35 research outputs found
AN IMPROVED PRICING SCHEME WITH ONE - STEP SURVIVAL METHOD
No full textBachelor'sBACHELOR OF SCIENCE (HONOURS
Dual-action self-healing protective coatings with photothermal responsive corrosion inhibitor nanocontainers
No full textThis work introduces a novel nanocomposite coating with dual-action self-healing corrosion protection activated by the photothermal response of plasmonic titanium nitride nanoparticles (TiN NPs). TiN@mesoporous SiO2 core–shell nanocontainers were developed as reservoirs for benzotriazole (BTA) corrosion inhibitors and incorporated into the shape memory epoxy coating matrix. Under near-infrared (NIR) light irradiation, the thermogenesis effect of TiN could not only promote the release of corrosion inhibitors from nanocontainers into the crevice, but also trigger the shape memory effect of damaged epoxy to merge the coating scratch. As such, the dual-action self-healing mechanisms combining the formation of an inhibitor-based protective layer and the scratch closure efficiently suppressed the corrosion process at the exposed metal surface. Surface characterization and electrochemical measurement results proved that the nanocomposite coating incorporated with 2 wt% of TiN-BTA@SiO2 exhibited the optimal corrosion protection as well as an excellent self-healing performance that can be initiated within 30 s of NIR illumination. This photo-controlled self-healing approach is potentially useful in designing next-generation self-healing coatings with ultrafast response time and high healing efficiency.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
Hypoxia-induced the upregulation of stromal cell-derived factor 1 in fibroblast-like synoviocytes contributes to migration of monocytes into synovium tissue in rheumatoid arthritis
No full textHypoxia-induced the upregulation of stromal cell-derived factor 1 in fibroblast-like synoviocytes contributes to migration of monocytes into synovium tissue in rheumatoid arthritis
No full textAbstract Background Rheumatoid arthritis (RA) is an auto-immune disease characterized by chronic inflammation of multiple joints. Hypoxia is a constant feature of synovial microenvironment in RA. Fibroblast-like synoviocytes (FLSs), which are potent effector cells in RA. It has been reported that large numbers of monocytes are recruited to the synovium and play an important role in synovial inflammation and tissue destruction in RA. However, the mechanism is still unclear. The aim of this study is to explore the role of hypoxia microenvironment on the recruitment of monocytes and then promote the development of RA. Methods Rheumatoid arthritis model was constructed. Monocytes and FLSs were isolated from rheumatoid arthritis mice. RT-PCR, western blot and ELISA were used to detect the expression of SDF-1 in FLSs. CXCR4 expression in monocytes was examined by cell immunofluorescence and flow cytometry analysis. Transwell assay was performed to evaluate the potential of cell migration. Results We demonstrated that hypoxia microenvironment enhanced SDF-1 production of FLSs, which attracted the recruitment of CXCR4-expressing monocytes to the synovium and induced monocytes differentiation into tissue macrophages. Moreover, these macrophages secreted inflammatory factors including IL-6, TNF-α, IL-1β and MMP-3, which contributed to the synovial inflammation and tissue destruction in RA. Conclusion The results of this study suggested that hypoxia microenvironment played an important role in enhancing SDF-1 production of FLSs. SDF-1/CXCR4 axis was involved in the recruitment of monocytes in RA synovium and it might be a possible way of inhibiting inflammation and bone erosion in RA
NIR Light-, Temperature-, pH-, and Redox-Responsive Polymer-Modified Reduced Graphene Oxide/Mesoporous Silica Sandwich-Like Nanocomposites for Controlled Release
No full textPhoto, pH and redox multi-responsive nanogels for drug delivery and fluorescence cell imaging
No full textA light, pH and redox triple-responsive spiropyran-based nanogel is prepared and applied for the efficient delivery of anticancer drugs and fluorescence cell imaging for the strong emission of merocyanine photoisomers.</p
Efficacy of the MIPO approach combined with inverted Philos plate fixation in the treatment of AO/OTA type 12B distal humeral shaft fractures
No full textHigh-temperature ferromagnetism in two-dimensional material MnSn originated from interlayer coupling
No full textMnSn monolayer synthesized recently is a novel two-dimensional ferromagnetic
material with a hexagonal lattice, in which three Mn atom come together to form
a trimer, making it remarkably different from other magnetic two-dimensional
materials. Most impressively, there happens a sharp increase of Curie
temperature from 54 K to 225 K when the number of layers increase from 1 to 3.
However, no quantitative explanation is reported in previous studies. Herein,
by means of first-principle calculations method and Monte carlo method, we
demonstrate that strong interlayer ferromagnetic coupling is the essential role
in enhancing its critical temperature, which act as a magnetic field to
stabilize the ferromagnetism in the MnSn multilayers
NIR-Light- and pH-Responsive Graphene Oxide Hybrid Cyclodextrin-Based Supramolecular Hydrogels
No full textHere, a novel triple-responsive graphene oxide hybrid supramolecular
hydrogel based on the electrostatic self-assembly between graphene
oxide and a quaternized polymer and the host–guest inclusion
between α-cyclodextrins and poly(ethylene glycol) monomethyl
ether (mPEG) was constructed. The quaternized polymer was synthesized
by quaternization between pH-sensitive poly(N,N-dimethylaminoethyl methacrylate) and bromine end-capped
poly(ethylene glycol) monomethyl ether. The supramolecular hydrogels
prepared from the host–guest inclusion of poly(ethylene glycol)
monomethyl ether and α-cyclodextrins would turn into a mobile
sol phase when the temperature was increased above a certain temperature
(Tgel–sol). Graphene oxide sheets not only acted as a core
material to provide additional cross-linking but also absorbed NIR
light and converted NIR light into heat to trigger the gel–sol
transition. The constructed graphene oxide hybrid cyclodextrin-based
supramolecular hydrogels could respond to NIR light, temperature,
and pH, which could be beneficial for controlled release of cargoes
and would hold great promise in the field of delivery systems
Positive Rates and Factors Associated with Abnormal Lung Function of Greenhouse Workers in China: A Cross-Sectional Study
No full textSince the number of greenhouse workers are increasing in China, this observational cross-sectional study was designed to evaluate lung function and discuss the potential risk factors, to provide evidence in the surveillance of greenhouse workers' health. 678 greenhouse workers in Gansu Province, China were enrolled. A questionnaire which included demographic and occupational information was used. Vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1: FVC ratios (FEV1/FVC), maximal expiratory flow after 50% of the FVC has not been exhaled (MEF50), maximal expiratory flow after 25% of the FVC has not been exhaled (MEF25) and maximal mid-expiratory flow curve (MMEF) were measured as lung function indicators. The mean values and standard deviations (SDs) of VC% predicted, FVC% predicted, FEV1% predicted and FEV1/FVC ratio were 106.07 +/- 13.36, 107.60 +/- 13.95, 97.19 +/- 14.80 and 89.76 +/- 10.78 respectively. The positive rates of above four and abnormal lung ventilation function were 2.9%, 2.8%, 11.2%, 4.6% and 6.5% respectively. Gender, age, BMI and number of greenhouses owned were influence factors of lung ventilation function (p < 0.05). The mean values and SDs of MEF50% predicted, MEF25% predicted and MMEF% predicted were 69.63 +/- 24.95, 54.04 +/- 24.94 and 66.81 +/- 24.53. The positive rates of above three and abnormal small airway function were 45.0%, 72.1%, 47.2% and 49.4% respectively. Age, education and number of greenhouses owned were influence factors for small airway function (p < 0.05). Working in a greenhouse might influence lung function of the workers. Small airway function indicators could be used as priority indicators for the surveillance of greenhouse workers' health.SCI(E)SSCIARTICLE91
