourage anyone with a passion for architecture and a desire to be completely inspired by current and emerging leaders in our exciting profession, to start making plans to attend next year’s conference
Discussion and evaluation of the updated UTAUT Model in IAMSs
No full textThe modern world is populated with a great many physical and virtual IAMS (Identity Access Management Systems), where people need to maintain various login credentials. There is a key issue associated with this approach, which is the ability to remember this information; however, this can be circumvented to some degree through utilising an innovative approach of a single sign-in mechanism. Throughout the course of recent times, a number of different systems have been developed in order to deliver both virtual and physical IAMS. Moreover, in addition to a greater level of awareness to ensure interoperable virtual and physical IAMS are implemented, there is a pressing urgency for clear guidelines to be devised relating to the integration of: security, comprising identity; user experience, involving usability; and acceptability, encompassing accessibility. Very few models adhere to such guidelines; therefore, this paper seeks to deal with the pressing need to devise, implement and evaluate a model for acceptable user experience, enabling the successful integration of physical and virtual public services in an e-government context. In regard to the users’ assessment, which tests the suggested Unified Theory of Acceptance and Use of Technology (UTAUT), it was observed that there is an indirect impact on behavioural intention to utilise a new prototype system (Ubiquitous Identity Access Management System ”UbIAMS” ) through various factors, namely effort expectancy, performance expectancy and social influence, as well as through items relating to acceptability and user experience
The application of Mike Urban model in drainage and waterlogging in Lincheng county, China
No full textRecently, the water disaster in cities especially in Chinese
mountainous cities is more serious, due to the coupling influences of
waterlogging and regional floods. It is necessary to study the surface
runoff process of mountainous cities and examine the regional drainage
pipeline network. In this study, the runoff processes of Lincheng county
(located in Hebei province, China) in different scenarios were simulated
through Mike Urban model. The results show that all of the runoff process of
the old town and the new residential area with larger slope, is significant
and full flow of these above zones exists in the part of the drainage
pipeline network; and the overflow exists in part of the drainage pipeline
network when the return period is ten years or twenty years, which
illuminates that the waterlogging risk in this zone of Lincheng is higher.
Therefore, remodeling drainage pipeline network in the old town of
Lincheng and adding water storage ponds in the new residential areas were
suggested. This research provides both technical support and decision-making
reference to local storm flood management, also give the experiences for the
study on the runoff process of similar cities
Flux pumping studies and T<inf>i</inf> peaking by q-profile shaping using ECCD in ASDEX Upgrade
No full textOn ASDEX Upgrade a prioritized ‘advanced Tokamak’ program has been run during the last two experimental campaigns, focusing on the effect of non-standard current profiles on the behavior of high beta plasmas. Two lines of non-standard (i.e. non-sawtoothing) q-profiles are followed: (1) plasma self-organization of centrally flat q-profiles (qmin ≈ 1) via ‘flux pumping’, here based on a naturally occurring continuous (1,1) mode and (2) externally shaped q-profiles with qmin > 1, allowing for more experimental freedom of the q-profile to be established. The advantages and requirements of both concepts are discussed. The invited presentation at the workshop focuses on specific effects of Electron Cyclotron Current Drive (ECCD). With respect to flux pumping it could be shown that increasing the plasma beta raises the flux pumping capability. More central co-ECCD can be redistributed if beta is increased. This is in line with qualitative theory. For the case with qmin > 1, it is shown that small variations of the ECCD profile can modify the peaking of the central ion temperature. For larger radii no significant changes of the kinetic profiles have been observed as the q-profile is changed. H-factors have not exceeded 1.2, well below the assumptions of several models for steady state tokamak operation. To achieve these changes of q at larger radii we have used ctr-ECCD in the plasma center, increasing the ohmic current globally. The net effect of central ctr-ECCD and increased ohmic current is a strong off-axis current drive, allowing H-modes with Te ≈ Ti ≈ 8 keV and n̄e ≈ 6 · 1019m−3 ≈ 0.5 nGW at q95 = 4 to be run stationary with qmin ≈ 1.4. The design of these discharges was strongly supported by inter-shot model based optimization.SPC-T
Visualization studies on evidence-based medicine domain knowledge (series 2): structural diagrams of author networks.
No full textOBJECTIVE: To investigate the output of evidence-based medicine (EBM) researchers in China and elsewhere by examining the EBM domains they work within and the networks that exist among them; using visualization methods to analyze these relationships. This maps the current situation and helps with the identification of areas for future growth. METHODS: We used co-citation matrixes with Pathfinder networks and hierarchical clustering algorithms, and constructed a co-author matrix which were analyzed with a whole network approach. The analyzed matrixes were visualized with the UCINET program. RESULTS: Much of the development of EBM has been centered around three authors, David Sackett, Gordon Guyatt and L Manchikanti, within three different clusters. The main authors of EBM articles in China were divided into nine academic domains. The relations among core authors of articles indexed by the Science Citation Index (SCI) was loose. There was a stronger co-authorship network among core authors in the Chinese literature, with three groups and 21 cliques. Nine distinct academic communities appeared to have formed around Li Youping, Liu Ming and Zhang Mingming. CONCLUSION: The EBM literature contains several key clusters, with universities in high-income countries being the source of the majority of articles. Outside China, McMaster University in Canada, the original home of EBM, is the dominant producer of EBM publications. In China, Sichuan University is the main source of EBM publications. The EBM cooperation network in China is comprised of three major groups, the largest and most productive in this sample is led by Li Youping with Liu Ming, Zhang Mingming, Li Jing, Wang Li, Wu Taixiang, and Liu Guanjian as central members
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